{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:00:49Z","timestamp":1792652449920,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.joca.2014.11.012","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T17:48:17Z","timestamp":1416505697000},"page":"308-318","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-0018","authenticated-orcid":false,"given":"L.","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.A.","family":"Petrigliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-7487","authenticated-orcid":false,"given":"J.","family":"Bogdanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"McAllister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-5020","authenticated-orcid":false,"given":"J.S.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.K.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Van Handel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.M.","family":"Crooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Evseenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2014.11.012_bib1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.7326\/0003-4819-133-5-200009050-00007","article-title":"Joint injury in young adults and risk for subsequent knee and hip osteoarthritis","volume":"133","author":"Gelber","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.joca.2014.11.012_bib2","first-page":"170","article-title":"Microfracture to treat full-thickness chondral defects: surgical technique, rehabilitation, and outcomes","volume":"15","author":"Steadman","year":"2002","journal-title":"J\u00a0Knee Surg"},{"key":"10.1016\/j.joca.2014.11.012_bib3","first-page":"669","article-title":"Cartilage repair and joint preservation: medical and surgical treatment options","volume":"108","author":"Madry","year":"2011","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.joca.2014.11.012_bib4","first-page":"347","article-title":"Mesenchymal stem cells in connective tissue engineering and regenerative medicine: applications in cartilage repair and osteoarthritis therapy","volume":"24","author":"Mobasheri","year":"2009","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.joca.2014.11.012_bib5","doi-asserted-by":"crossref","first-page":"e63718","DOI":"10.1371\/journal.pone.0063718","article-title":"Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment","volume":"8","author":"Evseenko","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2014.11.012_bib6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.bbalip.2008.06.005","article-title":"Two pathways for lysophosphatidic acid production","volume":"1781","author":"Aoki","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.joca.2014.11.012_bib7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.200204026","article-title":"Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production","volume":"158","author":"Umezu-Goto","year":"2002","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.joca.2014.11.012_bib8","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1128\/MCB.02419-05","article-title":"Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development","volume":"26","author":"van Meeteren","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.joca.2014.11.012_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bbrc.2011.04.084","article-title":"Blockade of lysophosphatidic acid receptors LPAR1\/3 ameliorates lung fibrosis induced by irradiation","volume":"409","author":"Gan","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joca.2014.11.012_bib10","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/art.30262","article-title":"Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma","volume":"63","author":"Castelino","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2014.11.012_bib11","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bbalip.2008.04.001","article-title":"Lysophosphatidic acid and renal fibrosis","volume":"1781","author":"Pradere","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.joca.2014.11.012_bib12","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/01.mcg.0000225642.90898.0e","article-title":"Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C","volume":"41","author":"Watanabe","year":"2007","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.joca.2014.11.012_bib13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.pharmtox.010909.105753","article-title":"LPA receptors: subtypes and biological actions","volume":"50","author":"Choi","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.joca.2014.11.012_bib14","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/cmdc.200600280","article-title":"Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA","volume":"2","author":"Jiang","year":"2007","journal-title":"ChemMedChem"},{"key":"10.1016\/j.joca.2014.11.012_bib15","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.joca.2008.11.003","article-title":"A\u00a0novel in\u00a0vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury","volume":"17","author":"Eltawil","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2014.11.012_bib16","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.stemcr.2013.10.012","article-title":"Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells","volume":"1","author":"Wu","year":"2013","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.joca.2014.11.012_bib17","doi-asserted-by":"crossref","first-page":"9293","DOI":"10.1016\/j.biomaterials.2010.08.041","article-title":"The use of BMP-2 coupled \u2013 nanosilver-PLGA composite grafts to induce bone repair in grossly infected segmental defects","volume":"31","author":"Zheng","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.joca.2014.11.012_bib18","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/gt.2009.49","article-title":"Lentiviral vectors with amplified beta cell-specific gene expression","volume":"16","author":"Shaw","year":"2009","journal-title":"Gene Ther"},{"key":"10.1016\/j.joca.2014.11.012_bib19","doi-asserted-by":"crossref","first-page":"e70941","DOI":"10.1371\/journal.pone.0070941","article-title":"A\u00a0metabolically-stabilized phosphonate analog of lysophosphatidic acid attenuates collagen-induced arthritis","volume":"8","author":"Nikitopoulou","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2014.11.012_bib20","doi-asserted-by":"crossref","first-page":"e22182","DOI":"10.1371\/journal.pone.0022182","article-title":"Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature","volume":"6","author":"Schleicher","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2014.11.012_bib21","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1158\/0008-5472.CAN-09-0302","article-title":"Dual activity lysophosphatidic acid receptor pan-antagonist\/autotaxin inhibitor reduces breast cancer cell migration in\u00a0vitro and causes tumor regression in\u00a0vivo","volume":"69","author":"Zhang","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.joca.2014.11.012_bib22","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1124\/jpet.108.141911","article-title":"S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool","volume":"327","author":"Ferry","year":"2008","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.joca.2014.11.012_bib23","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1021\/ol060414i","article-title":"Fluorogenic phospholipid substrate to detect lysophospholipase D\/autotaxin activity","volume":"8","author":"Ferguson","year":"2006","journal-title":"Org Lett"},{"key":"10.1016\/j.joca.2014.11.012_bib24","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1167\/iovs.03-1276","article-title":"p38 MAPK mediates the expression of type I collagen induced by TGF-beta 2 in human retinal pigment epithelial cells ARPE-19","volume":"45","author":"Kimoto","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.joca.2014.11.012_bib25","article-title":"Tacrolimus abrogates TGF-beta1-induced type I collagen production in normal human fibroblasts through suppressing p38MAPK signalling pathway: implications on treatment of chronic atopic dermatitis lesions","author":"Lan","year":"2013","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.joca.2014.11.012_bib26","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1167\/iovs.11-8670","article-title":"Suppression of type I collagen expression by miR-29b via PI3K, Akt, and Sp1 pathway in human Tenon's fibroblasts","volume":"53","author":"Li","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.joca.2014.11.012_bib27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1089\/ten.tec.2013.0056","article-title":"Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy","volume":"20","author":"Wu","year":"2014","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1016\/j.joca.2014.11.012_bib28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.joca.2014.11.012_bib29","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1111\/j.1742-1241.2010.02420.x","article-title":"Current strategies for knee cartilage repair","volume":"64","author":"Kalson","year":"2010","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.joca.2014.11.012_bib30","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1055\/s-0032-1333284","article-title":"The fibrotic role of Phosphatidylinositol-3-kinase\/Akt pathway in injured skeletal muscle after acute contusion","volume":"34","author":"Li","year":"2013","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.joca.2014.11.012_bib31","doi-asserted-by":"crossref","first-page":"728","DOI":"10.2519\/jospt.2006.2444","article-title":"The treatment of articular cartilage defects using the microfracture technique","volume":"36","author":"Gill","year":"2006","journal-title":"J\u00a0Orthop Sports Phys Ther"},{"key":"10.1016\/j.joca.2014.11.012_bib32","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.2106\/00004623-200509000-00002","article-title":"The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study","volume":"87","author":"Mithoefer","year":"2005","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.joca.2014.11.012_bib33","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.arthro.2008.06.015","article-title":"The microfracture technique for the treatment of full-thickness articular cartilage lesions of the knee: midterm results","volume":"24","author":"Asik","year":"2008","journal-title":"Arthroscopy"},{"key":"10.1016\/j.joca.2014.11.012_bib34","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.arthro.2006.06.020","article-title":"Is microfracture of chondral defects in the knee associated with different results in patients aged 40 years or younger?","volume":"22","author":"Kreuz","year":"2006","journal-title":"Arthroscopy"},{"key":"10.1016\/j.joca.2014.11.012_bib35","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1177\/0363546508328414","article-title":"Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence-based systematic analysis","volume":"37","author":"Mithoefer","year":"2009","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.joca.2014.11.012_bib36","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1089\/scd.2013.0118","article-title":"Fibroblast growth factor-1 is a mesenchymal stromal cell-secreted factor stimulating proliferation of osteoarthritic chondrocytes in co-culture","volume":"22","author":"Wu","year":"2013","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.joca.2014.11.012_bib37","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1089\/ten.tea.2010.0517","article-title":"Trophic effects of mesenchymal stem cells increase chondrocyte proliferation and matrix formation","volume":"17","author":"Wu","year":"2011","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.joca.2014.11.012_bib38","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/cbf.2950","article-title":"Novel aspects of parenchymal-mesenchymal interactions: from cell types to molecules and beyond","volume":"31","author":"Bluguermann","year":"2013","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.joca.2014.11.012_bib39","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1371\/journal.pgen.0010048","article-title":"Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis","volume":"1","author":"Aidinis","year":"2005","journal-title":"PLoS Genet"},{"key":"10.1016\/j.joca.2014.11.012_bib40","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1084\/jem.20112012","article-title":"Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis","volume":"209","author":"Nikitopoulou","year":"2012","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.joca.2014.11.012_bib41","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1124\/mol.107.038216","article-title":"Regulation of lysophosphatidic acid receptor expression and function in human synoviocytes: implications for rheumatoid arthritis?","volume":"73","author":"Zhao","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.joca.2014.11.012_bib42","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1006\/bbrc.1996.1819","article-title":"Treatment of fibroblast-like synoviocytes with IFN-gamma results in the down-regulation of autotaxin mRNA","volume":"229","author":"Santos","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joca.2014.11.012_bib43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1365-2249.2001.01432.x","article-title":"IL-1 beta- and IL-4-induced down-regulation of autotaxin mRNA and PC-1 in fibroblast-like synoviocytes of patients with rheumatoid arthritis (RA)","volume":"123","author":"Kehlen","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.joca.2014.11.012_bib44","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.4049\/jimmunol.181.7.5111","article-title":"Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells","volume":"181","author":"Nochi","year":"2008","journal-title":"J\u00a0Immunol"},{"issue":"Suppl 3","key":"10.1016\/j.joca.2014.11.012_bib45","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.joca.2010.05.030","article-title":"The OARSI histopathology initiative \u2013 recommendations for histological assessments of osteoarthritis in the rat","volume":"18","author":"Gerwin","year":"2010","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345841401334X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345841401334X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:36:37Z","timestamp":1761017797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S106345841401334X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S106345841401334X"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2014.11.012","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2014.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}