{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T18:57:42Z","timestamp":1762369062524,"version":"build-2065373602"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23K09371","21K17116"],"award-info":[{"award-number":["23K09371","21K17116"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral Biosciences"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.job.2025.100619","type":"journal-article","created":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T18:16:27Z","timestamp":1739729787000},"page":"100619","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["TMPRSS2 expression in oral mucosal cells induced by transfected double-stranded RNA and IL-1\u03b2"],"prefix":"10.1016","volume":"67","author":[{"given":"Misaki","family":"Akagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0603-9171","authenticated-orcid":false,"given":"Kouji","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Naruse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chieko","family":"Niwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Yamakado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiro","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Shigeishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonao","family":"Aikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.job.2025.100619_bib1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.job.2025.100619_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41580-021-00418-x","volume":"23","author":"Jackson","year":"2022","journal-title":"Mechanisms of SARSCoV-2 entry into cells. Nat. Rev. Mol. Cell Biol"},{"key":"10.1016\/j.job.2025.100619_bib3","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1128\/JVI.02232-10","article-title":"Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response","volume":"85","author":"Glowacka","year":"2021","journal-title":"J Virol"},{"key":"10.1016\/j.job.2025.100619_bib4","doi-asserted-by":"crossref","first-page":"12658","DOI":"10.1128\/JVI.01542-10","article-title":"Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2","volume":"84","author":"Matsuyama","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.job.2025.100619_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003774","article-title":"Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice","volume":"9","author":"Hatesuer","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.job.2025.100619_bib6","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/s41467-021-21171-x","article-title":"Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide","volume":"12","author":"Li","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.job.2025.100619_bib7","doi-asserted-by":"crossref","DOI":"10.15252\/embj.20105114","article-title":"SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells","volume":"39","author":"Lukassen","year":"2020","journal-title":"EMBO J"},{"key":"10.1016\/j.job.2025.100619_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110678","article-title":"ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19","volume":"131","author":"Dong","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.job.2025.100619_bib9","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/s41591-021-01296-8","article-title":"NIH COVID-19 autopsy consortium; HCA oral and craniofacial biological network; Frank K, Lee J, Boucher RC, Teichmann SA, Warner BM, Byrd KM. SARS-CoV-2 infection of the oral cavity and saliva","volume":"27","author":"Huang","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.job.2025.100619_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110559","article-title":"Contamination of inert surfaces by SARS-CoV-2: persistence, stability and infectivity. A review","volume":"193","author":"Marqu\u00e8s","year":"2021","journal-title":"Environ Res"},{"key":"10.1016\/j.job.2025.100619_bib11","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1111\/odi.14670","article-title":"ACE2 expression and spike S1 protein-mediated immune responses in oral mucosal cells","volume":"30","author":"Akagi","year":"2023","journal-title":"Oral Dis"},{"key":"10.1016\/j.job.2025.100619_bib12","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1073\/pnas.2002589117","article-title":"Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells","volume":"31","author":"Matsuyama","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.job.2025.100619_bib13","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/jcph.1641","article-title":"TMPRSS2: potential biomarker for COVID-19 outcomes","volume":"60","author":"Strope","year":"2020","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.job.2025.100619_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.667231","article-title":"Transmembrane serine protease 2 polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus type 2 infection: a German case control study","volume":"12","author":"Sch\u00f6nfelder","year":"2021","journal-title":"Front Genet"},{"key":"10.1016\/j.job.2025.100619_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2022.105206","article-title":"Genetic association of TMPRSS2 rs2070788 polymorphism with COVID-19 case fatality rate among Indian populations","volume":"98","author":"Pandey","year":"2022","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.job.2025.100619_bib16","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1093\/infdis\/jiv246","article-title":"Identification of TMPRSS2 as a susceptibility gene for severe 2009 pandemic A(H1N1) influenza and A(H7N9) influenza","volume":"212","author":"Cheng","year":"2015","journal-title":"J Infect Dis"},{"key":"10.1016\/j.job.2025.100619_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.781352","article-title":"IL1\u03b2 promotes TMPRSS2 expression and SARS-CoV-2 cell entry through the p38 MAPK-GATA2 Axis","volume":"12","author":"Cioccarelli","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.job.2025.100619_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.6014\/jjomm1995.8.1","article-title":"Establishment of immortalized human oral keratinocytes by gene transfer of a telomerase component","volume":"8","author":"Fujimoto","year":"2002","journal-title":"J Jpn Oral Muco Membr"},{"key":"10.1016\/j.job.2025.100619_bib19","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1600-0714.2004.00228.x","article-title":"Immortalization of human dental papilla, dental pulp, periodontal ligament cells and gingival fibroblasts by telomerase reverse transcriptase","volume":"33","author":"Kamata","year":"2004","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.job.2025.100619_bib20","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/odi.13725","article-title":"Immune response to cytosolic DNA via intercellular receptor modulation in oral keratinocytes and fibroblasts","volume":"28","author":"Naruse","year":"2022","journal-title":"Oral Dis"},{"key":"10.1016\/j.job.2025.100619_bib21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3892\/mmr.2022.12622","article-title":"Two PARP13 isoforms are associated with induction of antiviral factors in oral mucosal cells","volume":"25","author":"Kato","year":"2022","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.job.2025.100619_bib22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/cr.2008.288","article-title":"Structural basis for dsRNA recognition by NS1 protein of influenza A virus","volume":"19","author":"Cheng","year":"2009","journal-title":"Cell Res"},{"key":"10.1016\/j.job.2025.100619_bib23","article-title":"SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes","volume":"118","author":"Li","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.job.2025.100619_bib24","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1038\/s12276-023-01118-6","article-title":"Understanding nucleic acid sensing and its therapeutic applications","volume":"55","author":"Kong","year":"2023","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.job.2025.100619_bib25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/osi2.1205","article-title":"HPV16 E6 and E7 are involved in inhibition of autophagy and maintenance of cancer stem cell properties in HPV16-positive oral squamous cell carcinoma cell","volume":"21","author":"Shigeishi","year":"2024","journal-title":"Oral Sci Int"},{"key":"10.1016\/j.job.2025.100619_bib26","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1111\/odi.14126","article-title":"ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19","volume":"28","author":"Park","year":"2022","journal-title":"Oral Dis"},{"key":"10.1016\/j.job.2025.100619_bib27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41420-023-01474-2","article-title":"SARS-CoV-2 infection causes periodontal fibrotic pathogenesis through deregulating mitochondrial beta-oxidation","volume":"9","author":"Gao","year":"2023","journal-title":"Cell Death Dis"},{"issue":"6","key":"10.1016\/j.job.2025.100619_bib28","article-title":"Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells","volume":"19","author":"Schwerdtner","year":"2023","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.job.2025.100619_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.655666","article-title":"Fluticasone propionate suppresses poly(I:C)-Induced ACE2 in primary human nasal epithelial cells","volume":"11","author":"Nakazono","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.job.2025.100619_bib30","doi-asserted-by":"crossref","first-page":"9869","DOI":"10.3390\/ijms22189869","article-title":"Tumor necrosis factor-alpha exacerbates viral entry in SARS-CoV2-infected iPSC-derived cardiomyocytes","volume":"22","author":"Lee","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.job.2025.100619_bib31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.job.2022.04.004","article-title":"Periodontitis promotes the expression of gingival transmembrane serine protease 2 (TMPRSS2), a priming protease for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","volume":"64","author":"Ohnishi","year":"2022","journal-title":"J Oral Biosci"},{"key":"10.1016\/j.job.2025.100619_bib32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41368-019-0068-8","article-title":"Interleukin-1\u03b2 is a potential therapeutic target for periodontitis: a narrative review","volume":"12","author":"Cheng","year":"2020","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.job.2025.100619_bib33","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1186\/s12903-023-03378-0","article-title":"The impact of periodontal disease on the clinical outcomes of COVID-19: a systematic review and meta-analysis","volume":"23","author":"Al-Maweri","year":"2023","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.job.2025.100619_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115162","article-title":"JAK inhibition as a new treatment strategy for patients with COVID-19","volume":"202","author":"Huang","year":"2022","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.job.2025.100619_bib35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.imlet.2021.06.008","article-title":"SARS-CoV-2 Spike protein enhances ACE2 expression via facilitating Interferon effects in bronchial epithelium","volume":"237","author":"Zhou","year":"2021","journal-title":"Immunol Lett"},{"key":"10.1016\/j.job.2025.100619_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102567","article-title":"Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions","volume":"19","author":"Jamilloux","year":"2020","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.job.2025.100619_bib37","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1159\/000366359","article-title":"Expression and function of RIG-I in oral keratinocytes and fibroblasts","volume":"34","author":"Ohta","year":"2014","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.job.2025.100619_bib38","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.3390\/v13071362","article-title":"The mechanism behind influenza virus cytokine storm","volume":"13","author":"Gu","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.job.2025.100619_bib39","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s41577-021-00588-x","article-title":"Inflammasome activation at the crux of severe COVID-19","volume":"21","author":"Vora","year":"2021","journal-title":"Nat Rev Immunol"}],"container-title":["Journal of Oral Biosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007925000088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007925000088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T18:51:44Z","timestamp":1762368704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1349007925000088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1349007925000088"],"URL":"https:\/\/doi.org\/10.1016\/j.job.2025.100619","relation":{},"ISSN":["1349-0079"],"issn-type":[{"type":"print","value":"1349-0079"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TMPRSS2 expression in oral mucosal cells induced by transfected double-stranded RNA and IL-1\u03b2","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral Biosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.job.2025.100619","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Japanese Association for Oral Biology.","name":"copyright","label":"Copyright"}],"article-number":"100619"}}