{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:34:30Z","timestamp":1767922470561,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"China National Science & Technology","award":["2007BA125B04"],"award-info":[{"award-number":["2007BA125B04"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Fund of China","doi-asserted-by":"crossref","award":["81271976\/H0605-81171763"],"award-info":[{"award-number":["81271976\/H0605-81171763"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.joca.2013.05.005","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T23:47:37Z","timestamp":1369093657000},"page":"1108-1115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["An animal model of Kashin\u2013Beck disease induced by a low-nutrition diet and exposure to T-2 toxin"],"prefix":"10.1016","volume":"21","author":[{"given":"P.","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2013.05.005_bib1","first-page":"563","article-title":"Geological environment characteristics and etiology research on Kashin\u2013Beck\u00a0disease in China","volume":"37","author":"An","year":"2010","journal-title":"Geol China"},{"key":"10.1016\/j.joca.2013.05.005_bib2","first-page":"67","article-title":"Report of a national survey of Kashin\u2013Beck disease prevalence in 2005","volume":"25","author":"National Kashin\u2013Beck Disease Surveillance Group","year":"2006","journal-title":"Chin J Epidemiol"},{"key":"10.1016\/j.joca.2013.05.005_bib3","first-page":"147","article-title":"The monitoring report of Kashin\u2013Beck disease prevalence rate of the whole country in 2003","volume":"23","author":"National Kashin\u2013Beck Disease Surveillance Group","year":"2003","journal-title":"Chin J Epidemiol"},{"key":"10.1016\/j.joca.2013.05.005_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s002640000177","article-title":"Editorial: Kashin\u2013Beck disease","volume":"25","author":"Hinsenkamp","year":"2001","journal-title":"Int Orthop"},{"key":"10.1016\/j.joca.2013.05.005_bib5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s002640000218","article-title":"A\u00a04-year study of the mycological aspects of Kashin\u2013Beck disease in Tibet","volume":"25","author":"Chasseur","year":"2001","journal-title":"Int Orthop"},{"key":"10.1016\/j.joca.2013.05.005_bib6","first-page":"201","article-title":"Etiology of Kashin\u2013Beck disease","volume":"4","author":"Yang","year":"1995","journal-title":"Chin J Epidemiol"},{"key":"10.1016\/j.joca.2013.05.005_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s002640100240","article-title":"The prevalence of mycotoxins in Kashin\u2013Beck disease","volume":"25","author":"Haubruge","year":"2001","journal-title":"Int Orthop"},{"key":"10.1016\/j.joca.2013.05.005_bib8","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1056\/NEJM199810153391604","article-title":"Kashin\u2013Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status","volume":"339","author":"Moreno-Reyes","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.joca.2013.05.005_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.joca.2012.02.012","article-title":"Sodium selenium for treatment of Kashin\u2013Beck disease in children: a systematic review of randomized controlled trials","volume":"20","author":"Jirong","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2013.05.005_bib10","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.nut.2011.03.002","article-title":"Selenium, iodine and the relation with Kashin\u2013Beck disease","volume":"27","author":"Yao","year":"2011","journal-title":"Nutrition"},{"key":"10.1016\/j.joca.2013.05.005_bib11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s002640000194","article-title":"Kashin\u2013Beck disease and drinking water in Central Tibet","volume":"25","author":"La Grange","year":"2001","journal-title":"Int Orthop"},{"key":"10.1016\/j.joca.2013.05.005_bib12","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00264-009-0738-9","article-title":"Effects of physical environment on the evolution of Kashin\u2013Beck disease in Tibet","volume":"33","author":"Hinsenkamp","year":"2009","journal-title":"Int Orthop"},{"key":"10.1016\/j.joca.2013.05.005_bib13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s002640100248","article-title":"Diagnostic, clinical and radiological characteristics of Kashin\u2013Beck disease in Shaanxi Province, PR China","volume":"25","author":"Xiong","year":"2001","journal-title":"Int Orthop"},{"key":"10.1016\/j.joca.2013.05.005_bib14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s002640000178","article-title":"Kashin\u2013Beck disease: a historical overview","volume":"25","author":"Yamamuro","year":"2001","journal-title":"Int Orthop"},{"key":"10.1016\/j.joca.2013.05.005_bib15","first-page":"169","article-title":"A\u00a0preliminary assessment of environmental geology for Kashin\u2013Beck disease in Zamgtang, Aba","volume":"125","author":"Wang","year":"2005","journal-title":"Acta Geol Sichuan"},{"key":"10.1016\/j.joca.2013.05.005_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1023\/A:1023271403310","article-title":"Environmental Se-Mo-B deficiency and its possible effects on crops and Keshan\u2013Beck disease (KBD) in the Chousang area, Yao County, Shaanxi Province, China","volume":"25","author":"Fang","year":"2003","journal-title":"Environ Geochem Health"},{"key":"10.1016\/j.joca.2013.05.005_bib17","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.joca.2007.03.013","article-title":"Effects of selenium and iodine deficiency on bone, cartilage growth plate and chondrocyte differentiation in two generations of rats","volume":"15","author":"Ren","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2013.05.005_bib18","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.joca.2007.09.002","article-title":"Articular cartilage metabolism in patients with Kashin\u2013Beck disease: an endemic osteoarthropathy in China","volume":"16","author":"Cao","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2013.05.005_bib19","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s002640100247","article-title":"Epidemiological support for a multifactorial aetiology of Kashin\u2013Beck disease in Tibet","volume":"25","author":"Suetens","year":"2001","journal-title":"Int Orthop"},{"key":"10.1016\/j.joca.2013.05.005_bib20","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s00264-010-0966-z","article-title":"Study on the effect of T-2 toxin combined with low nutrition diet on rat epiphyseal plate growth and development","volume":"34","author":"Yao","year":"2010","journal-title":"Int Orthop"},{"key":"10.1016\/j.joca.2013.05.005_bib21","first-page":"325","article-title":"Necrosis in growth plate of cartilage of chickens fed with grain contaminated by Fusarium from Kashin\u2013Beck disease area","volume":"8","author":"Yang","year":"1993","journal-title":"Chin J Control Endem Dis"},{"key":"10.1016\/j.joca.2013.05.005_bib22","first-page":"116","article-title":"KBD cartilage necrosis histopathology and clinical significance","volume":"1","author":"Mo","year":"1982","journal-title":"Chin J Epidemiol"},{"key":"10.1016\/j.joca.2013.05.005_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2013.05.005_bib24","first-page":"361","article-title":"Chondronecrosis induced in rhesus monkeys fed with grains and water of Kashin\u2013Beck's disease endemic area","volume":"72","author":"Yang","year":"1993","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.joca.2013.05.005_bib25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s002640000190","article-title":"Histology of Kashin\u2013Beck lesions","volume":"25","author":"Pasteels","year":"2001","journal-title":"Int Orthop"},{"key":"10.1016\/j.joca.2013.05.005_bib26","first-page":"325","article-title":"Observation on the culture of Fusarium isolated from the cereal produced in KBD areas causing cartilage necrosis of growth plate in broiler chickens","volume":"8","author":"Yang","year":"1993","journal-title":"Chin J Endemiol"},{"key":"10.1016\/j.joca.2013.05.005_bib27","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1177\/0192623310396902","article-title":"T-2 toxin induces degenerative articular changes in rodents: link to Kashin\u2013Beck disease","volume":"39","author":"Wang","year":"2011","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.joca.2013.05.005_bib28","first-page":"4","article-title":"Toxic effect of T-2 toxin on articular cartilage in Chinese experimental mini-pig","volume":"12","author":"Xiong","year":"1997","journal-title":"Chin J Endemiol"},{"key":"10.1016\/j.joca.2013.05.005_bib29","first-page":"9232","article-title":"Preventive effects of supplemental selenium and selenium plus iodine on bone and cartilage development in rats fed with diet from Kashin\u2013Beck disease endemic area","volume":"11","author":"Yao","year":"2011","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.joca.2013.05.005_bib30","first-page":"325","article-title":"Geochemical characteristics of Kashin\u2013Beck disease districts in the Aba area, Sichuan","volume":"30","author":"Zhao","year":"2003","journal-title":"Geol China"},{"key":"10.1016\/j.joca.2013.05.005_bib31","first-page":"331","article-title":"The survey report of iodine deficiency in Sichuan Aba region","volume":"121","author":"Chen","year":"2005","journal-title":"J\u00a0Prev Med Inform"},{"key":"10.1016\/j.joca.2013.05.005_bib32","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/sj.ejcn.1601915","article-title":"Poor nutritional status of younger Tibetan children living at high altitudes","volume":"58","author":"Dang","year":"2004","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.joca.2013.05.005_bib33","first-page":"172","article-title":"The changes of nitric oxide, No synthase and sFas\/APo-1 in serum among the patients with Kashin\u2013Beck disease","volume":"23","author":"Zhang","year":"2004","journal-title":"Chin J Epidemiol"},{"key":"10.1016\/j.joca.2013.05.005_bib34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.tiv.2008.11.002","article-title":"Butenolide induced cytotoxicity by disturbing the prooxidant-antioxidant balance, and antioxidants partly quench in human chondrocytes","volume":"23","author":"Shi","year":"2009","journal-title":"Toxicol Vitro"},{"key":"10.1016\/j.joca.2013.05.005_bib35","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0753-3322(03)00035-0","article-title":"The antioxidant role of selenium and seleno-compounds","volume":"57","author":"Tapiero","year":"2003","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.joca.2013.05.005_bib36","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.nutr.21.1.453","article-title":"Mammalian selenium-containing proteins","volume":"21","author":"Behne","year":"2001","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.joca.2013.05.005_bib37","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1631\/jzus.B0900074","article-title":"Effects of moniliformin and selenium on human articular cartilage metabolism and their potential relationships to the pathogenesis of Kashin\u2013Beck disease","volume":"11","author":"Zhang","year":"2010","journal-title":"J\u00a0Zhejiang Univ Sci B"},{"key":"10.1016\/j.joca.2013.05.005_bib38","doi-asserted-by":"crossref","first-page":"264S","DOI":"10.1093\/ajcn\/57.2.264S","article-title":"The epidemiology of iodine deficiency diseases in China","volume":"957","author":"Ma","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.joca.2013.05.005_bib39","first-page":"32","article-title":"Pathological investigation of bone development retardation caused by iodine deficiency","volume":"24","author":"Guo","year":"2005","journal-title":"Chin J Endemiol"},{"key":"10.1016\/j.joca.2013.05.005_bib40","first-page":"248","article-title":"Impairment of bone development in iodine-deficient rats","volume":"20","author":"Guo","year":"2004","journal-title":"Chin J Endocrinol Metab"},{"key":"10.1016\/j.joca.2013.05.005_bib41","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.ecl.2007.04.005","article-title":"Thyroid and bone","volume":"36","author":"Wexler","year":"2007","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.joca.2013.05.005_bib42","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/(SICI)1099-0844(200006)18:2<143::AID-CBF857>3.0.CO;2-#","article-title":"Effect of iodide on total antioxidant status of human serum","volume":"18","author":"Winkler","year":"2000","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.joca.2013.05.005_bib43","series-title":"Selenium in Biology and Medicine: Proceedings of the Third International Symposium on Selenium in Biology and Medicine","first-page":"859","article-title":"Pathology of selenium deficiency in Kashin\u2013Beck disease","author":"Mo","year":"1987"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345841300798X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345841300798X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:30:49Z","timestamp":1761017449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S106345841300798X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S106345841300798X"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2013.05.005","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An animal model of Kashin\u2013Beck disease induced by a low-nutrition diet and exposure to T-2 toxin","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2013.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}