{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:15:54Z","timestamp":1789989354665,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":473,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.joca.2012.07.017","type":"journal-article","created":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T12:16:56Z","timestamp":1344428216000},"page":"1399-1408","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Intracellular calcium oscillations in articular chondrocytes induced by basic calcium phosphate crystals lead to cartilage degradation"],"prefix":"10.1016","volume":"20","author":[{"given":"C.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lieberherr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bordat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Velard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"C\u00f4me","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Liot\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-K.","family":"Ea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.joca.2012.07.017_bib1","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/art.1780261008","article-title":"Crystal populations in human synovial fluid. Identification of apatite, octacalcium phosphate, and tricalcium phosphate","volume":"26","author":"McCarty","year":"1983","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.joca.2012.07.017_bib2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/ard.54.5.339","article-title":"Magnesium whitlockite deposition in articular cartilage: a study of 80 specimens from 70 patients","volume":"54","author":"Scotchford","year":"1995","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.joca.2012.07.017_bib3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1063-4584(05)80041-X","article-title":"The isolation and characterization of magnesium whitlockite crystals from human articular cartilage","volume":"3","author":"Scotchford","year":"1995","journal-title":"Osteoarthritis Cartilage"},{"issue":"9","key":"10.1016\/j.joca.2012.07.017_bib4","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1002\/art.24774","article-title":"Calcification of articular cartilage in human osteoarthritis","volume":"60","author":"Fuerst","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.joca.2012.07.017_bib5","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/1471-2474-10-166","article-title":"Articular cartilage mineralization in osteoarthritis of the hip","volume":"10","author":"Fuerst","year":"2009","journal-title":"BMC Musculoskelet Disord"},{"issue":"2","key":"10.1016\/j.joca.2012.07.017_bib6","doi-asserted-by":"crossref","first-page":"R56","DOI":"10.1186\/ar2968","article-title":"Calcium deposition in osteoarthritic meniscus and meniscal cell culture","volume":"12","author":"Sun","year":"2010","journal-title":"Arthritis Res Ther"},{"issue":"9","key":"10.1016\/j.joca.2012.07.017_bib7","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1002\/art.27576","article-title":"Osteoarthritis, a basic calcium phosphate crystal-associated arthropathy? Comment on the article by Fuerst et\u00a0al","volume":"62","author":"Nguyen","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.joca.2012.07.017_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1053\/joca.2002.0861","article-title":"Synovial fluid features and their relations to osteoarthritis severity: new findings from sequential studies","volume":"11","author":"Nalbant","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.joca.2012.07.017_bib9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/art.27761","article-title":"Articular cartilage calcification in osteoarthritis: insights into crystal-induced stress","volume":"63","author":"Ea","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.joca.2012.07.017_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/art.1780350314","article-title":"Basic calcium phosphate crystals stimulate cell proliferation and collagenase message accumulation in cultured adult articular chondrocytes","volume":"35","author":"Mitchell","year":"1992","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.joca.2012.07.017_bib11","doi-asserted-by":"crossref","first-page":"R915","DOI":"10.1186\/ar1763","article-title":"Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes","volume":"7","author":"Ea","year":"2005","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1016\/j.joca.2012.07.017_bib12","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/ard.60.4.399","article-title":"Basic calcium phosphate crystals activate human osteoarthritic synovial fibroblasts and induce matrix metalloproteinase-13 (collagenase-3) in adult porcine articular chondrocytes","volume":"60","author":"McCarthy","year":"2001","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"10.1016\/j.joca.2012.07.017_bib13","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1136\/ard.2008.087718","article-title":"Annexin 5 overexpression increased articular chondrocyte apoptosis induced by basic calcium phosphate crystals","volume":"67","author":"Ea","year":"2008","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.joca.2012.07.017_bib14","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/BOR.0b013e3283257ba9","article-title":"Advances in understanding calcium-containing crystal disease","volume":"21","author":"Ea","year":"2009","journal-title":"Curr Opin Rheumatol"},{"issue":"5","key":"10.1016\/j.joca.2012.07.017_bib15","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1053\/joca.1998.0131","article-title":"Intracellular calcium responses to basic calcium phosphate crystals in fibroblasts","volume":"6","author":"Halverson","year":"1998","journal-title":"Osteoarthritis Cartilage"},{"issue":"19","key":"10.1016\/j.joca.2012.07.017_bib16","doi-asserted-by":"crossref","first-page":"19502","DOI":"10.1074\/jbc.M400437200","article-title":"Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP","volume":"279","author":"Fitzgerald","year":"2004","journal-title":"J\u00a0Biol Chem"},{"issue":"8","key":"10.1016\/j.joca.2012.07.017_bib17","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/art.1780390809","article-title":"Variation in the inflammatory properties of basic calcium phosphate crystals according to crystal type","volume":"39","author":"Prudhommeaux","year":"1996","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.joca.2012.07.017_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0304-4165(86)90306-5","article-title":"Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue","volume":"883","author":"Farndale","year":"1986","journal-title":"Biochim Biophys Acta"},{"issue":"27","key":"10.1016\/j.joca.2012.07.017_bib19","doi-asserted-by":"crossref","first-page":"13168","DOI":"10.1016\/S0021-9258(18)45183-6","article-title":"Effects of vitamin D3 metabolites on cytosolic free calcium in confluent mouse osteoblasts","volume":"262","author":"Lieberherr","year":"1987","journal-title":"J\u00a0Biol Chem"},{"issue":"10","key":"10.1016\/j.joca.2012.07.017_bib20","doi-asserted-by":"crossref","first-page":"7217","DOI":"10.1016\/S0021-9258(17)37270-8","article-title":"Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein","volume":"269","author":"Lieberherr","year":"1994","journal-title":"J\u00a0Biol Chem"},{"issue":"3","key":"10.1016\/j.joca.2012.07.017_bib21","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/(SICI)1097-4644(19970301)64:3<414::AID-JCB8>3.0.CO;2-Y","article-title":"Different mechanisms are involved in intracellular calcium increase by insulin-like growth factors 1 and 2 in articular chondrocytes: voltage-gated calcium channels, and\/or phospholipase C coupled to a pertussis-sensitive G-protein","volume":"64","author":"Poiraudeau","year":"1997","journal-title":"J\u00a0Cell Biochem"},{"issue":"6","key":"10.1016\/j.joca.2012.07.017_bib22","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A\u00a0new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J\u00a0Biol Chem"},{"issue":"8","key":"10.1016\/j.joca.2012.07.017_bib23","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1136\/ard.52.8.599","article-title":"Enhancement of crystal induced neutrophil responses by opsonisation of calcium pyrophosphate dihydrate crystals","volume":"52","author":"Burt","year":"1993","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.joca.2012.07.017_bib24","first-page":"138","article-title":"Cytosolic Ca2+ concentration determinations in neutrophils stimulated by monosodium urate and calcium pyrophosphate crystals: effect of protein adsorption","volume":"21","author":"Burt","year":"1994","journal-title":"J\u00a0Rheumatol"},{"issue":"2","key":"10.1016\/j.joca.2012.07.017_bib25","first-page":"341","article-title":"The involvement of phosphatidylinositol 3-kinase in crystal induced human neutrophil activation","volume":"24","author":"Jackson","year":"1997","journal-title":"J\u00a0Rheumatol"},{"issue":"3","key":"10.1016\/j.joca.2012.07.017_bib26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/art.1780340311","article-title":"Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals","volume":"34","author":"Naccache","year":"1991","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.1016\/j.joca.2012.07.017_bib27","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.4049\/jimmunol.146.12.4289","article-title":"Mechanism of neutrophil activation by an unopsonized inflammatory particulate. Monosodium urate crystals induce pertussis toxin-insensitive hydrolysis of phosphatidylinositol 4,5-bisphosphate","volume":"146","author":"Onello","year":"1991","journal-title":"J\u00a0Immunol"},{"issue":"10","key":"10.1016\/j.joca.2012.07.017_bib28","first-page":"2463","article-title":"The inhibition of spontaneous and tumor necrosis factor-alpha induced neutrophil apoptosis by crystals of calcium pyrophosphate dihydrate and monosodium urate monohydrate","volume":"27","author":"Tudan","year":"2000","journal-title":"J\u00a0Rheumatol"},{"issue":"2","key":"10.1016\/j.joca.2012.07.017_bib29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/cbf.1304","article-title":"Spontaneous oscillation and mechanically induced calcium waves in chondrocytes","volume":"24","author":"Kono","year":"2006","journal-title":"Cell Biochem Funct"},{"issue":"20","key":"10.1016\/j.joca.2012.07.017_bib30","doi-asserted-by":"crossref","first-page":"7817","DOI":"10.1523\/JNEUROSCI.17-20-07817.1997","article-title":"Intracellular calcium oscillations in astrocytes: a highly plastic, bidirectional form of communication between neurons and astrocytes in situ","volume":"17","author":"Pasti","year":"1997","journal-title":"J\u00a0Neurosci"},{"issue":"14","key":"10.1016\/j.joca.2012.07.017_bib31","doi-asserted-by":"crossref","first-page":"8259","DOI":"10.1073\/pnas.96.14.8259","article-title":"Intracellular Ca2+ oscillations drive spontaneous contractions in cardiomyocytes during early development","volume":"96","author":"Viatchenko-Karpinski","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"10.1016\/j.joca.2012.07.017_bib32","first-page":"75","article-title":"Intercellular Ca2+ waves in mechanically stimulated articular chondrocytes","volume":"37","author":"D'Andrea","year":"2000","journal-title":"Biorheology"},{"key":"10.1016\/j.joca.2012.07.017_bib33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.materresbull.2004.10.020","article-title":"Formation and structure of zinc-substituted calcium hydroxyapatite","volume":"40","author":"Miyaji","year":"2005","journal-title":"Mat Res Bull"},{"issue":"1\u20132","key":"10.1016\/j.joca.2012.07.017_bib34","first-page":"55","article-title":"Influence of ion channels on the proliferation of human chondrocytes","volume":"39","author":"Wohlrab","year":"2002","journal-title":"Biorheology"},{"issue":"1","key":"10.1016\/j.joca.2012.07.017_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s000110050719","article-title":"Hydrogen peroxide induces apoptosis of chondrocytes; involvement of calcium ion and extracellular signal-regulated protein kinase","volume":"50","author":"Asada","year":"2001","journal-title":"Inflamm Res"},{"issue":"Pt 2","key":"10.1016\/j.joca.2012.07.017_bib36","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1042\/bj3240653","article-title":"Interleukin 1-induced calcium signalling in chondrocytes requires focal adhesions","volume":"324","author":"Luo","year":"1997","journal-title":"Biochem J"},{"issue":"7","key":"10.1016\/j.joca.2012.07.017_bib37","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1002\/art.21941","article-title":"Effects of interleukin-1 on calcium signaling and the increase of filamentous actin in isolated and in situ articular chondrocytes","volume":"54","author":"Pritchard","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.joca.2012.07.017_bib38","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/ard.2009.117168","article-title":"Acid-sensing ion channel 3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release","volume":"69","author":"Kolker","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"10.1016\/j.joca.2012.07.017_bib39","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.joca.2008.09.007","article-title":"Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts","volume":"17","author":"Sanchez","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1016\/j.joca.2012.07.017_bib40","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1002\/art.22717","article-title":"Calcium signaling leads to mitochondrial depolarization in impact-induced chondrocyte death in equine articular cartilage explants","volume":"56","author":"Huser","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.joca.2012.07.017_bib41","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/art.20809","article-title":"Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes","volume":"52","author":"Boileau","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.joca.2012.07.017_bib42","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/ard.2005.041855","article-title":"PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in\u00a0vivo activation of the Erk1\/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect","volume":"65","author":"Boileau","year":"2006","journal-title":"Ann Rheum Dis"},{"issue":"22","key":"10.1016\/j.joca.2012.07.017_bib43","doi-asserted-by":"crossref","first-page":"19215","DOI":"10.1074\/jbc.M110.175448","article-title":"Calcium input potentiates the transforming growth factor (TGF)-beta1-dependent signaling to promote the export of inorganic pyrophosphate by articular chondrocyte","volume":"286","author":"Cailotto","year":"2011","journal-title":"J\u00a0Biol Chem"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458412009065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458412009065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:28:58Z","timestamp":1761017338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458412009065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S1063458412009065"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2012.07.017","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracellular calcium oscillations in articular chondrocytes induced by basic calcium phosphate crystals lead to cartilage degradation","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2012.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}