{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:26:21Z","timestamp":1790835981659,"version":"4.1.0"},"reference-count":93,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007422","name":"Li Shu Fan Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007422","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hong Kong Research Grant Council General Research Fund","award":["M17105314"],"award-info":[{"award-number":["M17105314"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.joca.2014.11.002","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T17:49:04Z","timestamp":1416505744000},"page":"516-524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["The emerging role of endothelin-1 in the pathogenesis of subchondral bone disturbance and osteoarthritis"],"prefix":"10.1016","volume":"23","author":[{"given":"A.","family":"Sin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.Y.","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.K.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.Y.","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.joca.2014.11.002_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrrheum.2010.197","article-title":"The bone-cartilage unit in osteoarthritis","volume":"7","author":"Lories","year":"2011","journal-title":"Nat Rev Rheumatol"},{"issue":"12","key":"10.1016\/j.joca.2014.11.002_bib2","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1038\/nm.2543","article-title":"Identification of a central role for complement in osteoarthritis","volume":"17","author":"Wang","year":"2011","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.joca.2014.11.002_bib3","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nm.3143","article-title":"Inhibition of TGF-beta signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis","volume":"19","author":"Zhen","year":"2013","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.joca.2014.11.002_bib4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/BOR.0b013e32835a9414","article-title":"Osteoarthritis, inflammation and obesity","volume":"25","author":"Berenbaum","year":"2013","journal-title":"Curr Opin Rheumatol"},{"issue":"1038","key":"10.1016\/j.joca.2014.11.002_bib5","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/pgmj.2010.146399rep","article-title":"Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype","volume":"88","author":"Berenbaum","year":"2012","journal-title":"Postgrad Med J"},{"issue":"11","key":"10.1016\/j.joca.2014.11.002_bib6","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.joca.2013.06.027","article-title":"Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus","volume":"21","author":"Wen","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.joca.2014.11.002_bib7","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrd3669","article-title":"Inflammatory bone loss: pathogenesis and therapeutic intervention","volume":"11","author":"Redlich","year":"2012","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"10.1016\/j.joca.2014.11.002_bib8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1053\/joca.2002.0528","article-title":"Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients","volume":"10","author":"Massicotte","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"issue":"10","key":"10.1016\/j.joca.2014.11.002_bib9","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1002\/jbmr.450","article-title":"Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor","volume":"26","author":"Clines","year":"2011","journal-title":"J\u00a0Bone Min Res"},{"issue":"1\u20132","key":"10.1016\/j.joca.2014.11.002_bib10","first-page":"51","article-title":"Serum and synovial fluid concentrations of endothelin-1 in patients with rheumatoid arthritis","volume":"30","author":"Haq","year":"1999","journal-title":"J\u00a0Med"},{"issue":"Pt 2","key":"10.1016\/j.joca.2014.11.002_bib11","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/000456329803500215","article-title":"Endothelin-1 production by human synoviocytes","volume":"35","author":"Yoshida","year":"1998","journal-title":"Ann Clin Biochem"},{"issue":"5","key":"10.1016\/j.joca.2014.11.002_bib12","first-page":"678","article-title":"Presence of immunoreactive endothelin in synovial fluid: analysis of 22 cases","volume":"18","author":"Nahir","year":"1991","journal-title":"J\u00a0Rheumatol"},{"issue":"1","key":"10.1016\/j.joca.2014.11.002_bib13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cyto.2007.02.005","article-title":"Articular chondrocyte aging and endothelin-1","volume":"37","author":"Khatib","year":"2007","journal-title":"Cytokine"},{"issue":"2","key":"10.1016\/j.joca.2014.11.002_bib14","doi-asserted-by":"crossref","first-page":"R324","DOI":"10.1186\/ar1489","article-title":"Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production","volume":"7","author":"Manacu","year":"2005","journal-title":"Arthritis Res Ther"},{"issue":"10","key":"10.1016\/j.joca.2014.11.002_bib15","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1002\/art.11247","article-title":"Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction","volume":"48","author":"Roy-Beaudry","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.joca.2014.11.002_bib16","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0895-7061(02)03060-1","article-title":"Elevated plasma endothelin-1 levels in diabetes mellitus","volume":"15","author":"Schneider","year":"2002","journal-title":"Am J Hypertens"},{"issue":"18","key":"10.1016\/j.joca.2014.11.002_bib17","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1073\/pnas.85.18.6964","article-title":"Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide","volume":"85","author":"Yanagisawa","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.joca.2014.11.002_bib18","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1056\/NEJM199508103330607","article-title":"Endothelins","volume":"333","author":"Levin","year":"1995","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1016\/j.joca.2014.11.002_bib19","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1096\/fasebj.4.12.2168326","article-title":"Cellular signaling by peptides of the endothelin gene family","volume":"4","author":"Simonson","year":"1990","journal-title":"FASEB J"},{"issue":"6473","key":"10.1016\/j.joca.2014.11.002_bib20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/368693a0","article-title":"Endothelin-1. A matter of life and breath","volume":"368","author":"Vanhoutte","year":"1994","journal-title":"Nature"},{"issue":"6 Pt 1","key":"10.1016\/j.joca.2014.11.002_bib21","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1161\/01.HYP.21.6.747","article-title":"Is endothelin involved in the pathogenesis of hypertension?","volume":"21","author":"Vanhoutte","year":"1993","journal-title":"Hypertension"},{"issue":"11","key":"10.1016\/j.joca.2014.11.002_bib22","doi-asserted-by":"crossref","first-page":"e26994","DOI":"10.1371\/journal.pone.0026994","article-title":"Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity","volume":"6","author":"Leung","year":"2011","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.joca.2014.11.002_bib23","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJM199803193381202","article-title":"The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators","volume":"338","author":"Krum","year":"1998","journal-title":"N\u00a0Engl J Med"},{"issue":"34","key":"10.1016\/j.joca.2014.11.002_bib24","doi-asserted-by":"crossref","first-page":"23251","DOI":"10.1016\/S0021-9258(18)54489-6","article-title":"Stimulation of endothelin-1 gene expression by insulin in endothelial cells","volume":"266","author":"Oliver","year":"1991","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"10.1016\/j.joca.2014.11.002_bib25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1365-201X.1997.00212.x","article-title":"Exogenous endothelin-1 causes peripheral insulin resistance in healthy humans","volume":"161","author":"Ottosson-Seeberger","year":"1997","journal-title":"Acta Physiol Scand"},{"issue":"35","key":"10.1016\/j.joca.2014.11.002_bib26","doi-asserted-by":"crossref","first-page":"30444","DOI":"10.1074\/jbc.M111.263657","article-title":"A\u00a0novel role of endothelin-1 in linking Toll-like receptor 7-mediated inflammation to fibrosis in congenital heart block","volume":"286","author":"Alvarez","year":"2011","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.joca.2014.11.002_bib27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/HYPERTENSIONAHA.111.173328","article-title":"Interleukin 6 underlies angiotensin II-induced hypertension and chronic renal damage","volume":"59","author":"Zhang","year":"2012","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.joca.2014.11.002_bib28","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/CIRCEP.109.924985","article-title":"Association of left atrial endothelin-1 with atrial rhythm, size, and fibrosis in patients with structural heart disease","volume":"3","author":"Mayyas","year":"2010","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"3","key":"10.1016\/j.joca.2014.11.002_bib29","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/art.27307","article-title":"Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis","volume":"62","author":"Lagares","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"14","key":"10.1016\/j.joca.2014.11.002_bib30","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1128\/MCB.00625-06","article-title":"Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors","volume":"26","author":"Shi-Wen","year":"2006","journal-title":"Mol Cell Biol"},{"issue":"11","key":"10.1016\/j.joca.2014.11.002_bib31","doi-asserted-by":"crossref","first-page":"6568","DOI":"10.4049\/jimmunol.1003756","article-title":"Endothelin-1 signaling promotes fibrosis in\u00a0vitro in a bronchopulmonary dysplasia model by activating the extrinsic coagulation cascade","volume":"186","author":"Kambas","year":"2011","journal-title":"J\u00a0Immunol"},{"issue":"22","key":"10.1016\/j.joca.2014.11.002_bib32","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.110.938217","article-title":"Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition","volume":"121","author":"Widyantoro","year":"2010","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.joca.2014.11.002_bib33","first-page":"CR616","article-title":"Elevated plasma endothelin-1 levels and vascular dysregulation in patients with rheumatoid arthritis","volume":"8","author":"Pache","year":"2002","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.joca.2014.11.002_bib34","first-page":"115","article-title":"Signaling in fibrosis: targeting the TGF beta, endothelin-1 and CCN2 axis in scleroderma","volume":"1","author":"Leask","year":"2009","journal-title":"Front Biosci (Elite Ed)"},{"key":"10.1016\/j.joca.2014.11.002_bib35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.brainres.2009.01.070","article-title":"Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion","volume":"1266","author":"Leung","year":"2009","journal-title":"Brain Res"},{"issue":"3","key":"10.1016\/j.joca.2014.11.002_bib36","first-page":"522","article-title":"Downregulation of intercellular adhesion molecule-1 expression on human synovial fibroblasts by endothelin-1","volume":"26","author":"Iwabuchi","year":"1999","journal-title":"J\u00a0Rheumatol"},{"issue":"4","key":"10.1016\/j.joca.2014.11.002_bib37","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3109\/03009749609069994","article-title":"Endothelin-1 modulates the expression of adhesion molecules on fibroblast-like synovial cells (FLS)","volume":"25","author":"Schwarting","year":"1996","journal-title":"Scand J Rheumatol"},{"issue":"3","key":"10.1016\/j.joca.2014.11.002_bib38","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1189\/jlb.1207827","article-title":"Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1","volume":"84","author":"Conte Fde","year":"2008","journal-title":"J\u00a0Leukoc Biol"},{"issue":"3","key":"10.1016\/j.joca.2014.11.002_bib39","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s10067-005-0007-2","article-title":"A\u00a0study on vascular endothelial growth factor and endothelin-1 in patients with extra-articular involvement of rheumatoid arthritis","volume":"25","author":"Kuryliszyn-Moskal","year":"2006","journal-title":"Clin Rheumatol"},{"issue":"9","key":"10.1016\/j.joca.2014.11.002_bib40","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/jor.22099","article-title":"Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritis","volume":"30","author":"Usmani","year":"2012","journal-title":"J\u00a0Orthop Res"},{"issue":"1","key":"10.1016\/j.joca.2014.11.002_bib41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0047-6374(99)00117-7","article-title":"Endothelin-1 in monolayer cultures of articular chondrocytes from young and old rats: regulation by growth factors and cytokines","volume":"114","author":"Messai","year":"2000","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.joca.2014.11.002_bib42","series-title":"The Thirteen International Conference on Endothelin Tokyo, Japan","article-title":"Development of osteoarthritis-like changes in transgenic endothelin-1 over-expressed mice","author":"Wen","year":"2013"},{"issue":"9","key":"10.1016\/j.joca.2014.11.002_bib43","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1006\/cyto.1998.0347","article-title":"Endothelin 1 receptors, signal transduction and effects on DNA and proteoglycan synthesis in rat articular chondrocytes","volume":"10","author":"Khatib","year":"1998","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.joca.2014.11.002_bib44","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/cyto.2001.1001","article-title":"Mechanism of inhibition of endothelin-1-stimulated proteoglycan and collagen synthesis in rat articular chondrocytes","volume":"17","author":"Khatib","year":"2002","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.joca.2014.11.002_bib45","doi-asserted-by":"crossref","first-page":"e60062","DOI":"10.1371\/journal.pone.0060062","article-title":"Association of endothelin-1 expression and cartilaginous endplate degeneration in humans","volume":"8","author":"Yuan","year":"2013","journal-title":"PLoS One"},{"issue":"14","key":"10.1016\/j.joca.2014.11.002_bib46","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1523\/JNEUROSCI.21-14-05358.2001","article-title":"Local injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in rats","volume":"21","author":"Gokin","year":"2001","journal-title":"J\u00a0Neurosci"},{"issue":"4","key":"10.1016\/j.joca.2014.11.002_bib47","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0026-895X(24)12544-8","article-title":"Endothelin B receptor modulates inflammatory pain and cutaneous inflammation","volume":"56","author":"Griswold","year":"1999","journal-title":"Mol Pharmacol"},{"issue":"3","key":"10.1016\/j.joca.2014.11.002_bib48","doi-asserted-by":"crossref","DOI":"10.1186\/ar3338","article-title":"Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis","volume":"13","author":"Kaufman","year":"2011","journal-title":"Arthritis Res Ther"},{"issue":"10","key":"10.1016\/j.joca.2014.11.002_bib49","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.joca.2006.03.015","article-title":"The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis","volume":"14","author":"Torres","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"issue":"11","key":"10.1016\/j.joca.2014.11.002_bib50","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1136\/ard.2006.063354","article-title":"Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis","volume":"66","author":"Suri","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.joca.2014.11.002_bib51","doi-asserted-by":"crossref","first-page":"R16","DOI":"10.1186\/ar4443","article-title":"Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain","volume":"16","author":"Pecchi","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"10.1016\/j.joca.2014.11.002_bib52","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1172\/JCI200419480","article-title":"Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression","volume":"113","author":"Ieda","year":"2004","journal-title":"J\u00a0Clin Invest"},{"issue":"1","key":"10.1016\/j.joca.2014.11.002_bib53","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/ar2601","article-title":"Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized","volume":"11","author":"Hunter","year":"2009","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"10.1016\/j.joca.2014.11.002_bib54","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/art.24489","article-title":"Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production","volume":"60","author":"Couchourel","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.joca.2014.11.002_bib55","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.joca.2005.07.012","article-title":"Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes","volume":"13","author":"Sanchez","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"issue":"6473","key":"10.1016\/j.joca.2014.11.002_bib56","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/368703a0","article-title":"Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1","volume":"368","author":"Kurihara","year":"1994","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.joca.2014.11.002_bib57","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1359\/jbmr.1998.13.2.237","article-title":"Gene expression of bone matrix proteins and endothelin receptors in endothelin-1-deficient mice revealed by in situ hybridization","volume":"13","author":"Kitano","year":"1998","journal-title":"J\u00a0Bone Min Res"},{"issue":"4","key":"10.1016\/j.joca.2014.11.002_bib58","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S8756-3282(03)00215-1","article-title":"Endothelin-1 promotes osteoprogenitor proliferation and differentiation in fetal rat calvarial cell cultures","volume":"33","author":"von Schroeder","year":"2003","journal-title":"Bone"},{"issue":"1\u20133","key":"10.1016\/j.joca.2014.11.002_bib59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejphar.2006.06.035","article-title":"Effect of YM598, a selective endothelin ETA receptor antagonist, on endothelin-1-induced bone formation","volume":"543","author":"Someya","year":"2006","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1016\/j.joca.2014.11.002_bib60","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/jcb.21390","article-title":"Endothelin-1 inhibits human osteoblastic cell differentiation: influence of connexin-43 expression level","volume":"103","author":"Niger","year":"2008","journal-title":"J\u00a0Cell Biochem"},{"issue":"4","key":"10.1016\/j.joca.2014.11.002_bib61","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s002239900245","article-title":"Endothelin-1 is a potent regulator of human bone cell metabolism in\u00a0vitro","volume":"60","author":"Kasperk","year":"1997","journal-title":"Calcif Tissue Int"},{"issue":"4 Pt 2","key":"10.1016\/j.joca.2014.11.002_bib62","first-page":"R1099","article-title":"Endothelins inhibit the mineralization of osteoblastic MC3T3-E1 cells through the A-type endothelin receptor","volume":"275","author":"Hiruma","year":"1998","journal-title":"Am J Physiol"},{"issue":"2","key":"10.1016\/j.joca.2014.11.002_bib63","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/jcb.240530211","article-title":"Endothelin modulates osteopontin and osteocalcin messenger ribonucleic acid expression in rat osteoblastic osteosarcoma cells","volume":"53","author":"Shioide","year":"1993","journal-title":"J\u00a0Cell Biochem"},{"issue":"1","key":"10.1016\/j.joca.2014.11.002_bib64","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1385\/ENDO:12:1:77","article-title":"Detection and characterization of endothelin in transformed human osteoblast cell culture medium","volume":"12","author":"Lam","year":"2000","journal-title":"Endocrine"},{"issue":"3","key":"10.1016\/j.joca.2014.11.002_bib65","first-page":"193","article-title":"Localization of endothelin-1 in the osteoclast","volume":"42","author":"Sasaki","year":"1993","journal-title":"J\u00a0Electron Microsc (Tokyo)"},{"issue":"6","key":"10.1016\/j.joca.2014.11.002_bib66","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1210\/endo.130.6.1597159","article-title":"Endothelin inhibits osteoclastic bone resorption by a direct effect on cell motility: implications for the vascular control of bone resorption","volume":"130","author":"Alam","year":"1992","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.joca.2014.11.002_bib67","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ajodo.2005.12.016","article-title":"Effects of endothelin antagonist tezosentan on orthodontic tooth movement in rats","volume":"129","author":"Drevensek","year":"2006","journal-title":"Am J Orthod Dentofac Orthop"},{"issue":"6","key":"10.1016\/j.joca.2014.11.002_bib68","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/ejo\/cjm064","article-title":"The effects of TBC3214, a selective endothelin ETA receptor antagonist, on orthodontic tooth movement in rats","volume":"29","author":"Sprogar","year":"2007","journal-title":"Eur J Orthod"},{"issue":"4","key":"10.1016\/j.joca.2014.11.002_bib69","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.bone.2008.06.012","article-title":"The endothelin system mediates bone modeling in the late stage of orthodontic tooth movement in rats","volume":"43","author":"Sprogar","year":"2008","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.joca.2014.11.002_bib70","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nm0995-944","article-title":"Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate","volume":"1","author":"Nelson","year":"1995","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.joca.2014.11.002_bib71","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1158\/1535-7163.MCT-06-0574","article-title":"Endothelin signaling in osteoblasts: global genome view and implication of the calcineurin\/NFAT pathway","volume":"6","author":"Van Sant","year":"2007","journal-title":"Mol Cancer Ther"},{"issue":"20 Pt 2","key":"10.1016\/j.joca.2014.11.002_bib72","doi-asserted-by":"crossref","first-page":"6296s","DOI":"10.1158\/1078-0432.CCR-06-0929","article-title":"Targeting bone metastasis in prostate cancer with endothelin receptor antagonists","volume":"12","author":"Carducci","year":"2006","journal-title":"Clin Cancer Res"},{"issue":"2","key":"10.1016\/j.joca.2014.11.002_bib73","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1210\/me.2006-0346","article-title":"Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation","volume":"21","author":"Clines","year":"2007","journal-title":"Mol Endocrinol"},{"issue":"2","key":"10.1016\/j.joca.2014.11.002_bib74","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.joca.2014.11.002_bib75","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3892\/ijmm.2013.1401","article-title":"The expression of glycophorin A and osteoprotegerin is locally increased in carotid atherosclerotic lesions of symptomatic compared to asymptomatic patients","volume":"32","author":"Hakimi","year":"2013","journal-title":"Int J Mol Med"},{"issue":"8","key":"10.1016\/j.joca.2014.11.002_bib76","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1182\/blood.V84.8.2531.2531","article-title":"Stimulation of interleukin-6 production by endothelin in rat bone marrow-derived stromal cells","volume":"84","author":"Agui","year":"1994","journal-title":"Blood"},{"issue":"3 Pt 1","key":"10.1016\/j.joca.2014.11.002_bib77","first-page":"E461","article-title":"Endothelin stimulates osteoblastic production of IL-6 but not macrophage colony-stimulating factor","volume":"272","author":"Perkins","year":"1997","journal-title":"Am J Physiol"},{"issue":"4","key":"10.1016\/j.joca.2014.11.002_bib78","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S8756-3282(99)00008-3","article-title":"Involvement of p42\/p44 MAP kinase in endothelin-1-induced interleukin-6 synthesis in osteoblast-like cells","volume":"24","author":"Kawamura","year":"1999","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.joca.2014.11.002_bib79","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0898-6568(00)00061-9","article-title":"Endothelin-1 induces vascular endothelial growth factor synthesis in osteoblasts: involvement of p38 mitogen-activated protein kinase","volume":"12","author":"Kozawa","year":"2000","journal-title":"Cell Signal"},{"issue":"2","key":"10.1016\/j.joca.2014.11.002_bib80","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0898-6568(97)00113-7","article-title":"Involvement of protein kinase C activation in endothelin-1-induced secretion of interleukin-6 in osteoblast-like cells","volume":"10","author":"Matsuno","year":"1998","journal-title":"Cell Signal"},{"issue":"4","key":"10.1016\/j.joca.2014.11.002_bib81","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.bbrc.2007.08.018","article-title":"Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts","volume":"362","author":"Tokuda","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"10.1016\/j.joca.2014.11.002_bib82","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.febslet.2007.02.052","article-title":"(-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44\/p42 MAP kinase activation","volume":"581","author":"Tokuda","year":"2007","journal-title":"FEBS Lett"},{"issue":"3","key":"10.1016\/j.joca.2014.11.002_bib83","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/0006-291X(90)90491-5","article-title":"The effects of the endothelin family peptides on cultured osteoblastic cells from rat calvariae","volume":"170","author":"Takuwa","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.joca.2014.11.002_bib84","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0303-7207(94)90169-4","article-title":"Effect of endothelin-1 on phospholipase D activity in osteoblast-like cells","volume":"105","author":"Suzuki","year":"1994","journal-title":"Mol Cell Endocrinol"},{"issue":"6 Pt 1","key":"10.1016\/j.joca.2014.11.002_bib85","first-page":"E797","article-title":"Endothelin-1 activates phospholipase C and mobilizes Ca2+ from extra- and intracellular pools in osteoblastic cells","volume":"257","author":"Takuwa","year":"1989","journal-title":"Am J Physiol"},{"issue":"1","key":"10.1016\/j.joca.2014.11.002_bib86","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/157016107779317161","article-title":"Endothelin-1-induced signaling pathways in vascular smooth muscle cells","volume":"5","author":"Bouallegue","year":"2007","journal-title":"Curr Vasc Pharmacol"},{"issue":"4","key":"10.1016\/j.joca.2014.11.002_bib87","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/art.1780350406","article-title":"Increased production of endothelin-1 in patients with inflammatory arthritides","volume":"35","author":"Miyasaka","year":"1992","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.joca.2014.11.002_bib88","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/jcp.1072","article-title":"Endothelin-1 expression in long-term cultures of fetal rat calvarial osteoblasts: regulation by BMP-7","volume":"187","author":"Kitten","year":"2001","journal-title":"J\u00a0Cell Physiol"},{"issue":"1","key":"10.1016\/j.joca.2014.11.002_bib89","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/jcb.1206","article-title":"Stimulatory effect of endothelin-1 on Na-dependent phosphate transport and its signaling mechanism in osteoblast-like cells","volume":"83","author":"Masukawa","year":"2001","journal-title":"J\u00a0Cell Biochem"},{"issue":"10","key":"10.1016\/j.joca.2014.11.002_bib90","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1359\/jbmr.2002.17.10.1774","article-title":"Involvement of Rho and p38 MAPK in endothelin-1-induced expression of PGHS-2 mRNA in osteoblast-like cells","volume":"17","author":"Windischhofer","year":"2002","journal-title":"J\u00a0Bone Min Res"},{"issue":"3","key":"10.1016\/j.joca.2014.11.002_bib91","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/S0022-3565(25)24528-1","article-title":"Endothelin-1-evoked calcium transients in Umr-106 osteoblastic osteosarcoma cells are mediated through endothelin-a and endothelin-B receptors","volume":"272","author":"Semler","year":"1995","journal-title":"J\u00a0Pharmacol Exp Ther"},{"issue":"1","key":"10.1016\/j.joca.2014.11.002_bib92","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0196-9781(92)90157-X","article-title":"Endothelin rapidly stimulates tyrosine phosphorylation in osteoblast-like cells","volume":"13","author":"Schvartz","year":"1992","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.joca.2014.11.002_bib93","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S8756-3282(97)00096-3","article-title":"ETA receptor mediates the signaling of endothelin-1 in osteoblast-like cells","volume":"21","author":"Suzuki","year":"1997","journal-title":"Bone"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458414013119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458414013119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:36:17Z","timestamp":1761017777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458414013119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":93,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1063458414013119"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2014.11.002","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The emerging role of endothelin-1 in the pathogenesis of subchondral bone disturbance and osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2014.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}