{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:04:41Z","timestamp":1790269481454,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":1661,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.joca.2009.02.015","type":"journal-article","created":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T09:04:33Z","timestamp":1238058273000},"page":"1056-1064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA"],"prefix":"10.1016","volume":"17","author":[{"given":"J.L.","family":"Huebner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.B.","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.","family":"Terkeltaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2009.02.015_bib1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.berh.2006.06.003","article-title":"Update on the biology of the chondrocyte and new approaches to treating cartilage diseases","volume":"20","author":"Goldring","year":"2006","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.joca.2009.02.015_bib2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.semarthrit.2004.03.003","article-title":"New insights into the major pathophysiological processes responsible for the development of osteoarthritis","volume":"34","author":"Martel-Pelletier","year":"2005","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.02.015_bib3","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/ncprheum0193","article-title":"Prospects for disease modification in osteoarthritis","volume":"2","author":"Abramson","year":"2006","journal-title":"Nat Clin Pract Rheumatol"},{"issue":"427 Suppl","key":"10.1016\/j.joca.2009.02.015_bib4","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1097\/01.blo.0000144854.66565.8f","article-title":"The role of cytokines in cartilage matrix degeneration in osteoarthritis","author":"Goldring","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.joca.2009.02.015_bib5","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nature03369","article-title":"Deletion of active ADAMTS-5 prevents cartilage degradation in a murine model of osteoarthritis","volume":"434","author":"Glasson","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.joca.2009.02.015_bib6","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.4049\/jimmunol.174.9.5781","article-title":"NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments","volume":"174","author":"Pulai","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.joca.2009.02.015_bib7","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1002\/art.22042","article-title":"Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: role of the receptor for advanced glycation end products","volume":"54","author":"Yammani","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.02.015_bib8","doi-asserted-by":"crossref","first-page":"8296","DOI":"10.4049\/jimmunol.175.12.8296","article-title":"Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products","volume":"175","author":"Cecil","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.joca.2009.02.015_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0002-9440(10)61682-3","article-title":"Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa","volume":"159","author":"Johnson","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.joca.2009.02.015_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0736-0266(01)00064-X","article-title":"Tissue transglutaminase localization and activity regulation in the extracellular matrix of articular cartilage","volume":"20","author":"Summey","year":"2002","journal-title":"J Orthop Res"},{"key":"10.1016\/j.joca.2009.02.015_bib11","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.2741\/1477","article-title":"Transglutaminase contributes to CPPD crystal formation in osteoarthritis","volume":"19","author":"Heinkel","year":"2004","journal-title":"Front. Biosci"},{"key":"10.1016\/j.joca.2009.02.015_bib12","doi-asserted-by":"crossref","first-page":"18824","DOI":"10.1074\/jbc.M301055200","article-title":"Distinct transglutaminase 2-independent and transglutaminase 2-dependent pathways mediate articular chondrocyte hypertrophy","volume":"278","author":"Johnson","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2009.02.015_bib13","doi-asserted-by":"crossref","first-page":"15004","DOI":"10.1074\/jbc.M500962200","article-title":"External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification","volume":"280","author":"Johnson","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2009.02.015_bib14","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nrm1014","article-title":"Transglutaminases: crosslinking enzymes with pleiotropic functions","volume":"4","author":"Lorand","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.joca.2009.02.015_bib15","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/(SICI)1097-0177(199607)206:3<260::AID-AJA4>3.0.CO;2-G","article-title":"Identification and characterization of up-regulated genes during chondrocyte hypertrophy","volume":"206","author":"Nurminskaya","year":"1996","journal-title":"Dev Dyn"},{"key":"10.1016\/j.joca.2009.02.015_bib16","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1083\/jcb.142.4.1135","article-title":"Plasma transglutaminase in hypertrophic chondrocytes: expression and cell-specific intracellular activation produce cell death and externalization","volume":"142","author":"Nurminskaya","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1016\/j.joca.2009.02.015_bib17","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/art.1780350715","article-title":"Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy","volume":"35","author":"von der Mark","year":"1992","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.02.015_bib18","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1002\/art.22041","article-title":"Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability","volume":"54","author":"Kamekura","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.02.015_bib19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.matbio.2006.10.004","article-title":"Osteopontin promotes pathologic mineralization in articular cartilage","volume":"26","author":"Rosenthal","year":"2007","journal-title":"Matrix Biol"},{"key":"10.1016\/j.joca.2009.02.015_bib20","first-page":"4406","article-title":"IL-8\/CXCL8 and growth-related oncogene\u03b1\/CXCL1induce chondrocyte hypertrophic differentiation","volume":"171","author":"Merz","year":"2003","journal-title":"Immunology"},{"key":"10.1016\/j.joca.2009.02.015_bib21","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1242\/jcs.011262","article-title":"Factor XIIIA mobilizes transglutaminase 2 to induce chondrocyte hypertrophic differentiation","volume":"121","author":"Johnson","year":"2008","journal-title":"J Cell Sci"},{"key":"10.1016\/j.joca.2009.02.015_bib22","doi-asserted-by":"crossref","first-page":"8378","DOI":"10.4049\/jimmunol.180.12.8378","article-title":"Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic cytokine for chondrocytes","volume":"180","author":"Cecil","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.joca.2009.02.015_bib23","doi-asserted-by":"crossref","first-page":"S175","DOI":"10.1097\/01.blo.0000144972.50849.d9","article-title":"Toward imaging biomarkers for osteoarthritis","author":"Gray","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.joca.2009.02.015_bib24","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.joca.2006.04.001","article-title":"Classification of osteoarthritis biomarkers: a proposed approach","volume":"14","author":"Bauer","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.02.015_bib25","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0889-857X(03)00056-5","article-title":"Biochemical\/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis","volume":"29","author":"Poole","year":"2003","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.joca.2009.02.015_bib26","first-page":"1142","article-title":"From biomarker to surrogate outcome to osteoarthritis \u2013 what are the challenges?","volume":"32","author":"Lohmander","year":"2005","journal-title":"J Rheumatol"},{"key":"10.1016\/j.joca.2009.02.015_bib27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000084235","article-title":"Transglutaminases in wound healing and inflammation","volume":"38","author":"Verderio","year":"2005","journal-title":"Prog Exp Tumor Res."},{"key":"10.1016\/j.joca.2009.02.015_bib28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/01.RES.0000151333.56089.66","article-title":"Small artery remodeling depends on tissue-type transglutaminase","volume":"96","author":"Bakker","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.joca.2009.02.015_bib29","article-title":"Transglutaminase-2 differently regulates cartilage destruction and osteophyte formation in a surgical model of osteoarthritis","author":"Orlandi","year":"2008","journal-title":"Amino Acids"},{"key":"10.1016\/j.joca.2009.02.015_bib30","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1002\/art.23973","article-title":"The effect of glucosamine and\/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine\/chondroitin arthritis intervention trial","volume":"58","author":"Sawitzke","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.02.015_bib31","article-title":"Glucosamine is an effective chemo-sensitizer via transglutaminase 2 inhibition","author":"Kim","year":"2008","journal-title":"Cancer Lett"},{"key":"10.1016\/j.joca.2009.02.015_bib32","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/art.1780340916","article-title":"Effects of body weight restriction on the development and progression of spontaneous osteoarthritis in guinea pigs","volume":"34","author":"Bendele","year":"1991","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.02.015_bib33","first-page":"598","article-title":"Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: histologic, radiologic, and biochemical changes","volume":"47","author":"Jimenez","year":"1997","journal-title":"Lab Anim Sci"},{"key":"10.1016\/j.joca.2009.02.015_bib34","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/1529-0131(199805)41:5<877::AID-ART16>3.0.CO;2-#","article-title":"Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis","volume":"41","author":"Huebner","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.02.015_bib35","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1053\/joca.2002.0821","article-title":"A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis","volume":"10","author":"Huebner","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.02.015_bib36","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/art.20291","article-title":"Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model","volume":"50","author":"Kraus","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.02.015_bib37","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/art.20149","article-title":"Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs","volume":"50","author":"Johnson","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.02.015_bib38","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.joca.2006.03.007","article-title":"Assessment of the utility of biomarkers of osteoarthritis in the guinea pig","volume":"14","author":"Huebner","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.02.015_bib39","first-page":"115","article-title":"Osteoarthrosis in guinea pigs: histopathologic and scanning electron microscopic features","volume":"39","author":"Bendele","year":"1989","journal-title":"Lab Anim Sci"},{"key":"10.1016\/j.joca.2009.02.015_bib40","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/art.20900","article-title":"Effect of inhibition of matrix metalloproteinases on cartilage loss in vitro and in a guinea pig model of osteoarthritis","volume":"52","author":"Sabatini","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.02.015_bib41","doi-asserted-by":"crossref","first-page":"17699","DOI":"10.1074\/jbc.M513538200","article-title":"Screening for the preferred substrate sequence of transglutaminase using a phage-displayed peptide library: identification of peptide substrates for TGASE 2 and Factor XIIIA","volume":"281","author":"Sugimura","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2009.02.015_bib42","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0002-9440(10)62955-0","article-title":"Proteolysis of cell-surface tissue transglutaminase by matrix metalloproteinase-2 contributes to the adhesive defect and matrix abnormalities in thrombospondin-2-null fibroblasts and mice","volume":"167","author":"Agah","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.joca.2009.02.015_bib43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1359\/jbmr.080901","article-title":"Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice","volume":"24","author":"Zhu","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joca.2009.02.015_bib44","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/ncprheum0841","article-title":"Drug insight: aggrecanases as therapeutic targets for osteoarthritis","volume":"4","author":"Fosang","year":"2008","journal-title":"Nat Clin Pract Rheumatol"},{"key":"10.1016\/j.joca.2009.02.015_bib45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/joca.2001.0481","article-title":"Expression of collagen and aggrecan genes in normal and osteoarthritic murine knee joints","volume":"10","author":"Chambers","year":"2002","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458409000685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458409000685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:19:37Z","timestamp":1761016777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458409000685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S1063458409000685"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2009.02.015","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2009.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}