{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:09:23Z","timestamp":1789877363527,"version":"4.0.1"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":1357,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.joca.2010.02.017","type":"journal-article","created":{"date-parts":[[2010,4,17]],"date-time":"2010-04-17T08:04:57Z","timestamp":1271491497000},"page":"S1-S6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"special_numbering":"S1","title":["Modulation of inflammation by chondroitin sulfate"],"prefix":"10.1016","volume":"18","author":[{"given":"M.","family":"Valli\u00e8res","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"du Souich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2010.02.017_bib1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/path.2271","article-title":"Nod-like proteins in inflammation and disease","volume":"214","author":"Carneiro","year":"2008","journal-title":"J Pathol"},{"key":"10.1016\/j.joca.2010.02.017_bib2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/CCM.0b013e31819267fb","article-title":"Molecular biology of inflammation and sepsis: a primer","volume":"37","author":"Cinel","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.joca.2010.02.017_bib3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1586\/17512433.1.5.627","article-title":"Inflammatory reactions and drug response: importance of cytochrome P450 and membrane transporters","volume":"1","author":"Dumais","year":"2008","journal-title":"Expert Rev Clin Pharmacol"},{"key":"10.1016\/j.joca.2010.02.017_bib4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/intimm\/dxn003","article-title":"Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12","volume":"20","author":"Osterloh","year":"2008","journal-title":"Int Immunol"},{"key":"10.1016\/j.joca.2010.02.017_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/s10165-006-0490-6","article-title":"Cartilage destruction by matrix degradation products","volume":"16","author":"Yasuda","year":"2006","journal-title":"Mod Rheumatol"},{"key":"10.1016\/j.joca.2010.02.017_bib6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.cellbio.23.090506.123337","article-title":"Hyaluronan in tissue injury and repair","volume":"23","author":"Jiang","year":"2007","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.joca.2010.02.017_bib7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1196\/annals.1391.019","article-title":"Extracellular heat shock proteins in cell signaling and immunity","volume":"1113","author":"Calderwood","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.joca.2010.02.017_bib8","doi-asserted-by":"crossref","first-page":"17952","DOI":"10.1074\/jbc.M602750200","article-title":"Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NF-kappaB and p38 MAP kinase in articular chondrocytes","volume":"281","author":"Ohno","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2010.02.017_bib9","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1002\/art.10502","article-title":"Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes","volume":"46","author":"Forsyth","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2010.02.017_bib10","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.molimm.2007.10.008","article-title":"TLR4 signaling induces functional nerve growth factor receptor p75NTR on mouse dendritic cells via p38MAPK and NF-kappa B pathways","volume":"45","author":"Jiang","year":"2008","journal-title":"Mol Immunol"},{"key":"10.1016\/j.joca.2010.02.017_bib11","doi-asserted-by":"crossref","first-page":"24246","DOI":"10.1074\/jbc.M703422200","article-title":"Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release","volume":"282","author":"Zhong","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2010.02.017_bib12","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nri2423","article-title":"New regulators of NF-kappaB in inflammation","volume":"8","author":"Ghosh","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.joca.2010.02.017_bib13","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2796.2008.01953.x","article-title":"NF-kappaB in inflammatory bowel disease","volume":"263","author":"Atreya","year":"2008","journal-title":"J Intern Med"},{"key":"10.1016\/j.joca.2010.02.017_bib14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/B:APPT.0000018794.26438.22","article-title":"Chronic inflammation, apoptosis and (pre-)malignant lesions in the gastro-intestinal tract","volume":"9","author":"van der Woude","year":"2004","journal-title":"Apoptosis"},{"key":"10.1016\/j.joca.2010.02.017_bib15","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/ar2457","article-title":"The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis","volume":"10","author":"Brown","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2010.02.017_bib16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2174\/187221309787158399","article-title":"NF-kappaB links keratinocytes and lymphocytes in the pathogenesis of psoriasis","volume":"3","author":"Tsuruta","year":"2009","journal-title":"Recent Pat Inflamm Allergy Drug Discov"},{"key":"10.1016\/j.joca.2010.02.017_bib17","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/01.mol.0000180167.15820.ae","article-title":"Nuclear factor kappa B signaling in macrophage function and atherogenesis","volume":"16","author":"Xanthoulea","year":"2005","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.joca.2010.02.017_bib18","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3233\/JAD-2009-0976","article-title":"Inflammation and NF-kappaB in Alzheimer\u2019s disease and diabetes","volume":"16","author":"Granic","year":"2009","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.joca.2010.02.017_bib19","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.2174\/138161207780858429","article-title":"Inflammation in Parkinson\u2019s diseases and other neurodegenerative diseases: cause and therapeutic implications","volume":"13","author":"Wilms","year":"2007","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.joca.2010.02.017_bib20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1513\/pats.200806-054RM","article-title":"Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control","volume":"6","author":"Janssen-Heininger","year":"2009","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.joca.2010.02.017_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1254\/jphs.CRJ06010X","article-title":"Systemic inflammatory response syndrome (SIRS): molecular pathophysiology and gene therapy","volume":"101","author":"Matsuda","year":"2006","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.joca.2010.02.017_bib22","article-title":"NF-kappaB and cancer: how intimate is this relationship","author":"Prasad","year":"2009","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.joca.2010.02.017_bib23","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s00018-007-6516-1","article-title":"Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases","volume":"64","author":"Lleo","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.joca.2010.02.017_bib24","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.bcp.2007.10.027","article-title":"Anti-inflammatory interventions of NF-kappaB signaling: potential applications and risks","volume":"75","author":"Uwe","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.joca.2010.02.017_bib25","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1080\/00365520510023774","article-title":"Saliva Interleukin-6 in patients with inflammatory bowel disease","volume":"40","author":"Aleksandra Nielsen","year":"2005","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.joca.2010.02.017_bib26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s10620-007-9849-6","article-title":"Serum interleukin-6, soluble interleukin-6 receptor and Crohn\u2019s disease activity","volume":"53","author":"Nancey","year":"2008","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.joca.2010.02.017_bib27","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1365-2230.2009.03410.x","article-title":"A comprehensive review of biomarkers in psoriasis","volume":"34","author":"Rashmi","year":"2009","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.joca.2010.02.017_bib28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1301\/nr.2007.dec.S253-S259","article-title":"Inflammatory biomarkers and risks of myocardial infarction, stroke, diabetes, and total mortality: implications for longevity","volume":"65","author":"Ridker","year":"2007","journal-title":"Nutr Rev"},{"key":"10.1016\/j.joca.2010.02.017_bib29","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s11936-008-0051-8","article-title":"Use of biomarkers to develop treatment strategies for atherosclerosis","volume":"10","author":"Crandall","year":"2008","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"10.1016\/j.joca.2010.02.017_bib30","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/aje\/kwm260","article-title":"Peripheral inflammatory biomarkers and risk of Parkinson\u2019s disease","volume":"167","author":"Chen","year":"2008","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.joca.2010.02.017_bib31","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1017\/S1041610208008107","article-title":"IL-6 release by LPS-stimulated peripheral blood mononuclear cells as a potential biomarker in Alzheimer\u2019s disease","volume":"21","author":"Kaplin","year":"2009","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.joca.2010.02.017_bib32","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S1474-4422(08)70293-X","article-title":"Biomarkers in amyotrophic lateral sclerosis","volume":"8","author":"Turner","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.joca.2010.02.017_bib33","first-page":"15","article-title":"Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis","volume":"20","author":"Heikkila","year":"2009","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.joca.2010.02.017_bib34","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bbi.2006.11.004","article-title":"The association between fatigue and inflammatory marker levels in cancer patients: a quantitative review","volume":"21","author":"Schubert","year":"2007","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.joca.2010.02.017_bib35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2174\/157339906776818532","article-title":"Relationship between inflammation, insulin resistance and type 2 diabetes: \u2018cause or effect\u2019?","volume":"2","author":"Greenfield","year":"2006","journal-title":"Curr Diabetes Rev"},{"key":"10.1016\/j.joca.2010.02.017_bib36","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.bcp.2006.06.029","article-title":"Inflammation and cancer: how hot is the link?","volume":"72","author":"Aggarwal","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.joca.2010.02.017_bib37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.joca.2004.11.006","article-title":"Cartilage degeneration in different human joints","volume":"13","author":"Kuettner","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2010.02.017_bib38","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1002\/art.21199","article-title":"Articular chondrocytes express the receptor for advanced glycation end products: potential role in osteoarthritis","volume":"52","author":"Loeser","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"Suppl 3","key":"10.1016\/j.joca.2010.02.017_bib39","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.joca.2008.06.008","article-title":"Anti-inflammatory activity of chondroitin sulfate","volume":"16","author":"Iovu","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2010.02.017_bib40","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1136\/ard.2006.068882","article-title":"Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues","volume":"67","author":"Monfort","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2010.02.017_bib41","doi-asserted-by":"crossref","first-page":"938","DOI":"10.2353\/ajpath.2007.061083","article-title":"Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage","volume":"171","author":"Fan","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.joca.2010.02.017_bib42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1742-7843.2007.00158.x","article-title":"Chondroitin sulfate inhibits the nuclear translocation of nuclear factor-kappaB in interleukin-1beta-stimulated chondrocytes","volume":"102","author":"Jomphe","year":"2008","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.joca.2010.02.017_bib43","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/glycob\/cwn045","article-title":"The ligand-binding profile of HARE: hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate, and CS-E","volume":"18","author":"Harris","year":"2008","journal-title":"Glycobiology"},{"key":"10.1016\/j.joca.2010.02.017_bib44","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1081\/RRS-120014614","article-title":"Binding of [99mTc]chondroitin sulfate to\u00a0scavenger receptors on human chondrocytes as compared to binding of oxidized [125I]LDL on human macrophages","volume":"22","author":"Sobal","year":"2002","journal-title":"J\u00a0Recept Signal Transduct Res"},{"key":"10.1016\/j.joca.2010.02.017_bib45","doi-asserted-by":"crossref","first-page":"35448","DOI":"10.1074\/jbc.M003387200","article-title":"Binding of a large chondroitin sulfate\/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44","volume":"275","author":"Kawashima","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2010.02.017_bib46","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1074\/jbc.M806927200","article-title":"Versican\/PG-M assembles hyaluronan into extracellular matrix and inhibits CD44-mediated signaling toward premature senescence in embryonic fibroblasts","volume":"284","author":"Suwan","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2010.02.017_bib47","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1021\/jf804020u","article-title":"Evaluation and comparison of the antioxidative potency of various carbohydrates using different methods","volume":"57","author":"Ajisaka","year":"2009","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.joca.2010.02.017_bib48","first-page":"523","article-title":"Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent","volume":"34","author":"Bondeson","year":"2007","journal-title":"J Rheumatol"},{"key":"10.1016\/j.joca.2010.02.017_bib49","doi-asserted-by":"crossref","DOI":"10.1186\/ar1958","article-title":"Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation","volume":"8","author":"Tas","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2010.02.017_bib50","first-page":"148","article-title":"Effects of chondroitin sulfate-C on articular cartilage destruction in murine collagen-induced arthritis","volume":"50","author":"Omata","year":"2000","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.joca.2010.02.017_bib51","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa052771","article-title":"Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis","volume":"354","author":"Clegg","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.joca.2010.02.017_bib52","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1096\/fj.05-4540fje","article-title":"A sulfated disaccharide derived from chondroitin sulfate proteoglycan protects against inflammation-associated neurodegeneration","volume":"20","author":"Rolls","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.joca.2010.02.017_bib53","doi-asserted-by":"crossref","first-page":"573","DOI":"10.2165\/00002512-200724070-00005","article-title":"Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis","volume":"24","author":"Bruyere","year":"2007","journal-title":"Drugs Aging"},{"key":"10.1016\/j.joca.2010.02.017_bib54","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.arthro.2008.07.020","article-title":"A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis","volume":"25","author":"Vangsness","year":"2009","journal-title":"Arthroscopy"},{"key":"10.1016\/j.joca.2010.02.017_bib55","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/art.24255","article-title":"Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial","volume":"60","author":"Kahan","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2010.02.017_bib56","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/bjp.2008.113","article-title":"Effect of chondroitin sulphate in a rabbit model of atherosclerosis aggravated by chronic arthritis","volume":"154","author":"Herrero-Beaumont","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.joca.2010.02.017_bib57","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1600-0560.2007.00841.x","article-title":"Evaluation of survivin and NF-kappaB in psoriasis, an immunohistochemical study","volume":"35","author":"Abdou","year":"2008","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.joca.2010.02.017_bib58","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/j.0022-202X.2005.23749.x","article-title":"Inverse regulation of the nuclear factor-kappaB binding to the p53 and interleukin-8 kappaB response elements in lesional psoriatic skin","volume":"124","author":"Johansen","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.joca.2010.02.017_bib59","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00403-008-0843-4","article-title":"Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris","volume":"300","author":"Li","year":"2008","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.joca.2010.02.017_bib60","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.0022-202X.2005.23735.x","article-title":"Differential expression of phosphorylated NF-kappaB\/RelA in normal and psoriatic epidermis and downregulation of NF-kappaB in response to treatment with etanercept","volume":"124","author":"Lizzul","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.joca.2010.02.017_bib61","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5070\/D32ZH8X3VF","article-title":"Clinical and histopathological improvement of psoriasis with oral chondroitin sulfate: a serendipitous finding","volume":"11","author":"Verges","year":"2005","journal-title":"Dermatol Online J"},{"key":"10.1016\/j.joca.2010.02.017_bib62","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1254\/jjp.85.155","article-title":"Effects of chondroitin sulfate on colitis induced by dextran sulfate sodium in rats","volume":"85","author":"Hori","year":"2001","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.joca.2010.02.017_bib63","first-page":"317","article-title":"Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats","volume":"22","author":"Yomogida","year":"2008","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.joca.2010.02.017_bib64","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2174\/187152908784533702","article-title":"Cardiac role of the transcription factor NF-kappaB","volume":"8","author":"Gutierrez","year":"2008","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"key":"10.1016\/j.joca.2010.02.017_bib65","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/CS20080196","article-title":"Role of TNF-alpha in vascular dysfunction","volume":"116","author":"Zhang","year":"2009","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.joca.2010.02.017_bib66","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJM200003233421202","article-title":"C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women","volume":"342","author":"Ridker","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.joca.2010.02.017_bib67","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/1358863X07077462","article-title":"Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease","volume":"12","author":"Steinhubl","year":"2007","journal-title":"Vasc Med"},{"key":"10.1016\/j.joca.2010.02.017_bib68","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/geronj\/17.1.30","article-title":"The effects of sulfated polysaccharides obtained from seaweeds on experimental atherosclerosis","volume":"17","author":"Murata","year":"1962","journal-title":"J Gerontol"},{"key":"10.1016\/j.joca.2010.02.017_bib69","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1532-5415.1969.tb02328.x","article-title":"Response of ischemic heart disease to chondroitin sulfate-A","volume":"17","author":"Morrison","year":"1969","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.joca.2010.02.017_bib70","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/000331977302400503","article-title":"Coronary heart disease: reduction of death rate by chondroitin sulfate A","volume":"24","author":"Morrison","year":"1973","journal-title":"Angiology"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458410000889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458410000889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:22:43Z","timestamp":1761016963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458410000889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":70,"alternative-id":["S1063458410000889"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2010.02.017","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of inflammation by chondroitin sulfate","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2010.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}