{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:01:07Z","timestamp":1789200067984,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":1814,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.joca.2008.07.015","type":"journal-article","created":{"date-parts":[[2008,9,18]],"date-time":"2008-09-18T12:26:02Z","timestamp":1221740762000},"page":"313-320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":122,"title":["Quantitative assessment of articular cartilage morphology via EPIC-\u03bcCT"],"prefix":"10.1016","volume":"17","author":[{"given":"L.","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.P.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.E.","family":"Levenston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.E.","family":"Guldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2008.07.015_bib1","first-page":"376","article-title":"Clinical aspects, pathology and pathophysiology of osteoarthritis","volume":"6","author":"Goldring","year":"2006","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1016\/j.joca.2008.07.015_bib2","first-page":"363","article-title":"Animal models of osteoarthritis","volume":"1","author":"Bendele","year":"2001","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1016\/j.joca.2008.07.015_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.berh.2003.09.007","article-title":"The usefulness and the limitations of animal models in identifying targets for therapy in arthritis","volume":"18","author":"Wooley","year":"2004","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.joca.2008.07.015_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0021-9290(94)00060-H","article-title":"Comparison of optical, needle probe and ultrasonic techniques for the measurement of articular cartilage thickness","volume":"28","author":"Jurvelin","year":"1995","journal-title":"J Biomech"},{"key":"10.1016\/j.joca.2008.07.015_bib5","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/j.jbiomech.2005.07.017","article-title":"Material properties of articular cartilage in the rabbit tibial plateau","volume":"39","author":"Roemhildt","year":"2006","journal-title":"J Biomech"},{"key":"10.1016\/j.joca.2008.07.015_bib6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.joca.2006.07.008","article-title":"Quantification of ankle articular cartilage topography and thickness using a high resolution stereophotography system","volume":"15","author":"Millington","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2008.07.015_bib7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1148\/radiology.219.2.r01ma32395","article-title":"T2 mapping of rat patellar cartilage","volume":"219","author":"Watrin","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.joca.2008.07.015_bib8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1148\/radiol.2341030394","article-title":"Effect of proteoglycan depletion on T2 mapping in rat patellar cartilage","volume":"234","author":"Watrin-Pinzano","year":"2005","journal-title":"Radiology"},{"key":"10.1016\/j.joca.2008.07.015_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1109\/TMI.2004.839360","article-title":"Monitoring osteoarthritis in the rat model using optical coherence tomography","volume":"24","author":"Patel","year":"2005","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.joca.2008.07.015_bib10","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00216-003-2225-2","article-title":"A new approach for assessing early osteoarthritis in the rat","volume":"377","author":"Roberts","year":"2003","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.joca.2008.07.015_bib11","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1088\/0031-9155\/49\/7\/012","article-title":"Use of optical coherence tomography in delineating airways microstructure: comparison of OCT images to histopathological sections","volume":"49","author":"Yang","year":"2004","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.joca.2008.07.015_bib12","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.joca.2007.01.013","article-title":"Automatic morphometric cartilage quantification in the medial tibial plateau from MRI for osteoarthritis grading","volume":"15","author":"Dam","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2008.07.015_bib13","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.acra.2007.07.001","article-title":"Accuracy evaluation of automatic quantification of the articular cartilage surface curvature from MRI","volume":"14","author":"Folkesson","year":"2007","journal-title":"Acad Radiol"},{"key":"10.1016\/j.joca.2008.07.015_bib14","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2214\/ajr.184.4.01841215","article-title":"Micro-CT arthrography: a pilot study for the ex vivo visualization of the rat knee joint","volume":"184","author":"Roemer","year":"2005","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.joca.2008.07.015_bib15","doi-asserted-by":"crossref","first-page":"19255","DOI":"10.1073\/pnas.0606406103","article-title":"Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography","volume":"103","author":"Palmer","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.joca.2008.07.015_bib16","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF02347054","article-title":"3D micro-computed tomography of trabecular and cortical bone architecture with application to a rat model of immobilisation osteoporosis","volume":"38","author":"Laib","year":"2000","journal-title":"Med Biol Eng Comput"},{"key":"10.1016\/j.joca.2008.07.015_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/01495739708936692","article-title":"Quantification of bone microarchitecture with the structure model index","volume":"1","author":"Hildebrand","year":"1997","journal-title":"Comput Methods Biomech Biomed Eng"},{"issue":"Suppl A","key":"10.1016\/j.joca.2008.07.015_bib18","doi-asserted-by":"crossref","first-page":"A46","DOI":"10.1016\/j.joca.2006.02.026","article-title":"Magnetic resonance imaging (MRI) of articular cartilage in knee osteoarthritis (OA): morphological assessment","volume":"14","author":"Eckstein","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2008.07.015_bib19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/096228029900800204","article-title":"Measuring agreement in method comparison studies","volume":"8","author":"Bland","year":"1999","journal-title":"Stat Methods Med Res"},{"key":"10.1016\/j.joca.2008.07.015_bib20","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0730-725X(97)00011-8","article-title":"A non-invasive technique for 3-dimensional assessment of articular cartilage thickness based on MRI. Part 2: Validation using CT arthrography","volume":"15","author":"Haubner","year":"1997","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.joca.2008.07.015_bib21","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.joca.2005.04.013","article-title":"Considerations in measuring cartilage thickness using MRI: factors influencing reproducibility and accuracy","volume":"13","author":"Koo","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2008.07.015_bib22","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1053\/joca.2002.0849","article-title":"No loss of cartilage volume over three years in patients with knee osteoarthritis as assessed by magnetic resonance imaging","volume":"10","author":"Gandy","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2008.07.015_bib23","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0730-725X(00)00186-7","article-title":"The influence of the resolution and contrast on measuring the articular cartilage volume in magnetic resonance images","volume":"18","author":"Hardya","year":"2000","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.joca.2008.07.015_bib24","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/03635465000280041601","article-title":"Comparison of knee joint cartilage thickness in triathletes and physically inactive volunteers based on magnetic resonance imaging and three-dimensional analysis","volume":"28","author":"Muhlbauer","year":"2000","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.joca.2008.07.015_bib25","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S1063-4584(03)00076-1","article-title":"The total volume and the complete thickness of articular cartilage determined by MRI","volume":"11","author":"Xia","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2008.07.015_bib26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s002239900373","article-title":"A morphometric comparison of trabecular structure of human ilium between microcomputed tomography and conventional histomorphometry","volume":"61","author":"Uchiyama","year":"1997","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.joca.2008.07.015_bib27","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00223-007-9063-8","article-title":"An automated algorithm to detect the trabecular\u2013cortical bone interface in micro-computed tomographic images","volume":"81","author":"Lublinsky","year":"2007","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.joca.2008.07.015_bib28","first-page":"191","article-title":"Noninvasive study of human cartilage structure by MRI","volume":"101","author":"Eckstein","year":"2004","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.joca.2008.07.015_bib29","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1359\/jbmr.070703","article-title":"Ultrastructural properties in cortical bone vary greatly in two inbred strains of mice as assessed by synchrotron light based micro- and nano-CT","volume":"22","author":"Schneider","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joca.2008.07.015_bib30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/mrm.1910310106","article-title":"Quantifying MRI geometric distortion in tissue","volume":"31","author":"Sumanaweera","year":"1994","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.joca.2008.07.015_bib31","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.joca.2007.01.017","article-title":"Quantitative 3D MR evaluation of autologous chondrocyte implantation in the knee: feasibility and initial results","volume":"15","author":"Glaser","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2008.07.015_bib32","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2746\/0425164054223769","article-title":"Functional adaptation of articular cartilage from birth to maturity under the influence of loading: a biomechanical analysis","volume":"37","author":"Brommer","year":"2005","journal-title":"Equine Vet J"},{"key":"10.1016\/j.joca.2008.07.015_bib33","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1136\/ard.36.6.563","article-title":"Effect of age on thickness of adult patellar articular cartilage","volume":"36","author":"Meachim","year":"1977","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2008.07.015_bib34","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1002\/1529-0131(200109)44:9<2072::AID-ART357>3.0.CO;2-3","article-title":"Magnetic resonance imaging-based assessment of cartilage loss in severe osteoarthritis: accuracy, precision, and diagnostic value","volume":"44","author":"Burgkart","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2008.07.015_bib35","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.joca.2008.01.012","article-title":"In vivo imaging of cartilage degeneration using muCT-arthrography","volume":"16","author":"Piscaer","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2008.07.015_bib36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s004290000154","article-title":"In vivo morphometry and functional analysis of human articular cartilage with quantitative magnetic resonance imaging\u2014from image to data, from data to theory","volume":"203","author":"Eckstein","year":"2001","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.joca.2008.07.015_bib37","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.joca.2007.08.005","article-title":"Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis","volume":"16","author":"Botter","year":"2008","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345840800263X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345840800263X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:19:43Z","timestamp":1761016783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S106345840800263X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S106345840800263X"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2008.07.015","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1159327.619672","asserted-by":"object"}]},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative assessment of articular cartilage morphology via EPIC-\u03bcCT","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2008.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}