{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:48:10Z","timestamp":1768315690150,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral Biosciences"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.job.2025.100625","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:15:40Z","timestamp":1738714540000},"page":"100625","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of short-term gravitational changes on the human minor salivary gland stem cell characteristics"],"prefix":"10.1016","volume":"67","author":[{"given":"Jeong Mi","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tri Ho","family":"Minh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jeong","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Mi","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-6005","authenticated-orcid":false,"given":"Sungryeal","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9669-2141","authenticated-orcid":false,"given":"Jeong-Seok","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.job.2025.100625_bib1","article-title":"Characterization of a self-renewing and multi-potent cell population isolated from human minor salivary glands","volume":"5","author":"Lu","year":"2015","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.job.2025.100625_bib2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s12105-019-01010-8","article-title":"Challenges in minor salivary gland biopsies: a practical approach to problematic histologic patterns","volume":"13","author":"Rooper","year":"2019","journal-title":"Head Neck Pathol"},{"issue":"3","key":"10.1016\/j.job.2025.100625_bib3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00784-013-1056-6","article-title":"Minor salivary glands of the lips: a novel, easily accessible source of potential stem\/progenitor cells","volume":"18","author":"Andreadis","year":"2014","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.job.2025.100625_bib4","article-title":"Therapeutic potential of human minor salivary gland epithelial progenitor cells in liver regeneration","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.job.2025.100625_bib5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13287-023-03445-x","article-title":"Maintenance of adult stem cells from human minor salivary glands via the Wnt signaling pathway","volume":"14","author":"Kang","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.job.2025.100625_bib6","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1038\/emm.2013.121","article-title":"Human salivary gland stem cells ameliorate hyposalivation of radiation-damaged rat salivary glands","volume":"45","author":"Jeong","year":"2013","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.job.2025.100625_bib6a","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2055-7124-18-9","article-title":"Adult stem cells and tissue engineering strategies for salivary gland regeneration: a review","volume":"18","author":"Yoo","year":"2014","journal-title":"Biomater Res"},{"key":"10.1016\/j.job.2025.100625_bib7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13287-024-03752-x","article-title":"Multipotent\/pluripotent stem cell populations in stromal tissues and peripheral blood: exploring diversity, potential, and therapeutic applications","volume":"15","author":"Aprile","year":"2024","journal-title":"Stem Cell Res Ther"},{"issue":"8","key":"10.1016\/j.job.2025.100625_bib8","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3390\/life12081151","article-title":"Regulation of embryonic stem cell self-renewal","volume":"12","author":"Chen","year":"2022","journal-title":"Life"},{"issue":"1","key":"10.1016\/j.job.2025.100625_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001125","article-title":"Stimuli-responsive biomaterials: scaffolds for stem cell control","volume":"10","author":"Gelmi","year":"2021","journal-title":"Adv Healthc Mater"},{"issue":"4","key":"10.1016\/j.job.2025.100625_bib10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/cbf.3027","article-title":"From mechanical stimulation to biological pathways in the regulation of stem cell fate","volume":"32","author":"Shah","year":"2014","journal-title":"Cell Biochem Funct"},{"issue":"8","key":"10.1016\/j.job.2025.100625_bib11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nbt.2978","article-title":"Modulating the stem cell niche for tissue regeneration","volume":"32","author":"Lane","year":"2014","journal-title":"Nat Biotechnol"},{"issue":"15","key":"10.1016\/j.job.2025.100625_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20153827","article-title":"Current strategies to enhance adipose stem cell function: an update","volume":"20","author":"Seo","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.job.2025.100625_bib13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.reth.2019.03.001","article-title":"\u201cMicrogravity\u201d as a unique and useful stem cell culture environment for cell-based therapy","volume":"12","author":"Imura","year":"2019","journal-title":"Regenerative Therapy"},{"key":"10.1016\/j.job.2025.100625_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41526-018-0045-0","article-title":"Simulated microgravity attenuates myogenic differentiation via epigenetic regulations","author":"Furukawa","year":"2018","journal-title":"npj Microgravity"},{"issue":"2","key":"10.1016\/j.job.2025.100625_bib15","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bbrc.2015.06.160","article-title":"Effects of hypergravity on adipose-derived stem cell morphology, mechanical property and proliferation","volume":"464","author":"Tavakolinejad","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.job.2025.100625_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12574","article-title":"Real microgravity condition promoted regeneration capacity of induced pluripotent stem cells during the TZ-1 space mission","volume":"52","author":"Zhou","year":"2019","journal-title":"Cell Prolif"},{"key":"10.1016\/j.job.2025.100625_bib17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/5584_2020_539","article-title":"Stem cell culture under simulated microgravity","volume":"1298","author":"Anil-Inevi","year":"2020","journal-title":"Adv Exp Med Biol"},{"issue":"Suppl 1","key":"10.1016\/j.job.2025.100625_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1089\/scd.2014.0408","article-title":"Stem cell health and tissue regeneration in microgravity","volume":"23","author":"Blaber","year":"2014","journal-title":"Stem Cells Dev"},{"issue":"22","key":"10.1016\/j.job.2025.100625_bib19","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1089\/scd.2015.0218","article-title":"Microgravity reduces the differentiation and regenerative potential of embryonic stem cells","volume":"24","author":"Blaber","year":"2015","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.job.2025.100625_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/srep36303","article-title":"Single cell clones purified from human parotid glands display features of multipotent epitheliomesenchymal stem cells","volume":"6","author":"Yi","year":"2016","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.job.2025.100625_bib21","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.stem.2011.04.007","article-title":"Eyes wide open: a critical review of sphere-formation as an assay for stem cells","volume":"8","author":"Pastrana","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.job.2025.100625_bib22","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/mt.2009.62","article-title":"Repair of tissues by adult stem\/progenitor cells (MSCs): controversies, myths, and changing paradigms","volume":"17","author":"Prockop","year":"2009","journal-title":"Mol Ther: the Journal of the American Society of Gene Therapy"},{"issue":"24","key":"10.1016\/j.job.2025.100625_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252413562","article-title":"Immortalization of mesenchymal stem cells for application in regenerative medicine and their potential risks of tumorigenesis","volume":"25","author":"Yamaguchi","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.job.2025.100625_bib24","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1177\/0963689719837897","article-title":"The pros and cons of mesenchymal stem cell-based therapies","volume":"28","author":"Musia\u0142-Wysocka","year":"2019","journal-title":"Cell Transplant"},{"key":"10.1016\/j.job.2025.100625_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108887","article-title":"SOX2 maintains the stemness of retinoblastoma stem-like cells through Hippo\/YAP signaling pathway","volume":"214","author":"Zhao","year":"2022","journal-title":"Exp Eye Res"},{"issue":"4","key":"10.1016\/j.job.2025.100625_bib26","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00424-008-0544-z","article-title":"Hypergravity induces ATP release and actin reorganization via tyrosine phosphorylation and RhoA activation in bovine endothelial cells","volume":"457","author":"Koyama","year":"2009","journal-title":"Pflugers Archiv European Journal of Physiology"},{"key":"10.1016\/j.job.2025.100625_bib27","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s40778-017-0100-x","article-title":"Integrin and FAK regulation of human pluripotent stem cells","volume":"3","author":"Vitillo","year":"2017","journal-title":"Curr Stem Cell Rep"},{"issue":"1","key":"10.1016\/j.job.2025.100625_bib28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s12015-021-10260-5","article-title":"Integrins in the regulation of mesenchymal stem cell differentiation by mechanical signals","volume":"18","author":"Wang","year":"2022","journal-title":"Stem Cell Rev Rep"},{"issue":"6","key":"10.1016\/j.job.2025.100625_bib29","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.devcel.2021.02.020","article-title":"Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells","volume":"56","author":"Biswas","year":"2021","journal-title":"Dev Cell"},{"issue":"18","key":"10.1016\/j.job.2025.100625_bib30","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/j.cub.2016.07.012","article-title":"Occluding junctions maintain stem cell niche homeostasis in the fly testes","volume":"26","author":"Fairchild","year":"2016","journal-title":"Curr Biol"},{"issue":"12","key":"10.1016\/j.job.2025.100625_bib31","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1089\/scd.2014.0497","article-title":"Identification and dynamic regulation of tight junction protein expression in human neural stem cells","volume":"24","author":"Watters","year":"2015","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.job.2025.100625_bib32","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1002\/stem.1172","article-title":"ZO-1 regulates Erk, Smad1\/5\/8, Smad2, and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells","volume":"30","author":"Xu","year":"2012","journal-title":"Stem Cell"},{"issue":"6","key":"10.1016\/j.job.2025.100625_bib33","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1152\/ajpcell.00484.2008","article-title":"ZO-1 is involved in trophoblastic cell differentiation in human placenta","volume":"298","author":"Pidoux","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.job.2025.100625_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-53862-3","article-title":"A stimulated microgravity environment causes a sustained defect in epithelial barrier function","volume":"9","author":"Alvarez","year":"2019","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.job.2025.100625_bib35","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.biomaterials.2011.11.049","article-title":"The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities","volume":"33","author":"Cheng","year":"2012","journal-title":"Biomaterials"}],"container-title":["Journal of Oral Biosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007925000143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007925000143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T15:47:45Z","timestamp":1741967265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1349007925000143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S1349007925000143"],"URL":"https:\/\/doi.org\/10.1016\/j.job.2025.100625","relation":{},"ISSN":["1349-0079"],"issn-type":[{"value":"1349-0079","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of short-term gravitational changes on the human minor salivary gland stem cell characteristics","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral Biosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.job.2025.100625","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Japanese Association for Oral Biology.","name":"copyright","label":"Copyright"}],"article-number":"100625"}}