{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:51:42Z","timestamp":1789685502623,"version":"4.0.1"},"reference-count":104,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral Biosciences"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.job.2021.02.007","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T07:14:49Z","timestamp":1615101289000},"page":"111-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Critical features of periodontal flaps with regard to blood clot stability: A review"],"prefix":"10.1016","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2128-9010","authenticated-orcid":false,"given":"Muhammad Saad","family":"Shaikh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5157-7067","authenticated-orcid":false,"given":"Muhammad Sohail","family":"Zafar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Pisani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohid Abrar","family":"Lone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5815-8263","authenticated-orcid":false,"given":"Yasser Riaz","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.job.2021.02.007_bib1","first-page":"158","article-title":"Significance of early healing events on periodontal repair: a review","volume":"63","author":"Wikesjo","year":"1992","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib2","first-page":"1528","article-title":"The wound healing process: an overview of the cellular and molecular mechanisms","volume":"37","author":"Velnar","year":"2009","journal-title":"J\u00a0Int Med"},{"key":"10.1016\/j.job.2021.02.007_bib3","first-page":"5","article-title":"Early healing events at the dentin-connective tissue interface. Light and transmission electron microscopy observations","volume":"62","author":"Wikesjo","year":"1991","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1600-0757.2006.00157.x","article-title":"Biology and principles of periodontal wound healing\/regeneration","volume":"41","author":"Polimeni","year":"2006","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.job.2021.02.007_bib5","first-page":"758","article-title":"Collagen linkage in periodontal connective tissue reattachment. An ultrastructural study in beagle dogs","volume":"59","author":"Selvig","year":"1988","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/2231-0754.134135","article-title":"Histological and clinical evaluation of gingival healing following gingivectomy using different treatment modalities","volume":"5","author":"Meenawat","year":"2013","journal-title":"J\u00a0Int Clin Dent Res Organ"},{"key":"10.1016\/j.job.2021.02.007_bib7","first-page":"11","article-title":"Repair following mucoperiosteal flap surgery with full gingival retention","volume":"39","author":"Hiatt","year":"1968","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1177\/154411130201300605","article-title":"Cementum and periodontal wound healing and regeneration","volume":"13","author":"Grzesik","year":"2002","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.job.2021.02.007_bib9","first-page":"637","article-title":"Occlusal forces promote periodontal healing of transplanted teeth and prevent dentoalveolar ankylosis: an experimental study in rats","volume":"75","author":"Mine","year":"2005","journal-title":"Angle Orthod"},{"key":"10.1016\/j.job.2021.02.007_bib10","series-title":"Clinical periodontology and implant dentistry","author":"Lindhe","year":"2015"},{"key":"10.1016\/j.job.2021.02.007_bib11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0163-7258(91)90034-J","article-title":"Angiogenesis in wound healing","volume":"52","author":"Arnold","year":"1991","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.job.2021.02.007_bib12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1046\/j.1087-0024.2000.00014.x","article-title":"Angiogenesis in wound healing","author":"Tonnesen","year":"2000","journal-title":"J\u00a0Invest Dermatol Symp Proc"},{"key":"10.1016\/j.job.2021.02.007_bib13","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1177\/0022034514563750","article-title":"Gingival wound healing: an essential response disturbed by aging?","volume":"94","author":"Smith","year":"2015","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.job.2021.02.007_bib14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1600-0501.2005.01225.x","article-title":"Angiogenesis pattern of native and cross-linked collagen membranes: an immunohistochemical study in the rat","volume":"17","author":"Schwarz","year":"2006","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.job.2021.02.007_bib15","first-page":"681","article-title":"Blood supply of human gingiva following periodontal surgery. A fluorescein angiographic study","volume":"48","author":"Mormann","year":"1977","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib16","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1600-051X.2007.01119.x","article-title":"Comparison of gingival blood flow during healing of simplified papilla preservation and modified Widman flap surgery: a clinical trial using laser Doppler flowmetry","volume":"34","author":"Retzepi","year":"2007","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib17","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1600-051X.2007.01062.x","article-title":"Gingival blood flow changes following periodontal access flap surgery using laser Doppler flowmetry","volume":"34","author":"Retzepi","year":"2007","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1600-051X.1982.tb02095.x","article-title":"New attachment following surgical treatment of human periodontal disease","volume":"9","author":"Nyman","year":"1982","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib19","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1600-051X.1984.tb00901.x","article-title":"New attachment formation as the result of controlled tissue regeneration","volume":"11","author":"Gottlow","year":"1984","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib20","first-page":"114","article-title":"Guided bone regeneration (GBR) on healing bone defects: a histological study in rabbits","volume":"2","author":"Aslan","year":"2004","journal-title":"J\u00a0Contemp Dent Pract"},{"key":"10.1016\/j.job.2021.02.007_bib21","first-page":"395","article-title":"Evaluation of two membranes in guided bone tissue regeneration: histological study in rabbits","author":"De Macedo","year":"2016","journal-title":"Braz J Oral Sci"},{"key":"10.1016\/j.job.2021.02.007_bib22","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/j.1600-051X.2005.00763.x","article-title":"Prognostic factors for alveolar regeneration: effect of space provision","volume":"32","author":"Polimeni","year":"2005","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/jcpe.12071","article-title":"Periodontal repair in dogs: space-provision supports alveolar bone and cementum formation","volume":"40","author":"Chiu","year":"2013","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib24","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1177\/0022034512461016","article-title":"Human oral mucosa and gingiva: a unique reservoir for mesenchymal stem cells","volume":"91","author":"Zhang","year":"2012","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.job.2021.02.007_bib25","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1177\/0022034513497961","article-title":"Gingivae contain neural-crest-and mesoderm-derived mesenchymal stem cells","volume":"92","author":"Xu","year":"2013","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.job.2021.02.007_bib26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4252\/wjsc.v6.i3.266","article-title":"Periosteum derived stem cells for regenerative medicine proposals: boosting current knowledge","volume":"6","author":"Ferretti","year":"2014","journal-title":"World J Stem Cells"},{"key":"10.1016\/j.job.2021.02.007_bib27","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/stem.503","article-title":"Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing","volume":"28","author":"Zhang","year":"2010","journal-title":"Stem cells"},{"key":"10.1016\/j.job.2021.02.007_bib28","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/jre.12455","article-title":"Efficacy of stem cells on periodontal regeneration: systematic review of pre-clinical studies","volume":"52","author":"Tassi","year":"2017","journal-title":"J\u00a0Periodontal Res"},{"key":"10.1016\/j.job.2021.02.007_bib29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-051X.2008.01263.x","article-title":"Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials - biological foundation and preclinical evidence: a systematic review","volume":"35","author":"Sculean","year":"2008","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib30","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1111\/clr.13014","article-title":"Guided bone regeneration of non-contained mandibular buccal bone defects using deproteinized bovine bone mineral and a collagen membrane: an experimental in\u00a0vivo investigation","volume":"28","author":"Sanz","year":"2017","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.job.2021.02.007_bib31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1600-051X.1991.tb01120.x","article-title":"Periodontal repair in dogs. Effect of heparin treatment of the root surface","volume":"18","author":"Wikesjo","year":"1991","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib32","first-page":"719","article-title":"Periodontal repair in dogs: effect of wound stabilization on healing","volume":"61","author":"Wikesjo","year":"1990","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib33","first-page":"515","article-title":"Scanning electron microscopic observations of cell populations and bacterial contamination of membranes used for guided periodontal tissue regeneration in humans","volume":"61","author":"Selvig","year":"1990","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib34","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/prd.12078","article-title":"Influence of suturing on wound healing","volume":"68","author":"Burkhardt","year":"2015","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.job.2021.02.007_bib35","first-page":"16","article-title":"The attachment of calculus to root surfaces","volume":"24","author":"Zander","year":"1953","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib36","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1902\/jop.1988.59.4.222","article-title":"Ultrastructural observations on bacterial invasion in cementum and radicular dentin of periodontally diseased human teeth","volume":"59","author":"Adriaens","year":"1988","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib37","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/prd.12147","article-title":"Microbial colonization of the periodontal pocket and its significance for periodontal therapy","volume":"76","author":"Mombelli","year":"2018","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.job.2021.02.007_bib38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0003-9969(71)90170-1","article-title":"Cytotoxic effects of periodontally involved surfaces of human teeth","volume":"16","author":"Hatfield","year":"1971","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.job.2021.02.007_bib39","first-page":"672","article-title":"The presence and biologic activity of cementum-bound endotoxin","volume":"45","author":"Aleo","year":"1974","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib40","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1600-0765.1980.tb00257.x","article-title":"Preliminary characterization of material eluted from the roots of periodontally diseased teeth","volume":"15","author":"Fine","year":"1980","journal-title":"J\u00a0Periodontal Res"},{"key":"10.1016\/j.job.2021.02.007_bib41","first-page":"1260","article-title":"In\u00a0vitro effect of laser irradiation on cementum-bound endotoxin isolated from periodontally diseased roots","volume":"73","author":"Liu","year":"2002","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib42","first-page":"177","article-title":"Histological assessment of root cementum at periodontally healthy and diseased human teeth","volume":"41","author":"\u00d6kte","year":"1999","journal-title":"J\u00a0Oral Sci"},{"key":"10.1016\/j.job.2021.02.007_bib43","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10266-018-0347-4","article-title":"Histological healing after nonsurgical periodontal treatment with enamel matrix derivatives in canine experimental periodontitis","volume":"106","author":"Addin","year":"2018","journal-title":"Odontology"},{"key":"10.1016\/j.job.2021.02.007_bib44","first-page":"559","article-title":"Periodontal repair in dogs: effect of saliva contamination of the root surface","volume":"61","author":"Wikesj\u00f6","year":"1990","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib45","first-page":"719","article-title":"Periodontal repair in dogs: effect of wound stabilization on healing","volume":"61","author":"Wikesj","year":"1990","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib46","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1600-051X.1991.tb01120.x","article-title":"Periodontal repair in dogs Effect of heparin treatment of the root surface","volume":"18","author":"Wikesj\u00f6","year":"1991","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib47","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1902\/jop.1991.62.4.258","article-title":"Periodontal repair in dogs: healing in experimentally created chronic periodontal defects","volume":"62","author":"Wikesj\u00f6","year":"1991","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib48","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1600-051X.1988.tb01558.x","article-title":"Repair of periodontal furcation defects in beagle dogs following reconstructive surgery including root surface demineralization with tetracycline hydrochloride and topical fibronectin application","volume":"15","author":"Wikesj\u00f6","year":"1988","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib49","first-page":"447","article-title":"The histologic evaluation of new attachment in periodontally diseased human roots treated with tetracycline-hydrochloride and fibronectin","volume":"61","author":"Alger","year":"1990","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib50","first-page":"21","article-title":"Periodontal healing following guided tissue regeneration with citric acid and fibronectin application","volume":"62","author":"Caffesse","year":"1991","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib51","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1902\/jop.1992.63.2.107","article-title":"Periodontal repair in dogs: effect of a composite graft protocol on healing in supraalveolar periodontal defects","volume":"63","author":"Wikesj\u00f6","year":"1992","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib52","first-page":"180","article-title":"Periodontal repair in dogs: effect of root surface treatment with stannous fluoride or citric acid on root resorption","volume":"62","author":"Wikesj\u00f6","year":"1991","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib53","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1600-0765.1978.tb00208.x","article-title":"The effect of topical citric acid application on the healing of experimental furcation defects in dogs","volume":"13","author":"Crigger","year":"1978","journal-title":"J\u00a0Periodontal Res"},{"key":"10.1016\/j.job.2021.02.007_bib54","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1600-0765.1983.tb00355.x","article-title":"New connective tissue attachment in beagles with advanced natural periodontitis","volume":"18","author":"Bogle","year":"1983","journal-title":"J\u00a0Periodontal Res"},{"key":"10.1016\/j.job.2021.02.007_bib55","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10103-017-2395-3","article-title":"Comparison of the effect of root surface modification with citric acid, EDTA, and aPDT on adhesion and proliferation of human gingival fibroblasts and osteoblasts: an in\u00a0vitro study","volume":"33","author":"Ferreira","year":"2018","journal-title":"Lasers Med Sci"},{"key":"10.1016\/j.job.2021.02.007_bib56","doi-asserted-by":"crossref","first-page":"111528","DOI":"10.1016\/j.jphotobiol.2019.111528","article-title":"Root surface demineralization by citric acid\/tetracycline gel and aPDT associated to subepithelial connective tissue graft improves root coverage outcomes. A 12-month preliminary randomized clinical trial","volume":"197","author":"Damante","year":"2019","journal-title":"J\u00a0Photochem Photobiol B Biol"},{"key":"10.1016\/j.job.2021.02.007_bib57","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/00016358709098852","article-title":"Topical application of tetracycline in regenerative periodontal surgery in beagles","volume":"45","author":"Claffey","year":"1987","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.job.2021.02.007_bib58","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1590\/0103-6440201600427","article-title":"Biological effects of a root conditioning treatment on periodontally affected teeth-An in\u00a0vitro analysis","volume":"27","author":"Silva","year":"2016","journal-title":"Braz Dent J"},{"key":"10.1016\/j.job.2021.02.007_bib59","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-0757.2004.37101.x","article-title":"Guided tissue regeneration for periodontal intrabony defects\u2013a Cochrane Systematic Review","volume":"37","author":"Needleman","year":"2005","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.job.2021.02.007_bib60","first-page":"3","article-title":"Guided tissue regeneration for periodontal infra-bony defects","volume":"2","author":"Needleman","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.job.2021.02.007_bib61","first-page":"4","article-title":"Enamel matrix derivative (Emdogain\u00ae) for periodontal tissue regeneration in intrabony defects","volume":"4","author":"Esposito","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.job.2021.02.007_bib62","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1902\/jop.2011.110266","article-title":"Periodontal regeneration with enamel matrix derivative in reconstructive periodontal therapy: a systematic review","volume":"83","author":"Koop","year":"2012","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib63","first-page":"31","article-title":"Long-term clinical performance of regeneration versus conservative surgery in the treatment of infra-bony defects: a systematic review","volume":"23","author":"Shaikh","year":"2021","journal-title":"J\u00a0Int Acad Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib64","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1902\/annals.2003.8.1.227","article-title":"The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic review","volume":"8","author":"Reynolds","year":"2003","journal-title":"Ann Periodontol"},{"issue":"12","key":"10.1016\/j.job.2021.02.007_bib65","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.2217\/rme-2020-0113","article-title":"Clinical effectiveness of anorganic bovine-derived hydroxyapatite matrix\/cell-binding peptide grafts for regeneration of periodontal defects: a systematic review and meta-analysis","volume":"15","author":"Shaikh","year":"2020","journal-title":"Regen Med"},{"key":"10.1016\/j.job.2021.02.007_bib66","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1600-051X.1995.tb00829.x","article-title":"No detrimental effect of fibrin glue on the regeneration of intrabony defects. A controlled clinical trial","volume":"22","author":"Cortellini","year":"1995","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib67","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1600-051X.1996.tb01823.x","article-title":"Factors affecting the healing response of intrabony defects following guided tissue regeneration and access flap surgery","volume":"23","author":"Tonetti","year":"1996","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib68","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1034\/j.1600-051X.2003.00362.x","article-title":"Periodontal repair in dogs: gingival tissue occlusion, a critical requirement for GTR?","volume":"30","author":"Wikesjo","year":"2003","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib69","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/j.1600-051X.1996.tb00534.x","article-title":"Bacterial colonization of barrier material and periodontal regeneration","volume":"23","author":"De Sanctis","year":"1996","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib70","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1902\/jop.1970.41.41.566","article-title":"Iliac transplants in periodontal therapy","volume":"41","author":"Schallhorn","year":"1970","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib71","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1600-051X.2006.00911.x","article-title":"Guided tissue regeneration\/deproteinized bovine bone mineral or papilla preservation flaps alone for treatment of intrabony defects. II: radiographic predictors and outcomes","volume":"33","author":"Linares","year":"2006","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib72","first-page":"269","article-title":"Periodontal regeneration of human infrabony defects. III. Diagnostic strategies to detect bone gain","volume":"64","author":"Tonetti","year":"1993","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib73","first-page":"934","article-title":"Periodontal regeneration of human intrabony defects. IV. Determinants of healing response","volume":"64","author":"Tonetti","year":"1993","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib74","first-page":"378","article-title":"Guided tissue regeneration of deep intrabony defects in strategically important prosthetic abutments","volume":"16","author":"Tonetti","year":"1996","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.job.2021.02.007_bib75","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1034\/j.1600-051X.2002.290407.x","article-title":"Enamel matrix proteins in the regenerative therapy of deep intrabony defects","volume":"29","author":"Tonetti","year":"2002","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib76","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1600-051X.2004.00562.x","article-title":"Clinical outcomes following treatment of human intrabony defects with GTR\/bone replacement material or access flap alone. A multicenter randomized controlled clinical trial","volume":"31","author":"Tonetti","year":"2004","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib77","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1600-051X.2004.00615.x","article-title":"Healing, post-operative morbidity and patient perception of outcomes following regenerative therapy of deep intrabony defects","volume":"31","author":"Tonetti","year":"2004","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib78","first-page":"204","article-title":"Flap technique for periodontal bone implants. Papilla preservation technique","volume":"56","author":"Takei","year":"1985","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib79","first-page":"261","article-title":"The modified papilla preservation technique. A new surgical approach for interproximal regenerative procedures","volume":"66","author":"Cortellini","year":"1995","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib80","first-page":"589","article-title":"The simplified papilla preservation flap. A novel surgical approach for the management of soft tissues in regenerative procedures","volume":"19","author":"Cortellini","year":"1999","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.job.2021.02.007_bib81","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1034\/j.1600-051X.2003.00013.x","article-title":"Microsurgical access flap and enamel matrix derivative for the treatment of periodontal intrabony defects: a controlled clinical study","volume":"30","author":"Wachtel","year":"2003","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib82","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-051X.2006.01020.x","article-title":"A\u00a0minimally invasive surgical technique with an enamel matrix derivative in the regenerative treatment of intra-bony defects: a novel approach to limit morbidity","volume":"34","author":"Cortellini","year":"2007","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib83","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-051X.2008.01352.x","article-title":"Improved wound stability with a modified minimally invasive surgical technique in the regenerative treatment of isolated interdental intrabony defects","volume":"36","author":"Cortellini","year":"2009","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib84","first-page":"353","article-title":"Single-flap approach with buccal access in periodontal reconstructive procedures","volume":"80","author":"Trombelli","year":"2009","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib85","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1600-051X.2011.01705.x","article-title":"Clinical and radiographic outcomes of the modified minimally invasive surgical technique with and without regenerative materials: a randomized-controlled trial in intra-bony defects","volume":"38","author":"Cortellini","year":"2011","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib86","doi-asserted-by":"crossref","first-page":"475","DOI":"10.11607\/prd.2550","article-title":"Minimally invasive surgical technique in periodontal regeneration: a randomized controlled clinical trial pilot study","volume":"36","author":"Ghezzi","year":"2016","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.job.2021.02.007_bib87","doi-asserted-by":"crossref","first-page":"497","DOI":"10.11607\/prd.2050","article-title":"Single-flap approach in combination with enamel matrix derivative in the treatment of periodontal intraosseous defects","volume":"34","author":"Farina","year":"2014","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.job.2021.02.007_bib88","first-page":"1038","article-title":"Change in the gingival margin profile After the single flap approach in periodontal intraosseous defects","volume":"86","author":"Farina","year":"2015","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib89","first-page":"348","article-title":"Effect of a connective tissue graft in combination with a single flap approach in the regenerative treatment of intraosseous defects","volume":"88","author":"Trombelli","year":"2017","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib90","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.11607\/prd.1628","article-title":"The soft tissue wall technique for the regenerative treatment of non-contained infrabony defects: a case series","volume":"33","author":"Rasperini","year":"2013","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.job.2021.02.007_bib91","doi-asserted-by":"crossref","first-page":"601","DOI":"10.11607\/prd.1978","article-title":"The connective tissue graft wall technique and enamel matrix derivative to improve root coverage and clinical attachment levels in Miller Class IV gingival recession","volume":"34","author":"Zucchelli","year":"2014","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.job.2021.02.007_bib92","doi-asserted-by":"crossref","first-page":"673","DOI":"10.11607\/prd.3083","article-title":"Connective tissue graft wall technique and enamel matrix derivative for the treatment of infrabony defects","volume":"37","author":"Zucchelli","year":"2017","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.job.2021.02.007_bib93","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/jcpe.12780","article-title":"Entire papilla preservation technique in the regenerative treatment of deep intrabony defects: 1-Year results","volume":"44","author":"Aslan","year":"2017","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib94","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/jcpe.13255","article-title":"Clinical outcomes of the entire papilla preservation technique with and without biomaterials in the treatment of isolated intrabony defects: a randomized controlled clinical trial","volume":"47","author":"Aslan","year":"2020","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib95","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1600-0765.1968.tb01908.x","article-title":"Microscopic evaluation of the healing and revascularization of free gingival grafts","volume":"3","author":"Oliver","year":"1968","journal-title":"J\u00a0Periodontal Res"},{"key":"10.1016\/j.job.2021.02.007_bib96","first-page":"639","article-title":"Microvascularization of the free gingival autograft","volume":"59","author":"Nobuto","year":"1988","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib97","first-page":"121","article-title":"Free autogenous gingival grafts. I. Principles of successful grafting","volume":"6","author":"Sullivan","year":"1968","journal-title":"Periodontics"},{"key":"10.1016\/j.job.2021.02.007_bib98","first-page":"890","article-title":"Creeping attachment associated with the connective tissue with partial-thickness double pedicle graft","volume":"68","author":"Harris","year":"1997","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib99","first-page":"14","article-title":"Root coverage using the free soft tissue autograft following citric acid application. III. A successful and predictable procedure in areas of deep-wide recession","volume":"5","author":"Miller","year":"1985","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.job.2021.02.007_bib100","first-page":"470","article-title":"Histological evaluation of healing and revascularization of the subepithelial connective tissue graft","volume":"72","author":"Guiha","year":"2001","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.job.2021.02.007_bib101","doi-asserted-by":"crossref","first-page":"551","DOI":"10.11607\/prd.3020","article-title":"Vascularization and innervation of connective tissue grafts in the treatment of gingival recessions: a histologic and immunohistochemical study","volume":"37","author":"Perotto","year":"2017","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.job.2021.02.007_bib102","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jcms.2011.04.020","article-title":"Effects of Choukroun's platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: a histological and histomorphometric study","volume":"40","author":"Zhang","year":"2012","journal-title":"J\u00a0Cranio-Maxillo-Fac Surg"},{"key":"10.1016\/j.job.2021.02.007_bib103","doi-asserted-by":"crossref","first-page":"265","DOI":"10.11607\/prd.2741","article-title":"The use of platelet-rich fibrin versus subepithelial connective tissue graft in treatment of multiple gingival recessions: a randomized clinical trial","volume":"37","author":"\u00d6nc\u00fc","year":"2017","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.job.2021.02.007_bib104","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1007\/s00784-015-1697-8","article-title":"Vascularization after treatment of gingival recession defects with platelet-rich fibrin or connective tissue graft","volume":"20","author":"Eren","year":"2016","journal-title":"Clin Oral Investig"}],"container-title":["Journal of Oral Biosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007921000475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007921000475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:07:25Z","timestamp":1761163645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1349007921000475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":104,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S1349007921000475"],"URL":"https:\/\/doi.org\/10.1016\/j.job.2021.02.007","relation":{},"ISSN":["1349-0079"],"issn-type":[{"value":"1349-0079","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Critical features of periodontal flaps with regard to blood clot stability: A review","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral Biosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.job.2021.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}