{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:45:58Z","timestamp":1789479958125,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":443,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.joca.2012.08.008","type":"journal-article","created":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T23:50:07Z","timestamp":1345506607000},"page":"1583-1590","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Evaluation of the inflammatory response in experimentally induced synovitis in the horse: a comparison of recombinant equine interleukin 1 beta and lipopolysaccharide"],"prefix":"10.1016","volume":"20","author":[{"given":"T.N.","family":"Ross","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.","family":"Kisiday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.W.","family":"McIlwraith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2012.08.008_bib1","first-page":"625","article-title":"The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis","volume":"6","author":"Sellam","year":"2010","journal-title":"Nat Rev"},{"key":"10.1016\/j.joca.2012.08.008_bib2","first-page":"65","article-title":"Frank Milne Lecture: from arthroscopy to gene therapy-30 years of looking in joints","volume":"51","author":"McIlwraith","year":"2005","journal-title":"Proceedings Am Assoc Equine Pract"},{"key":"10.1016\/j.joca.2012.08.008_bib3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/sj.gt.3301608","article-title":"Treatment of experimental equine osteoarthritis by in\u00a0vivo delivery of the equine interleukin-1 receptor antagonist gene","volume":"9","author":"Frisbie","year":"2002","journal-title":"Gene Ther"},{"key":"10.1016\/j.joca.2012.08.008_bib4","first-page":"237","article-title":"The role of cytokines in osteoarthritis pathophysiology","volume":"39","author":"Fernandes","year":"2002","journal-title":"Biorheology"},{"key":"10.1016\/j.joca.2012.08.008_bib5","first-page":"365","article-title":"Synovial membrane inflammation and cytokine production in patients with early osteoarthritis","volume":"24","author":"Malcolm","year":"1997","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2012.08.008_bib6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2174\/138945007779940179","article-title":"Cytokine targeting in osteoarthritis","volume":"8","author":"Blom","year":"2007","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.joca.2012.08.008_bib7","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/art.1780400604","article-title":"In\u00a0vivo suppression of early experimental osteoarthritis by interleukin-1 receptor anatagonist using gene therapy","volume":"40","author":"Pelletier","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2012.08.008_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2460\/ajvr.1979.40.01.11","article-title":"Experimentally induced arthritis of the equine carpus: clinical determinations","volume":"40","author":"McIlwraith","year":"1979","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.joca.2012.08.008_bib9","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.2460\/ajvr.1996.57.07.1080","article-title":"Immunohistochemical analysis of an equine model of synovitis-induced arthritis","volume":"57","author":"Todhunter","year":"1996","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.joca.2012.08.008_bib10","first-page":"107","article-title":"An induced synovitis disease model in ponies","volume":"77","author":"Firth","year":"1987","journal-title":"Cornell Vet"},{"key":"10.1016\/j.joca.2012.08.008_bib11","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.2042-3306.1994.tb04056.x","article-title":"Experimentally-induced synovitis as a model for acute synovitis in the horse","volume":"26","author":"Palmer","year":"1994","journal-title":"Equine Vet J"},{"key":"10.1016\/j.joca.2012.08.008_bib12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2460\/ajvr.1993.54.03.379","article-title":"Effects of intra-articularly administered endotoxin on clinical signs of disease and synovial fluid tumor necrosis factor, interleukin 6, and prostaglandin E2 values in horses","volume":"54","author":"Hawkins","year":"1993","journal-title":"Am J Vet Res"},{"issue":"R35","key":"10.1016\/j.joca.2012.08.008_bib13","article-title":"Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: a longitudinal experimental study","volume":"11","author":"deGrauw","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2012.08.008_bib14","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.2460\/ajvr.1998.59.09.1149","article-title":"Anti-inflammatory effects of topically applied dimethyl sulfoxide gel on endotoxin-induced synovitis in horses","volume":"59","author":"Smith","year":"1998","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.joca.2012.08.008_bib15","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1467-2995.2009.00452.x","article-title":"Effects of intraarticular ropivacaine and morphine on lipopolysaccharide-induced synovitis in horses","volume":"36","author":"Santos","year":"2009","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.joca.2012.08.008_bib16","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.2460\/ajvr.69.12.1646","article-title":"Anti-inflammatory and analgesic effects of intra-articular injection of triamcinolone acetone, mepivacaine hydrochloride, or both on lipopolysaccharide-induced lameness in horses","volume":"69","author":"Kay","year":"2008","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.joca.2012.08.008_bib17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.rvsc.2004.07.006","article-title":"Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis","volume":"78","author":"Morton","year":"2005","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.joca.2012.08.008_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4102\/jsava.v69i1.801","article-title":"The effect of endotoxin and anti-endotoxin serum on synovial fluid parameters in the horse","volume":"69","author":"Gottschalk","year":"1998","journal-title":"J\u00a0S Afr Vet Assoc"},{"key":"10.1016\/j.joca.2012.08.008_bib19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1590\/S0102-09352004000300001","article-title":"Effects of lidocaine on lipopolysaccharide-induced synovitis in horses","volume":"56","author":"Campebell","year":"2004","journal-title":"Arq Bras Med Vet Zootec"},{"key":"10.1016\/j.joca.2012.08.008_bib20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1365-2885.2001.00336.x","article-title":"Enantiospecific pharmacokinetics of ketoprofen in plasma and synovial fluid of horses with acute synovitis","volume":"24","author":"Verde","year":"2001","journal-title":"J\u00a0Vet Pharmacol Therap"},{"key":"10.1016\/j.joca.2012.08.008_bib21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2460\/ajvr.1998.59.01.88","article-title":"Cell trafficking, mediator release and articular metabolism in acute inflammation of innervated or denervated isolated equine joints","volume":"59","author":"Hardy","year":"1998","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.joca.2012.08.008_bib22","doi-asserted-by":"crossref","first-page":"848","DOI":"10.2460\/ajvr.70.7.848","article-title":"Evaluation of inflammatory responses induced via intra-articular injection of interleukin-1 in horses receiving a dietary nutraceutical and assessment of the clinical effects of long-term nutraceutical administration","volume":"70","author":"Pearson","year":"2009","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.joca.2012.08.008_bib23","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.joca.2008.09.016","article-title":"Correlation of gene and mediator expression with clinical endpoints in an acute interleukin-1\u03b2-driven model of joint pathology","volume":"17","author":"Scott","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.08.008_bib24","doi-asserted-by":"crossref","first-page":"551","DOI":"10.2460\/ajvr.2002.63.551","article-title":"Effects of equine recombinant interleukin-1alpha and interleukin-1beta on proteoglycan metabolism and prostaglandin E2 synthesis in equine articular cartilage explants","volume":"63","author":"Takafuji","year":"2002","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.joca.2012.08.008_bib25","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.2042-3306.1983.tb01826.x","article-title":"Relationship between condition score, physical measurements and body fat percentage in mares","volume":"15","author":"Henneke","year":"1983","journal-title":"Equine Vet J"},{"key":"10.1016\/j.joca.2012.08.008_bib26","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/PHM.0b013e3181157718","article-title":"Effects of intra-articular botulinum toxin type A in an equine model of acute synovitis","volume":"86","author":"DePuy","year":"2007","journal-title":"Am J Phys Med Rehabil"},{"key":"10.1016\/j.joca.2012.08.008_bib27","series-title":"Guide for Veterinary Services and Judging of\u00a0Equestrian Events","author":"Anonymous","year":"1991"},{"key":"10.1016\/j.joca.2012.08.008_bib28","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.2460\/ajvr.1998.59.12.1619","article-title":"Effects of 6alpha-methylprednisolone acetate on an equine osteochondral fragment exercise model","volume":"59","author":"Frisbie","year":"1998","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.joca.2012.08.008_bib29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.abb.2009.11.022","article-title":"Mechanical injury of explants from the articulating surface of the inner meniscus","volume":"494","author":"Kisiday","year":"2010","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.joca.2012.08.008_bib30","series-title":"Adams' Lameness in Horses","first-page":"483","article-title":"Diseases of joints, tendons, ligaments and related structures","author":"McIlwraith","year":"2002"},{"key":"10.1016\/j.joca.2012.08.008_bib31","series-title":"Joint Disease in the Horse","first-page":"1","article-title":"Anatomy and physiology of synovial joints","author":"Todhunter","year":"1996"},{"key":"10.1016\/j.joca.2012.08.008_bib32","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2746\/0425164054530740","article-title":"Influence of repeated arthrocentesis and exercise on synovial fluid concentrations of nitric oxide, prostaglandin E2 and glycoaminoglycans in healthy equine joints","volume":"37","author":"van den Boom","year":"2005","journal-title":"Equine Vet J"},{"key":"10.1016\/j.joca.2012.08.008_bib33","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1002\/art.10531","article-title":"Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in\u00a0vivo and in\u00a0vitro","volume":"46","author":"Bau","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2012.08.008_bib34","doi-asserted-by":"crossref","first-page":"R187","DOI":"10.1186\/ar2099","article-title":"The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis","volume":"8","author":"Bondeson","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2012.08.008_bib35","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2460\/ajvr.71.2.176","article-title":"Effects of glucocorticoids and interleukin-1\u03b2 on expression and activity of aggrecanases in equine chondrocytes","volume":"71","author":"Busschers","year":"2010","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.joca.2012.08.008_bib36","first-page":"139","article-title":"The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review","volume":"26","author":"Bondeson","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.joca.2012.08.008_bib37","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature03417","article-title":"ADAMTS5 is the major aggrecanase in mouse cartilage in\u00a0vivo and in\u00a0vitro","volume":"434","author":"Stanton","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.joca.2012.08.008_bib38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.22203\/eCM.v015a02","article-title":"ADAMTS-5: the story so far","volume":"15","author":"Fosang","year":"2008","journal-title":"Euro Cells Mater"},{"key":"10.1016\/j.joca.2012.08.008_bib39","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/ard.60.4.391","article-title":"Down regulation of interleukin 1\u03b2 production in human osteoarthritic synovial tissue and cartilage cultures by aminoguanidine","volume":"60","author":"Shirazi","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2012.08.008_bib40","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1053\/joca.1998.0201","article-title":"Anti-interleukin-1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures","volume":"7","author":"Yaron","year":"1999","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.08.008_bib41","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1365-2249.1993.tb07967.x","article-title":"Production of IL-1 and IL-1 receptor antagonist and the pathological significance in lipopolysaccaharide-induced arthritis in rabbits","volume":"93","author":"Matsukawa","year":"1993","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.joca.2012.08.008_bib42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0165-2427(90)90019-O","article-title":"The characterization of equine interleukin-1","volume":"24","author":"May","year":"1990","journal-title":"Vet Immunol Immunopathol"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458412009302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458412009302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:29:27Z","timestamp":1761017367000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458412009302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1063458412009302"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2012.08.008","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the inflammatory response in experimentally induced synovitis in the horse: a comparison of recombinant equine interleukin 1 beta and lipopolysaccharide","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2012.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}