{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:35:49Z","timestamp":1792650949621,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":1112,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.joca.2010.11.006","type":"journal-article","created":{"date-parts":[[2010,11,20]],"date-time":"2010-11-20T04:36:18Z","timestamp":1290227778000},"page":"163-170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity"],"prefix":"10.1016","volume":"19","author":[{"given":"J.P.","family":"Moodie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.S.","family":"Stok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.L.","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J.","family":"Shefelbine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.joca.2010.11.006_bib1","first-page":"1","article-title":"Degenerative joint disease","volume":"47","author":"Buckwalter","year":"1995","journal-title":"Clin Symp"},{"issue":"10","key":"10.1016\/j.joca.2010.11.006_bib2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/01.bot.0000246468.80635.ef","article-title":"Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease","volume":"20","author":"Brown","year":"2006","journal-title":"J\u00a0Orthop Trauma"},{"issue":"3","key":"10.1016\/j.joca.2010.11.006_bib3","first-page":"142","article-title":"Osteoarthritis: a problem of joint failure","volume":"58","author":"Nuki","year":"1999","journal-title":"Z\u00a0Rheumatol"},{"issue":"3","key":"10.1016\/j.joca.2010.11.006_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.mpmed.2009.11.008","article-title":"Osteoarthritis","volume":"38","author":"Vincent","year":"2010","journal-title":"Medicine"},{"issue":"3","key":"10.1016\/j.joca.2010.11.006_bib5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1053\/joca.1998.0181","article-title":"Bone remodeling in osteoarthritis: subchondral and osteophytic responses","volume":"7","author":"Moskowitz","year":"1999","journal-title":"Osteoarthritis Cartilage"},{"issue":"9","key":"10.1016\/j.joca.2010.11.006_bib6","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"8","key":"10.1016\/j.joca.2010.11.006_bib7","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1002\/art.20558","article-title":"Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice","volume":"50","author":"Glasson","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"7033","key":"10.1016\/j.joca.2010.11.006_bib8","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nature03369","article-title":"Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis","volume":"434","author":"Glasson","year":"2005","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.joca.2010.11.006_bib9","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.joca.2006.11.005","article-title":"Osteoarthritis severity is sex dependent in a surgical mouse model","volume":"15","author":"Ma","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1016\/j.joca.2010.11.006_bib10","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/art.24654","article-title":"Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis","volume":"60","author":"Shi-Lu","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.joca.2010.11.006_bib11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/00002142-199906000-00002","article-title":"Importance of subchondral bone to articular cartilage in health and disease","volume":"10","author":"Imhof","year":"1999","journal-title":"Top Magn Reson Imaging"},{"issue":"5","key":"10.1016\/j.joca.2010.11.006_bib12","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.joca.2008.09.018","article-title":"ADAMTS5\u2212\/\u2212 mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes","volume":"17","author":"Botter","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.joca.2010.11.006_bib13","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/ar2120","article-title":"Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis","volume":"9","author":"Appleton","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2010.11.006_bib14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00003086-198612000-00005","article-title":"Role of subchondral bone in the initiation and progression of cartilage damage","volume":"213","author":"Radin","year":"1986","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"10.1016\/j.joca.2010.11.006_bib15","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/00002281-199805000-00017","article-title":"The importance of subchondral bone in osteoarthrosis","volume":"10","author":"Burr","year":"1998","journal-title":"Curr Opin Rheumatol"},{"issue":"5","key":"10.1016\/j.joca.2010.11.006_bib16","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/ageing\/30.5.374","article-title":"The role of bone in osteoarthritis","volume":"30","author":"Bailey","year":"2001","journal-title":"Age Ageing"},{"issue":"4","key":"10.1016\/j.joca.2010.11.006_bib17","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.joca.2007.08.005","article-title":"Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis","volume":"16","author":"Botter","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"10.1016\/j.joca.2010.11.006_bib18","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.joca.2004.09.001","article-title":"A\u00a0pilot, two-year longitudinal study of the interrelationship between trabecular bone and articular cartilage in the osteoarthritic knee","volume":"12","author":"Blumenkrantz","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"10.1016\/j.joca.2010.11.006_bib19","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1302\/0301-620X.88B12.18140","article-title":"The consequences of meniscectomy","volume":"88-B","author":"McDermott","year":"2006","journal-title":"J\u00a0Bone Joint Surg Br"},{"issue":"4","key":"10.1016\/j.joca.2010.11.006_bib20","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.joca.2007.08.008","article-title":"Knee varus\u2013valgus motion during gait \u2013 a measure of joint stability in patients with osteoarthritis?","volume":"16","author":"van der Esch","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.joca.2010.11.006_bib21","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0021-9290(95)00130-1","article-title":"In vitro laxity-testers for knee joints of mice","volume":"29","author":"Blankevoort","year":"1996","journal-title":"J\u00a0Biomech"},{"issue":"5","key":"10.1016\/j.joca.2010.11.006_bib22","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/jor.1100130519","article-title":"Laxity characteristics of normal and pathological murine knee joints in vitro","volume":"13","author":"van Osch","year":"1995","journal-title":"J\u00a0Orthop Res"},{"issue":"3","key":"10.1016\/j.joca.2010.11.006_bib23","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bone.2009.05.017","article-title":"Revealing the interplay of bone and cartilage in osteoarthritis through multimodal imaging of murine joints","volume":"45","author":"Stok","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.joca.2010.11.006_bib24","author":"Schmid"},{"issue":"S02E","key":"10.1016\/j.joca.2010.11.006_bib25","first-page":"1678","article-title":"Computing local thickness of 3D structures with ImageJ","volume":"13","author":"Dougherty","year":"2007","journal-title":"Microsc Microanal"},{"key":"10.1016\/j.joca.2010.11.006_bib26","doi-asserted-by":"crossref","unstructured":"Doube MKM, Arganda-Carreras I, Cordelires F, Dougherty RP, Jackson JSB, Hutchinson JR, et-al. Extensible bone image analysis in ImageJ. 2010 [updated 2010; cited]; Available from: http:\/\/www.bonej.org.","DOI":"10.1016\/j.bone.2010.08.023"},{"issue":"Suppl 1","key":"10.1016\/j.joca.2010.11.006_bib27","article-title":"Whole joint imaging allows quantification of bone and cartilage degeneration in a murine model of osteoarthritis","volume":"44","author":"Stok","year":"2009","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.joca.2010.11.006_bib28","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1109\/TSMC.1978.4310039","article-title":"Picture thresholding using an iterative selection method","volume":"8","author":"Ridler","year":"1978","journal-title":"IEEE Trans Syst Man Cybern B Cybern"},{"key":"10.1016\/j.joca.2010.11.006_bib29","series-title":"53rd Annual Meeting of the Orthopaedic Research Society","year":"2007"},{"issue":"10","key":"10.1016\/j.joca.2010.11.006_bib30","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1002\/art.23870","article-title":"Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system","volume":"58","author":"Inglis","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.joca.2010.11.006_bib31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/8756-3282(88)90029-4","article-title":"Bone histomorphometry: standardization of nomenclature, symbols and units (summary of proposed system)","volume":"9","author":"Parfitt","year":"1988","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.joca.2010.11.006_bib32","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000213866","article-title":"Do subchondral bone changes exacerbate or precede articular cartilage destruction in osteoarthritis of the elderly?","volume":"43","author":"Bailey","year":"1997","journal-title":"Gerontology"},{"issue":"10","key":"10.1016\/j.joca.2010.11.006_bib33","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1136\/ard.2006.058347","article-title":"Yet more evidence that osteoarthritis is not a cartilage disease","volume":"65","author":"Brandt","year":"2006","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.joca.2010.11.006_bib34","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/8756-3282(96)00047-6","article-title":"Genetic variability in adult bone density among inbred strains of mice","volume":"18","author":"Beamer","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.joca.2010.11.006_bib35","unstructured":"Laboratory TJ. JAX\u00ae Mice Database. 2009 [updated 2009; cited]; Available from: http:\/\/jaxmice.jax.org\/query\/f?p=205:1:3633989967120115798."},{"issue":"10","key":"10.1016\/j.joca.2010.11.006_bib36","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1002\/art.22921","article-title":"Role of subchondral bone in osteoarthritis development: a comparative study of two strains of guinea pigs with and without spontaneously occurring osteoarthritis","volume":"56","author":"Tomoya","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.joca.2010.11.006_bib37","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s002239900554","article-title":"Bone response to in vivo mechanical loading in two breeds of mice","volume":"63","author":"Akhter","year":"1998","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.joca.2010.11.006_bib38","doi-asserted-by":"crossref","DOI":"10.1096\/fj.01-0913fje","article-title":"Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton","author":"Judex","year":"2002","journal-title":"FASEB J"},{"issue":"6","key":"10.1016\/j.joca.2010.11.006_bib39","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s10237-010-0210-1","article-title":"Mechanical loading of mouse caudal vertebrae increases trabecular and cortical bone mass-dependence on dose and genotype","volume":"9","author":"Webster","year":"2010","journal-title":"Biomech Model Mechanobiol"},{"issue":"8","key":"10.1016\/j.joca.2010.11.006_bib40","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1002\/art.23638","article-title":"Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis","volume":"58","author":"Kadri","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"9","key":"10.1016\/j.joca.2010.11.006_bib41","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/jemt.20713","article-title":"Morphometric characterization of murine articular cartilage \u2013 novel application of confocal laser scanning microscopy","volume":"72","author":"Stok","year":"2009","journal-title":"Microsc Res Tech"},{"issue":"Pt 3","key":"10.1016\/j.joca.2010.11.006_bib42","first-page":"411","article-title":"The interrelationship of cell density and cartilage thickness in mammalian articular cartilage","volume":"109","author":"Stockwell","year":"1971","journal-title":"J\u00a0Anat"},{"issue":"3","key":"10.1016\/j.joca.2010.11.006_bib43","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/art.1780130305","article-title":"Scale effects in animal joints. I. articular cartilage thickness and compressive stress","volume":"13","author":"William","year":"1970","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.joca.2010.11.006_bib44","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1115\/1.2246237","article-title":"Compressive properties of mouse articular cartilage determined in a novel micro-indentation test method and biphasic finite element model","volume":"128","author":"Cao","year":"2006","journal-title":"J\u00a0Biomech Eng"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458410003912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458410003912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:25:00Z","timestamp":1761017100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458410003912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S1063458410003912"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2010.11.006","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.11879956.12983054","asserted-by":"object"}]},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2010.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2010 Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}