{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:10:10Z","timestamp":1792606210382,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":591,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.joca.2013.11.014","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T14:31:15Z","timestamp":1386253875000},"page":"302-312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Reducing dietary loading decreases mouse temporomandibular joint degradation induced by anterior crossbite prosthesis"],"prefix":"10.1016","volume":"22","author":[{"given":"Y.-D.","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.-F.","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-Y.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-J.","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-P.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-Q.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2013.11.014_bib1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2842.1989.tb01331.x","article-title":"Effects of texture of food on chewing patterns in the human subject","volume":"16","author":"Horio","year":"1989","journal-title":"J\u00a0Oral Rehabil"},{"key":"10.1016\/j.joca.2013.11.014_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0003-9969(74)90221-0","article-title":"Time sequence of the activity of the temporal and masseter muscles in healthy young human adults during habitual chewing of different test foods","volume":"19","author":"Steiner","year":"1974","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joca.2013.11.014_bib3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1177\/154405910308200415","article-title":"New animal model for studying mastication in oral motor disorders","volume":"82","author":"Okayasu","year":"2003","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.joca.2013.11.014_bib4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/aja.1001700109","article-title":"The effect of dietary consistency on gross and histologic morphology in the craniofacial region of young rats","volume":"170","author":"Bouvier","year":"1984","journal-title":"Am J Anat"},{"key":"10.1016\/j.joca.2013.11.014_bib5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/ejo\/cjp060","article-title":"Effects of mastication on mandibular growth evaluated by microcomputed tomography","volume":"32","author":"Enomoto","year":"2010","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.joca.2013.11.014_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ejo\/26.1.1","article-title":"Effect of decreased loading on the metabolic activity of the mandibular condylar cartilage in the rat","volume":"26","author":"Pirttiniemi","year":"2004","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.joca.2013.11.014_bib7","first-page":"68","article-title":"Effect of diet hardness on mandibular condylar cartilage metabolism","volume":"25","author":"Tiilikainen","year":"2011","journal-title":"J\u00a0Orofac Pain"},{"key":"10.1016\/j.joca.2013.11.014_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0003-9969(91)90075-6","article-title":"The effect of dietary consistency on bone mass and turnover in the growing rat mandible","volume":"36","author":"Yamada","year":"1991","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joca.2013.11.014_bib9","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.joca.2008.05.021","article-title":"Altered functional loading causes differential effects in the subchondral bone and condylar cartilage in the temporomandibular joint from young mice","volume":"17","author":"Chen","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2013.11.014_bib10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00223-011-9498-9","article-title":"Sex differences in chondrocyte maturation in the mandibular condyle from a decreased occlusal loading model","volume":"89","author":"Chen","year":"2011","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.joca.2013.11.014_bib11","doi-asserted-by":"crossref","first-page":"e45036","DOI":"10.1371\/journal.pone.0045036","article-title":"Progression of cartilage degradation, bone resorption and pain in rat temporomandibular joint osteoarthritis induced by injection of iodoacetate","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2013.11.014_bib12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/0022034512473482","article-title":"Occlusal effects on longitudinal bone alterations of the temporomandibular joint","volume":"92","author":"Zhang","year":"2013","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.joca.2013.11.014_bib13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/0810209","article-title":"Experimentally induced unilateral tooth loss: histochemical studies of the temporomandibular joint","volume":"81","author":"Huang","year":"2002","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.joca.2013.11.014_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajodo.2009.09.018","article-title":"Mandibular condylar cartilage response to moving 2 molars in rats","volume":"137","author":"Jiao","year":"2010","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.joca.2013.11.014_bib15","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1177\/0022034509344387","article-title":"Missing posterior teeth and risk of temporomandibular disorders","volume":"88","author":"Wang","year":"2009","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.joca.2013.11.014_bib16","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.bone.2010.09.010","article-title":"Subchondral bone loss following orthodontically induced cartilage degradation in the mandibular condyles of rats","volume":"48","author":"Jiao","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.joca.2013.11.014_bib17","article-title":"Cartilage degradation in temporomandibular joint induced by unilateral anterior crossbite prosthesis","author":"Wang","year":"2013","journal-title":"Oral Dis"},{"key":"10.1016\/j.joca.2013.11.014_bib18","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/joor.12072","article-title":"Experimentally created unilateral anterior crossbite induces a degenerative ossification phenotype in mandibular condyle of growing Sprague-Dawley rats","volume":"40","author":"Zhang","year":"2013","journal-title":"J\u00a0Oral Rehabil"},{"key":"10.1016\/j.joca.2013.11.014_bib19","article-title":"Changes of temporomandibular joint (TMJ) and Semaphorin 4D\/Plexin-B1 expression in TMJ in a mouse model of incisor malocclusion","author":"Lu","year":"2014","journal-title":"J\u00a0Orofac Pain"},{"key":"10.1016\/j.joca.2013.11.014_bib20","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1002\/art.23638","article-title":"Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis","volume":"58","author":"Kadri","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2013.11.014_bib21","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1093\/rheumatology\/kep300","article-title":"Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis","volume":"48","author":"Kwan Tat","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.joca.2013.11.014_bib22","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1359\/jbmr.071025","article-title":"Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2","volume":"23","author":"Usui","year":"2008","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.joca.2013.11.014_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/art.38195","article-title":"Chondrocyte \u03b2-catenin signaling regulates postnatal bone remodeling through modulation of Rankl\/Opg expression and osteoclast formation","author":"Wang","year":"2014","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2013.11.014_bib24","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bone.2012.12.044","article-title":"Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats","volume":"53","author":"Zhu","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.joca.2013.11.014_bib25","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1002\/art.22941","article-title":"Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor\/osteoprotegerin in a murine model of osteoarthritis","volume":"56","author":"Shimizu","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2013.11.014_bib26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ajodo.2012.08.024","article-title":"Combined degenerative and regenerative remodeling responses of the mandibular condyle to experimentally induced disordered occlusion","volume":"143","author":"Kuang","year":"2013","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.joca.2013.11.014_bib27","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/art.27204","article-title":"Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis","volume":"62","author":"Moreno-Rubio","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2013.11.014_bib28","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1177\/154405910608500709","article-title":"Increase in RANKL: OPG ratio in synovia of patients with temporomandibular joint disorder","volume":"85","author":"Wakita","year":"2006","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.joca.2013.11.014_bib29","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1177\/0022034511421930","article-title":"Role of subchondral bone during early-stage experimental TMJ osteoarthritis","volume":"90","author":"Embree","year":"2011","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.joca.2013.11.014_bib30","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1037\/0033-2909.86.2.420","article-title":"Intraclass correlations: uses in assessing rater reliability","volume":"86","author":"Shrout","year":"1979","journal-title":"Psychol Bull"},{"key":"10.1016\/j.joca.2013.11.014_bib31","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.joca.2012.02.011","article-title":"Repeated measurements, bilateral observations and pseudoreplicates, why does it matter?","volume":"20","author":"Ranstam","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2013.11.014_bib32","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.joca.2005.04.016","article-title":"Accelerated osteoarthritis in the temporomandibular joint of biglycan\/fibromodulin double-deficient mice","volume":"13","author":"Wadhwa","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2013.11.014_bib33","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.joca.2009.01.002","article-title":"Early-onset osteoarthritis of mouse temporomandibular joint induced by partial discectomy","volume":"17","author":"Xu","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2013.11.014_bib34","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bone.2005.08.007","article-title":"Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis","volume":"38","author":"Hayami","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.joca.2013.11.014_bib35","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1177\/154405910308200914","article-title":"A\u00a0repetitive, steady mouth opening induced an osteoarthritis-like lesion in the rabbit temporomandibular joint","volume":"82","author":"Fujisawa","year":"2003","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.joca.2013.11.014_bib36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s10495-008-0279-5","article-title":"Death and proliferation of chondrocytes in the degraded mandibular condylar cartilage of rats induced by experimentally created disordered occlusion","volume":"14","author":"Jiao","year":"2009","journal-title":"Apoptosis"},{"key":"10.1016\/j.joca.2013.11.014_bib37","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/154405910808700406","article-title":"Degenerative disorders of the temporomandibular joint: etiology, diagnosis, and treatment","volume":"87","author":"Tanaka","year":"2008","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.joca.2013.11.014_bib38","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/rheumatology\/kes419","article-title":"Body weight at early and middle adulthood, weight gain and persistent overweight from early adulthood are predictors of the risk of total knee and hip replacement for osteoarthritis","volume":"52","author":"Wang","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.joca.2013.11.014_bib39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2842.2012.02333.x","article-title":"A\u00a0possible biomechanical role of occlusal cusp-fossa contact relationships","volume":"40","author":"Wang","year":"2013","journal-title":"J\u00a0Oral Rehabil"},{"key":"10.1016\/j.joca.2013.11.014_bib40","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2319\/083012-698.1","article-title":"Influence of malocclusion on the development of masticatory function and mandibular growth","volume":"83","author":"Nakamura","year":"2013","journal-title":"Angle Orthod"},{"key":"10.1016\/j.joca.2013.11.014_bib41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12548-011-0068-6","article-title":"Motor coordination of masseter and temporalis muscle during mastication in mice","volume":"3","author":"Utsumi","year":"2010","journal-title":"J\u00a0Stomat Occ Med"},{"key":"10.1016\/j.joca.2013.11.014_bib42","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0003-9969(83)90090-0","article-title":"An electromyographic study of mastication in the freely-moving rat","volume":"28","author":"Thomas","year":"1983","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joca.2013.11.014_bib43","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/0278-2391(88)90148-6","article-title":"The effect of diet texture on healing following temporomandibular joint discectomy in rabbits","volume":"46","author":"Block","year":"1988","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.joca.2013.11.014_bib44","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/0278-2391(90)90235-T","article-title":"Adaptive remodeling of the rabbit temporomandibular joint following discectomy and dietary variations","volume":"48","author":"Block","year":"1990","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.joca.2013.11.014_bib45","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0278-2391(97)90181-6","article-title":"Effect of postoperative diet on condylar cartilage response to discectomy","volume":"55","author":"Hinton","year":"1997","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.joca.2013.11.014_bib46","doi-asserted-by":"crossref","first-page":"e53312","DOI":"10.1371\/journal.pone.0053312","article-title":"The identification of CD163 expressing phagocytic chondrocytes in joint cartilage and its novel scavenger role in cartilage degradation","volume":"8","author":"Jiao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2013.11.014_bib47","doi-asserted-by":"crossref","first-page":"R149","DOI":"10.1186\/ar3884","article-title":"RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis","volume":"14","author":"Martinez-Calatrava","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2013.11.014_bib48","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/01.blo.0000131233.83640.91","article-title":"The role of biomechanics and inflammation in cartilage injury and repair","volume":"423","author":"Guilak","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.joca.2013.11.014_bib49","first-page":"295","article-title":"Temporomandibular disorders: osteoarthritis","volume":"13","author":"Zarb","year":"1999","journal-title":"J\u00a0Orofac Pain"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458413010327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458413010327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:31:52Z","timestamp":1761017512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458413010327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S1063458413010327"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2013.11.014","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reducing dietary loading decreases mouse temporomandibular joint degradation induced by anterior crossbite prosthesis","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2013.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}