{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T06:21:38Z","timestamp":1769926898202,"version":"3.49.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K10277"],"award-info":[{"award-number":["22K10277"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K10302"],"award-info":[{"award-number":["JP19K10302"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral Biosciences"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.job.2024.01.001","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T14:12:31Z","timestamp":1705673551000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ser252Trp mutation in fibroblast growth factor receptor 2 promotes branching morphogenesis in mouse salivary glands"],"prefix":"10.1016","volume":"66","author":[{"given":"Daiki","family":"Iwata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3642-289X","authenticated-orcid":false,"given":"Kaori","family":"Kometani-Gunjigake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Nakao-Kuroishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Mizuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8713-210X","authenticated-orcid":false,"given":"Mitsushiro","family":"Nakatomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0580-4510","authenticated-orcid":false,"given":"Keiji","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3098-5440","authenticated-orcid":false,"given":"Tatsuo","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.job.2024.01.001_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/ng0295-165","article-title":"Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome","volume":"9","author":"Wilkie","year":"1995","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.job.2024.01.001_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/hmg\/6.1.137","article-title":"Genotype-phenotype correlation for nucleotide substitutions in the IgII-IgIII linker of FGFR2","volume":"6","author":"Oldridge","year":"1997","journal-title":"Hum Mol Genet"},{"issue":"9","key":"10.1016\/j.job.2024.01.001_bib3","article-title":"Apert syndrome: an insight into dentofacial features","volume":"13","author":"Jose","year":"2021","journal-title":"Cureus"},{"issue":"25","key":"10.1016\/j.job.2024.01.001_bib4","doi-asserted-by":"crossref","first-page":"15292","DOI":"10.1074\/jbc.271.25.15292","article-title":"Receptor specificity of the fibroblast growth factor family","volume":"271","author":"Ornitz","year":"1996","journal-title":"J Biol Chem"},{"issue":"23","key":"10.1016\/j.job.2024.01.001_bib5","doi-asserted-by":"crossref","first-page":"15694","DOI":"10.1074\/jbc.M601252200","article-title":"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family","volume":"281","author":"Zhang","year":"2006","journal-title":"J Biol Chem"},{"issue":"26","key":"10.1016\/j.job.2024.01.001_bib6","doi-asserted-by":"crossref","first-page":"14536","DOI":"10.1073\/pnas.97.26.14536","article-title":"Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome","volume":"97","author":"Yu","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"10.1016\/j.job.2024.01.001_bib7","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/hmg\/7.9.1475","article-title":"Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand","volume":"7","author":"Anderson","year":"1998","journal-title":"Hum Mol Genet"},{"issue":"3","key":"10.1016\/j.job.2024.01.001_bib8","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/(SICI)1097-0185(19991101)256:3<252::AID-AR5>3.0.CO;2-6","article-title":"Submandibular gland morphogenesis: stage-specific expression of TGF-alpha\/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations","volume":"256","author":"Jaskoll","year":"1999","journal-title":"Anat Rec"},{"issue":"5991","key":"10.1016\/j.job.2024.01.001_bib9","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1126\/science.1191880","article-title":"Btbd7 regulates epithelial cell dynamics and branching morphogenesis","volume":"329","author":"Onodera","year":"2010","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.job.2024.01.001_bib10","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1242\/dev.01690","article-title":"FGFR2\u2162b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis","volume":"132","author":"Steinberg","year":"2005","journal-title":"Development"},{"issue":"7","key":"10.1016\/j.job.2024.01.001_bib11","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1440-169X.2008.01053.x","article-title":"Signaling pathways activated by epidermal growth factor receptor or fibroblast growth factor receptor differentially regulate branching morphogenesis in fetal mouse submandibular glands","volume":"50","author":"Koyama","year":"2008","journal-title":"Dev Growth Differ"},{"issue":"3","key":"10.1016\/j.job.2024.01.001_bib12","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1242\/dev.127.3.483","article-title":"An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis","volume":"127","author":"De Moerlooze","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.job.2024.01.001_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-213X-5-11","article-title":"FGF10\/FGFR2\u2162b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis","volume":"5","author":"Jaskoll","year":"2005","journal-title":"BMC Dev Biol"},{"issue":"11","key":"10.1016\/j.job.2024.01.001_bib14","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/dvdy.24673","article-title":"Maldevelopment of the submandibular gland in a mouse model of apert syndrome","volume":"247","author":"Yamaji","year":"2018","journal-title":"Dev Dynam"},{"issue":"2","key":"10.1016\/j.job.2024.01.001_bib15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.job.2021.02.008","article-title":"A Ser252Trp substitution in mouse FGFR2 results in hyperplasia of embryonic salivary gland parenchyma","volume":"63","author":"Watanabe","year":"2021","journal-title":"J Oral Biosci"},{"issue":"9","key":"10.1016\/j.job.2024.01.001_bib16","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ng2096","article-title":"RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis","volume":"39","author":"Shukla","year":"2007","journal-title":"Nat Genet"},{"issue":"24","key":"10.1016\/j.job.2024.01.001_bib17","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1242\/dev.00172","article-title":"Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms","volume":"129","author":"Hoffman","year":"2002","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.job.2024.01.001_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ydbio.2007.04.031","article-title":"Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling","volume":"308","author":"Rebustini","year":"2007","journal-title":"Dev Biol"},{"issue":"4","key":"10.1016\/j.job.2024.01.001_bib19","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.diff.2016.05.005","article-title":"Efficient regulation of branching morphogenesis via fibroblast growth factor receptor 2c in early-stage embryonic mouse salivary glands","volume":"92","author":"Shibuya","year":"2016","journal-title":"Differentiation"},{"issue":"2","key":"10.1016\/j.job.2024.01.001_bib20","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/(SICI)1097-0177(199906)215:2<148::AID-DVDY7>3.0.CO;2-V","article-title":"EGF-dependent lobule formation and FGF7-dependent stalk elongation in branching morphogenesis of mouse salivary epithelium in vitro","volume":"215","author":"Morita","year":"1999","journal-title":"Dev Dynam"},{"issue":"18","key":"10.1016\/j.job.2024.01.001_bib21","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1111\/febs.14937","article-title":"Role of the mTOR signaling pathway in salivary gland development","volume":"286","author":"Sakai","year":"2019","journal-title":"FEBS J"}],"container-title":["Journal of Oral Biosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S134900792400001X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S134900792400001X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:09:05Z","timestamp":1761163745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S134900792400001X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S134900792400001X"],"URL":"https:\/\/doi.org\/10.1016\/j.job.2024.01.001","relation":{},"ISSN":["1349-0079"],"issn-type":[{"value":"1349-0079","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ser252Trp mutation in fibroblast growth factor receptor 2 promotes branching morphogenesis in mouse salivary glands","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral Biosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.job.2024.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V. on behalf of Japanese Association for Oral Biology.","name":"copyright","label":"Copyright"}]}}