{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:31:25Z","timestamp":1789810285451,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":443,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.joca.2012.08.021","type":"journal-article","created":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T01:35:00Z","timestamp":1346463300000},"page":"1507-1513","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Pain in patients with equal radiographic grades of osteoarthritis in both knees: the value of gray scale ultrasound"],"prefix":"10.1016","volume":"20","author":[{"given":"P.-T.","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.-J.","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.-C.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.-T.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.-C.","family":"Chern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.-C.","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.-M.","family":"Jou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2012.08.021_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1053\/berh.1999.0016","article-title":"Frequency and impact of regional musculoskeletal disorders","volume":"13","author":"Linaker","year":"1999","journal-title":"Baillieres Clin Rheumatol"},{"key":"10.1016\/j.joca.2012.08.021_bib2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/BF02231535","article-title":"Increased levels of urinary collagen crosslinks in females with rheumatoid arthritis","volume":"12","author":"Spector","year":"1993","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.joca.2012.08.021_bib3","first-page":"1943","article-title":"Correlates of knee pain among US adults with and without radiographic knee osteoarthritis","volume":"19","author":"Davis","year":"1992","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2012.08.021_bib4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/art.1790080311","article-title":"Association of radiographic features of osteoarthritis of the knee with knee pain: data from the Baltimore Longitudinal Study of Aging","volume":"8","author":"Lethbridge-Cejku","year":"1995","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.joca.2012.08.021_bib5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/ard.50.7.467","article-title":"Clinical signs of early osteoarthritis: reproducibility and relation to X ray changes in 541 women in the general population","volume":"50","author":"Hart","year":"1991","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2012.08.021_bib6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0049-0172(90)90046-I","article-title":"The epidemiology of knee osteoarthritis: results from the Framingham Osteoarthritis Study","volume":"20","author":"Felson","year":"1990","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.joca.2012.08.021_bib7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/ard.49.10.771","article-title":"Do clinical findings associate with radiographic osteoarthritis of the knee?","volume":"49","author":"Claessens","year":"1990","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2012.08.021_bib8","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1471-2474-9-116","article-title":"The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature","volume":"9","author":"Bedson","year":"2008","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.joca.2012.08.021_bib9","first-page":"204","article-title":"Inflammatory synovitis in degenerative joint disease","volume":"9","author":"Goldenberg","year":"1982","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2012.08.021_bib10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/02841850600551508","article-title":"Indications of inflammation visualized by ultrasound in osteoarthritis of the knee","volume":"47","author":"Kristoffersen","year":"2006","journal-title":"Acta Radiol"},{"key":"10.1016\/j.joca.2012.08.021_bib11","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1136\/ard.2005.037994","article-title":"EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: prevalence of inflammation in osteoarthritis","volume":"64","author":"D'Agostino","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2012.08.021_bib12","first-page":"966","article-title":"Ultrasonography is superior to clinical examination in the detection and localization of knee joint effusion in rheumatoid arthritis","volume":"30","author":"Kane","year":"2003","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2012.08.021_bib13","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1136\/ard.2009.124875","article-title":"Pain in hand osteoarthritis is associated with inflammation: the value of ultrasound","volume":"69","author":"Kortekaas","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2012.08.021_bib14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/1529-0131(200102)44:2<331::AID-ANR50>3.0.CO;2-0","article-title":"Correlation of power Doppler sonography with vascularity of the synovial tissue of the knee joint in patients with osteoarthritis and rheumatoid arthritis","volume":"44","author":"Walther","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2012.08.021_bib15","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.joca.2005.12.012","article-title":"Clinical and ultrasonographic findings related to knee pain in osteoarthritis","volume":"14","author":"de Miguel Mendieta","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.08.021_bib16","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s10067-011-1701-x","article-title":"Clinic and ultrasound findings related to pain in patients with knee osteoarthritis","volume":"8","author":"Mermerci","year":"2011","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.joca.2012.08.021_bib17","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.joca.2005.02.008","article-title":"Ultrasonographic findings in knee osteoarthritis: a comparative study with clinical and radiographic assessment","volume":"13","author":"Naredo","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.08.021_bib18","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2012.08.021_bib19","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1136\/ard.55.8.552","article-title":"Recommendations for the registration of drugs used in the treatment of osteoarthritis. Group for the respect of ethics and excellence in science (GREES): osteoarthritis section","volume":"55","year":"1996","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2012.08.021_bib20","first-page":"907","article-title":"Musculoskeletal ultrasonography","volume":"30","author":"van Holsbeeck","year":"1992","journal-title":"Radiol Clin North Am"},{"key":"10.1016\/j.joca.2012.08.021_bib21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s002560100380","article-title":"Ultrasound of the knee","volume":"30","author":"Friedman","year":"2001","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.joca.2012.08.021_bib22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/art.20054","article-title":"Validation and reproducibility of ultrasonography in the detection of synovitis in the knee: a comparison with arthroscopy and clinical examination","volume":"50","author":"Karim","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2012.08.021_bib23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/ard.2007.080382","article-title":"Contrast-enhanced ultrasound in monitoring the efficacy of a bradykinin receptor 2 antagonist in painful knee osteoarthritis compared with MRI","volume":"68","author":"Song","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2012.08.021_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1471-2474-10-133","article-title":"Empirical evaluation of the inter-relationship of articular elements involved in the pathoanatomy of knee osteoarthritis using magnetic resonance imaging","volume":"10","author":"Meredith","year":"2009","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.joca.2012.08.021_bib25","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1053\/joca.1999.0256","article-title":"Meniscal subluxation: association with osteoarthritis and joint space narrowing","volume":"7","author":"Gale","year":"1999","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.08.021_bib26","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/(SICI)1097-0258(19980615)17:11<1261::AID-SIM846>3.0.CO;2-Z","article-title":"Extending the simple linear regression model to account for correlated responses: an introduction to generalized estimating equations and multi-level mixed modelling","volume":"17","author":"Burton","year":"1998","journal-title":"Stat Med"},{"key":"10.1016\/j.joca.2012.08.021_bib27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.joca.2010.10.029","article-title":"Systematic review of the concurrent and predictive validity of MRI biomarkers in OA","volume":"19","author":"Hunter","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.08.021_bib28","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1148\/radiol.2393050253","article-title":"Osteoarthritis of the knee: association between clinical features and MR imaging findings","volume":"239","author":"Kornaat","year":"2006","journal-title":"Radiology"},{"key":"10.1016\/j.joca.2012.08.021_bib29","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/ard.2006.066183","article-title":"The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston Leeds Osteoarthritis Knee Score)","volume":"67","author":"Hunter","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2012.08.021_bib30","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/rheumatology\/33.3.267","article-title":"Osteoarthritis of the knee following meniscectomy","volume":"33","author":"Neyret","year":"1994","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.joca.2012.08.021_bib31","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1080\/02841859709172428","article-title":"MR imaging of meniscal subluxation in the knee","volume":"38","author":"Breitenseher","year":"1997","journal-title":"Acta Radiol"},{"key":"10.1016\/j.joca.2012.08.021_bib32","first-page":"1330","article-title":"Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis","volume":"28","author":"Hill","year":"2001","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2012.08.021_bib33","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F","article-title":"Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets","volume":"44","author":"Pelletier","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2012.08.021_bib34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.joca.2005.01.005","article-title":"Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis \u2013 results of a 1 year longitudinal arthroscopic study in 422 patients","volume":"13","author":"Ayral","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.08.021_bib35","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1136\/ard.2006.067470","article-title":"Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis","volume":"66","author":"Hill","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2012.08.021_bib36","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.joca.2008.09.020","article-title":"Semiquantitative assessment of synovitis in osteoarthritis on non contrast-enhanced MRI","volume":"17","author":"Roemer","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.08.021_bib37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0730-725X(94)00119-N","article-title":"Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis","volume":"13","author":"Fernandez-Madrid","year":"1995","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.joca.2012.08.021_bib38","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1002\/art.21373","article-title":"Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity","volume":"52","author":"Loeuille","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"Suppl 4","key":"10.1016\/j.joca.2012.08.021_bib39","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.1016\/S1063-4584(08)60428-8","article-title":"Peripatellar synovitis in osteoarthritis: comparison of nonenhanced and enhanced magnetic resonance imaging (MRI) and its association with peripatellar knee pain: the MOSTstudy","volume":"16","author":"Marra","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2012.08.021_bib40","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.rcl.2009.04.001","article-title":"MR imaging of intra- and periarticular soft tissues and subchondral bone in knee osteoarthritis","volume":"47","author":"Crema","year":"2009","journal-title":"Radiol Clin North Am"},{"key":"10.1016\/j.joca.2012.08.021_bib41","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/00003086-200007000-00024","article-title":"Distribution of neuropeptides in synovium of the knee with osteoarthritis","author":"Saito","year":"2000","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.joca.2012.08.021_bib42","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.semarthrit.2010.12.003","article-title":"Imaging of synovitis in osteoarthritis: current status and outlook","volume":"41","author":"Hayashi","year":"2011","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.joca.2012.08.021_bib43","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/art.10818","article-title":"Power Doppler sonography: improving disease activity assessment in inflammatory musculoskeletal disease","volume":"48","author":"Wakefield","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2012.08.021_bib44","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/rheumatology\/35.2.155","article-title":"Long-term sonographic follow-up of rheumatoid and psoriatic proliferative knee joint synovitis","volume":"35","author":"Fiocco","year":"1996","journal-title":"Br J Rheumatol"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458412009442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458412009442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:27:48Z","timestamp":1761017268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458412009442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1063458412009442"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2012.08.021","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pain in patients with equal radiographic grades of osteoarthritis in both knees: the value of gray scale ultrasound","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2012.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}