{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:09:20Z","timestamp":1780384160423,"version":"3.54.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral Biosciences"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.job.2026.100785","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:36:22Z","timestamp":1776371782000},"page":"100785","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cinobufagin suppresses malignant progression of oral squamous cell carcinoma through inhibition of p65 nuclear translocation"],"prefix":"10.1016","volume":"68","author":[{"given":"Yi-Xiao","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.job.2026.100785_bib1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.job.2024.05.006","article-title":"Epithelial-mesenchymal transition in oral cancer cells induced by prolonged and persistent Fusobacterium nucleatum stimulation","volume":"66","author":"Nakano","year":"2024","journal-title":"J Oral Biosci"},{"issue":"4","key":"10.1016\/j.job.2026.100785_bib2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.job.2024.09.003","article-title":"Antihypertensive agent losartan promotes tongue squamous cell carcinoma cell proliferation via EGFR\/ERK1\/2\/cyclin D1 signaling axis","volume":"66","author":"Wu","year":"2024","journal-title":"J Oral Biosci"},{"key":"10.1016\/j.job.2026.100785_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155489","article-title":"Comprehensive insights into oral squamous cell carcinoma: diagnosis, pathogenesis, and therapeutic advances","author":"Jagadeesan","year":"2024","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.job.2026.100785_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1198269","article-title":"The emerging role of oral microbiota in oral cancer initiation, progression and stemness","author":"Saikia","year":"2023","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.job.2026.100785_bib5","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1177\/00220345241271992","article-title":"A review of immunotherapy for head and neck cancer","volume":"103","author":"Goetz","year":"2024","journal-title":"J Dent Res"},{"key":"10.1016\/j.job.2026.100785_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108801","article-title":"Bufadienolides as bioorganic anticancer agents: mechanistic insights into apoptosis, cell cycle arrest and signal pathway modulation","volume":"164","author":"Hern\u00e1ndez-Parra","year":"2025","journal-title":"Bioorg Chem"},{"issue":"7","key":"10.1016\/j.job.2026.100785_bib7","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1007\/s00210-025-03902-9","article-title":"Cinobufagin: unveiling the hidden bufadienolide\u2019s promise in combating alimentary canal cancer development and progression - a comprehensive review","volume":"398","author":"Boaro","year":"2025","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.job.2026.100785_bib8","series-title":"Exploring the mechanism of Huachansu injection for lung cancer based on network pharmacology and molecular docking. Curr Pharm Des. United Arab Emirates","author":"Liu","year":"2025"},{"issue":"3","key":"10.1016\/j.job.2026.100785_bib9","doi-asserted-by":"crossref","first-page":"887","DOI":"10.5114\/aoms\/174578","article-title":"Cinobufagin disrupts the stability of lipid rafts by inhibiting the expression of caveolin-1 to promote non-small cell lung cancer cell apoptosis","volume":"20","author":"Xu","year":"2024","journal-title":"Arch Med Sci"},{"issue":"1","key":"10.1016\/j.job.2026.100785_bib10","article-title":"Cinobufacini injection delays hepatocellular carcinoma progression by regulating lipid metabolism via SREBP1 signaling pathway and affecting macrophage polarization","volume":"32","author":"Wang","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.job.2026.100785_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.109938","article-title":"Cinobufagin restrains the growth and triggers DNA damage of human hepatocellular carcinoma cells via proteasome-dependent degradation of thymidylate synthase","volume":"360","author":"Yang","year":"2022","journal-title":"Chem Biol Interact"},{"issue":"1","key":"10.1016\/j.job.2026.100785_bib12","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1080\/13880209.2022.2118792","article-title":"Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the \u03b2-catenin signalling pathway","volume":"60","author":"Bian","year":"2022","journal-title":"Pharm Biol"},{"key":"10.1016\/j.job.2026.100785_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.109936","article-title":"Cinobufagin inhibits proliferation of acute myeloid leukaemia cells by repressing c-Myc pathway-associated genes","volume":"360","author":"Hirasaki","year":"2022","journal-title":"Chem Biol Interact"},{"issue":"1","key":"10.1016\/j.job.2026.100785_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12964-025-02077-3","article-title":"TNFAIP2 promotes NF-\u03baB signaling mediate lymph node metastasis of oral squamous cell carcinoma by protecting IKK\u03b2 from ubiquitin proteasome degradation","volume":"23","author":"Xu","year":"2025","journal-title":"Cell Commun Signal"},{"issue":"2","key":"10.1016\/j.job.2026.100785_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2025.114661","article-title":"The NF-\u03baB\/LY6E axis promotes oral squamous cell carcinoma stemness by responding to interaction with macrophages","volume":"450","author":"Hu","year":"2025","journal-title":"Exp Cell Res"},{"issue":"3","key":"10.1016\/j.job.2026.100785_bib16","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1080\/02648725.2023.2199236","article-title":"Cinobufacini suppresses malignant behaviors of endometrial cancer by regulating NF-\u03baB pathway","volume":"40","author":"Sun","year":"2024","journal-title":"Biotechnol Genet Eng Rev"},{"issue":"2","key":"10.1016\/j.job.2026.100785_bib17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.toxlet.2012.11.006","article-title":"The glycogen synthase kinase-3\u03b2\/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells","volume":"218","author":"Yin","year":"2013","journal-title":"Toxicol Lett"},{"issue":"5","key":"10.1016\/j.job.2026.100785_bib18","first-page":"1619","article-title":"Cinobufocini inhibits NF-\u03baB and COX-2 activation induced by TNF-\u03b1 in lung adenocarcinoma cells","volume":"27","author":"Wang","year":"2012","journal-title":"Oncol Rep"},{"key":"10.1016\/j.job.2026.100785_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113198","article-title":"Zingerone attenuates concanavalin A-induced acute liver injury by restricting inflammatory responses","volume":"142","author":"Liu","year":"2024","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"10.1016\/j.job.2026.100785_bib20","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/jre.13118","article-title":"Cannabidiol attenuates periodontal inflammation through inhibiting TLR4\/NF-\u03baB pathway","volume":"58","author":"Chen","year":"2023","journal-title":"J Periodontal Res"},{"issue":"2","key":"10.1016\/j.job.2026.100785_bib21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","article-title":"Cell death","volume":"187","author":"Newton","year":"2024","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.job.2026.100785_bib22","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41580-023-00689-6","article-title":"A guide to cell death pathways","volume":"25","author":"Yuan","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"41","key":"10.1016\/j.job.2026.100785_bib23","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1038\/onc.2012.591","article-title":"Claudin-1 as a promoter of EMT in hepatocellular carcinoma","volume":"32","author":"Stebbing","year":"2013","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.job.2026.100785_bib24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","article-title":"New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer","volume":"20","author":"Dongre","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.job.2026.100785_bib25","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s13046-024-03243-0","article-title":"SNAI1 promotes epithelial-mesenchymal transition and maintains cancer stem cell-like properties in thymic epithelial tumors through the PIK3R2\/p-EphA2 Axis","volume":"43","author":"E","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"issue":"3","key":"10.1016\/j.job.2026.100785_bib26","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["Journal of Oral Biosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007926000538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1349007926000538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:39:59Z","timestamp":1780382399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1349007926000538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S1349007926000538"],"URL":"https:\/\/doi.org\/10.1016\/j.job.2026.100785","relation":{},"ISSN":["1349-0079"],"issn-type":[{"value":"1349-0079","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cinobufagin suppresses malignant progression of oral squamous cell carcinoma through inhibition of p65 nuclear translocation","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral Biosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.job.2026.100785","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100785"}}