{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T20:24:52Z","timestamp":1782591892370,"version":"3.54.5"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral Biosciences"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.job.2023.03.001","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T11:17:32Z","timestamp":1678533452000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of anti-RANKL antibodies administered to pregnant mice on bone and tooth development in neonates"],"prefix":"10.1016","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3202-099X","authenticated-orcid":false,"given":"Maho","family":"Yamaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Takami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Azetsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Karakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Chatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2886-6901","authenticated-orcid":false,"given":"Takahiro","family":"Funatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0240-6480","authenticated-orcid":false,"given":"Nobuhiro","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.job.2023.03.001_bib1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1056\/NEJMcp042092","article-title":"Clinical practice. Screening for osteoporosis","volume":"353","author":"Raisz","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.job.2023.03.001_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1749-6632.2011.06217.x","article-title":"Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8","volume":"1237","author":"Ivashkiv","year":"2011","journal-title":"Ann N Y Acad Sci"},{"issue":"10329","key":"10.1016\/j.job.2023.03.001_bib3","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0140-6736(21)02646-5","article-title":"Drug therapy for osteoporosis in older adults","volume":"399","author":"Reid","year":"2022","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.job.2023.03.001_bib4","first-page":"632","article-title":"Effects of anti-receptor activator of nuclear factor kappa B ligand antibody and zoledronic acid on periapical lesion development in mice","volume":"48","author":"Ikeda","year":"2022","journal-title":"J\u00a0Endod"},{"issue":"4","key":"10.1016\/j.job.2023.03.001_bib5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1248\/bpb.b18-00026","article-title":"Anti-mouse RANKL antibodies inhibit alveolar bone destruction in periodontitis model mice","volume":"41","author":"Kuritani","year":"2018","journal-title":"Biol Pharm Bull"},{"issue":"4","key":"10.1016\/j.job.2023.03.001_bib6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S8756-3282(03)00024-3","article-title":"Involvement of vacuolar H+ -ATPase in incorporation of risedronate into osteoclasts","volume":"32","author":"Takami","year":"2003","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.job.2023.03.001_bib7","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1345\/aph.1M102","article-title":"Denosumab in osteoporosis and oncology","volume":"43","author":"Burkiewicz","year":"2009","journal-title":"Ann Pharmacother"},{"issue":"1","key":"10.1016\/j.job.2023.03.001_bib8","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s12253-017-0362-8","article-title":"Vitro study of the effects of denosumab on giant cell tumor of bone: comparison with zoledronic acid","volume":"25","author":"Shibuya","year":"2019","journal-title":"Pathol Oncol Res"},{"issue":"5","key":"10.1016\/j.job.2023.03.001_bib9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrd3705","article-title":"Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab","volume":"11","author":"Lacey","year":"2012","journal-title":"Nat Rev Drug Discov"},{"issue":"8","key":"10.1016\/j.job.2023.03.001_bib10","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.job.2023.03.001_bib11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s004419900092","article-title":"Osteoblastic cells induce fusion and activation of osteoclasts through a mechanism independent of macrophage-colony-stimulating factor production","volume":"298","author":"Takami","year":"1999","journal-title":"Cell Tissue Res"},{"issue":"12","key":"10.1016\/j.job.2023.03.001_bib12","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1210\/endo.141.12.7852","article-title":"Intracellular calcium and protein kinase C mediate expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in osteoblasts","volume":"141","author":"Takami","year":"2000","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.job.2023.03.001_bib13","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1089\/ten.tea.2009.0065","article-title":"Osteoclast differentiation induced by synthetic octacalcium phosphate through receptor activator of NF-kappaB ligand expression in osteoblasts","volume":"15","author":"Takami","year":"2009","journal-title":"Tissue Eng Part A"},{"issue":"3","key":"10.1016\/j.job.2023.03.001_bib14","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.febslet.2004.12.066","article-title":"Phosphodiesterase inhibitors stimulate osteoclast formation via TRANCE\/RANKL expression in osteoblasts: possible involvement of ERK and p38 MAPK pathways","volume":"579","author":"Takami","year":"2005","journal-title":"FEBS Lett"},{"issue":"2","key":"10.1016\/j.job.2023.03.001_bib15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"issue":"6759","key":"10.1016\/j.job.2023.03.001_bib16","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/46303","article-title":"Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand","volume":"402","author":"Kong","year":"1999","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.job.2023.03.001_bib17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1601-6343.2009.01443.x","article-title":"Osteoclast polarization and orthodontic tooth movement","volume":"12","author":"Holliday","year":"2009","journal-title":"Orthod Craniofac Res"},{"issue":"1","key":"10.1016\/j.job.2023.03.001_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56151-1","article-title":"Biological effects of anti-RANKL antibody and zoledronic acid on growth and tooth eruption in growing mice","volume":"9","author":"Isawa","year":"2019","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.job.2023.03.001_bib19","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1002\/jbmr.131","article-title":"Dysosteosclerosis presents as an \"osteoclast-poor\" form of osteopetrosis: comprehensive investigation of a 3-year-old girl and literature review","volume":"25","author":"Whyte","year":"2010","journal-title":"J\u00a0Bone Miner Res"},{"issue":"1","key":"10.1016\/j.job.2023.03.001_bib20","first-page":"13","article-title":"Neonatal changes of osteoclasts in osteopetrosis (op\/op) mice defective in production of functional macrophage colony-stimulating factor (M-CSF) protein and effects of M-CSF on osteoclast development and differentiation","volume":"28","author":"Umeda","year":"1996","journal-title":"J\u00a0Submicrosc Cytol Pathol"},{"issue":"3","key":"10.1016\/j.job.2023.03.001_bib21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1177\/10454411910020030601","article-title":"Osteoclast differentiation","volume":"2","author":"Roodman","year":"1991","journal-title":"Crit Rev Oral Biol Med"},{"issue":"3","key":"10.1016\/j.job.2023.03.001_bib22","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.bbrc.2017.07.154","article-title":"Biological effects of anti-RANKL antibody administration in pregnant mice and their newborns","volume":"491","author":"Okamatsu","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.job.2023.03.001_bib23","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s00774-022-01331-9","article-title":"The relationship between chronic kidney disease and denosumab-induced hypocalcemia in high-age osteoporotic patients","volume":"40","author":"Horikawa","year":"2022","journal-title":"J\u00a0Bone Miner Metabol"},{"issue":"12","key":"10.1016\/j.job.2023.03.001_bib24","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1248\/bpb.b21-00653","article-title":"Risk analysis of denosumab-induced hypocalcemia in bone metastasis treatment: renal dysfunction is not a risk factor for its incidence in a strict denosumab administration management system with calcium\/vitamin D supplementation","volume":"44","author":"Saito","year":"2021","journal-title":"Biol Pharm Bull"},{"issue":"1","key":"10.1016\/j.job.2023.03.001_bib25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00198-021-06059-2","article-title":"Denosumab-induced hypocalcemia in a patient with hyperthyroidism: a case report","volume":"33","author":"Park","year":"2022","journal-title":"Osteoporos Int"},{"issue":"3","key":"10.1016\/j.job.2023.03.001_bib26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.clinthera.2012.02.002","article-title":"Role of RANK ligand and denosumab, a targeted RANK ligand inhibitor, in bone health and osteoporosis: a review of preclinical and clinical data","volume":"34","author":"Dempster","year":"2012","journal-title":"Clin Therapeut"},{"issue":"Suppl 1","key":"10.1016\/j.job.2023.03.001_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/adj.12132","article-title":"Three-dimensional analysis of molar development in the mouse from the cap to bell stage","volume":"59","author":"Lesot","year":"2014","journal-title":"Aust Dent J"},{"issue":"4","key":"10.1016\/j.job.2023.03.001_bib28","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1177\/00220345990780040201","article-title":"Molecular genetics of tooth morphogenesis and patterning: the right shape in the right place","volume":"78","author":"Tucker","year":"1999","journal-title":"J\u00a0Dent Res"}],"container-title":["Journal of Oral Biosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007923000452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007923000452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:07:56Z","timestamp":1761163676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1349007923000452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S1349007923000452"],"URL":"https:\/\/doi.org\/10.1016\/j.job.2023.03.001","relation":{},"ISSN":["1349-0079"],"issn-type":[{"value":"1349-0079","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of anti-RANKL antibodies administered to pregnant mice on bone and tooth development in neonates","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral Biosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.job.2023.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}