{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:58:22Z","timestamp":1788872302186,"version":"build-2803163510"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Pfizer (Groton, CT, USA)"},{"name":"Dutch Arthritis Association"},{"name":"Netherlands Organization of Scientific Research"},{"DOI":"10.13039\/501100005039","name":"Leiden University Medical Center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Center of Medical System Biology"},{"name":"Netherlands Consortium for Healthy Aging"},{"name":"Netherlands Genomics Initiative (NGI)"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.joca.2013.01.011","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T22:36:32Z","timestamp":1359153392000},"page":"565-569","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association study of candidate genes for the progression of hand osteoarthritis"],"prefix":"10.1016","volume":"21","author":[{"given":"J.","family":"Bijsterbosch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kloppenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Reijnierse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.R.","family":"Rosendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.W.J.","family":"Huizinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.E.","family":"Slagboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Meulenbelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2013.01.011_bib1","series-title":"The Burden of Musculoskeletal Conditions at the Start of the New Millennium","author":"World Health Organization","year":"2003"},{"key":"10.1016\/j.joca.2013.01.011_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1136\/ard.48.4.271","article-title":"Epidemiology of osteoarthritis: Zoetermeer survey. Comparison of radiological osteoarthritis in a Dutch population with that in 10 other populations","volume":"48","author":"van Saase","year":"1989","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2013.01.011_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mcna.2008.08.007","article-title":"The contribution of genes to osteoarthritis","volume":"93","author":"Valdes","year":"2009","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.joca.2013.01.011_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.berh.2009.08.005","article-title":"The clinical relevance of genetic susceptibility to osteoarthritis","volume":"24","author":"Valdes","year":"2010","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.joca.2013.01.011_bib5","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/art.22680","article-title":"Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: a prospective longitudinal cohort study","volume":"57","author":"Botha-Scheepers","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2013.01.011_bib6","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/hmg\/ddn038","article-title":"A\u00a0meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5\u2032 UTR of GDF5 with osteoarthritis susceptibility","volume":"17","author":"Chapman","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.joca.2013.01.011_bib7","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/art.24524","article-title":"Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand","volume":"60","author":"Evangelou","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2013.01.011_bib8","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1002\/art.20634","article-title":"Microsatellite association mapping of a primary osteoarthritis susceptibility locus on chromosome 6p12.3-q13","volume":"50","author":"Southam","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2013.01.011_bib9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1471-2350-10-141","article-title":"Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis","volume":"10","author":"Wilkins","year":"2009","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.joca.2013.01.011_bib10","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/ng1496","article-title":"An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis","volume":"37","author":"Kizawa","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.joca.2013.01.011_bib11","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/hmg\/ddm115","article-title":"Meta-analysis of association between the ASPN\u00a0D-repeat and osteoarthritis","volume":"16","author":"Nakamura","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.joca.2013.01.011_bib12","doi-asserted-by":"crossref","first-page":"724","DOI":"10.2174\/092986708783885237","article-title":"Expression, regulation and function of asporin, a susceptibility gene in common bone and joint diseases","volume":"15","author":"Ikegawa","year":"2008","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.joca.2013.01.011_bib13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1136\/ard.2010.133017","article-title":"Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years","volume":"70","author":"Bijsterbosch","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2013.01.011_bib14","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1136\/ard.2004.024661","article-title":"Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP study","volume":"64","author":"Riyazi","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2013.01.011_bib15","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1136\/ard.2008.087981","article-title":"Progression of hand osteoarthritis over 2 years: a clinical and radiological follow-up study","volume":"68","author":"Botha-Scheepers","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2013.01.011_bib16","series-title":"The Epidemiology of Chronic Rheumatism. Atlas of Standard Radiographs of Arthritis","author":"Kellgren","year":"1963"},{"key":"10.1016\/j.joca.2013.01.011_bib17","doi-asserted-by":"crossref","first-page":"e495","DOI":"10.1371\/journal.pmed.0030495","article-title":"Lipoprotein particle profiles mark familial and sporadic human longevity","volume":"3","author":"Heijmans","year":"2006","journal-title":"PLoS Med"},{"issue":"Suppl A","key":"10.1016\/j.joca.2013.01.011_bib18","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1016\/j.joca.2006.11.009","article-title":"Atlas of individual radiographic features in osteoarthritis, revised","volume":"15","author":"Altman","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2013.01.011_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/ard.2003.018457","article-title":"Deciding on progression of joint damage in paired films of individual patients: smallest detectable difference or change","volume":"64","author":"Bruynesteyn","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2013.01.011_bib20","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1002\/art.20443","article-title":"Association study of candidate genes for the prevalence and progression of knee osteoarthritis","volume":"50","author":"Valdes","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2013.01.011_bib21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.joca.2005.10.012","article-title":"Asporin and knee osteoarthritis in patients of Greek origin","volume":"14","author":"Kaliakatsos","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2013.01.011_bib22","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1002\/art.21399","article-title":"Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis in a UK Caucasian population","volume":"52","author":"Mustafa","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2013.01.011_bib23","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1186\/ar1920","article-title":"Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case\u2013control studies in Spanish Caucasians","volume":"8","author":"Rodriguez-Lopez","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2013.01.011_bib24","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.joca.2008.03.007","article-title":"Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians","volume":"16","author":"Atif","year":"2008","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458413000265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458413000265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:29:43Z","timestamp":1761017383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458413000265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S1063458413000265"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2013.01.011","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association study of candidate genes for the progression of hand osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2013.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}