{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:32:23Z","timestamp":1790382743671,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral Biology and Craniofacial Research"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.jobcr.2015.11.003","type":"journal-article","created":{"date-parts":[[2015,12,5]],"date-time":"2015-12-05T15:15:15Z","timestamp":1449328515000},"page":"85-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis \u2013 A clinicobiochemical study"],"prefix":"10.1016","volume":"6","author":[{"given":"Harpreet Singh","family":"Grover","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajita","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jobcr.2015.11.003_bib0165","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2492\/inflammregen.27.107","article-title":"Anti-inflammatory effects of simvastatin on human oral cells","volume":"27","author":"Sakoda","year":"2007","journal-title":"Inflamm Regener"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0170","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1902\/jop.2009.090429","article-title":"Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial","volume":"81","author":"Pradeep","year":"2010","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0175","series-title":"Periodontal Disease Pathogens and Host Immune Response","first-page":"265","article-title":"Production of cytokines by human gingival fibroblasts","author":"Takada","year":"1991"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0180","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1902\/jop.1993.64.10.980","article-title":"Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease","volume":"64","author":"Geivelis","year":"1993","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0185","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1902\/jop.2000.71.10.1535","article-title":"Levels of interleukin-1\u03b2, -8, and -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment","volume":"71","author":"Gamonal","year":"2000","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0190","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1902\/jop.2005.76.2.295","article-title":"Simvastatin promotes cell metabolism, proliferation and osteoblastic differentiation in human periodontal ligament cells","volume":"76","author":"Yazawa","year":"2005","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0195","article-title":"Cholesterol, C-reactive protein, and periodontitis: HMG-CoA-reductase inhibitors (statins) as effect modifiers","volume":"2011","author":"Meisel","year":"2011","journal-title":"ISRN Dent"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0200","first-page":"236","article-title":"Interleukin-8 and MCAF: novel leukocyte recruitment and activating cytokines","volume":"51","author":"Matsushima","year":"1992","journal-title":"Chem Immunol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0205","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1126\/science.2648569","article-title":"The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes","volume":"243","author":"Larsen","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0210","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4049\/jimmunol.147.11.3815","article-title":"IL-10 inhibits cytokine production by activated macrophages","volume":"147","author":"Fiorentino","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0215","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jdent.2004.04.003","article-title":"Effect of periodontal therapy on crevicular fluid interleukin-1\u03b2 and interleukin-10 levels in chronic periodontitis","volume":"32","author":"Goutoudi","year":"2004","journal-title":"J Dent"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0220","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/00016356408993968","article-title":"Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition","volume":"22","author":"Silness","year":"1964","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0225","first-page":"300","article-title":"Evaluation of gingival fluid measurement","volume":"16","author":"Bjorn","year":"1965","journal-title":"Odont Revy"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0230","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/00016355909007506","article-title":"Effect of chewing on flow of tissue fluid into gingival pocket","volume":"17","author":"Brill","year":"1959","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0235","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1902\/jop.2002.73.10.1141","article-title":"Effects of simvastatin gels on murine calvarial bone","volume":"73","author":"Thylin","year":"2002","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0240","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1902\/jop.2005.76.11.1861","article-title":"Local simvastatin effects on mandibular bone growth and inflammation","volume":"76","author":"Stein","year":"2005","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0245","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1600-0765.2007.01024.x","article-title":"Topical administration of simvastatin recovers alveolar bone loss in rats","volume":"43","author":"Seto","year":"2008","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0250","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1902\/jop.1996.67.11.1143","article-title":"Microbiological response to mechanical treatment in combination with adjunctive therapy: a review of the literature","volume":"67","author":"Bollen","year":"1996","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0255","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1902\/jop.1984.55.12.697","article-title":"The effectiveness of hand versus ultrasonic instrumentation in open flap root planing","volume":"55","author":"Hunter","year":"1984","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0260","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1600-051X.1985.tb01373.x","article-title":"The removal of root surface deposits","volume":"12","author":"Eaton","year":"1985","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0265","first-page":"1","article-title":"Statin use is associated with fewer periodontal lesions: a retrospective study","volume":"16","author":"Lindy","year":"2008","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0270","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1902\/jop.1988.59.12.783","article-title":"Evaluation of four modalities of periodontal therapy: mean probing depth, probing attachment level and recession changes","volume":"59","author":"Kaldahl","year":"1988","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0275","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1034\/j.1600-051X.29.s2.4.x","article-title":"Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing","volume":"29","author":"Cobb","year":"2002","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0280","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1600-051X.1987.tb00972.x","article-title":"The effect of plaque control and root debridement in molar teeth","volume":"14","author":"Nordland","year":"1987","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0285","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1600-0765.1991.tb02072.x","article-title":"Interleukin-6 production by human gingival fibroblasts","volume":"26","author":"Bartold","year":"1991","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0290","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1600-0714.1994.tb00074.x","article-title":"IL-4 and IL-6 producing cells in human periodontal disease tissue","volume":"23","author":"Yamazaki","year":"1994","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0295","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1600-0765.1996.tb00473.x","article-title":"Comparison of the proinflammatory cytokine stimulating activity of the surface association proteins of periodontopathic bacteria","volume":"31","author":"Reddi","year":"1996","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0300","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/362905","article-title":"Effect of periodontal therapy on crevicular fluid interleukin-6 and interleukin-8 levels in chronic periodontitis","author":"Goutoudi","year":"2012","journal-title":"Int J Dent"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0305","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1902\/jop.1995.66.10.852","article-title":"Levels of interleukin-1\u03b2 and interleukin-8 in gingival crevicular fluids in adult periodontitis","volume":"66","author":"Tsai","year":"1995","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0310","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/S0140-6736(05)75195-3","article-title":"Statins and C-reactive protein","volume":"353","author":"Ikeda","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0315","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1177\/154405910608500608","article-title":"Simvastatin decreases IL-6 and IL-8 production in epithelial cells","volume":"85","author":"Sakoda","year":"2006","journal-title":"J Dent Res"},{"key":"10.1016\/j.jobcr.2015.11.003_bib0320","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1600-051X.1997.tb00483.x","article-title":"Interleukin-8 and \u03b2-glucuronidase in gingival crevicular fluid","volume":"24","author":"Chung","year":"1997","journal-title":"J Clin Periodontol"}],"container-title":["Journal of Oral Biology and Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221242681500127X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221242681500127X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:23:59Z","timestamp":1761945839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221242681500127X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S221242681500127X"],"URL":"https:\/\/doi.org\/10.1016\/j.jobcr.2015.11.003","relation":{},"ISSN":["2212-4268"],"issn-type":[{"value":"2212-4268","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of topical simvastatin (1.2mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis \u2013 A clinicobiochemical study","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral Biology and Craniofacial Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jobcr.2015.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Craniofacial Research Foundation. All rights reserved.","name":"copyright","label":"Copyright"}]}}