{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:04:40Z","timestamp":1790269480130,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":3214,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.joca.2005.01.002","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T19:44:48Z","timestamp":1109447088000},"page":"395-404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Chondrocyte calcium-sensing receptor expression is up-regulated in early guinea pig knee osteoarthritis and modulates PTHrP, MMP-13, and TIMP-3 expression"],"prefix":"10.1016","volume":"13","author":[{"given":"D.W.","family":"Burton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hiramoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.J.","family":"Deftos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Terkeltaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2005.01.002_bib1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1053\/joca.1999.0304","article-title":"Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage","volume":"8","author":"Kirsch","year":"2000","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2005.01.002_bib2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/art.1780350715","article-title":"Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy","volume":"35","author":"von der Mark","year":"1992","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2005.01.002_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1056\/NEJM200001203420306","article-title":"The physiology of parathyroid hormone-related protein","volume":"342","author":"Strewler","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.joca.2005.01.002_bib4","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1128\/MCB.15.8.4064","article-title":"Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death","volume":"15","author":"Henderson","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.joca.2005.01.002_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/(SICI)1097-4652(199610)169:1<33::AID-JCP4>3.0.CO;2-F","article-title":"Constitutive expression of parathyroid hormone-related peptide (PTHrP) stimulates growth and inhibits differentiation of CFK2 chondrocytes","volume":"169","author":"Henderson","year":"1996","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.joca.2005.01.002_bib6","doi-asserted-by":"crossref","first-page":"13030","DOI":"10.1073\/pnas.95.22.13030","article-title":"The parathyroid hormone\/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation","volume":"95","author":"Chung","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2005.01.002_bib7","doi-asserted-by":"crossref","first-page":"23249","DOI":"10.1074\/jbc.274.33.23249","article-title":"Parathyroid hormone-(1-34) enhances aggrecan synthesis via an insulin-like growth factor-I pathway","volume":"274","author":"Harvey","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2005.01.002_bib8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1677\/joe.0.1500359","article-title":"Parathyroid hormone-related protein (PTHrP) action in rat articular chondrocytes: comparison of PTH (1-34), PTHrP (1-34), PTHrP (1-141), PTHrP (100-114) and antisense oligonucleotides against PTHrP","volume":"150","author":"Tsukazaki","year":"1996","journal-title":"J Endocrinol"},{"key":"10.1016\/j.joca.2005.01.002_bib9","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1210\/endo.139.4.5941","article-title":"Effects of parathyroid hormone (PTH) and PTH-related peptide on expressions of matrix metalloproteinase-2, -3, and -9 in growth plate chondrocyte cultures","volume":"139","author":"Kawashima-Ohya","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.joca.2005.01.002_bib10","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1210\/en.2003-0254","article-title":"Collagenase cleavage of type I collagen is essential for both basal and parathyroid hormone (PTH)\/PTH-related peptide receptor-induced osteoclast activation and has differential effects on discrete bone compartments","volume":"144","author":"Chiusaroli","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.joca.2005.01.002_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1053\/joca.2002.0860","article-title":"Runx2 expression and action in chondrocytes are regulated by retinoid signaling and parathyroid hormone-related peptide (PTHrP)","volume":"11","author":"Iwamoto","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2005.01.002_bib12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1073\/pnas.98.1.160","article-title":"The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones","volume":"98","author":"Huang","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2005.01.002_bib13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1172\/JCI11706","article-title":"Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development","volume":"107","author":"Chung","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joca.2005.01.002_bib14","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1002\/1529-0131(199812)41:12<2152::AID-ART10>3.0.CO;2-X","volume":"41","author":"Terkeltaub","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2005.01.002_bib15","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1136\/ard.2003.008904","article-title":"Sequential changes of parathyroid hormone related protein in articular cartilage during progression of inflammatory and degenerative arthritis","volume":"63","author":"Gomez-Barrena","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2005.01.002_bib16","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1210\/endo.141.12.7812","article-title":"The tetrabasic KKKK (147-150) motif determines intracrine regulatory effects of PTHrP 1-173 on chondrocyte PPi metabolism and matrix synthesis","volume":"141","author":"Goomer","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.joca.2005.01.002_bib17","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1172\/JCI200418776","article-title":"The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport","volume":"113","author":"VanHouten","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joca.2005.01.002_bib18","first-page":"289","article-title":"The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism","volume":"17","author":"Chattopadhyay","year":"1996","journal-title":"Endocr Rev"},{"key":"10.1016\/j.joca.2005.01.002_bib19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ceca.2003.10.013","article-title":"Calcium sensing receptors as integrators of multiple metabolic signals","volume":"35","author":"Breitwieser","year":"2004","journal-title":"Cell Calcium"},{"key":"10.1016\/j.joca.2005.01.002_bib20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ceca.2003.10.012","article-title":"Extracellular Ca2+-sensing receptors \u2013 an overview","volume":"35","author":"Chang","year":"2004","journal-title":"Cell Calcium"},{"key":"10.1016\/j.joca.2005.01.002_bib21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1159\/000025892","article-title":"Calcium-sensing receptor: regulation of electrolyte transport in the thick ascending limb of Henle's loop","volume":"21","author":"Desfleurs","year":"1998","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.joca.2005.01.002_bib22","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/endo.140.4.6639","article-title":"Calcium sensing in cultured chondrogenic RCJ3.1C5.18 cells","volume":"140","author":"Chang","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.joca.2005.01.002_bib23","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1210\/endo.140.12.7190","article-title":"Expression and signal transduction of calcium-sensing receptors in cartilage and bone","volume":"140","author":"Chang","year":"1999","journal-title":"Endocrinolology"},{"key":"10.1016\/j.joca.2005.01.002_bib24","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1210\/endo.143.4.8709","article-title":"Extracellular Ca2+-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells","volume":"143","author":"Chang","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.joca.2005.01.002_bib25","doi-asserted-by":"crossref","first-page":"33995","DOI":"10.1074\/jbc.M007757200","article-title":"Alterations in the sensing and transport of phosphate and calcium by differentiating chondrocytes","volume":"276","author":"Wang","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2005.01.002_bib26","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/art.1780310416","article-title":"Spontaneous cartilage degeneration in guinea pigs","volume":"31","author":"Bendele","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2005.01.002_bib27","first-page":"598","article-title":"Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: histologic, radiologic, and biochemical changes","volume":"47","author":"Jimenez","year":"1997","journal-title":"Lab Anim Sci"},{"key":"10.1016\/j.joca.2005.01.002_bib28","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/art.20149","article-title":"Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs","volume":"50","author":"Johnson","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2005.01.002_bib29","first-page":"345","article-title":"Characterization of immortalized human chondrocytes originated from osteoarthritis cartilage","volume":"8","author":"Yoshimatsu","year":"2001","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.joca.2005.01.002_bib30","doi-asserted-by":"crossref","first-page":"R301","DOI":"10.1186\/ar795","article-title":"A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer","volume":"5","author":"Gouze","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2005.01.002_bib31","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1002\/art.10428","article-title":"Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13","volume":"46","author":"Wu","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2005.01.002_bib32","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0014-5793(03)01295-X","article-title":"TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors","volume":"555","author":"Gendron","year":"2003","journal-title":"FEBS Lett"},{"key":"10.1016\/j.joca.2005.01.002_bib33","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1073\/pnas.95.7.4040","article-title":"Calcimimetics with potent and selective activity on the parathyroid calcium receptor","volume":"95","author":"Nemeth","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2005.01.002_bib34","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/art.10927","article-title":"One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist","volume":"48","author":"Johnson","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2005.01.002_bib35","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1136\/ard.62.10.991","article-title":"Histamine stimulates the proliferation of human articular chondrocytes in vitro and is expressed by chondrocytes in osteoarthritic cartilage","volume":"62","author":"Tetlow","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2005.01.002_bib36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1053\/joca.2002.0873","article-title":"Osteophyte development \u2013 molecular characterization of differentiation stages","volume":"11","author":"Gelse","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2005.01.002_bib37","first-page":"115","article-title":"Proteolysis of the collagen fibril in osteoarthritis","author":"Poole","year":"2003","journal-title":"Biochem Soc Symp"},{"key":"10.1016\/j.joca.2005.01.002_bib38","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1016\/S0021-9258(18)53634-6","article-title":"Recombinant Chinese hamster ovary cell matrix metalloprotease-3 (MMP-3, stromelysin-1). Role of calcium in promatrix metalloprotease-3 (pro-MMP-3, prostromelysin-1) activation and thermostability of the low mass catalytic domain of MMP-3","volume":"268","author":"Housley","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2005.01.002_bib39","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1002\/art.11355","volume":"48","author":"Clements","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2005.01.002_bib40","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1002\/art.11356","article-title":"The usual suspects: verdict not guilty?","volume":"48","author":"Tortorella","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2005.01.002_bib41","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1002\/1529-0131(199911)42:11<2399::AID-ANR19>3.0.CO;2-Y","volume":"42","author":"Martel-Pelletier","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2005.01.002_bib42","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1074\/jbc.273.12.7059","article-title":"Requirements of focal adhesions and calcium fluxes for interleukin-1-induced ERK kinase activation and c-fos expression in fibroblasts","volume":"273","author":"Lo","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2005.01.002_bib43","doi-asserted-by":"crossref","first-page":"17602","DOI":"10.1074\/jbc.270.29.17602","article-title":"Calcium ionophores decrease pericellular gelatinolytic activity via inhibition of 92-kDa gelatinase expression and decrease of 72-kDa gelatinase activation","volume":"270","author":"Lohi","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2005.01.002_bib44","doi-asserted-by":"crossref","first-page":"21505","DOI":"10.1016\/S0021-9258(17)31833-1","article-title":"Calcium influx modulates expression of matrix metalloproteinase-2 (72-kDa type IV collagenase, gelatinase A)","volume":"269","author":"Kohn","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2005.01.002_bib45","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1172\/JCI118501","article-title":"Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor","volume":"97","author":"Bikle","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joca.2005.01.002_bib46","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11926-003-0073-x","article-title":"Calcium pyrophosphate dihydrate and hydroxyapatite crystal deposition in the joint: new developments relevant to the clinician","volume":"5","author":"Pay","year":"2003","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.joca.2005.01.002_bib47","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1074\/jbc.275.7.5037","article-title":"Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor 1","volume":"275","author":"Selvamurugan","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2005.01.002_bib48","first-page":"201","article-title":"Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors","author":"Nagase","year":"2003","journal-title":"Biochem Soc Symp"},{"key":"10.1016\/j.joca.2005.01.002_bib49","first-page":"17124","article-title":"Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme","volume":"271","author":"Knauper","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2005.01.002_bib50","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1074\/jbc.271.3.1544","article-title":"Biochemical characterization of human collagenase-3","volume":"271","author":"Knauper","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2005.01.002_bib51","doi-asserted-by":"crossref","first-page":"7608","DOI":"10.1074\/jbc.272.12.7608","article-title":"The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction","volume":"272","author":"Knauper","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2005.01.002_bib52","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1042\/bss0700115","article-title":"Proteolysis of the collagen fibril in osteoarthritis","volume":"70","author":"Poole","year":"2003","journal-title":"Biochem Soc Symp"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345840500018X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345840500018X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:05:35Z","timestamp":1761015935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S106345840500018X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S106345840500018X"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2005.01.002","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chondrocyte calcium-sensing receptor expression is up-regulated in early guinea pig knee osteoarthritis and modulates PTHrP, MMP-13, and TIMP-3 expression","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2005.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}