{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:44:10Z","timestamp":1770831850454,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23wm0325066"],"award-info":[{"award-number":["JP23wm0325066"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["25K02804"],"award-info":[{"award-number":["25K02804"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["25K00123"],"award-info":[{"award-number":["25K00123"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["JP23wm0325066"],"award-info":[{"award-number":["JP23wm0325066"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23KK0281"],"award-info":[{"award-number":["23KK0281"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral Biosciences"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.job.2025.100704","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:10:47Z","timestamp":1761109847000},"page":"100704","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dextrin utilization in Streptococcus pyogenes pathogenesis and growth"],"prefix":"10.1016","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6338-4767","authenticated-orcid":false,"given":"Yujiro","family":"Hirose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-0422","authenticated-orcid":false,"given":"Victor","family":"Nizet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigetada","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.job.2025.100704_bib1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1473-3099(05)70267-X","article-title":"The global burden of group A streptococcal diseases","volume":"5","author":"Carapetis","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.job.2025.100704_bib2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1172\/JCI124994","article-title":"Gene fitness landscape of group A streptococcus during necrotizing myositis","volume":"129","author":"Zhu","year":"2019","journal-title":"J Clin Investig"},{"key":"10.1016\/j.job.2025.100704_bib3","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01428-19","article-title":"Streptococcus pyogenes transcriptome changes in the inflammatory environment of necrotizing fasciitis","volume":"85","author":"Hirose","year":"2019","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.job.2025.100704_bib4","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1365-2958.2011.07708.x","article-title":"Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein","volume":"81","author":"Shelburne","year":"2011","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.job.2025.100704_bib5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1186\/1471-2164-14-745","article-title":"RegPrecise 3.0--a resource for genome-scale exploration of transcriptional regulation in bacteria","volume":"14","author":"Novichkov","year":"2013","journal-title":"BMC Genom"},{"key":"10.1016\/j.job.2025.100704_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00247-23","article-title":"Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins","volume":"8","author":"Hirose","year":"2023","journal-title":"mSystems"},{"key":"10.1016\/j.job.2025.100704_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-32558-0","article-title":"CcpA coordinates Growth\/Damage balance for Streptococcus pyogenes pathogenesis","volume":"8","author":"Paluscio","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.job.2025.100704_bib8","doi-asserted-by":"crossref","first-page":"13855","DOI":"10.1073\/pnas.202353699","article-title":"Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modeling","volume":"99","author":"Graham","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.job.2025.100704_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000817","article-title":"A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection","volume":"6","author":"Shelburne","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.job.2025.100704_bib10","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1038\/s41598-018-23366-7","article-title":"Glucose levels alter the Mga Virulence Regulon in the Group A Streptococcus","volume":"8","author":"Valdes","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.job.2025.100704_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cell.2013.12.007","article-title":"An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation","volume":"156","author":"Baruch","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.job.2025.100704_bib12","doi-asserted-by":"crossref","first-page":"5698","DOI":"10.1128\/IAI.00175-07","article-title":"The Streptococcus pyogenes serotype M49 Nra-Ralp3 transcriptional regulatory network and its control of virulence factor expression from the novel eno ralp3 epf sagA pathogenicity region","volume":"75","author":"Kreikemeyer","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.job.2025.100704_bib13","doi-asserted-by":"crossref","first-page":"7230","DOI":"10.1128\/JB.00877-06","article-title":"The Rgg regulator of Streptococcus pyogenes influences utilization of nonglucose carbohydrates, prophage induction, and expression of the NAD-glycohydrolase virulence operon","volume":"188","author":"Dmitriev","year":"2006","journal-title":"J Bacteriol"},{"key":"10.1016\/j.job.2025.100704_bib14","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.4049\/jimmunol.173.2.1194","article-title":"Engagement of the pathogen survival response used by group A Streptococcus to avert destruction by innate host defense","volume":"173","author":"Voyich","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.job.2025.100704_bib15","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.1038\/s41467-019-13483-w","article-title":"The Escherichia coli transcriptome mostly consists of independently regulated modules","volume":"10","author":"Sastry","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.job.2025.100704_bib16","doi-asserted-by":"crossref","first-page":"17228","DOI":"10.1073\/pnas.2008413117","article-title":"Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators, and role in key physiological response","volume":"117","author":"Poudel","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.job.2025.100704_bib17","doi-asserted-by":"crossref","first-page":"D112","DOI":"10.1093\/nar\/gkaa810","article-title":"iModulonDB: a knowledgebase of microbial transcriptional regulation derived from machine learning","volume":"49","author":"Rychel","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.job.2025.100704_bib18","doi-asserted-by":"crossref","first-page":"D99","DOI":"10.1093\/nar\/gkae1009","article-title":"iModulonDB 2.0: dynamic tools to facilitate knowledge-mining and user-enabled analyses of curated transcriptomic datasets","volume":"53","author":"Catoiu","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.job.2025.100704_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00736-24","article-title":"A genome-scale metabolic model of a globally disseminated hyperinvasive M1 strain of Streptococcus pyogenes","volume":"9","author":"Hirose","year":"2024","journal-title":"mSystems"},{"key":"10.1016\/j.job.2025.100704_bib20","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/msb.2013.18","article-title":"Basic and applied uses of genome-scale metabolic network reconstructions of Escherichia coli","volume":"9","author":"McCloskey","year":"2013","journal-title":"Mol Syst Biol"},{"key":"10.1016\/j.job.2025.100704_bib21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tim.2011.12.004","article-title":"A metabolic network approach for the identification and prioritization of antimicrobial drug targets","volume":"20","author":"Chavali","year":"2012","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.job.2025.100704_bib22","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.cell.2015.05.019","article-title":"Using genome-scale models to predict biological capabilities","volume":"161","author":"O'Brien","year":"2015","journal-title":"Cell"}],"container-title":["Journal of Oral Biosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007925000933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007925000933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T02:55:17Z","timestamp":1763693717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1349007925000933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1349007925000933"],"URL":"https:\/\/doi.org\/10.1016\/j.job.2025.100704","relation":{},"ISSN":["1349-0079"],"issn-type":[{"value":"1349-0079","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dextrin utilization in Streptococcus pyogenes pathogenesis and growth","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral Biosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.job.2025.100704","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Japanese Association for Oral Biology.","name":"copyright","label":"Copyright"}],"article-number":"100704"}}