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Although thyroid dysfunction is considered to be a common and potentially serious adverse effect of amiodarone therapy, the exact pathogenesis remains unknown because of its complex manifestations. Therefore, the prevalence of, and risk factors for, amiodarone\u2010induced thyroid dysfunction in Japanese patients were investigated in the present study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of patients treated with amiodarone between January 2012 and December 2013 was performed. A total of 317 patients with euthyroidism, or subclinical hyperthyroidism or hypothyroidism, were enrolled in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After being treated with amiodarone, 30 (9.5%) and 60 patients (18.9%) developed amiodarone\u2010induced hyperthyroidism and amiodarone\u2010induced hypothyroidism, respectively. Ten (33.3%) patients with amiodarone\u2010induced hyperthyroidism and 40 (66.6%) with amiodarone\u2010induced hypothyroidism were diagnosed within two years of the initiation of amiodarone therapy. Dilated cardiomyopathy (DCM) [Adjusted odds ratio (OR) 3.30 (95% confidence interval (CI): 1.26\u20138.90)], and cardiac sarcoidosis [Adjusted OR 6.47 (95% CI: 1.60\u201325.77)] were identified as predictors of amiodarone\u2010induced hyperthyroidism. The baseline free thyroxine (T4) level [Adjusted OR 0.13 (95% CI: 0.03\u20130.68)], and thyroid\u2010stimulating hormone (TSH) level [Adjusted OR1.47 (95% CI: 1.26\u20131.74)] were identified as predictors of amiodarone\u2010induced hypothyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DCM and cardiac sarcoidosis were identified as risk factors for amiodarone\u2010induced hyperthyroidism. Risk factors for amiodarone\u2010induced hypothyroidism included higher baseline TSH level and lower baseline free T4 level, suggesting that subclinical hypothyroidism may be a potential risk factor for the development of amiodarone\u2010induced hypothyroidism.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.joa.2016.03.008","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T15:28:45Z","timestamp":1462462125000},"page":"474-480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Risk factors for amiodarone\u2010induced thyroid dysfunction in 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