{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:35:49Z","timestamp":1791221749939,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":2938,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.joca.2005.08.009","type":"journal-article","created":{"date-parts":[[2005,11,11]],"date-time":"2005-11-11T07:14:49Z","timestamp":1131693289000},"page":"139-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":120,"title":["Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint"],"prefix":"10.1016","volume":"14","author":[{"given":"A.","family":"Ostalowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Birkner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wiecha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kasperczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kasperczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kapolka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Zon-Giebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2005.08.009_bib1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s00117-002-0750-1","article-title":"Coxarthrosis","volume":"42","author":"Imhof","year":"2002","journal-title":"Radiology"},{"key":"10.1016\/j.joca.2005.08.009_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/01.blo.0000131233.83640.91","article-title":"The role of biomechanics and inflammation in cartilage injury and repair","volume":"423","author":"Guilak","year":"2004","journal-title":"Clin Orthop"},{"key":"10.1016\/j.joca.2005.08.009_bib3","first-page":"73","article-title":"Mechanism of cartilage destruction in osteoarthritis","volume":"65","author":"Ishiguro","year":"2002","journal-title":"Nagoya J Med Sci"},{"key":"10.1016\/j.joca.2005.08.009_bib4","first-page":"5","article-title":"Understanding osteoarthritis of the knee-causes and effects","volume":"33","author":"Moskowitz","year":"2004","journal-title":"Am J Orthop"},{"key":"10.1016\/j.joca.2005.08.009_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0049-0172(91)90018-U","article-title":"Oxygen radicals, inflammation, and arthritis","volume":"20","author":"Greenwald","year":"1991","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.joca.2005.08.009_bib6","first-page":"479","article-title":"Post-traumatic osteoarthritis: the role of accelerated chondrocyte senescence","volume":"41","author":"Martin","year":"2004","journal-title":"Biorheology"},{"key":"10.1016\/j.joca.2005.08.009_bib7","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1097\/01.blo.0000143818.74887.b1","article-title":"Chondrocyte senescence, joint loading and osteoarthritis","volume":"427","author":"Martin","year":"2004","journal-title":"Clin Orthop"},{"key":"10.1016\/j.joca.2005.08.009_bib8","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1063-4584(03)00150-X","article-title":"The role of reactive oxygen species in homeostasis and degradation of cartilage","volume":"11910","author":"Henrotin","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2005.08.009_bib9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2746\/042516400777591129","article-title":"Evidence supporting an increased presence of reactive oxygen species in the diseased equine joint","volume":"32","author":"Dimock","year":"2000","journal-title":"Equine Vet J"},{"key":"10.1016\/j.joca.2005.08.009_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/00003086-200210000-00021","article-title":"Oxygen radicals and nitric oxide levels in chondral or meniscal lesions or both","volume":"403","author":"Haklar","year":"2002","journal-title":"Clin Orthop"},{"key":"10.1016\/j.joca.2005.08.009_bib11","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1177\/00220345000790071001","article-title":"Reactive oxygen species participation in experimentally induced arthritis of the temporomandibular joint in rats","volume":"79","author":"Kawai","year":"2000","journal-title":"J Dent Res"},{"key":"10.1016\/j.joca.2005.08.009_bib12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0891-5849(94)90079-5","article-title":"Importance of Se-glutathione peroxidase, catalase, and Cu\/Zn-SOD for cell survival against oxidative stress","volume":"17","author":"Michiels","year":"1994","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.joca.2005.08.009_bib13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0047-6374(90)90078-T","article-title":"Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals","volume":"51","author":"Pigeolet","year":"1990","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.joca.2005.08.009_bib14","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0003-2697(84)90467-6","article-title":"Reevaluation of assay methods and establishment of kit for superoxide dismutase activity","volume":"142","author":"Oyanagui","year":"1984","journal-title":"Anal Biochem"},{"key":"10.1016\/j.joca.2005.08.009_bib15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.joca.2005.08.009_bib16","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.joca.2005.08.009_bib17","first-page":"366","article-title":"Glutathione reductase","volume":"2","author":"Richterich","year":"1971","journal-title":"Clin Chem"},{"key":"10.1016\/j.joca.2005.08.009_bib18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0076-6879(81)77053-8","article-title":"Assays for differentiation of glutathione S-transferases","volume":"77","author":"Habig","year":"1981","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.joca.2005.08.009_bib19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.joca.2005.08.009_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/10408449309104073","article-title":"Free radicals as mediators of tissue injury and disease","volume":"23","author":"Kehrer","year":"1993","journal-title":"Crit Rev Toxicol"},{"key":"10.1016\/j.joca.2005.08.009_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/10715769309111598","article-title":"Free radicals in disease processes: a compilation of cause and consequence","volume":"19","author":"Gutteridge","year":"1993","journal-title":"Free Radic Res Commun"},{"key":"10.1016\/j.joca.2005.08.009_bib22","first-page":"26","article-title":"An imaginative approach to synovitis: the role of hypoxic reperfusion damage in arthritis","volume":"20","author":"Edmonds","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1016\/j.joca.2005.08.009_bib23","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.freeradbiomed.2004.03.022","article-title":"Reactive oxygen species in immune responses","volume":"36","author":"Grisham","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.joca.2005.08.009_bib24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00003086-199411000-00029","article-title":"Oxygen scavengers in simple bone cysts","volume":"308","author":"Komiya","year":"1994","journal-title":"Clin Orthop"},{"key":"10.1016\/j.joca.2005.08.009_bib25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1043-4682(05)80006-6","article-title":"NADPH oxidase and the respiratory burst","volume":"6","author":"Wientjes","year":"1995","journal-title":"Semin Cell Biol"},{"key":"10.1016\/j.joca.2005.08.009_bib26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/bj2860345","article-title":"Activation of neutrophil reactive-oxidant production by synovial fluid from patients with inflammatory joint disease","volume":"286","author":"Robinson","year":"1992","journal-title":"Biochem J"},{"key":"10.1016\/j.joca.2005.08.009_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/10715769800300211","article-title":"Hydroxyl radical formation in chondrocytes and cartilage as detected by electron paramagnetic resonance spectroscopy using spin trapping reagents","volume":"29","author":"Tiku","year":"1998","journal-title":"Free Radic Res"},{"key":"10.1016\/j.joca.2005.08.009_bib28","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/cs1010593","article-title":"Differential roles of nitric oxide and oxygen radicals in chondrocytes affected by osteoarthritis and rheumatoid arthritis","volume":"101","author":"Mazzetti","year":"2001","journal-title":"Clin Sci"},{"key":"10.1016\/j.joca.2005.08.009_bib29","first-page":"7","article-title":"From osteoarthrosis to osteoarthritis \u2013 current view on the pathogenesis of degenerative joint disease","volume":"12","author":"Hrycaj","year":"2002","journal-title":"Nowa Medycyna"},{"key":"10.1016\/j.joca.2005.08.009_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0022-1759(99)00146-5","article-title":"Respiratory burst in human neutrophils","volume":"232","author":"Dahlgren","year":"1999","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.joca.2005.08.009_bib31","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/00016470310013941","article-title":"Activated PMNs lead to oxidative stress on chondrocytes: a study of swine knees","volume":"74","author":"Borsiczky","year":"2003","journal-title":"Acta Orthop Scand"},{"key":"10.1016\/j.joca.2005.08.009_bib32","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1254\/jjp.60.347","article-title":"Phorbol 12-myristate 13-acetate (PMA)-induced oxyradical production in rheumatoid synovial cells","volume":"73","author":"Tanabe","year":"1997","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.joca.2005.08.009_bib33","first-page":"176","article-title":"The role of oxygen in metabolism of articular cartilage","volume":"40","author":"Gajewski","year":"2002","journal-title":"Rheumatologia"},{"key":"10.1016\/j.joca.2005.08.009_bib34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-5793(86)80626-3","article-title":"Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides","volume":"201","author":"Gutteridge","year":"1986","journal-title":"FEBS Lett"},{"key":"10.1016\/j.joca.2005.08.009_bib35","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1042\/bj2730459","article-title":"Oxidative damage to hyaluronate and glucose in synovial fluid during exercise of the inflamed rheumatoid joint","volume":"273","author":"Grootveld","year":"1991","journal-title":"J Biochem"},{"key":"10.1016\/j.joca.2005.08.009_bib36","first-page":"15","article-title":"Intra-articular hyaluronans in knee osteoarthritis: rationale and practical considerations","volume":"33","author":"Kelly","year":"2004","journal-title":"Am J Orthop"},{"key":"10.1016\/j.joca.2005.08.009_bib37","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1002\/art.11305","article-title":"Cyclic tensile stretch loaded on bovine chondrocytes causes depolymerization of hyaluronan: involvement of reactive oxygen species","volume":"48","author":"Yamazaki","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2005.08.009_bib38","doi-asserted-by":"crossref","first-page":"30200","DOI":"10.1016\/S0021-9258(18)43797-0","article-title":"Free metal ion-dependent oxidation damage of collagen","volume":"169","author":"Mukhopadhyay","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2005.08.009_bib39","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.0904-2512.2004.00024.x","article-title":"A decrease in the molecular weight of hyaluronic acid in synovial fluid from patients with temporomandibular disorders","volume":"33","author":"Takahasi","year":"2004","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.joca.2005.08.009_bib40","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/0006-291X(85)91191-X","article-title":"Hyaluronic acid synthesis in articular cartilage. An inhibition by hydrogen peroxide","volume":"132","author":"Bates","year":"1985","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joca.2005.08.009_bib41","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0304-4165(85)90082-0","article-title":"Inhibition of proteoglycan synthesis by hydrogen peroxide in cultured bovine articular cartilage","volume":"838","author":"Bates","year":"1985","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.joca.2005.08.009_bib42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/jor.1100100104","article-title":"Effect of hyaluronan on cartilage and chondrocyte cultures","volume":"10","author":"Larsen","year":"1992","journal-title":"J Orthop Res"},{"key":"10.1016\/j.joca.2005.08.009_bib43","first-page":"345","article-title":"Enhanced lipid peroxidation in synoviocytes from patients with osteoarthritis","volume":"30","author":"Grigolo","year":"2003","journal-title":"J Rheumatol"},{"key":"10.1016\/j.joca.2005.08.009_bib44","first-page":"686","article-title":"Effect of arthrocentesis and sodium hyaluronate injection on nitrite, nitrate, and thiobarbituric acid-reactive substance levels in the synovial fluid","volume":"89","author":"Alpaslan","year":"2000","journal-title":"Oral Surg"},{"key":"10.1016\/j.joca.2005.08.009_bib45","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1002\/art.11338","article-title":"Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels","volume":"48","author":"Carlo","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2005.08.009_bib46","first-page":"49","article-title":"Mechanisms of extracellular antioxidant defend","volume":"4","author":"Ivanova","year":"2000","journal-title":"Exp Pathol"},{"key":"10.1016\/j.joca.2005.08.009_bib47","series-title":"Textbook of Rheumatology","article-title":"Synovial fluid analysis and synovial biopsy","author":"Schumacher","year":"1997"},{"key":"10.1016\/j.joca.2005.08.009_bib48","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1515\/CCLM.2001.196","article-title":"The basis of the synovial fluid analysis","volume":"39","author":"Ter\u010di\u010d","year":"2001","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.joca.2005.08.009_bib49","first-page":"51","article-title":"Superoxide dismutase activity in arthropathy: its role and measurement in the joints","volume":"45","author":"Sumii","year":"1996","journal-title":"Hiroshima J Med Sci"},{"key":"10.1016\/j.joca.2005.08.009_bib50","first-page":"189","article-title":"Oxidative injury and its defense system in vivo","volume":"47","author":"Niwa","year":"1999","journal-title":"Jpn J Clin Pathol"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458405002359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458405002359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:07:44Z","timestamp":1761016064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458405002359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S1063458405002359"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2005.08.009","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2005.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}