{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:37:10Z","timestamp":1790336230416,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":626,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Walloon Government of Belgium FIRST","award":["5291"],"award-info":[{"award-number":["5291"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.joca.2012.02.638","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T02:38:03Z","timestamp":1331001483000},"page":"557-561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Coll2-1, Coll2-1NO2 and myeloperoxidase serum levels in erosive and non-erosive osteoarthritis of the hands"],"prefix":"10.1016","volume":"20","author":[{"given":"L.","family":"Punzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ramonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Deberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Frallonardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Campana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Musacchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Henrotin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2012.02.638_bib1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0049-0172(05)80009-5","article-title":"Erosive osteoarthritis","volume":"22","author":"Belhorn","year":"1993","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.joca.2012.02.638_bib2","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.1961.03040120011003","article-title":"Interphalangeal osteoarthritis characterised by painful, inflammatory episodes resulting in deformity of the proximal and distal articulations","volume":"175","author":"Crain","year":"1961","journal-title":"JAMA"},{"key":"10.1016\/j.joca.2012.02.638_bib3","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0009-9260(05)82114-2","article-title":"Erosive osteoarthritis: is it a separate disease entity?","volume":"42","author":"Cobby","year":"1990","journal-title":"Clin Radiol"},{"key":"10.1016\/j.joca.2012.02.638_bib4","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.berh.2004.05.010","article-title":"Erosive osteoarthritis","volume":"18","author":"Punzi","year":"2004","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.joca.2012.02.638_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/ard.2007.084772","article-title":"EULAR evidence based recommendations for the diagnosis of hand OA report of a task force of the EULAR Standing Committee for International Clinical Studies including therapeutics (ESCISIT)","volume":"68","author":"Zang","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2012.02.638_bib6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.berh.2009.12.007","article-title":"Inflammatory osteoarthritis of the hand","volume":"24","author":"Punzi","year":"2010","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.joca.2012.02.638_bib7","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/ard.2010.131151","article-title":"Assessing health-related quality of life in hand osteoarthritis: a literature review","volume":"70","author":"Michon","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"10.1016\/j.joca.2012.02.638_bib8","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1136\/ard.2009.125435","article-title":"Clinical burden of erosive hand osteoarthritis and its relationship to nodes","volume":"69","author":"Bijsterbosch","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 1","key":"10.1016\/j.joca.2012.02.638_bib9","first-page":"27S","article-title":"Numerical scoring systems for the progression of osteoarthritis of the finger joints","volume":"62","author":"Verbruggen","year":"1995","journal-title":"Rev Rhum Engl Ed"},{"key":"10.1016\/j.joca.2012.02.638_bib10","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/art.1780390221","article-title":"Numerical scoring systems for the anatomic evolution of osteoarthritis of the finger joints","volume":"39","author":"Verbruggen","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2012.02.638_bib11","series-title":"Osteoarthritis. Diagnosis and Medical\/Surgical Management","first-page":"239","article-title":"Radiological diagnosis","author":"Chandnani","year":"2001"},{"key":"10.1016\/j.joca.2012.02.638_bib12","first-page":"292","article-title":"Erosive arthrosis of the hand. Criteria of the differential diagnosis","volume":"71","author":"Scutellari","year":"1985","journal-title":"Radiol Med"},{"key":"10.1016\/j.joca.2012.02.638_bib13","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/ard.2004.029892","article-title":"Value of C reactive protein in the assessment of erosive osteoarthritis of the hand","volume":"64","author":"Punzi","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2012.02.638_bib14","first-page":"107","article-title":"Comparison of clinical, laboratory, radiographic, and scintigraphic findings in erosive and non-erosive hand osteoarthritis. Results of a two-year study","volume":"67","author":"Olejarova","year":"2000","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.joca.2012.02.638_bib15","first-page":"1477","article-title":"Soluble interleukin-2 receptors and the treatment with hydroxychloroquine in erosive osteoarthritis","volume":"23","author":"Punzi","year":"1996","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2012.02.638_bib16","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1136\/ard.2005.040642","article-title":"Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study","volume":"65","author":"Meulenbelt","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2012.02.638_bib17","first-page":"25","article-title":"Hematic levels of type I collagen C-telopeptide in erosive versus nonerosive osteoarthritis of the hands","volume":"25","author":"Rovetta","year":"2003","journal-title":"Int J Tissue React"},{"issue":"2","key":"10.1016\/j.joca.2012.02.638_bib18","first-page":"81","article-title":"Biomarkers, type II collagen, glucosamine and chondroitin sulfate in osteoarthritis follow-up: the \u201cMagenta osteoarthritis study\u201d","volume":"9","author":"Scarpellini","year":"2008","journal-title":"J\u00a0Orthop Traumatol"},{"key":"10.1016\/j.joca.2012.02.638_bib19","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.joca.2009.06.002","article-title":"Serum hyaluronic acid as a potential marker with a predictive value for further radiographic progression of hand osteoarthritis","volume":"17","author":"Filkov\u00e1","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.02.638_bib20","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1172\/JCI119316","article-title":"Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage","volume":"99","author":"Billinghurst","year":"1997","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.joca.2012.02.638_bib21","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.joca.2004.12.002","article-title":"New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis","volume":"13","author":"Deberg","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.02.638_bib22","first-page":"167","article-title":"Infliximab reduces oxidative stress in ankylosing spondylitis","volume":"27","author":"Feij\u00f3o","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.joca.2012.02.638_bib23","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/ard.2007.073452","article-title":"One-year follow-up of Coll2-1, Coll2-1NO2 and myeloperoxydase serum levels in osteoarthritis patients after hip or knee replacement","volume":"67","author":"Deberg","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2012.02.638_bib24","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/art.1780331101","article-title":"The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand","volume":"33","author":"Altman","year":"1990","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2012.02.638_bib25","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/anr.1780321213","article-title":"New radiographic grading scales for osteoarthritis of the hand","volume":"32","author":"Kallman","year":"1989","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2012.02.638_bib26","first-page":"543","article-title":"Type II collagen peptides for measuring cartilage degradation","volume":"41","author":"Henrotin","year":"2004","journal-title":"Biorheology"},{"key":"10.1016\/j.joca.2012.02.638_bib27","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1063-4584(03)00150-X","article-title":"The role of reactive oxygen species in homeostasis and cartilage degradation","volume":"11","author":"Henrotin","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.02.638_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joca.2005.04.002","article-title":"Oxygen and reactive oxygen species in cartilage degradation: friends or foes?","volume":"13","author":"Henrotin","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.02.638_bib29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0065-2423(09)49002-4","article-title":"Biochemical biomarkers of oxidative collagen damage","volume":"49","author":"Henrotin","year":"2009","journal-title":"Adv Clin Chem"},{"key":"10.1016\/j.joca.2012.02.638_bib30","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.joca.2009.04.020","article-title":"Ultrasonographic evidence of inflammation is frequent in hands of patients with erosive osteoarthritis","volume":"17","author":"Vlychou","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"issue":"10","key":"10.1016\/j.joca.2012.02.638_bib31","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.joca.2010.06.006","article-title":"Ultrasound-detected synovitis with power Doppler signal is associated with severe radiographic damage and reduced cartilage thickness in hand osteoarthritis","volume":"18","author":"Mancarella","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.02.638_bib32","first-page":"2381","article-title":"High resolution ultrasonography in detection of\u00a0bone erosions in patients with hand osteoarthritis","volume":"32","author":"Iagnocco","year":"2005","journal-title":"J\u00a0Rheumatol"},{"issue":"12","key":"10.1016\/j.joca.2012.02.638_bib33","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1002\/art.24312","article-title":"An ultrasonographic study of osteoarthritis of the hand: synovitis and its relationship to structural pathology and symptoms","volume":"59","author":"Keen","year":"2008","journal-title":"Arthritis Rheum"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458412007108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458412007108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:27:43Z","timestamp":1761017263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458412007108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S1063458412007108"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2012.02.638","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coll2-1, Coll2-1NO2 and myeloperoxidase serum levels in erosive and non-erosive osteoarthritis of the hands","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2012.02.638","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}