{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:28:24Z","timestamp":1761946104667,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["BSC0103"],"award-info":[{"award-number":["BSC0103"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral Biology and Craniofacial Research"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.jobcr.2018.04.003","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T12:06:47Z","timestamp":1524053207000},"page":"226-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plasminogen activator inhibitor-1 polymorphisms as a risk factor for chronic periodontitis in North Indian population"],"prefix":"10.1016","volume":"9","author":[{"given":"Puja","family":"Debnath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayant","family":"Dewangan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Tandon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Govila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virendra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita","family":"Govila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srikanta Kumar","family":"Rath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 6","key":"10.1016\/j.jobcr.2018.04.003_bib0005","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1600-051X.2005.00799.x","article-title":"Analytical epidemiology of periodontitis","volume":"32","author":"Borrell","year":"2005","journal-title":"J Clin Periodontol"},{"issue":"9","key":"10.1016\/j.jobcr.2018.04.003_bib0010","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1093\/emboj\/16.9.2319","article-title":"Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants","volume":"16","author":"Mazzieri","year":"1997","journal-title":"EMBO J"},{"issue":"1\u20133","key":"10.1016\/j.jobcr.2018.04.003_bib0015","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000468621","article-title":"Plasminogen activators and matrix metalloproteinases in angiogenesis","volume":"49","author":"Mignatti","year":"1996","journal-title":"Enzyme Protein"},{"issue":"7","key":"10.1016\/j.jobcr.2018.04.003_bib0020","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1902\/jop.2007.060383","article-title":"Tissue plasminogen activator and plasminogen activator inhibitor-1 gene polymorphisms in patients with chronic periodontitis","volume":"78","author":"Gurkan","year":"2007","journal-title":"J Periodontol"},{"issue":"1","key":"10.1016\/j.jobcr.2018.04.003_bib0025","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1515\/BC.2002.008","article-title":"The plasminogen activating system in periodontal health and disease","volume":"383","author":"Kinnby","year":"2002","journal-title":"Biol Chem"},{"issue":"1","key":"10.1016\/j.jobcr.2018.04.003_bib0030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1600-0765.1998.tb02287.x","article-title":"Immunohistochemical demonstration of the plasminogen activator system in human gingival tissues and gingival fibroblasts","volume":"33","author":"Xiao","year":"1998","journal-title":"J Periodont Res"},{"issue":"3","key":"10.1016\/j.jobcr.2018.04.003_bib0035","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1034\/j.1600-051x.2000.027003149.x","article-title":"Detection of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 2(PAI-2) in gingival crevicular fluid from healthy, gingivitis and periodontitis patients","volume":"27","author":"Yin","year":"2000","journal-title":"J Clin Periodontol"},{"issue":"12","key":"10.1016\/j.jobcr.2018.04.003_bib0040","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0003-9969(99)00098-9","article-title":"Localization of plasminogen activators and plasminogen-activator inhibitors in human gingival tissues demonstrated by immunohistochemistry and in situ hybridization","volume":"44","author":"Kinnby","year":"1999","journal-title":"Arch Oral Biol"},{"issue":"2","key":"10.1016\/j.jobcr.2018.04.003_bib0045","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1023\/A:1008882113177","article-title":"Gene polymorphisms for PAI-1 are associated with the angiographic extent of coronary artery disease","volume":"5","author":"Benza","year":"1998","journal-title":"J Thromb Thrombolysis"},{"issue":"21","key":"10.1016\/j.jobcr.2018.04.003_bib0050","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1161\/01.CIR.98.21.2248","article-title":"Gene polymorphisms for plasminogen activator inhibitor-1\/tissue plasminogen activator and development of allograft coronary artery disease","volume":"98","author":"Benza","year":"1998","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.jobcr.2018.04.003_bib0055","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.2337\/diacare.20.8.1304","article-title":"Diabetic retinopathy, promoter (4G\/5G) polymorphism of PAI-1 gene, and PAI-1 activity in Pima Indians with type 2 diabetes","volume":"20","author":"Nagi","year":"1997","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.jobcr.2018.04.003_bib0060","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0021-9150(97)00191-3","article-title":"The 4G\/5G polymorphism of the plasminogen activator inhibitor gene is associated with the time course of progression to acute coronary syndromes","volume":"136","author":"Iwai","year":"1998","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.jobcr.2018.04.003_bib0065","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0049-3848(96)00211-3","article-title":"A novel G\/A and the 4G\/5G polymorphism within the promoter of the plasminogen activator inhibitor-1 gene in patients with deep vein thrombosis","volume":"84","author":"Grubic","year":"1996","journal-title":"Thromb Res"},{"issue":"4","key":"10.1016\/j.jobcr.2018.04.003_bib0070","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1159\/000047656","article-title":"4G\/5G polymorphism of the plasminogen activator inhibitor-1 gene and insertion\/deletion polymorphism of the tissue-type plasminogen activator gene in atherothrombotic stroke","volume":"11","author":"Bang","year":"2001","journal-title":"Cerebrovas Dis (Basel, Switzerland)"},{"issue":"3","key":"10.1016\/j.jobcr.2018.04.003_bib0075","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0049-3848(00)00236-X","article-title":"The role of the t-PA I\/D and PAI-1 4G\/5G polymorphisms in African-American adults with a diagnosis of myocardial infarction or venous thromboembolism","volume":"99","author":"Hooper","year":"2000","journal-title":"Thromb Res"},{"issue":"1","key":"10.1016\/j.jobcr.2018.04.003_bib0080","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1161\/01.ATV.17.1.33","article-title":"Plasminogen activator inhibitor-1 promoter 4G\/5G genotype and plasma levels in relation to a history of myocardial infarction in patients characterized by coronary angiography","volume":"17","author":"Ossei-Gerning","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9178","key":"10.1016\/j.jobcr.2018.04.003_bib0085","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0140-6736(98)09376-3","article-title":"Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock","volume":"354","author":"Westendorp","year":"1999","journal-title":"Lancet (London, England)"},{"issue":"5","key":"10.1016\/j.jobcr.2018.04.003_bib0090","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/sj.gene.6363874","article-title":"Plasminogen-activator-inhibitor-1 promoter polymorphism as a risk factor for adult periodontitis in non-smokers","volume":"3","author":"Izakovicova Holla","year":"2002","journal-title":"Genes Immun"},{"issue":"1","key":"10.1016\/j.jobcr.2018.04.003_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"Armitage","year":"1999","journal-title":"Ann Periodontol Am Acad Periodontol"},{"issue":"2","key":"10.1016\/j.jobcr.2018.04.003_bib0100","first-page":"13","article-title":"Classification of periodontal diseases","volume":"1993","author":"Ranney","year":"2000","journal-title":"Periodontology"},{"key":"10.1016\/j.jobcr.2018.04.003_bib0105","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/00016356408993968","article-title":"Periodontal Disease in Pregnancy. Ii. correlation between oral hygiene and periodontal condtion","volume":"22","author":"Silness","year":"1964","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.jobcr.2018.04.003_bib0110","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/00016356309011240","article-title":"Periodontal disease in pregnancy. I. prevalence and severity","volume":"21","author":"Loe","year":"1963","journal-title":"Acta Odontol Scand"},{"issue":"5","key":"10.1016\/j.jobcr.2018.04.003_bib0115","doi-asserted-by":"crossref","first-page":"624","DOI":"10.4103\/0972-124X.119279","article-title":"Clinical and radiographical evaluation of a bioresorbable collagen membrane of fish origin in the treatment of periodontal intrabony defects: a preliminary study","volume":"17","author":"Santosh Kumar","year":"2013","journal-title":"J Indian Soc Periodontol"},{"issue":"8","key":"10.1016\/j.jobcr.2018.04.003_bib0120","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/sj.ejhg.5201011","article-title":"Genetic variation at the human tissue-type plasminogen activator (tPA) locus: haplotypes and analysis of association to plasma levels of tPA","volume":"11","author":"Ladenvall","year":"2003","journal-title":"Eur J Hum Genet"},{"issue":"12","key":"10.1016\/j.jobcr.2018.04.003_bib0125","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1161\/01.CIR.95.12.2623","article-title":"Tissue plasminogen activator and risk of myocardial infarction","volume":"95","author":"van der Bom","year":"1997","journal-title":"The Rotterdam Study. Circulation"},{"issue":"4","key":"10.1016\/j.jobcr.2018.04.003_bib0130","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1600-0765.2006.00949.x","article-title":"Association of gene polymorphisms for plasminogen activators with alveolar bone loss","volume":"42","author":"DeCarlo","year":"2007","journal-title":"J Periodont Res"},{"year":"1997","series-title":"Peopling of India","author":"Gadgil","key":"10.1016\/j.jobcr.2018.04.003_bib0135"},{"issue":"1","key":"10.1016\/j.jobcr.2018.04.003_bib0140","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1055\/s-0038-1646385","article-title":"Inflammation and coagulation: linked processes potentially regulated through a common pathway mediated by protein C","volume":"66","author":"Esmon","year":"1991","journal-title":"Thromb Haemost"},{"issue":"6","key":"10.1016\/j.jobcr.2018.04.003_bib0145","first-page":"355","article-title":"Studies on the biology of the periodontium of marmosets. VI. Arteriosclerotic changes in the blood vessels of the periodontium","volume":"40","author":"Bernick","year":"1969","journal-title":"J Periodontol"},{"issue":"2","key":"10.1016\/j.jobcr.2018.04.003_bib0150","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1834-7819.1994.tb01380.x","article-title":"The vascular response in chronic periodontitis","volume":"39","author":"Zoellner","year":"1994","journal-title":"Aust Dent J"},{"issue":"9","key":"10.1016\/j.jobcr.2018.04.003_bib0155","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1902\/jop.1974.45.9.676","article-title":"Vascular basement lamina thickness in the normal and inflamed gingiva of diabetics and non-diabetics","volume":"45","author":"Listgarten","year":"1974","journal-title":"J Periodontol"},{"issue":"7","key":"10.1016\/j.jobcr.2018.04.003_bib0160","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1902\/jop.1971.42.7.406","article-title":"The ultrastructure of capillary basement membranes in the attached gingiva of diabetic and nondiabetic patients with periodontal disease","volume":"42","author":"Frantzis","year":"1971","journal-title":"J Periodontol"},{"issue":"4","key":"10.1016\/j.jobcr.2018.04.003_bib0165","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1034\/j.1600-051X.2002.290409.x","article-title":"5 polymorphisms in the transforming growth factor-beta 1 gene (TGF-beta 1) in adult periodontitis","volume":"29","author":"Holla","year":"2002","journal-title":"J Clin Periodontol"},{"issue":"8","key":"10.1016\/j.jobcr.2018.04.003_bib0170","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1177\/00220345010800080301","article-title":"Polymorphisms of the interleukin-1 gene family, oral microbial pathogens, and smoking in adult periodontitis","volume":"80","author":"Laine","year":"2001","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.jobcr.2018.04.003_bib0175","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1902\/jop.2001.72.1.85","article-title":"Interactions of lymphotoxin alpha (TNF-beta), angiotensin-converting enzyme (ACE), and endothelin-1 (ET-1) gene polymorphisms in adult periodontitis","volume":"72","author":"Holla","year":"2001","journal-title":"J Periodontol"}],"container-title":["Journal of Oral Biology and Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212426818300435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212426818300435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:24:56Z","timestamp":1761945896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212426818300435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S2212426818300435"],"URL":"https:\/\/doi.org\/10.1016\/j.jobcr.2018.04.003","relation":{},"ISSN":["2212-4268"],"issn-type":[{"type":"print","value":"2212-4268"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasminogen activator inhibitor-1 polymorphisms as a risk factor for chronic periodontitis in North Indian population","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral Biology and Craniofacial Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jobcr.2018.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V. on behalf of Craniofacial Research Foundation.","name":"copyright","label":"Copyright"}]}}