{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:25:58Z","timestamp":1787243158867,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004847","name":"Zahedan University of Medical Sciences","doi-asserted-by":"publisher","award":["6925"],"award-info":[{"award-number":["6925"]}],"id":[{"id":"10.13039\/501100004847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral Biology and Craniofacial Research"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jobcr.2022.08.019","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T02:37:18Z","timestamp":1661481438000},"page":"727-732","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Immunoexpression of interferon-gamma in the interdental gingiva of chronic periodontitis patients with interferon-gamma (+874A\/T) rs62559044 polymorphism"],"prefix":"10.1016","volume":"12","author":[{"given":"Nadia","family":"Sheibak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3732-2586","authenticated-orcid":false,"given":"Hamidreza","family":"Mahmoudzadeh-Sagheb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jobcr.2022.08.019_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.14712\/23362936.2017.4","article-title":"Quantitative parameters of interdental gingiva in chronic periodontitis patients with IFN-gamma gene polymorphism","volume":"118","author":"Sheibak","year":"2017","journal-title":"Prague Med Rep"},{"key":"10.1016\/j.jobcr.2022.08.019_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.archoralbio.2016.02.018","article-title":"Cytokine expression in gingival and intestinal tissues of patients with periodontitis and inflammatory bowel disease: an exploratory study","volume":"66","author":"Menegat","year":"2016","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.jobcr.2022.08.019_bib3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13005-017-0148-y","article-title":"The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian population","volume":"13","author":"Heidari","year":"2017","journal-title":"Head Face Med"},{"key":"10.1016\/j.jobcr.2022.08.019_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/375359","article-title":"Association between IFN-y +874A\/T and IFN-yR1 (-611A\/G, +189T\/G, and +95C\/T) gene polymorphisms and chronic periodontitis in a sample of Iranian population","volume":"2015","author":"Heidari","year":"2015","journal-title":"Int. J. Dentistry"},{"key":"10.1016\/j.jobcr.2022.08.019_bib5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4103\/1735-3327.223614","article-title":"Analysis of interleukin-10 gene polymorphisms in patients with chronic periodontitis and healthy controls","volume":"15","author":"Moudi","year":"2018","journal-title":"Dent Res J"},{"key":"10.1016\/j.jobcr.2022.08.019_bib6","doi-asserted-by":"crossref","DOI":"10.17795\/gct-21898","article-title":"The association between proinflammatory gene polymorphisms and level of gingival tissue degradation in chronic periodontitis","volume":"1","author":"Heidari","year":"2014","journal-title":"Gene Cell Tissue"},{"key":"10.1016\/j.jobcr.2022.08.019_bib7","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.3390\/ijms19071908","article-title":"Interferon crevicular fluid profile and correlation with periodontal disease and wound healing: a systemic review of recent data","volume":"19","author":"Fiorillo","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jobcr.2022.08.019_bib8","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.3390\/ijms19071908","article-title":"Interferon crevicular fluid profile and correlation with periodontal disease and wound healing: a systemic review of recent data","volume":"19","author":"Fiorillo","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jobcr.2022.08.019_bib9","doi-asserted-by":"crossref","first-page":"E85","DOI":"10.25011\/cim.v33i2.12346","article-title":"Association between TNF-\u03b1, TGF-\u03b21, IL-10, IL-6 and IFN-\u03b3 gene polymorphisms and generalized aggressive periodontitis","volume":"33","author":"Erciyas","year":"2010","journal-title":"Clin Investigative Med"},{"key":"10.1016\/j.jobcr.2022.08.019_bib10","doi-asserted-by":"crossref","DOI":"10.17795\/gct-18315","article-title":"Stereological analysis of interdental gingiva in chronic periodontitis patients with tumor necrosis factor-alpha (-308 G\/A) gene polymorphisms","volume":"1","author":"Heidari","year":"2014","journal-title":"Gene, Cell and Tissue"},{"key":"10.1016\/j.jobcr.2022.08.019_bib11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1902\/jop.2013.130087","article-title":"Quantitative analysis of interdental gingiva in patients with chronic periodontitis and transforming growth factor\u2010\u03b21 29C\/T gene polymorphisms","volume":"85","author":"Heidari","year":"2014","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2022.08.019_bib12","first-page":"44","article-title":"Stereological analysis of the dental pulp in patients with advanced periodontitis","volume":"15","author":"Heidari","year":"2013","journal-title":"Zahedan J Res Med Sci"},{"key":"10.1016\/j.jobcr.2022.08.019_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12903-019-0715-7","article-title":"Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview","volume":"19","author":"Heidari","year":"2019","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.jobcr.2022.08.019_bib14","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/JPER.17-0674","article-title":"Memory T cell subsets in healthy gingiva and periodontitis tissues","volume":"89","author":"Mahanonda","year":"2018","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2022.08.019_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/cyto.2001.0879","article-title":"Presence of IFN-\u03b3 and IL-4 in human periapical granulation tissues and regeneration tissues","volume":"14","author":"Kabashima","year":"2001","journal-title":"Cytokine"},{"key":"10.1016\/j.jobcr.2022.08.019_bib16","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1034\/j.1600-051X.2002.290807.x","article-title":"Some cytokine profiles of T\u2010helper cells in lesions of advanced periodontitis","volume":"29","author":"Berglundh","year":"2002","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jobcr.2022.08.019_bib17","doi-asserted-by":"crossref","DOI":"10.1590\/1678-7757-2017-0291","article-title":"IFN-\u03b3R2 is strongly expressed on endothelial cells of gingival tissues from patients with chronic periodontitis","volume":"26","author":"Franco-Topete","year":"2018","journal-title":"J Appl Oral Sci"},{"key":"10.1016\/j.jobcr.2022.08.019_bib18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2319\/122105-451R.1","article-title":"Effects of interferon-gamma on bone remodeling during experimental tooth movement","volume":"77","author":"Mermut","year":"2007","journal-title":"Angle Orthod"},{"key":"10.1016\/j.jobcr.2022.08.019_bib19","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0003-9969(01)00057-7","article-title":"Immunohistological study of interferon-\u03b3-and interleukin-4-bearing cells in human periodontitis gingiva","volume":"46","author":"Ukai","year":"2001","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.jobcr.2022.08.019_bib20","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000007288","article-title":"Is there an association between IFN-\u03b3+ 874A\/T polymorphism and periodontitis susceptibility?: a meta-analysis","volume":"96","author":"Shi","year":"2017","journal-title":"Medicine"},{"key":"10.1016\/j.jobcr.2022.08.019_bib21","article-title":"Positive correlation between the level of interferon-gamma and the severity of periodontitis","volume":"19","author":"Maulani","year":"2020","journal-title":"Pesqui Bras em Odontopediatria Cl\u00ednica Integr"},{"key":"10.1016\/j.jobcr.2022.08.019_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/569632","article-title":"The landscape of protein biomarkers proposed for periodontal disease: markers with functional meaning","volume":"2014","author":"Rosa","year":"2014","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.jobcr.2022.08.019_bib23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.archoralbio.2010.09.005","article-title":"Interferon-\u03b3+ 874A\/T polymorphism in relation to generalized chronic periodontitis and the presence of periodontopathic bacteria","volume":"56","author":"Holla","year":"2011","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.jobcr.2022.08.019_bib24","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/1348-0421.12382","article-title":"Gene polymorphisms of macrophage migration inhibitory factor affect susceptibility to chronic hepatitis B virus infection in an Iranian cohort","volume":"60","author":"Moudi","year":"2016","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.jobcr.2022.08.019_bib25","first-page":"64","article-title":"Immunohistochemical expression of myeloperoxidase in placental samples of systematic lupus erythematosus pregnancies","volume":"10","author":"Heidari","year":"2016","journal-title":"J Fam Reprod Health"},{"key":"10.1016\/j.jobcr.2022.08.019_bib26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2249.2006.03028.x","article-title":"Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions","volume":"144","author":"Honda","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jobcr.2022.08.019_bib27","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1902\/jop.2008.070637","article-title":"Interferon\u2010gamma and interleukin\u201012 gene polymorphisms and their relation to aggressive and chronic periodontitis and key periodontal pathogens","volume":"79","author":"Reichert","year":"2008","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2022.08.019_bib28","doi-asserted-by":"crossref","DOI":"10.17795\/gct-31698","article-title":"Association between TGF-Beta1 (-509) C\/T gene polymorphism and tissue degradation level in chronic periodontitis: a stereological study","volume":"2","author":"Heidari","year":"2015","journal-title":"Gene, Cell and Tissue"},{"key":"10.1016\/j.jobcr.2022.08.019_bib29","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1007\/s00784-011-0634-8","article-title":"Expression and secretion levels of Th1 and Th2 cytokines in patients with aggressive periodontitis","volume":"16","author":"Gonzales","year":"2012","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.jobcr.2022.08.019_bib30","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1902\/jop.1997.68.3.284","article-title":"CD40 mediated activation of gingival and periodontal ligament fibroblasts","volume":"68","author":"Sempowski","year":"1997","journal-title":"J Periodontol"},{"key":"10.1016\/j.jobcr.2022.08.019_bib31","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1034\/j.1600-0714.2000.291004.x","article-title":"Vascular remodelling in chronic inflammatory periodontal disease","volume":"29","author":"Chapple","year":"2000","journal-title":"J Oral Pathol Med"}],"container-title":["Journal of Oral Biology and Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212426822001105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212426822001105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:29:11Z","timestamp":1761946151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212426822001105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S2212426822001105"],"URL":"https:\/\/doi.org\/10.1016\/j.jobcr.2022.08.019","relation":{},"ISSN":["2212-4268"],"issn-type":[{"value":"2212-4268","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunoexpression of interferon-gamma in the interdental gingiva of chronic periodontitis patients with interferon-gamma (+874A\/T) rs62559044 polymorphism","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral Biology and Craniofacial Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jobcr.2022.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Craniofacial Research Foundation. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}