{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:47:11Z","timestamp":1777888031548,"version":"3.51.4"},"reference-count":74,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-77603"],"award-info":[{"award-number":["MOP-77603"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["179860"],"award-info":[{"award-number":["179860"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["183830"],"award-info":[{"award-number":["183830"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral Biosciences"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.job.2024.100587","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T01:43:50Z","timestamp":1731030230000},"page":"100587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["CCN2: A potential contributor to gingival overgrowth"],"prefix":"10.1016","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4231-429X","authenticated-orcid":false,"given":"Asmaa","family":"Fadl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-283X","authenticated-orcid":false,"given":"Andrew","family":"Leask","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.job.2024.100587_bib1","doi-asserted-by":"crossref","first-page":"C1046","DOI":"10.1152\/ajpcell.00028.2020","article-title":"Conjunction junction, what's the function? CCN proteins as targets in fibrosis and cancers","volume":"318","author":"Leask","year":"2020","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/excr.2001.5364","article-title":"Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome","volume":"271","author":"Chen","year":"2001","journal-title":"Exp Cell Res"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1755-1536-1-3","article-title":"Connective tissue growth factor promoter activity in normal and wounded skin","volume":"1","author":"Kapoor","year":"2008","journal-title":"Fibrogenesis Tiss. Rep."},{"issue":"2","key":"10.1016\/j.job.2024.100587_bib4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/jcb.20810","article-title":"CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and \u03b16\u2010and \u03b21 integrins","volume":"98","author":"Heng","year":"2006","journal-title":"J Cell Biochem"},{"issue":"5","key":"10.1016\/j.job.2024.100587_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019756","article-title":"Mechanical tension increases CCN2\/CTGF expression and proliferation in gingival fibroblasts via a TGF\u03b2-dependent mechanism","volume":"6","author":"Guo","year":"2011","journal-title":"PLoS One"},{"issue":"16","key":"10.1016\/j.job.2024.100587_bib6","doi-asserted-by":"crossref","first-page":"10715","DOI":"10.1074\/jbc.M511343200","article-title":"CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts","volume":"281","author":"Shi-wen","year":"2006","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/art.30074","article-title":"CCN2 is required for bleomycin-induced skin fibrosis in mice","volume":"63","author":"Liu","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ajpath.2019.09.006","article-title":"Insights into fibroblast plasticity: cellular communication network 2 is required for activation of cancer-associated fibroblasts in a murine model of melanoma","volume":"190","author":"Tsang","year":"2020","journal-title":"Am J Pathol"},{"issue":"9","key":"10.1016\/j.job.2024.100587_bib9","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1517\/14728222.2013.812074","article-title":"CCN2: a novel, specific and valid target for anti-fibrotic drug intervention","volume":"17","author":"Leask","year":"2013","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.job.2024.100587_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1233800","article-title":"Fibroblasts - the cellular choreographers of wound healing","volume":"14","author":"Knoedler","year":"2023","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib11","first-page":"115","article-title":"Signaling in fibrosis: targeting the TGF beta, endothelin-1 and CCN2 axis in scleroderma","volume":"1","author":"Leask","year":"2009","journal-title":"Front Biosci"},{"issue":"16","key":"10.1016\/j.job.2024.100587_bib12","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.3390\/cells12162021","article-title":"Hiding in plain sight: human gingival fibroblasts as an essential, yet overlooked, tool in regenerative medicine","volume":"12","author":"Fadl","year":"2023","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.job.2024.100587_bib13","doi-asserted-by":"crossref","first-page":"779","DOI":"10.12998\/wjcc.v3.i9.779","article-title":"Gingival enlargements: differential diagnosis and review of literature","volume":"3","author":"Agrawal","year":"2015","journal-title":"World J Clin Cases"},{"issue":"3","key":"10.1016\/j.job.2024.100587_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/154411130401500305","article-title":"Connective tissue metabolism and gingival overgrowth","volume":"15","author":"Trackman","year":"2004","journal-title":"Crit Rev Oral Biol Med"},{"issue":"7","key":"10.1016\/j.job.2024.100587_bib15","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1902\/jop.2010.100599","article-title":"Hereditary gingival fibromatosis: a three-generation case and pathogenic mechanism research on progress of the disease","volume":"82","author":"Shi","year":"2011","journal-title":"J Periodontol"},{"issue":"4","key":"10.1016\/j.job.2024.100587_bib16","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1177\/0022034515571265","article-title":"Molecular and clinical aspects of drug-induced gingival overgrowth","volume":"94","author":"Trackman","year":"2015","journal-title":"J Dent Res"},{"issue":"7","key":"10.1016\/j.job.2024.100587_bib17","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1902\/jop.2001.72.7.921","article-title":"Connective tissue growth factor in drug-induced gingival overgrowth","volume":"72","author":"Uzel","year":"2001","journal-title":"J Periodontol"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/path.2000","article-title":"Epithelial and connective tissue cell CTGF\/CCN2 expression in gingival fibrosis","volume":"210","author":"Kantarci","year":"2006","journal-title":"J Pathol"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib19","article-title":"Phenytoin-induced gingival overgrowth: a review of the molecular, immune, and inflammatory features","volume":"2011","author":"Corr\u00eaa","year":"2011","journal-title":"Int Sch Res Notices"},{"issue":"7","key":"10.1016\/j.job.2024.100587_bib20","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1034\/j.1600-051x.2000.027007506.x","article-title":"Factors influencing phenytoin-induced gingival enlargement","volume":"27","author":"Majola","year":"2000","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.job.2024.100587_bib21","doi-asserted-by":"crossref","DOI":"10.2174\/1874210601913010430","article-title":"An update on the mechanisms of phenytoin induced gingival overgrowth","volume":"13","author":"Farook","year":"2019","journal-title":"Open Dent J"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib22","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1186\/s13023-021-02104-9","article-title":"Clinics and genetic background of hereditary gingival fibromatosis","volume":"16","author":"Strzelec","year":"2021","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1902\/jop.2005.76.1.3","article-title":"Gingival overgrowth in children: epidemiology, pathogenesis, and complications. A literature review","volume":"76","author":"Doufexi","year":"2005","journal-title":"J Periodontol"},{"issue":"2","key":"10.1016\/j.job.2024.100587_bib24","doi-asserted-by":"crossref","first-page":"e1185","DOI":"10.1111\/j.1741-2358.2011.00564.x","article-title":"Surgical and prosthetic treatment in an elderly patient affected by unilateral idiopathic gingival fibromatosis: a case report","volume":"29","author":"Millet","year":"2012","journal-title":"Gerodontology"},{"issue":"5","key":"10.1016\/j.job.2024.100587_bib25","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1902\/jop.2006.050379","article-title":"Hereditary gingival fibromatosis: a systematic review","volume":"77","author":"Coletta","year":"2006","journal-title":"J Periodontol"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib26","first-page":"19","article-title":"Chronic inflammatory gingival enlargement associated with orthodontic therapy \u2013 a case report","volume":"87","author":"Jadhav","year":"2013","journal-title":"Am Dental Hygienists Association"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib27","first-page":"109","article-title":"Inflammatory gingival enlargement-a case report","volume":"2","author":"Tomar","year":"2014","journal-title":"J Adv Med Dental Sci"},{"key":"10.1016\/j.job.2024.100587_bib28","series-title":"Emerging trends in oral health sciences and dentistry","article-title":"Epithelial-mesenchymal transition\u2014a possible pathogenic pathway of fibrotic gingival overgrowth","author":"Bani\u0163\u0103","year":"2015"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib29","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1177\/0022034509353403","article-title":"Nicotine-induced CCN2: from smoking to periodontal fibrosis","volume":"89","author":"Takeuchi","year":"2010","journal-title":"J Dent Res"},{"issue":"11","key":"10.1016\/j.job.2024.100587_bib30","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/JPER.20-0670","article-title":"Hypoxia stimulates collagen hydroxylation in gingival fibroblasts and periodontal ligament cells","volume":"92","author":"Morimoto","year":"2021","journal-title":"J Periodontol"},{"issue":"12","key":"10.1016\/j.job.2024.100587_bib31","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1902\/jop.2000.71.12.1846","article-title":"Oxygen sufficiency in the gingiva of smokers and non-smokers with periodontal disease","volume":"71","author":"Hanioka","year":"2000","journal-title":"J Periodontol"},{"issue":"3","key":"10.1016\/j.job.2024.100587_bib32","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/jre.12723","article-title":"Evaluation of apoptosis and hypoxia-related factors in gingival tissues of smoker and non-smoker periodontitis patients","volume":"55","author":"Karatas","year":"2020","journal-title":"J Periodontal Res"},{"issue":"10","key":"10.1016\/j.job.2024.100587_bib33","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1600-051X.2004.00585.x","article-title":"Cytokine profile in gingival crevicular fluid of aggressive periodontitis: influence of smoking and stress","volume":"31","author":"Kamma","year":"2004","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib34","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1600-0722.1988.tb01405.x","article-title":"Influence of cigarette smoking on vascular reaction during experimental gingivitis","volume":"96","author":"Bergstro\u00f6m","year":"1988","journal-title":"Eur J Oral Sci"},{"issue":"2","key":"10.1016\/j.job.2024.100587_bib35","first-page":"285","article-title":"Role of transforming growth factor \u03b2-connective tissue growth factor pathway in dihydropyridine calcium channel blockers-induced gingival overgrowth","volume":"55","author":"Pisoschi","year":"2014","journal-title":"Rom J Morphol Embryol"},{"issue":"4","key":"10.1016\/j.job.2024.100587_bib36","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s12079-015-0303-9","article-title":"Nifedipine and phenytoin induce matrix synthesis, but not proliferation, in intact human gingival connective tissue ex vivo","volume":"9","author":"Kim","year":"2015","journal-title":"J. Cell Commun. Signal."},{"issue":"7","key":"10.1016\/j.job.2024.100587_bib37","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"Faseb J"},{"issue":"23","key":"10.1016\/j.job.2024.100587_bib38","doi-asserted-by":"crossref","first-page":"19945","DOI":"10.1074\/jbc.M102382200","article-title":"Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts","volume":"276","author":"Piek","year":"2001","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.job.2024.100587_bib39","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1177\/0022034510379020","article-title":"ALK5 inhibition blocks TGF\u03b2-induced CCN2 expression in gingival fibroblasts","volume":"89","author":"Thompson","year":"2010","journal-title":"J Dent Res"},{"issue":"4","key":"10.1016\/j.job.2024.100587_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123689","article-title":"5Z-7-Oxozeanol inhibits the effects of TGF\u03b21 on human gingival fibroblasts","volume":"10","author":"Kuk","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.job.2024.100587_bib41","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/j.0022-202X.2005.23750.x","article-title":"Smad3 and extracellular signal-regulated kinase 1\/2 coordinately mediate transforming growth factor-\u03b2-induced expression of connective tissue growth factor in human fibroblasts","volume":"124","author":"Leivonen","year":"2005","journal-title":"J Invest Dermatol"},{"issue":"2","key":"10.1016\/j.job.2024.100587_bib42","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1600-0765.2008.01093.x","article-title":"Effect of transforming growth factor-beta1 on expression of the connective tissue growth factor (CCN2\/CTGF) gene in normal human gingival fibroblasts and periodontal ligament cells","volume":"44","author":"Takeuchi","year":"2009","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.job.2024.100587_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2024.105910","article-title":"The yes-associated protein-1 (YAP1) inhibitor celastrol suppresses the ability of transforming growth factor \u03b2 to activate human gingival fibroblasts","volume":"160","author":"Naik","year":"2024","journal-title":"Arch Oral Biol"},{"issue":"13","key":"10.1016\/j.job.2024.100587_bib44","doi-asserted-by":"crossref","first-page":"7117","DOI":"10.1074\/jbc.270.13.7117","article-title":"Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells","volume":"270","author":"Hartsough","year":"1995","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.job.2024.100587_bib45","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1038\/sj.onc.1202521","article-title":"Cross-talk between the Smad1 and Ras\/MEK signaling pathways for TGFbeta","volume":"18","author":"Yue","year":"1999","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.job.2024.100587_bib46","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1177\/0022034513488139","article-title":"Curcumin inhibits TGF\u03b21-induced CCN2 via Src, JNK, and Smad3 in gingiva","volume":"92","author":"Yang","year":"2013","journal-title":"J Dent Res"},{"issue":"10","key":"10.1016\/j.job.2024.100587_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186740","article-title":"Antioxidants and NOX1\/NOX4 inhibition blocks TGF\u03b21-induced CCN2 and \u03b1-SMA expression in dermal and gingival fibroblasts","volume":"12","author":"Murphy-Marshman","year":"2017","journal-title":"PLoS One"},{"issue":"238","key":"10.1016\/j.job.2024.100587_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008234","article-title":"Photoactivation of endogenous latent transforming growth factor-\u03b21 directs dental stem cell differentiation for regeneration","volume":"6","author":"Arany","year":"2014","journal-title":"Sci Transl Med"},{"issue":"12","key":"10.1016\/j.job.2024.100587_bib49","first-page":"1287","article-title":"Phenytoin activates Smad3 phosphorylation and periostin expression in drug-induced gingival enlargement","volume":"33","author":"Kim","year":"2018","journal-title":"Histol Histopathol"},{"issue":"6","key":"10.1016\/j.job.2024.100587_bib50","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/jre.13058","article-title":"Phenytoin induces connective tissue growth factor (CTGF\/CCN2) production through NADPH oxidase 4-mediated latent TGF\u03b21 activation in human gingiva fibroblasts: suppression by curcumin","volume":"57","author":"Deng","year":"2022","journal-title":"J Periodontal Res"},{"issue":"21","key":"10.1016\/j.job.2024.100587_bib51","doi-asserted-by":"crossref","first-page":"15416","DOI":"10.1074\/jbc.M610432200","article-title":"Tissue-specific mechanisms for CCN2\/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase","volume":"282","author":"Black","year":"2007","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.job.2024.100587_bib52","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1177\/154405910708601115","article-title":"Stimulation of cells derived from nifedipine-induced gingival overgrowth with Porphyromonas gingivalis, lipopolysaccharide, and interleukin-1beta","volume":"86","author":"Lu","year":"2007","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib53","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2334\/josnusd.21-0419","article-title":"Hepatocyte growth factor exhibits anti-fibrotic effects in an in vitro model of nifedipine-induced gingival overgrowth","volume":"64","author":"Yamazaki","year":"2022","journal-title":"J Oral Sci"},{"issue":"4","key":"10.1016\/j.job.2024.100587_bib54","first-page":"451","article-title":"Flutamide inhibits nifedipine- and interleukin-1\u03b2-induced collagen overproduction in gingival fibroblasts","volume":"45","author":"Lu","year":"2010","journal-title":"J Periodontal Res"},{"issue":"11","key":"10.1016\/j.job.2024.100587_bib55","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1177\/0022034513503659","article-title":"Nifedipine induces periostin expression in gingival fibroblasts through TGF-beta","volume":"92","author":"Kim","year":"2013","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib56","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/jispcd.JISPCD_403_17","article-title":"Immunohistochemical analysis of the role connective tissue growth factor in drug-induced gingival overgrowth in response to phenytoin, cyclosporine, and nifedipine","volume":"8","author":"Anand","year":"2018","journal-title":"J Int Soc Prev Community Dent"},{"issue":"11","key":"10.1016\/j.job.2024.100587_bib57","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.jfma.2014.01.008","article-title":"Cyclosporine A induces connective tissue growth factor expression in human gingival fibroblasts: suppression by epigallocatechin-3-gallate","volume":"113","author":"Wu","year":"2014","journal-title":"J Formos Med Assoc"},{"issue":"2","key":"10.1016\/j.job.2024.100587_bib58","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-0765.2011.01412.x","article-title":"Molecular events associated with ciclosporin A-induced gingival overgrowth are attenuated by Smad7 overexpression in fibroblasts","volume":"47","author":"Sobral","year":"2012","journal-title":"J Periodontal Res"},{"issue":"28","key":"10.1016\/j.job.2024.100587_bib59","doi-asserted-by":"crossref","first-page":"20245","DOI":"10.1074\/jbc.M701609200","article-title":"Germ line gain of function with SOS1 mutation in hereditary gingival fibromatosis","volume":"282","author":"Jang","year":"2007","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib60","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41368-023-00244-1","article-title":"Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis","volume":"15","author":"Chen","year":"2023","journal-title":"Int J Oral Sci"},{"issue":"2","key":"10.1016\/j.job.2024.100587_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188445","article-title":"SOS GEFs in health and disease","volume":"1874","author":"Baltan\u00e1s","year":"2020","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.job.2024.100587_bib62","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1749-6632.1997.tb51984.x","article-title":"Fluid shear stress-mediated signal transduction: how do endothelial cells transduce mechanical force into biological responses?","volume":"811","author":"Ishida","year":"1997","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.job.2024.100587_bib63","article-title":"Roles and inhibitors of FAK in cancer: current advances and future directions","volume":"15","author":"Hu","year":"2024","journal-title":"Front Pharmacol"},{"issue":"12","key":"10.1016\/j.job.2024.100587_bib64","first-page":"1655","article-title":"Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-beta1 and detection in human gingiva","volume":"79","author":"Hong","year":"1999","journal-title":"Lab Invest"},{"issue":"5","key":"10.1016\/j.job.2024.100587_bib65","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.yexcr.2007.12.010","article-title":"Connective tissue growth factor\/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness","volume":"314","author":"Mori","year":"2008","journal-title":"Exp Cell Res"},{"issue":"16","key":"10.1016\/j.job.2024.100587_bib66","doi-asserted-by":"crossref","first-page":"10715","DOI":"10.1074\/jbc.M511343200","article-title":"CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts","volume":"281","author":"Shi-wen","year":"2006","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib67","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/(SICI)1097-4652(199910)181:1<153::AID-JCP16>3.0.CO;2-K","article-title":"Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: a mouse fibrosis model","volume":"181","author":"Mori","year":"1999","journal-title":"J Cell Physiol"},{"issue":"6","key":"10.1016\/j.job.2024.100587_bib68","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.ajpath.2015.02.004","article-title":"Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice","volume":"185","author":"Assaggaf","year":"2015","journal-title":"Am J Pathol"},{"key":"10.1016\/j.job.2024.100587_bib69","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jim.2017.03.003","article-title":"A novel gingival overgrowth mouse model induced by the combination of CsA and ligature-induced inflammation","volume":"445","author":"Okanobu","year":"2017","journal-title":"J Immunol Methods"},{"issue":"1","key":"10.1016\/j.job.2024.100587_bib70","doi-asserted-by":"crossref","first-page":"9785","DOI":"10.1038\/s41598-020-66660-z","article-title":"SPOCK1 is a novel inducer of epithelial to mesenchymal transition in drug-induced gingival overgrowth","volume":"10","author":"Alshargabi","year":"2020","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.job.2024.100587_bib71","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0003-9969(03)00153-5","article-title":"Connective tissue growth factor expressed in rat alveolar bone regeneration sites after tooth extraction","volume":"48","author":"Kanyama","year":"2003","journal-title":"Arch Oral Biol"},{"issue":"3","key":"10.1016\/j.job.2024.100587_bib72","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s12105-020-01270-9","article-title":"The role of increased connective tissue growth factor in the pathogenesis of oral submucous fibrosis and its malignant transformation-an immunohistochemical study","volume":"15","author":"Shah","year":"2021","journal-title":"Head Neck Pathol"},{"issue":"6","key":"10.1016\/j.job.2024.100587_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109864","article-title":"The role of yes activated protein (YAP) in melanoma metastasis","volume":"27","author":"Leask","year":"2024","journal-title":"iScience"},{"issue":"8","key":"10.1016\/j.job.2024.100587_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042513","article-title":"Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling","volume":"7","author":"Hough","year":"2012","journal-title":"PLoS One"}],"container-title":["Journal of Oral Biosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007924002330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007924002330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:32:52Z","timestamp":1777609972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1349007924002330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S1349007924002330"],"URL":"https:\/\/doi.org\/10.1016\/j.job.2024.100587","relation":{},"ISSN":["1349-0079"],"issn-type":[{"value":"1349-0079","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CCN2: A potential contributor to gingival overgrowth","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral Biosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.job.2024.100587","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100587"}}