{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:53:17Z","timestamp":1788871997136,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Wellcome Trust Senior Research Fellowship","award":["084353\/Z\/07\/Z"],"award-info":[{"award-number":["084353\/Z\/07\/Z"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.joca.2015.01.001","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T19:45:55Z","timestamp":1421437555000},"page":"661-670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization"],"prefix":"10.1016","volume":"23","author":[{"given":"T.L.","family":"Cameron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.L.","family":"Gresshoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.A.","family":"Pir\u00f3g","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sampurno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.L.","family":"Hartley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.M.","family":"Sanford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.P.","family":"Boot-Handford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.H.","family":"Glimcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Briggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.F.","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2015.01.001_bib1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/jb\/mvr041","article-title":"The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology","volume":"149","author":"Asada","year":"2011","journal-title":"J\u00a0Biochem"},{"key":"10.1016\/j.joca.2015.01.001_bib2","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/ncb1962","article-title":"Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis","volume":"11","author":"Saito","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.joca.2015.01.001_bib3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.joca.2015.01.001_bib4","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1242\/dev.043281","article-title":"Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription","volume":"136","author":"Wang","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.joca.2015.01.001_bib5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.200903014","article-title":"Regulated Ire1-dependent decay of messenger RNAs in mammalian cells","volume":"186","author":"Hollien","year":"2009","journal-title":"J\u00a0Cell Biol"},{"issue":"Suppl 1","key":"10.1016\/j.joca.2015.01.001_bib6","doi-asserted-by":"crossref","first-page":"i67","DOI":"10.1136\/ard.2009.119388","article-title":"XBP1: the last two decades","volume":"69","author":"Glimcher","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.01.001_bib7","doi-asserted-by":"crossref","first-page":"34500","DOI":"10.1074\/jbc.M112.385922","article-title":"XBP1S associates with RUNX2 and regulates chondrocyte hypertrophy","volume":"287","author":"Liu","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.joca.2015.01.001_bib8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1073\/pnas.0711094105","article-title":"Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis","volume":"105","author":"Hetz","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.joca.2015.01.001_bib9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<145::AID-GENE14>3.0.CO;2-C","article-title":"Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice","volume":"26","author":"Ovchinnikov","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.joca.2015.01.001_bib10","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1126\/science.1158042","article-title":"Regulation of hepatic lipogenesis by the transcription factor XBP1","volume":"320","author":"Lee","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.joca.2015.01.001_bib11","doi-asserted-by":"crossref","first-page":"e1003746","DOI":"10.1371\/journal.pgen.1003746","article-title":"Cauli: a mouse strain with an Ift140 mutation that results in a skeletal ciliopathy modelling Jeune syndrome","volume":"9","author":"Miller","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.joca.2015.01.001_bib12","doi-asserted-by":"crossref","first-page":"e1000691","DOI":"10.1371\/journal.pgen.1000691","article-title":"Targeted induction of endoplasmic reticulum stress induces cartilage pathology","volume":"5","author":"Rajpar","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1016\/j.joca.2015.01.001_bib13","doi-asserted-by":"crossref","first-page":"15544","DOI":"10.1074\/jbc.M410758200","article-title":"Misfolding of collagen X chains harboring Schmid metaphyseal chondrodysplasia mutations results in aberrant disulfide bond formation, intracellular retention, and activation of the unfolded protein response","volume":"280","author":"Wilson","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.joca.2015.01.001_bib14","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1093\/hmg\/ddm155","article-title":"Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP","volume":"16","author":"Pirog-Garcia","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.joca.2015.01.001_bib15","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1074\/mcp.M000014-MCP201","article-title":"Comprehensive profiling of cartilage extracellular matrix formation and maturation using sequential extraction and label-free quantitative proteomics","volume":"9","author":"Wilson","year":"2010","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.joca.2015.01.001_bib16","doi-asserted-by":"crossref","first-page":"e24600","DOI":"10.1371\/journal.pone.0024600","article-title":"Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophy","volume":"6","author":"Cameron","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2015.01.001_bib17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-213X-9-20","article-title":"Global comparative transcriptome analysis of cartilage formation in\u00a0vivo","volume":"9","author":"Cameron","year":"2009","journal-title":"BMC Dev Biol"},{"key":"10.1016\/j.joca.2015.01.001_bib18","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbagrm.2008.02.010","article-title":"A\u00a0microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage","volume":"1779","author":"Belluoccio","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.joca.2015.01.001_bib19","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/379262a0","article-title":"Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice","volume":"379","author":"Reimold","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.joca.2015.01.001_bib20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-2199-7-30","article-title":"The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription","volume":"7","author":"James","year":"2006","journal-title":"BMC Mol Biol"},{"key":"10.1016\/j.joca.2015.01.001_bib21","doi-asserted-by":"crossref","first-page":"12948","DOI":"10.1074\/jbc.275.17.12948","article-title":"Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes","volume":"275","author":"Beier","year":"2000","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.joca.2015.01.001_bib22","doi-asserted-by":"crossref","first-page":"D493","DOI":"10.2741\/LuValle","article-title":"Cell cycle control in growth plate chondrocytes","volume":"5","author":"LuValle","year":"2000","journal-title":"Front Biosci"},{"key":"10.1016\/j.joca.2015.01.001_bib23","doi-asserted-by":"crossref","first-page":"a008334","DOI":"10.1101\/cshperspect.a008334","article-title":"Development of the endochondral skeleton","volume":"5","author":"Long","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.joca.2015.01.001_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1346.002","article-title":"PTHrP and skeletal development","volume":"1068","author":"Kronenberg","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.joca.2015.01.001_bib25","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1101\/gad.13.16.2072","article-title":"Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation","volume":"13","author":"St-Jacques","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.joca.2015.01.001_bib26","doi-asserted-by":"crossref","first-page":"8885","DOI":"10.1073\/pnas.1105564108","article-title":"Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion","volume":"108","author":"Lee","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.joca.2015.01.001_bib27","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/sj.embor.embor801","article-title":"Integrin-linked kinase regulates chondrocyte shape and proliferation","volume":"4","author":"Grashoff","year":"2003","journal-title":"EMBO Rep"},{"key":"10.1016\/j.joca.2015.01.001_bib28","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1101\/gad.277003","article-title":"Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis","volume":"17","author":"Aszodi","year":"2003","journal-title":"Genes Dev"},{"key":"10.1016\/j.joca.2015.01.001_bib29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1129631","article-title":"Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response","volume":"313","author":"Hollien","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.joca.2015.01.001_bib30","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.1128\/MCB.22.16.5639-5649.2002","article-title":"Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis","volume":"22","author":"Raggo","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.joca.2015.01.001_bib31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bbrc.2005.03.141","article-title":"Luman is capable of binding and activating transcription from the unfolded protein response element","volume":"331","author":"DenBoer","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joca.2015.01.001_bib32","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/art.37900","article-title":"Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction","volume":"65","author":"Bateman","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.01.001_bib33","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2613.2010.00758.x","article-title":"Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage","volume":"92","author":"Takada","year":"2011","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.joca.2015.01.001_bib34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/1759720X12448454","article-title":"Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis","volume":"4","author":"Goldring","year":"2012","journal-title":"Ther Adv Musculoskelet Dis"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458415000047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458415000047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:37:21Z","timestamp":1761017841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458415000047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1063458415000047"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2015.01.001","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725319410.793503420","asserted-by":"object"}]},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2015.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}