{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:22:51Z","timestamp":1773012171154,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":1235,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.joca.2010.07.011","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T04:51:02Z","timestamp":1281070262000},"page":"1256-1262","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Treatment with TNF-\u03b1 inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis"],"prefix":"10.1016","volume":"18","author":[{"given":"M.","family":"G\u00fcler-Y\u00fcksel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.F.","family":"Allaart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Watt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.P.M.","family":"Goekoop-Ruiterman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.K.","family":"de Vries-Bouwstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"van Schaardenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.V.","family":"van Krugten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.A.C.","family":"Dijkmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.W.J.","family":"Huizinga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.F.","family":"Lems","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kloppenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2010.07.011_bib1","first-page":"244","article-title":"Osteoarthritis: a tale of three tissues","volume":"66","author":"Samuels","year":"2008","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"10.1016\/j.joca.2010.07.011_bib2","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/art.23079","article-title":"Health-related quality of life in women with symptomatic hand osteoarthritis: a comparison with rheumatoid arthritis patients, healthy controls, and normative data","volume":"57","author":"Slatkowsky-Christensen","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2010.07.011_bib3","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/art.20136","article-title":"Is osteoarthritis a systemic disorder of bone?","volume":"50","author":"Rogers","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2010.07.011_bib4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/art.1780400419","article-title":"Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease","volume":"40","author":"Spector","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2010.07.011_bib5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/ard.59.1.71","article-title":"Increased serum C reactive protein may reflect events precede radiographic progression in osteoarthritis of the knee","volume":"59","author":"Sharif","year":"2000","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2010.07.011_bib6","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.joca.2006.10.010","article-title":"Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis","volume":"15","author":"Pearle","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2010.07.011_bib7","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1136\/ard.2007.079228","article-title":"Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive C-reactive protein levels in the GARP study","volume":"67","author":"Bos","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2010.07.011_bib8","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1002\/art.21210","article-title":"High-resolution magnetic resonance imaging for the assessment of hand osteoarthritis","volume":"52","author":"Tan","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2010.07.011_bib9","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00256-007-0287-5","article-title":"MR imaging of erosions in interphalangeal joint osteoarthritis: is all osteoarthritis erosive?","volume":"36","author":"Grainger","year":"2007","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.joca.2010.07.011_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/03008209909005273","article-title":"The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models","volume":"40","author":"Goldring","year":"1999","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.joca.2010.07.011_bib11","first-page":"237","article-title":"The role of cytokines in osteoarthritis pathophysiology","volume":"39","author":"Fernandes","year":"2002","journal-title":"Biorheology"},{"key":"10.1016\/j.joca.2010.07.011_bib12","first-page":"365","article-title":"Synovial membrane inflammation and cytokine production in patients with early osteoarthritis","volume":"24","author":"Smith","year":"1997","journal-title":"J Rheumatol"},{"key":"10.1016\/j.joca.2010.07.011_bib13","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1002\/art.21014","article-title":"Association of the risk of osteoarthritis with high innate production of interleukin-1\u00df and low innate production of interleukin-10 ex vivo upon lipopolysaccharide stimulation","volume":"52","author":"Riyazi","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2010.07.011_bib14","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1136\/ard.2007.084657","article-title":"Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis","volume":"67","author":"Botha-Scheepers","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2010.07.011_bib15","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.addr.2006.01.008","article-title":"Biologics in development for rheumatoid arthritis: relevance to osteoarthritis","volume":"58","author":"Abramson","year":"2006","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.joca.2010.07.011_bib16","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F","article-title":"Osteoarthritis an inflammatory disease: potential implications for the selection of new therapeutic agents","volume":"44","author":"Pelletier","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2010.07.011_bib17","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1517\/14712598.1.5.817","article-title":"Anticytokine therapy for osteoarthritis","volume":"1","author":"Goldring","year":"2001","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.joca.2010.07.011_bib18","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/ard.52.12.870","article-title":"Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis","volume":"52","author":"Farahat","year":"1993","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2010.07.011_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/art.1780340205","article-title":"Synovium membrane histology and immunopathology in rheumatoid arthritis and osteoarthritis. In vivo effects of anti-rheumatic drugs","volume":"34","author":"Haraoui","year":"1991","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2010.07.011_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1063-4584(96)80004-5","article-title":"Tumor necrosis factor-alpha (TNF-alpha) in canine osteoarthritis: immunolocalization of TNF-alpha, stromelysin and TNF receptors in canine osteoarthritic cartilage","volume":"4","author":"Kammermann","year":"1996","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2010.07.011_bib21","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/art.1780360613","article-title":"Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis","volume":"36","author":"Venn","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2010.07.011_bib22","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1136\/ard.49.9.676","article-title":"Synovial fluid concentration of five different cytokines in rheumatic diseases","volume":"49","author":"Westacott","year":"1990","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2010.07.011_bib23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF00307738","article-title":"Detection of tumor necrosis factor alpha and interleukin-1 in the rheumatoid osteoarthritic cartilage-pannus junction by immunohistochemical methods","volume":"13","author":"Miller","year":"1993","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.joca.2010.07.011_bib24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1053\/joca.2002.0521","article-title":"Effects of TNF-\u03b1 antagonists on nitric oxide production in human cartilage","volume":"10","author":"Vuolteenaho","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2010.07.011_bib25","first-page":"1323","article-title":"A pilot study of tumor necrosis factor inhibition in erosive\/inflammatory osteoarthritis of the hands","volume":"34","author":"Magnano","year":"2007","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2010.07.011_bib26","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00296-009-0872-0","article-title":"Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study","volume":"29","author":"Fioravanti","year":"2009","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.joca.2010.07.011_bib27","doi-asserted-by":"crossref","first-page":"406","DOI":"10.7326\/0003-4819-146-6-200703200-00005","article-title":"Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial","volume":"146","author":"Goekoop-Ruiterman","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.joca.2010.07.011_bib28","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.joca.2006.11.009","article-title":"Atlas of individual radiographic features in osteoarthritis, revised","volume":"15","author":"Altman","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2010.07.011_bib29","first-page":"731","article-title":"How to read radiographs according to the Sharp-van der Heijde method","volume":"26","author":"van der Heijde","year":"1999","journal-title":"J Rheumatol"},{"key":"10.1016\/j.joca.2010.07.011_bib30","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1001\/jama.280.19.1690","article-title":"What\u2019s the relative risk?","volume":"280","author":"Zhang","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.joca.2010.07.011_bib31","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1136\/ard.2006.053272","article-title":"Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockkade","volume":"65","author":"Grunke","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2010.07.011_bib32","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.joca.2006.11.006","article-title":"Osteophytes: relevance and biology","volume":"15","author":"van der Kraan","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2010.07.011_bib33","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.joca.2008.01.014","article-title":"Should subchondral bone turnover be targeted when treating osteoarthritis?","volume":"16","author":"Karsdal","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2010.07.011_bib34","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/art.20124","article-title":"The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transaction model","volume":"50","author":"Hayami","year":"2004","journal-title":"Arthritis Rheum"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458410002487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458410002487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:24:10Z","timestamp":1761017050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458410002487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S1063458410002487"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2010.07.011","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment with TNF-\u03b1 inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2010.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}