{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:10:55Z","timestamp":1779243055072,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T00:00:00Z","timestamp":1476835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","journalofarrhythmia.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ablation targeting complex fractionated atrial electrograms (CFAEs) or high dominant frequency (DF) sites is generally effective for persistent atrial fibrillation (AF). CFAEs and\/or high DF sites may exist in low\u2010voltage regions, which theoretically represent abnormal substrates. However, whether CFAEs or high DF sites reflect low voltage substrates during sinus rhythm (SR) is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen patients with AF (8 with paroxysmal AF; 8, persistent AF) underwent high\u2010density mapping of the left atrium (LA) with a 3\u2010dimensional electroanatomic mapping system before ablation. The LA was divided into 7 segments and the mean bipolar voltage recorded during AF and SR, CFAEs (cycle lengths of 50\u2013120 ms), and DF sites were assessed in each segment with either a duo\u2010decapolar ring catheter (n=10) or a 64\u2010pole basket catheter (n=6). Low\u2010voltage areas were defined as those of &lt;0.5 mV during AF and &lt;1.0 mV during SR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regional mean voltage recorded from the basket catheter showed good correlation between AF and SR (r=0.60, <jats:italic>p<\/jats:italic>&lt;0.01); however, the % low\u2010voltage area in the LA recorded from the ring catheter showed weak correlation (r=0.34, <jats:italic>p<\/jats:italic>=0.05). Mean voltage was lower during AF than during SR (1.0 mV [IQR, 0.5\u20131.4] vs. 2.6 mV [IQR, 1.8\u20133.6], <jats:italic>p<\/jats:italic>&lt;0.01). The regional and overall % low\u2010voltage area of the LA was greater during AF than during SR (20% vs. 11%, <jats:italic>p<\/jats:italic>=0.05). CFAEs and high DF sites (&gt;8 Hz) did not correlate with % low\u2010voltage sites during SR; however, CFAEs sites were located in high\u2010voltage regions during AF and high DF sites were located in low voltage regions during AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CFAEs and high DF areas during AF do not reflect damaged atrial myocardium as shown by the SR voltage. However, CFAEs and high DF sites may demonstrate different electrophysiologic properties because of different voltage amplitude during AF.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.joa.2016.10.001","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T01:01:40Z","timestamp":1477616500000},"page":"185-191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Complex fractionated atrial electrograms, high dominant frequency regions, and left atrial voltages during sinus rhythm and atrial fibrillation"],"prefix":"10.1002","volume":"33","author":[{"given":"Naoko","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Nagashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikitake","family":"Kogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Sonoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Iso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuta","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimie","family":"Ohkubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiko","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Nikaido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct1109977"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.054"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.00307.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-006-9045-1"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00930.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02128.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12166"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2015.07.010"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur197"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-012-9748-4"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-011-9637-2"},{"key":"e_1_2_7_13_2","first-page":"S272","article-title":"Targeted ablation of atrial fibrillation low voltage regions is associated with high rate of AF freedom despite low RF delivery \u2013 a novel substrate\u2010based ablation approach for persistent atrial fibrillation","volume":"11","author":"Jadidi A.","year":"2014","journal-title":"Heart Rhythm"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.112.971200"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.812024"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.10.024"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.06.019"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.4264\/numa.75.6_260"},{"key":"e_1_2_7_19_2","article-title":"Ablation of persistent atrial fibrillation targeting low voltage areas with selective activation characteristics","volume":"9","author":"Jadidi A.S.","year":"2016","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"e_1_2_7_20_2","first-page":"I\u20102310","article-title":"Efficacy of line ablation based on low voltage areas in patients with cardioversion resistent atrial fibrillation","volume":"80","author":"Yamazaki T.","year":"2016","journal-title":"Circ J."},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.001251"},{"key":"e_1_2_7_22_2","first-page":"I\u2010741","article-title":"Low voltage zone (LVZ) harbors rotors: an analysis with a novel (quasi\u2010) real time phase mapping system called \u201cExTRa Mapping\u201d","volume":"79","author":"Fukui A.","year":"2015","journal-title":"Circ J."},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-013-9838-y"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus321"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.02.023"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2011.03071.x"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.964197"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.081"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euq033"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.05.021"}],"container-title":["Journal of Arrhythmia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1880427616301387?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1880427616301387?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.joa.2016.10.001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:17:22Z","timestamp":1695975442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.joa.2016.10.001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,27]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1016\/j.joa.2016.10.001"],"URL":"https:\/\/doi.org\/10.1016\/j.joa.2016.10.001","archive":["Portico"],"relation":{},"ISSN":["1880-4276","1883-2148"],"issn-type":[{"value":"1880-4276","type":"print"},{"value":"1883-2148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,27]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complex fractionated atrial electrograms, high dominant frequency regions, and left atrial voltages during sinus rhythm and atrial fibrillation","name":"articletitle","label":"Article Title"},{"value":"Journal of Arrhythmia","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.joa.2016.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Japanese Heart Rhythm Society. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}