{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:47:02Z","timestamp":1776854822832,"version":"3.51.2"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":1477,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.joca.2009.08.002","type":"journal-article","created":{"date-parts":[[2009,8,30]],"date-time":"2009-08-30T08:09:33Z","timestamp":1251619773000},"page":"175-183","source":"Crossref","is-referenced-by-count":18,"title":["Region of interest analysis: by selecting regions with denuded areas can we detect greater amounts of change?"],"prefix":"10.1016","volume":"18","author":[{"given":"D.J.","family":"Hunter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.Q.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Totterman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tamez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.K.","family":"Kwoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.B.","family":"Eaton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.-P.","family":"Hellio Le Graverand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.R.","family":"Beals","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2009.08.002_bib1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/nbm.1063","article-title":"Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis","volume":"19","author":"Eckstein","year":"2006","journal-title":"NMR Biomed"},{"key":"10.1016\/j.joca.2009.08.002_bib2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/art.20000","article-title":"Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changes","volume":"50","author":"Raynauld","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.08.002_bib3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1136\/ard\/2003.007666","article-title":"How does tibial cartilage volume relate to symptoms in subjects with knee osteoarthritis?","volume":"63","author":"Wluka","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2009.08.002_bib4","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1136\/ard.2004.021253","article-title":"Rate of cartilage loss at two years predicts subsequent total knee arthroplasty: a prospective study","volume":"63","author":"Cicuttini","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2009.08.002_bib5","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/art.11483","article-title":"Longitudinal study of changes in tibial and femoral cartilage in knee osteoarthritis","volume":"50","author":"Cicuttini","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.08.002_bib6","doi-asserted-by":"crossref","first-page":"R74","DOI":"10.1186\/ar2272","article-title":"Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study","volume":"9","author":"Pelletier","year":"2007","journal-title":"Arthritis Res Ther"},{"issue":"Suppl 1","key":"10.1016\/j.joca.2009.08.002_bib7","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.joca.2006.02.027","article-title":"Responsiveness, effect size, and smallest detectable difference of Magnetic Resonance Imaging in knee osteoarthritis","volume":"14","author":"Hunter","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.08.002_bib8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1136\/ard.2007.082107","article-title":"Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative","volume":"68","author":"Hunter","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2009.08.002_bib9","doi-asserted-by":"crossref","unstructured":"Hellio Le Graverand M, Buck R, Wyman B, Vignon E, Mazzuca S, Brandt K et\u00a0al. Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls \u2013 a multicenter study using 3.0 Tesla MRI and Lyon Schuss radiography. Ann Rheum Dis 2008 Dec 22 [Epub ahead of print].","DOI":"10.1136\/ard.2008.099762"},{"key":"10.1016\/j.joca.2009.08.002_bib10","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1002\/art.23462","article-title":"Relationship of meniscal damage, meniscal extrusion, malalignment, and joint laxity to subsequent cartilage loss in osteoarthritic knees","volume":"58","author":"Sharma","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.08.002_bib11","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/art.24208","article-title":"Patterns of femorotibial cartilage loss in knees with neutral, varus, and valgus alignment","volume":"59","author":"Eckstein","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.08.002_bib12","doi-asserted-by":"crossref","unstructured":"Eckstein F, Maschek S, Wirth W, Wyman B, Hudelmaier M, Nevitt M et\u00a0al. One year change of knee cartilage morphology in the first release of participants from the Osteoarthritis Initiative Progression Subcohort \u2013 association with sex, Body Mass Index, symptoms, and radiographic OA status. Ann Rheum Dis 2009;68:674\u20139.","DOI":"10.1136\/ard.2008.089904"},{"key":"10.1016\/j.joca.2009.08.002_bib13","first-page":"6","article-title":"Obesity and osteoarthritis of the knee","volume":"41","author":"Felson","year":"1992","journal-title":"Bull Rheum Dis"},{"key":"10.1016\/j.joca.2009.08.002_bib14","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/art.10576","article-title":"Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis","volume":"46","author":"Garnero","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.08.002_bib15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1001\/jama.286.2.188","article-title":"The role of knee alignment in disease progression and functional decline in knee osteoarthritis","volume":"286","author":"Sharma","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.joca.2009.08.002_bib16","doi-asserted-by":"crossref","first-page":"330","DOI":"10.7326\/0003-4819-139-5_Part_1-200309020-00008","article-title":"Bone marrow edema and its relation to progression of knee osteoarthritis","volume":"139","author":"Felson","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.joca.2009.08.002_bib17","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/art.21724","article-title":"The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis","volume":"54","author":"Hunter","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.08.002_bib18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.joca.2004.11.007","article-title":"Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown","volume":"13","author":"Ding","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.08.002_bib19","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1002\/art.21474","article-title":"Association of prevalent and incident knee cartilage defects with loss of tibial and patellar cartilage: a longitudinal study","volume":"52","author":"Ding","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.08.002_bib20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.joca.2007.01.003","article-title":"Tibial subchondral bone size and knee cartilage defects: relevance to knee osteoarthritis","volume":"15","author":"Ding","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.08.002_bib21","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s00256-002-0603-z","article-title":"Comparison of fixed-flexion positioning with fluoroscopic semi-flexed positioning for quantifying radiographic joint-space width in the knee: test\u2013retest reproducibility","volume":"32","author":"Peterfy","year":"2003","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.joca.2009.08.002_bib22","series-title":"Atlas of Standard Radiographs","author":"Kellgren","year":"1963"},{"issue":"Suppl A","key":"10.1016\/j.joca.2009.08.002_bib23","first-page":"3","article-title":"Atlas of individual radiographic features in osteoarthritis","volume":"3","author":"Altman","year":"1995","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.08.002_bib24","doi-asserted-by":"crossref","unstructured":"Tamez-Pena J, Barbu-McInnis M, Totterman S. Knee Cartilage Extraction and Bone\u2013Cartilage Interface Analysis from 3D MRI Data Sets. Proceedings of SPIE, Medical Imaging. 2004. Proceedings of the SPIE, Medical Imaging.","DOI":"10.1117\/12.535902"},{"key":"10.1016\/j.joca.2009.08.002_bib25","doi-asserted-by":"crossref","DOI":"10.1117\/12.654164","article-title":"Unsupervised Definition of the Tibia-Femoral Joint Regions of the Human Knee and its Applications to Cartilage Analysis","author":"Tamez-Pena","year":"2006","journal-title":"SPIE: Medical Imaging"},{"issue":"9","key":"10.1016\/j.joca.2009.08.002_bib26","first-page":"S282","article-title":"Twelve month longitudinal change in regional cartilage morphology in a multicenter, multivendor MRI study at 3.0 Tesla\u2013The A9001140 Study","volume":"56","author":"Hellio Le Graverand","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2009.08.002_bib27","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1136\/ard.2007.076810","article-title":"Premorbid knee OA is not characterized by diffuse thinness: the Framingham study","volume":"67","author":"Hunter","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2009.08.002_bib28","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/2191260a0","article-title":"Permeability of articular cartilage","volume":"219","author":"Maroudas","year":"1968","journal-title":"Nature"},{"key":"10.1016\/j.joca.2009.08.002_bib29","first-page":"21P","article-title":"Physical chemistry and the structure of cartilage","volume":"223","author":"Maroudas","year":"1972","journal-title":"J Physiol"},{"key":"10.1016\/j.joca.2009.08.002_bib30","series-title":"Osteoarthritis","first-page":"108","article-title":"Mechanical properties of normal and osteoarthritis articular cartilage","author":"Mow","year":"1998"},{"key":"10.1016\/j.joca.2009.08.002_bib31","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/ard.36.5.399","article-title":"Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. II. Swelling","volume":"36","author":"Maroudas","year":"1977","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2009.08.002_bib32","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.joca.2004.07.007","article-title":"Histopathological correlation of cartilage swelling detected by magnetic resonance imaging in early experimental osteoarthritis","volume":"12","author":"Calvo","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2009.08.002_bib33","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1136\/ard.2004.029678","article-title":"Accuracy of quantitative magnetic resonance imaging in the detection of ex vivo focal cartilage defects","volume":"64","author":"Graichen","year":"2005","journal-title":"Ann Rheum Dis"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458409002015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458409002015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T12:56:02Z","timestamp":1545051362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458409002015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S1063458409002015"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2009.08.002","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}