{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:50:42Z","timestamp":1773273042177,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":2179,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.joca.2007.06.017","type":"journal-article","created":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T07:08:24Z","timestamp":1187334504000},"page":"287-291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Promoter polymorphisms of the vascular endothelial growth factor gene is associated with an osteonecrosis of the femoral head in the Korean population"],"prefix":"10.1016","volume":"16","author":[{"given":"T.-H.","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.K.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.-K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.-C.","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.-Y.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.joca.2007.06.017_bib1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/01.TP.0000101433.99651.96","article-title":"Relationship between postrenal transplant osteonecrosis of the femoral head and gene polymorphisms related to the coagulation and fibrinolytic systems in Japanese subjects","volume":"77","author":"Asano","year":"2004","journal-title":"Transplantation"},{"issue":"3","key":"10.1016\/j.joca.2007.06.017_bib2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2106\/00004623-199503000-00018","article-title":"Non-traumatic avascular necrosis of the femoral head","volume":"77","author":"Mont","year":"1995","journal-title":"J Bone Joint Surg Am"},{"issue":"2","key":"10.1016\/j.joca.2007.06.017_bib3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/sarh.2002.33724b","article-title":"Pathogenesis and natural history of osteonecrosis","volume":"32","author":"Assouline-Dayan","year":"2002","journal-title":"Semin Arthritis Rheum"},{"issue":"22","key":"10.1016\/j.joca.2007.06.017_bib4","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1056\/NEJMoa042480","article-title":"Type II collagen gene variants and inherited osteonecrosis of the femoral head","volume":"352","author":"Liu","year":"2005","journal-title":"N Engl J Med"},{"issue":"277","key":"10.1016\/j.joca.2007.06.017_bib5","first-page":"22","article-title":"Role of impairment of blood supply of the femoral head in the pathogenesis of idiopathic osteonecrosis","author":"Atsumi","year":"1992","journal-title":"Clin Orthop Relat Res"},{"issue":"130","key":"10.1016\/j.joca.2007.06.017_bib6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/00003086-197801000-00006","article-title":"The role of fat embolism in the etiology of corticosteroid-induced avascular necrosis: clinical and experimental results","author":"Fisher","year":"1978","journal-title":"Clin Orthop Relat Res"},{"issue":"410","key":"10.1016\/j.joca.2007.06.017_bib7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/01.blo.0000063602.67412.83","article-title":"Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis","author":"Wang","year":"2003","journal-title":"Clin Orthop Relat Res"},{"issue":"4","key":"10.1016\/j.joca.2007.06.017_bib8","first-page":"783","article-title":"Procoagulants and osteonecrosis","volume":"30","author":"Jones","year":"2003","journal-title":"J\u00a0Rheumatol"},{"issue":"1","key":"10.1016\/j.joca.2007.06.017_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/CRIAI:25:1:13","article-title":"Osteonecrosis in patients with SLE","volume":"25","author":"Abu-Shakra","year":"2003","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.joca.2007.06.017_bib10","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1302\/0301-620X.45B3.572","article-title":"The vascular contribution to osteogenesis. V. The vasculature supplying the epiphysial cartilage in rachitic rats","volume":"45","author":"Trueta","year":"1963","journal-title":"J Bone Joint Surg Br"},{"issue":"10","key":"10.1016\/j.joca.2007.06.017_bib11","first-page":"1544","article-title":"Vascular endothelial growth factor gene transfection to enhance the repair of avascular necrosis of the femoral head of rabbit","volume":"116","author":"Yang","year":"2003","journal-title":"Chin Med J (Engl)"},{"issue":"2","key":"10.1016\/j.joca.2007.06.017_bib12","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.orthres.2004.08.013","article-title":"Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone","volume":"23","author":"Katsube","year":"2005","journal-title":"J Orthop Res"},{"issue":"5","key":"10.1016\/j.joca.2007.06.017_bib13","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/jor.20097","article-title":"Expression of the angiomatrix and angiogenic proteins CYR61, CTGF, and VEGF in osteonecrosis of the femoral head","volume":"24","author":"Radke","year":"2006","journal-title":"J Orthop Res"},{"issue":"15","key":"10.1016\/j.joca.2007.06.017_bib14","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1073\/pnas.152324099","article-title":"Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover","volume":"99","author":"Street","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"10.1016\/j.joca.2007.06.017_bib15","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1101\/gad.934301","article-title":"Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival","volume":"15","author":"Schipani","year":"2001","journal-title":"Genes Dev"},{"issue":"4","key":"10.1016\/j.joca.2007.06.017_bib16","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.bone.2003.12.024","article-title":"Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair","volume":"34","author":"Komatsu","year":"2004","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.joca.2007.06.017_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molmed.2003.11.006","article-title":"VEGF and ALS: the luckiest growth factor?","volume":"10","author":"Greenberg","year":"2004","journal-title":"Trends Mol Med"},{"issue":"12","key":"10.1016\/j.joca.2007.06.017_bib18","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1172\/JCI200317977","article-title":"VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia","volume":"111","author":"Sun","year":"2003","journal-title":"J\u00a0Clin Invest"},{"issue":"4","key":"10.1016\/j.joca.2007.06.017_bib19","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1210\/er.2003-0027","article-title":"Vascular endothelial growth factor: basic science and clinical progress","volume":"25","author":"Ferrara","year":"2004","journal-title":"Endocr Rev"},{"issue":"5","key":"10.1016\/j.joca.2007.06.017_bib20","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.2337\/diabetes.51.5.1635","article-title":"A\u00a0common polymorphism in the 5\u2032-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes","volume":"51","author":"Awata","year":"2002","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.joca.2007.06.017_bib21","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2337\/diabetes.53.3.861","article-title":"Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes","volume":"53","author":"Ray","year":"2004","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.joca.2007.06.017_bib22","first-page":"3369","article-title":"Influence of cytokine gene polymorphisms on the development of prostate cancer","volume":"62","author":"McCarron","year":"2002","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.joca.2007.06.017_bib23","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0090-4295(03)00268-1","article-title":"Vascular endothelial growth factor gene-460 C\/T polymorphism is a biomarker for prostate cancer","volume":"62","author":"Lin","year":"2003","journal-title":"Urology"},{"issue":"4","key":"10.1016\/j.joca.2007.06.017_bib24","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/ijc.11238","article-title":"A common 936 C\/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer risk","volume":"106","author":"Krippl","year":"2003","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.joca.2007.06.017_bib25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/ajmg.b.30317","article-title":"Haplotype analysis of single nucleotide polymorphisms in VEGF gene for vascular dementia","volume":"141","author":"Kim","year":"2006","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"10","key":"10.1016\/j.joca.2007.06.017_bib26","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/rheumatology\/kei013","article-title":"Influence of VEGF gene polymorphisms on the severity of ankylosing spondylitis","volume":"44","author":"Seo","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.joca.2007.06.017_bib27","series-title":"Bone Circulation and Vascularization in Normal and Pathologic Conditions","first-page":"375","article-title":"The ARCO perspective for reaching one uniform staging system of osteonecrosis","author":"Gardeniers","year":"1993"},{"issue":"5\u20136","key":"10.1016\/j.joca.2007.06.017_bib30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1050-3862(98)00019-9","article-title":"Allelic discrimination using fluorogenic probes and the 5\u2032 nuclease assay","volume":"14","author":"Livak","year":"1999","journal-title":"Genet Anal"},{"issue":"5","key":"10.1016\/j.joca.2007.06.017_bib31","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1086\/344207","article-title":"Partition\u2013ligation\u2013expectation\u2013maximization algorithm for haplotype inference with single-nucleotide polymorphisms","volume":"71","author":"Qin","year":"2002","journal-title":"Am J Hum Genet"},{"issue":"191","key":"10.1016\/j.joca.2007.06.017_bib32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00003086-198412000-00028","article-title":"Angiography in Perthes' disease","author":"de Camargo","year":"1984","journal-title":"Clin Orthop Relat Res"},{"issue":"4","key":"10.1016\/j.joca.2007.06.017_bib33","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/10623320600904211","article-title":"Avascular necrosis of the femoral head: vascular hypotheses","volume":"13","author":"Kerachian","year":"2006","journal-title":"Endothelium"},{"issue":"6","key":"10.1016\/j.joca.2007.06.017_bib34","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S8756-3282(01)00460-4","article-title":"Osteonecrosis induced by a single administration of low-dose lipopolysaccharide in rabbits","volume":"28","author":"Irisa","year":"2001","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.joca.2007.06.017_bib35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S8756-3282(01)00663-9","article-title":"Bone marrow fat cell enlargement and a rise in intraosseous pressure in steroid-treated rabbits with osteonecrosis","volume":"30","author":"Miyanishi","year":"2002","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.joca.2007.06.017_bib36","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/02770909909065152","article-title":"The pathogenesis of osteonecrosis and the relationships to corticosteroids","volume":"36","author":"Mirzai","year":"1999","journal-title":"J Asthma"},{"issue":"6","key":"10.1016\/j.joca.2007.06.017_bib37","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00776-003-0716-9","article-title":"Risk factors for nontraumatic osteonecrosis of the femoral head after renal transplantation","volume":"8","author":"Inoue","year":"2003","journal-title":"J Orthop Sci"},{"issue":"47","key":"10.1016\/j.joca.2007.06.017_bib38","doi-asserted-by":"crossref","first-page":"43836","DOI":"10.1074\/jbc.M106534200","article-title":"Regulation of vascular endothelial growth factor expression by advanced glycation end products","volume":"276","author":"Treins","year":"2001","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.joca.2007.06.017_bib39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/88842","article-title":"Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration","volume":"28","author":"Oosthuyse","year":"2001","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.joca.2007.06.017_bib40","first-page":"812","article-title":"Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter","volume":"63","author":"Stevens","year":"2003","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.joca.2007.06.017_bib41","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1172\/JCI15153","article-title":"Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4","volume":"110","author":"Peng","year":"2002","journal-title":"J Clin Invest"},{"issue":"10","key":"10.1016\/j.joca.2007.06.017_bib42","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1167\/iovs.02-0655","article-title":"Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia","volume":"44","author":"Lukiw","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.joca.2007.06.017_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1056-8727(02)00181-2","article-title":"Polymorphisms of the vascular endothelial growth factor and susceptibility to diabetic microvascular complications in patients with type 1 diabetes mellitus","volume":"17","author":"Yang","year":"2003","journal-title":"J Diabetes Complications"},{"issue":"8","key":"10.1016\/j.joca.2007.06.017_bib44","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1006\/cyto.2000.0692","article-title":"Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production","volume":"12","author":"Watson","year":"2000","journal-title":"Cytokine"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458407002385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458407002385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:16:24Z","timestamp":1761016584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458407002385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S1063458407002385"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2007.06.017","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Promoter polymorphisms of the vascular endothelial growth factor gene is associated with an osteonecrosis of the femoral head in the Korean population","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2007.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}