{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:01:17Z","timestamp":1778734877794,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.joca.2013.06.029","type":"journal-article","created":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T11:32:20Z","timestamp":1373023940000},"page":"1707-1715","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Differential accumulation of lead and zinc in double-tidemarks of articular cartilage"],"prefix":"10.1016","volume":"21","author":[{"given":"A.","family":"Roschger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.G.","family":"Hofstaetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Pemmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Zoeger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Wobrauschek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Falkenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Berzlanovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.W.","family":"Thaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Roschger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Klaushofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Streli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2013.06.029_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/bmb\/ldg032","article-title":"Hazards of heavy metal contamination","volume":"68","author":"Jarup","year":"2003","journal-title":"Br Med Bull"},{"key":"10.1016\/j.joca.2013.06.029_bib2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/00039896.1988.9935855","article-title":"Lead in bone. IV. Distribution of lead in the human skeleton","volume":"43","author":"Wittmers","year":"1988","journal-title":"Arch Environ Health"},{"key":"10.1016\/j.joca.2013.06.029_bib3","first-page":"783","article-title":"Osteoblasts and chondrocytes are important target cells for the toxic effects of lead","volume":"13","author":"Puzas","year":"1992","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.joca.2013.06.029_bib4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0013-9351(88)80023-9","article-title":"Lead and osteoporosis: mobilization of lead from bone in postmenopausal women","volume":"47","author":"Silbergeld","year":"1988","journal-title":"Environ Res"},{"key":"10.1016\/j.joca.2013.06.029_bib5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s002239900214","article-title":"Effect of lead on bone development and bone mass: a morphometric, densitometric, and histomorphometric study in growing rats","volume":"60","author":"Escribano","year":"1997","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.joca.2013.06.029_bib6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/ajim.20567","article-title":"Osteoporosis in a Chinese population due to occupational exposure to lead","volume":"51","author":"Sun","year":"2008","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.joca.2013.06.029_bib7","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1289\/ehp.7596","article-title":"Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency","volume":"113","author":"Carmouche","year":"2005","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.joca.2013.06.029_bib8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0046-8177(88)80353-8","article-title":"Lead arthritis and lead poisoning following bullet wounds: a clinicopathologic, ultrastructural, and microanalytic study of two cases","volume":"19","author":"Slavin","year":"1988","journal-title":"Hum Pathol"},{"key":"10.1016\/j.joca.2013.06.029_bib9","first-page":"951","article-title":"Experimental lead arthropathy: an animal model","volume":"47","author":"Harding","year":"1999","journal-title":"J\u00a0Trauma"},{"key":"10.1016\/j.joca.2013.06.029_bib10","first-page":"668","article-title":"Intra-articular histopathologic changes secondary to local lead intoxication in rabbit knee joints","volume":"38","author":"Bolanos","year":"1995","journal-title":"J\u00a0Trauma"},{"key":"10.1016\/j.joca.2013.06.029_bib11","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.envres.2011.08.002","article-title":"Whole blood lead levels are associated with biomarkers of joint tissue metabolism in African American and white men and women: the Johnston County Osteoarthritis Project","volume":"111","author":"Nelson","year":"2011","journal-title":"Environ Res"},{"key":"10.1016\/j.joca.2013.06.029_bib12","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1186\/ar3270","article-title":"Whole blood lead levels are associated with radiographic and symptomatic knee osteoarthritis: a cross-sectional analysis in the Johnston County Osteoarthritis Project","volume":"13","author":"Nelson","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2013.06.029_bib13","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/07315724.1996.10718608","article-title":"Zinc and growth","volume":"15","author":"Nishi","year":"1996","journal-title":"J\u00a0Am Coll Nutr"},{"key":"10.1016\/j.joca.2013.06.029_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0928-4931(02)00108-X","article-title":"Zinc-releasing calcium phosphate for stimulating bone formation","volume":"22","author":"Ito","year":"2002","journal-title":"Mater Sci Eng C"},{"key":"10.1016\/j.joca.2013.06.029_bib15","first-page":"703","article-title":"Long-term marginal zinc supply is not detrimental to the skeleton of aged female rats","volume":"139","author":"Erben","year":"2009","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.joca.2013.06.029_bib16","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.joca.2006.03.001","article-title":"Lead accumulation in tidemark of articular cartilage","volume":"14","author":"Zoeger","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2013.06.029_bib17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/ard.12.2.105","article-title":"Histochemical studies of rheumatic conditions. I. Observations on the fine structures of the matrix of normal bone and cartilage","volume":"12","author":"Fawns","year":"1953","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2013.06.029_bib18","first-page":"1070","article-title":"Mechanical strength of osteochondral junction","volume":"65","author":"Kumar","year":"1991","journal-title":"Nippon Seikeigeka Gakkai Zasshi"},{"key":"10.1016\/j.joca.2013.06.029_bib19","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1302\/0301-620X.39B3.548","article-title":"The reactions of injured human articular cartilage","volume":"39-B","author":"Landells","year":"1957","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.joca.2013.06.029_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00549758","article-title":"The subchondral bone plate of the femoral head in adult rabbits. I. Spontaneous remodelling studied by microradiography and tetracycline labelling","volume":"352","author":"Lemperg","year":"1971","journal-title":"Virchows Arch A Pathol Pathol Anat"},{"key":"10.1016\/j.joca.2013.06.029_bib21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02274838","article-title":"Metabolic activity in the calcified zone of cartilage: observations on tetracycline labelled articular cartilage in human osteoarthritic hips","volume":"10","author":"Revell","year":"1990","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.joca.2013.06.029_bib22","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1302\/0301-620X.62B3.7410471","article-title":"Age-related changes in the thickness of the calcified zone and the number of tidemarks in adult human articular cartilage","volume":"62","author":"Lane","year":"1980","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.joca.2013.06.029_bib23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1600-0463.2005.apm_113506.x","article-title":"The area of the tidemark in osteoarthritis \u2013 a three-dimensional stereological study in 21 patients","volume":"113","author":"Bonde","year":"2005","journal-title":"APMIS"},{"key":"10.1016\/j.joca.2013.06.029_bib24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S8756-3282(98)00112-4","article-title":"Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies","volume":"23","author":"Roschger","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.joca.2013.06.029_bib25","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.bone.2007.10.021","article-title":"Bone mineralization density distribution in health and disease","volume":"42","author":"Roschger","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.joca.2013.06.029_bib26","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00223-009-9289-8","article-title":"Combination of nanoindentation and quantitative backscattered electron imaging revealed altered bone material properties associated with femoral neck fragility","volume":"85","author":"Fratzl-Zelman","year":"2009","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.joca.2013.06.029_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/xrs.998","article-title":"Determination of the elemental distribution in human joint bones by SR micro XRF","volume":"37","author":"Zoeger","year":"2008","journal-title":"X\u00a0Ray Spectrom"},{"key":"10.1016\/j.joca.2013.06.029_bib28","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/xrs.788","article-title":"Distribution of Pb and Zn in slices of human bone by synchrotron \u03bc-XRF","author":"Zoeger","year":"2005","journal-title":"X\u00a0Ray Spectrom"},{"key":"10.1016\/j.joca.2013.06.029_bib29","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.sab.2004.07.025","article-title":"Confocal microscopic X-ray fluorescence at the HASYLAB microfocus beamline: characteristics and possibilities","volume":"59","author":"Janssens","year":"2004","journal-title":"Spectrochim Acta B Atom Spectros"},{"key":"10.1016\/j.joca.2013.06.029_bib30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0168-583X(03)01321-1","article-title":"A\u00a0new 3D micro X-ray fluorescence analysis set-up \u2013 first archaeometric applications","volume":"211","author":"Kanngie\u00dfer","year":"2003","journal-title":"Nucl Instrum Methods Phys Res B"},{"key":"10.1016\/j.joca.2013.06.029_bib31","first-page":"64","article-title":"Depth resolved X-ray fluorescence analysis of copper charged muscovite mica","volume":"50","author":"Simon","year":"2007","journal-title":"Adv X Ray Anal"},{"key":"10.1016\/j.joca.2013.06.029_bib32","doi-asserted-by":"crossref","first-page":"6786","DOI":"10.1021\/ac049274l","article-title":"Three-dimensional trace element analysis by confocal X-ray microfluorescence imaging","volume":"76","author":"Vincze","year":"2004","journal-title":"Anal Chem"},{"key":"10.1016\/j.joca.2013.06.029_bib33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/xrs.482","article-title":"Upgrade of the X-ray fluorescence beamline at HASYLAB\/DESY","volume":"30","author":"Falkenberg","year":"2001","journal-title":"X\u00a0Ray Spectrom"},{"key":"10.1016\/j.joca.2013.06.029_bib34","series-title":"X-ray Optics for the Microfocus Beamline L","author":"Falkenberg","year":"2001"},{"key":"10.1016\/j.joca.2013.06.029_bib35","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0168-583X(02)01418-0","article-title":"The X-ray-fluorescence facility at ANKA, Karlsruhe: minimum detection limits and micro probe capabilities","volume":"199","author":"Simon","year":"2003","journal-title":"Nucl Instrum Methods Phys Res B"},{"key":"10.1016\/j.joca.2013.06.029_bib36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0169-7439(86)80031-4","article-title":"AXIL-PC: software for the analysis of complex X-ray spectra","volume":"1","author":"Van Espen","year":"1986","journal-title":"Chemometr Intell Lab Syst"},{"key":"10.1016\/j.joca.2013.06.029_bib37","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"issue":"Pt 2","key":"10.1016\/j.joca.2013.06.029_bib38","first-page":"341","article-title":"Topographical variation in the calcified zone of upper femoral articular cartilage","volume":"139","author":"Meachim","year":"1984","journal-title":"J\u00a0Anat"},{"key":"10.1016\/j.joca.2013.06.029_bib39","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1107\/S0108768189001928","article-title":"Structure refinements of lead-substituted calcium hydroxyapatite by X-ray powder fitting","volume":"45","author":"Bigi","year":"1989","journal-title":"Acta Crystallogr B"},{"key":"10.1016\/j.joca.2013.06.029_bib40","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1107\/S0909049510052040","article-title":"Assessment of chemical species of lead accumulated in tidemarks of human articular cartilage by X-ray absorption near-edge structure analysis","volume":"18","author":"Meirer","year":"2011","journal-title":"J\u00a0Synchrotron Radiat"},{"key":"10.1016\/j.joca.2013.06.029_bib41","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1359\/jbmr.091028","article-title":"Bone material quality in transiliac bone biopsies of postmenopausal osteoporotic women after 3 years of strontium ranelate treatment","volume":"25","author":"Roschger","year":"2010","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.joca.2013.06.029_bib42","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1107\/S090904951103038X","article-title":"Increased strontium uptake in trabecular bone of ovariectomized calcium-deficient rats treated with strontium ranelate or strontium chloride","volume":"18","author":"Pemmer","year":"2011","journal-title":"J\u00a0Synchrotron Radiat"},{"key":"10.1016\/j.joca.2013.06.029_bib43","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1001\/jama.1994.03520040046039","article-title":"The decline in blood lead levels in the United States. The National Health and Nutrition Examination Surveys (NHANES)","volume":"272","author":"Pirkle","year":"1994","journal-title":"JAMA"},{"key":"10.1016\/j.joca.2013.06.029_bib44","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/jgs.2000.48.11.1501","article-title":"Lead toxicity in older adults","volume":"48","author":"Vig","year":"2000","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.joca.2013.06.029_bib45","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/thy.2000.10.161","article-title":"Increased lead excretion correlates with desoxypyridinoline crosslinks in hyperthyroid patients","volume":"10","author":"Osterode","year":"2000","journal-title":"Thyroid"},{"key":"10.1016\/j.joca.2013.06.029_bib46","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.bone.2004.05.022","article-title":"Effects of parathyroidectomy on lead mobilization from bone in patients with primary hyperparathyroidism","volume":"35","author":"Osterode","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.joca.2013.06.029_bib47","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1289\/ehp.01109995","article-title":"Influence of bone resorption on the mobilization of lead from bone among middle-aged and elderly men: the Normative Aging Study","volume":"109","author":"Tsaih","year":"2001","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.joca.2013.06.029_bib48","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/art.20124","article-title":"The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model","volume":"50","author":"Hayami","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2013.06.029_bib49","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bone.2005.08.007","article-title":"Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis","volume":"38","author":"Hayami","year":"2006","journal-title":"Bone"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458413008650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458413008650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:31:09Z","timestamp":1761017469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458413008650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S1063458413008650"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2013.06.029","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential accumulation of lead and zinc in double-tidemarks of articular cartilage","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2013.06.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}