{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:28:51Z","timestamp":1791026931948,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":3548,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1016\/j.joca.2004.02.004","type":"journal-article","created":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T05:31:41Z","timestamp":1081834301000},"page":"440-447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Serum levels of type IIA procollagen amino terminal propeptide (PIIANP) are decreased in patients with knee osteoarthritis and rheumatoid arthritis."],"prefix":"10.1016","volume":"12","author":[{"given":"J.-C.","family":"Rousseau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Miossec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.J.","family":"Sandell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Garnero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.D.","family":"Delmas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2004.02.004_BIB1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2106\/00004623-197153030-00009","article-title":"Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips","volume":"53","author":"Mankin","year":"1971","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.joca.2004.02.004_BIB2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1042\/bj1880823","article-title":"Biosynthesis of collagen and other matrix proteins by articular cartilage in experimental osteoarthritis","volume":"188","author":"Eyre","year":"1980","journal-title":"Biochem J"},{"key":"10.1016\/j.joca.2004.02.004_BIB3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/jor.1100020301","article-title":"Demonstration of increased proteoglycan turnover in cartilage explants from dogs with experimental osteoarthritis","volume":"2","author":"Carney","year":"1984","journal-title":"J Ortho Res"},{"key":"10.1016\/j.joca.2004.02.004_BIB4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/art.1780270405","article-title":"In vivo and in vitro stimulation of chondrocyte biosynthetic activity in early experimental osteoarthritis","volume":"27","author":"Sandy","year":"1984","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2004.02.004_BIB5","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/art.1780380320","article-title":"Discoordinate gene expression of aggrecan and type II collagen in experimental osteoarthritis","volume":"38","author":"Matyas","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2004.02.004_BIB6","first-page":"1765","article-title":"Procollagen II-C propeptide in joint fluid: changes in concentration with age, time after injury and osteoarthritis","volume":"23","author":"Lohmander","year":"1996","journal-title":"J Rheumatol"},{"key":"10.1016\/j.joca.2004.02.004_BIB7","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/art.1780400607","article-title":"Changes in messenger RNA and protein levels of proteoglycans and link protein in human osteoarthritic cartilage samples","volume":"40","author":"Cs-Szabo","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2004.02.004_BIB8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1063-4584(97)80013-1","article-title":"Activation of fibrillar collagen synthesis and phenotypic modulation of chondrocytes in early human osteoarthritis cartilage lesions","volume":"5","author":"Aigner","year":"1997","journal-title":"Osteoarthr Cart"},{"key":"10.1016\/j.joca.2004.02.004_BIB9","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/1529-0131(200008)43:8<1742::AID-ANR10>3.0.CO;2-U","article-title":"Up-regulation of cartilage oligomeric matrix protein at the onset of articular cartilage degeneration in a transgenic mouse model of osteoarthritis","volume":"43","author":"Salminen","year":"2000","journal-title":"Arthritis and Rheum"},{"key":"10.1016\/j.joca.2004.02.004_BIB10","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1096\/fasebj.5.13.1916105","article-title":"Collagen family of proteins","volume":"5","author":"van der Rest","year":"1991","journal-title":"FASEB J"},{"key":"10.1016\/j.joca.2004.02.004_BIB11","series-title":"Dynamics of bone and cartilage metabolism, principles and clinical applications","first-page":"465","article-title":"Laboratory assessment of postmenopausal osteoporosis","author":"Garnero","year":"1998"},{"key":"10.1016\/j.joca.2004.02.004_BIB12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1063-4584(05)80027-5","article-title":"Joint fluid carboxy-terminal type II procollagen peptide as a marker of cartilage biosynthesis","volume":"Apr.,1(2)","author":"Shinmei","year":"1993","journal-title":"Osteoarthr Cart"},{"key":"10.1016\/j.joca.2004.02.004_BIB13","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1172\/JCI117753","article-title":"Cartilage and bone metabolism in rheumatoid arthritis: differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism","volume":"95","author":"Mansson","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joca.2004.02.004_BIB14","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1172\/JCI4853","article-title":"Evidence for altered synthesis of type II collagen patients with osteoarthritis","volume":"102","author":"Nelson","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joca.2004.02.004_BIB15","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1083\/jcb.114.6.1307","article-title":"Alternatively spliced type II procollagen mRNAs define distinct populations of cells during vertebral development: differential expression of the amino-propeptide","volume":"114","author":"Sandell","year":"1991","journal-title":"J Cell Biol"},{"key":"10.1016\/j.joca.2004.02.004_BIB16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1006\/dbio.1993.1251","article-title":"Preferential expression of alternatively spliced mRNAs encoding type II procollagen with a cysteine-rich amino-propeptide in differentiating cartilage and nonchondrogenic tissues during early mouse development","volume":"159","author":"Ng","year":"1993","journal-title":"Dev Biol"},{"key":"10.1016\/j.joca.2004.02.004_BIB17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/aja.1001990206","article-title":"Alternative splice form of type II procollagen mRNA (IIA) is predominant in skeletal precursors and non-cartilaginous tissues during early mouse development","volume":"199","author":"Sandell","year":"1994","journal-title":"Dev Dyn"},{"key":"10.1016\/j.joca.2004.02.004_BIB18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1063-4584(97)80003-9","article-title":"Gene expression of type II collagens in chondro-osteophytes in experimental osteoarthritis","volume":"5","author":"Matyas","year":"1997","journal-title":"Osteoarthr Cart"},{"key":"10.1016\/j.joca.2004.02.004_BIB19","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/jbmr.5650100405","article-title":"Shared phenotypic expression of osteoblasts and chondrocytes in fracture callus","volume":"10","author":"Hughes","year":"1995","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joca.2004.02.004_BIB20","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1002\/1529-0131(199907)42:7<1443::AID-ANR18>3.0.CO;2-A","article-title":"Reexpression of type IIA procollagen by adult articular chondrocytes in osteoarthritic cartilage","volume":"42","author":"Aigner","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2004.02.004_BIB21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/dvdy.1109","article-title":"Type IIA procollagen: expression in developing chicken limb cartilage and human osteoarthritic articular cartilage","volume":"220","author":"Nah","year":"2001","journal-title":"Dev Dyn"},{"key":"10.1016\/j.joca.2004.02.004_BIB22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jbmr.5650110307","article-title":"Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis","volume":"11","author":"Garnero","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joca.2004.02.004_BIB23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S8756-3282(99)00255-0","article-title":"Cross-sectional assessment of age-related bone loss in men: the MINOS study","volume":"26","author":"Szulc","year":"2000","journal-title":"Bone"},{"key":"10.1016\/j.joca.2004.02.004_BIB24","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2004.02.004_BIB25","first-page":"1833","article-title":"Validation of the WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy","year":"1988","journal-title":"J Rheumatol"},{"key":"10.1016\/j.joca.2004.02.004_BIB26","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2004.02.004_BIB27","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1177\/002215549704501104","article-title":"Type IIA procollagen aminopropeptide is localized in human embryonic tissues","volume":"45","author":"Oganesian","year":"1997","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.joca.2004.02.004_BIB28","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/clinchem\/42.6.947","article-title":"Immunoassay for intact aminoterminal propeptide of human type I procollagen (PINP)","volume":"42","author":"Melkko","year":"1996","journal-title":"Cli Chem"},{"key":"10.1016\/j.joca.2004.02.004_BIB29","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0006-291X(78)91646-7","article-title":"A technique for the removal of pyroglutamic acid from the amino terminus of proteins using calf liver pyroglutamate amino peptidase","volume":"81","author":"Podell","year":"1978","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joca.2004.02.004_BIB30","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1074\/jbc.M105485200","article-title":"Processing of type II procollagen aminopropeptide by matrix metalloproteinases","volume":"277","author":"Fukui","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2004.02.004_BIB31","doi-asserted-by":"crossref","first-page":"10334","DOI":"10.1016\/S0021-9258(18)86950-2","article-title":"Differential expression of a cysteine-rich domain in the amino-terminal propeptide of type II (cartilage) procollagen by alternative splicing of mRNA","volume":"265","author":"Ryan","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2004.02.004_BIB32","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/art.1780400608","article-title":"Major role of collagen IIB in the elevation of total type II procollagen messenger RNA in the hypertrophic phase of experimental osteoarthritis","volume":"40","author":"Matyas","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2004.02.004_BIB33","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1053\/joca.1998.0145","article-title":"Collagen type I antisense and collagen type IIA messenger RNA is expressed in adult murine articular cartilage","volume":"6","author":"van der Kraan","year":"1998","journal-title":"Osteoarthr Cart"},{"key":"10.1016\/j.joca.2004.02.004_BIB34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/(SICI)1097-4644(19991001)75:1<13::AID-JCB2>3.0.CO;2-7","article-title":"Distribution of two alternatively spliced variants of type II collagen N-propeptide compared with the C-propeptide in bovine chondrocyte pellet cultures","volume":"75","author":"Rebuck","year":"1999","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.joca.2004.02.004_BIB35","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0945-053X(00)00058-5","article-title":"Localisation of pN-type IIA procollagen on adult bovine vitreous collagen fibrils","volume":"19","author":"Reardon","year":"2000","journal-title":"Matrix Biol"},{"key":"10.1016\/j.joca.2004.02.004_BIB36","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/bbrc.1994.2180","article-title":"Identification of alternatively spliced variants of type II procollagen in vitreous","volume":"203","author":"Bishop","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joca.2004.02.004_BIB37","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/dvdy.1115","article-title":"Type IIA procollagen in development of the human intervertebral disc: regulated expression of the NH2-propeptide by enzymatic processing reveals a unique developmental pathway","volume":"220","author":"Zhu","year":"2001","journal-title":"Dev Dyn"},{"key":"10.1016\/j.joca.2004.02.004_BIB38","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/art.10576","article-title":"Uncoupling of type II collagen and degradation predicts progression of joint damage in patients with knee osteoarthritis","volume":"46","author":"Garnero","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2004.02.004_BIB39","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/rheumatology\/31.12.801","article-title":"Localization of interleukin-1 alpha, type 1 interleukin-1 receptor and interleukin-1 receptor antagonist in the synovial membrane and cartilage\/pannus junction in rheumatoid arthritis","volume":"31","author":"Deleuran","year":"1992","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.joca.2004.02.004_BIB40","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/ard.52.12.870","article-title":"Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis","volume":"52","author":"Farahat","year":"1993","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2004.02.004_BIB41","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF00307738","article-title":"Detection of tumour necrosis factor alpha and interleukin-1 beta in the rheumatoid osteoarthritic cartilage-pannus junction by immunohistochemical methods","volume":"13","author":"Miller","year":"1993","journal-title":"Rheumatol Int"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458404000287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458404000287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:03:17Z","timestamp":1761015797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458404000287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["S1063458404000287"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2004.02.004","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2004,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum levels of type IIA procollagen amino terminal propeptide (PIIANP) are decreased in patients with knee osteoarthritis and rheumatoid arthritis.","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2004.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}