{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:10:24Z","timestamp":1790856624753,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":1600,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.joca.2009.04.008","type":"journal-article","created":{"date-parts":[[2009,4,18]],"date-time":"2009-04-18T05:05:01Z","timestamp":1240031101000},"page":"1356-1361","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Development of osteoarthritic features in estrogen receptor knockout mice"],"prefix":"10.1016","volume":"17","author":[{"given":"Y.H.","family":"Sniekers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.J.V.M.","family":"van Osch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.G.H.","family":"Ederveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Inzunza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-\u00c5.","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.T.M.","family":"van Leeuwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Weinans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2009.04.008_bib1","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/art.1780380817","article-title":"Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization","volume":"38","author":"Oliveria","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.04.008_bib2","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/S0025-6196(12)62745-1","article-title":"Idiopathic symptomatic osteoarthritis of the hip and knee: a population-based incidence study","volume":"65","author":"Wilson","year":"1990","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.joca.2009.04.008_bib3","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.joca.2008.01.002","article-title":"Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment \u2013 a systematic approach","volume":"16","author":"Sniekers","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.04.008_bib4","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1186\/ar1152","article-title":"Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application","volume":"6","author":"Hoegh-Andersen","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2009.04.008_bib5","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1002\/art.10406","article-title":"Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys","volume":"46","author":"Ham","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.04.008_bib6","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/art.11046","article-title":"Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women","volume":"48","author":"Bergink","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.04.008_bib7","doi-asserted-by":"crossref","first-page":"R415","DOI":"10.1186\/ar1207","article-title":"Estrogen receptor-alpha gene haplotype is associated with primary knee osteoarthritis in Korean population","volume":"6","author":"Jin","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2009.04.008_bib8","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1399-0004.2005.00495.x","article-title":"Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis","volume":"68","author":"Fytili","year":"2005","journal-title":"Clin Genet"},{"key":"10.1016\/j.joca.2009.04.008_bib9","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1002\/1529-0131(200009)43:9<2081::AID-ANR20>3.0.CO;2-I","article-title":"Functional estrogen receptors in adult articular cartilage: estrogen replacement therapy increases chondrocyte synthesis of proteoglycans and insulin-like growth factor binding protein 2","volume":"43","author":"Richmond","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.04.008_bib10","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1053\/joca.1999.0260","article-title":"Expression of genes for estrogen receptors alpha and beta in human articular chondrocytes","volume":"7","author":"Ushiyama","year":"1999","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.04.008_bib11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/ard.2003.006510","article-title":"Dual effects of 17beta-oestradiol on interleukin 1beta-induced proteoglycan degradation in chondrocytes","volume":"63","author":"Richette","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2009.04.008_bib12","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.joca.2004.12.003","article-title":"Human articular chondrocytes exhibit sexual dimorphism in their responses to 17beta-estradiol","volume":"13","author":"Kinney","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.04.008_bib13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00003086-198612000-00005","article-title":"Role of subchondral bone in the initiation and progression of cartilage damage","author":"Radin","year":"1986","journal-title":"Clin Orthop"},{"key":"10.1016\/j.joca.2009.04.008_bib14","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.bone.2003.11.021","article-title":"The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K","volume":"34","author":"Pelletier","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.joca.2009.04.008_bib15","first-page":"379","article-title":"Quantification of subchondral bone changes in a murine osteoarthritis model using micro-CT","volume":"43","author":"Botter","year":"2006","journal-title":"Biorheology"},{"key":"10.1016\/j.joca.2009.04.008_bib16","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.joca.2007.08.005","article-title":"Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis","volume":"16","author":"Botter","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.04.008_bib17","unstructured":"Sniekers YH, van Osch GJ, Weinans H, van Leeuwen JP. Loss of estrogen increases susceptibility for osteoarthritic changes. (Submitted for publication)."},{"key":"10.1016\/j.joca.2009.04.008_bib18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2474-9-20","article-title":"A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models","volume":"9","author":"Sniekers","year":"2008","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.joca.2009.04.008_bib19","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1210\/endo.138.10.5575","article-title":"Expression of estrogen receptor beta in rat bone","volume":"138","author":"Onoe","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.joca.2009.04.008_bib20","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1359\/jbmr.1999.14.6.923","article-title":"Expression and localization of estrogen receptor-beta in murine and human bone","volume":"14","author":"Vidal","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joca.2009.04.008_bib21","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.1210\/endo.138.11.5652","article-title":"Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells","volume":"138","author":"Arts","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.joca.2009.04.008_bib22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1359\/jbmr.2001.16.2.214","article-title":"Localization of estrogen receptor beta protein expression in adult human bone","volume":"16","author":"Braidman","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joca.2009.04.008_bib23","doi-asserted-by":"crossref","first-page":"6613","DOI":"10.1073\/pnas.88.15.6613","article-title":"Avian osteoclasts as estrogen target cells","volume":"88","author":"Oursler","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2009.04.008_bib24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1677\/joe.0.1710229","article-title":"Estrogen receptor specificity in the regulation of the skeleton in female mice","volume":"171","author":"Lindberg","year":"2001","journal-title":"J Endocrinol"},{"key":"10.1016\/j.joca.2009.04.008_bib25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S8756-3282(01)00643-3","article-title":"Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males","volume":"30","author":"Sims","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.joca.2009.04.008_bib26","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1359\/jbmr.2001.16.8.1388","article-title":"Female estrogen receptor beta-\/- mice are partially protected against age-related trabecular bone loss","volume":"16","author":"Windahl","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joca.2009.04.008_bib27","doi-asserted-by":"crossref","first-page":"11162","DOI":"10.1073\/pnas.90.23.11162","article-title":"Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene","volume":"90","author":"Lubahn","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2009.04.008_bib28","unstructured":"Rose UM, Wimmers-Bertens A, Grijsbach-de Breet I, Boerakker-Tijsen R, van de Kant M, van Duin M, et al. Absence of estrogen receptor beta results in impaired ovulation and oocyte maturation. In: Pandalai SG, editor. Recent Research Developments in Endocrinology, volume 4, part II, chapter 14, pp. 283\u2013296. Trivandrum, India: Transworld Research Networks 2004."},{"key":"10.1016\/j.joca.2009.04.008_bib29","doi-asserted-by":"crossref","first-page":"15677","DOI":"10.1073\/pnas.95.26.15677","article-title":"Generation and reproductive phenotypes of mice lacking estrogen receptor beta","volume":"95","author":"Krege","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2009.04.008_bib30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.04.008_bib31","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1359\/JBMR.040705","article-title":"An improved segmentation method for in-vivo micro-CT imaging","volume":"19","author":"Waarsing","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joca.2009.04.008_bib32","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.joca.2006.11.005","article-title":"Osteoarthritis severity is sex dependent in a surgical mouse model","volume":"15","author":"Ma","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.04.008_bib33","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1002\/art.22009","article-title":"Effects of ovariectomy and estrogen therapy on type II collagen degradation and structural integrity of articular cartilage in rats: implications of the time of initiation","volume":"54","author":"Oestergaard","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.04.008_bib34","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/01.WCB.0000121484.18437.98","article-title":"Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a selective estrogen-receptor modulator (SERM)","volume":"11","author":"Christgau","year":"2004","journal-title":"Menopause"},{"key":"10.1016\/j.joca.2009.04.008_bib35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0047-6374(90)90125-Y","article-title":"Hypothalamic-pituitary axis during reproductive aging in mice","volume":"52","author":"Belisle","year":"1990","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.joca.2009.04.008_bib36","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1210\/endo-115-1-114","article-title":"Pituitary gonadotropin-releasing hormone receptor regulation in mice. II: females","volume":"115","author":"Naik","year":"1984","journal-title":"Endocrinology"},{"key":"10.1016\/j.joca.2009.04.008_bib37","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0278-2391(96)90352-3","article-title":"The effect of ovariectomy on the temporomandibular joints of growing rats","volume":"54","author":"Okuda","year":"1996","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joca.2009.04.008_bib38","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1002\/art.20443","article-title":"Association study of candidate genes for the prevalence and progression of knee osteoarthritis","volume":"50","author":"Valdes","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.04.008_bib39","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/art.1780361019","article-title":"A longitudinal study of subchondral plate and trabecular bone in cruciate-deficient dogs with osteoarthritis followed up for 54 months","volume":"36","author":"Dedrick","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.04.008_bib40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1063-4584(97)80036-2","article-title":"Analysis of heat shock proteins and cytokines expressed during early stages of osteoarthritis in a mouse model","volume":"5","author":"Takahashi","year":"1997","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.04.008_bib41","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1359\/jbmr.1998.13.9.1451","article-title":"Variation in the short-term changes in bone cell activity in three regions of the distal femur immediately following ovariectomy","volume":"13","author":"Baldock","year":"1998","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joca.2009.04.008_bib42","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1126\/science.1106943","article-title":"A transmembrane intracellular estrogen receptor mediates rapid cell signaling","volume":"307","author":"Revankar","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.joca.2009.04.008_bib43","first-page":"S170","article-title":"A high dose of 17beta-estradiol increases femoral bone mineral density and uterine weight in the ovariectomised ERalpha knock out mouse","volume":"14","author":"Ederveen","year":"1999","journal-title":"J Bone Miner Res"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458409001046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458409001046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:19:53Z","timestamp":1761016793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458409001046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S1063458409001046"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2009.04.008","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of osteoarthritic features in estrogen receptor knockout mice","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2009.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}