{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:14:55Z","timestamp":1761092095314,"version":"build-2065373602"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.joca.2015.01.004","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:50:50Z","timestamp":1421196650000},"page":"559-564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Familial effects on structural changes relevant to knee osteoarthritis: a prospective cohort study"],"prefix":"10.1016","volume":"23","author":[{"given":"F.","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Winzenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Martel-Pelletier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-P.","family":"Pelletier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cicuttini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2015.01.004_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bmb\/lds038","article-title":"Epidemiology and burden of osteoarthritis","volume":"105","author":"Litwic","year":"2013","journal-title":"Br Med Bull"},{"key":"10.1016\/j.joca.2015.01.004_bib2","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1136\/ard.2003.015875","article-title":"Genetic mechanisms of knee osteoarthritis: a population based case-control study","volume":"63","author":"Jones","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.01.004_bib3","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1097\/01.blo.0000144971.12731.a2","article-title":"Risk factors for osteoarthritis: understanding joint vulnerability","author":"Felson","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.joca.2015.01.004_bib4","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/BOR.0b013e32835cfb8e","article-title":"Genetic epidemiology of osteoarthritis: recent developments and future directions","volume":"25","author":"Hochberg","year":"2013","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.joca.2015.01.004_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399405009257","article-title":"The genetic epidemiology of human primary osteoarthritis: current status","volume":"7","author":"Loughlin","year":"2005","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.joca.2015.01.004_bib6","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/bmj.312.7036.940","article-title":"Genetic influences on osteoarthritis in women: a twin study","volume":"312","author":"Spector","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.joca.2015.01.004_bib7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrrheum.2011.199","article-title":"Etiology of osteoarthritis: genetics and synovial joint development","volume":"8","author":"Sandell","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2015.01.004_bib8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrrheum.2013.121","article-title":"Insights from human genetic studies into the pathways involved in osteoarthritis","volume":"9","author":"Reynard","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2015.01.004_bib9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.semarthrit.2012.03.009","article-title":"Magnetic resonance imaging of subchondral bone marrow lesions in association with osteoarthritis","volume":"42","author":"Xu","year":"2012","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.01.004_bib10","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/art.20108","article-title":"The genetic contribution to muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis: a sibpair study","volume":"50","author":"Zhai","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.01.004_bib11","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1002\/art.21267","article-title":"The genetic contribution to longitudinal changes in knee structure and muscle strength: a sibpair study","volume":"52","author":"Zhai","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.01.004_bib12","first-page":"1937","article-title":"The genetic contribution and relevance of knee cartilage defects: case-control and sib-pair studies","volume":"32","author":"Ding","year":"2005","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2015.01.004_bib13","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1093\/rheumatology\/keg400","article-title":"Genetic contribution to cartilage volume in women: a classical twin study","volume":"42","author":"Hunter","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.joca.2015.01.004_bib14","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/ar2027","article-title":"Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair study","volume":"8","author":"Zhai","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2015.01.004_bib15","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1186\/ar2132","article-title":"Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volume","volume":"9","author":"Ding","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2015.01.004_bib16","first-page":"776","article-title":"Meniscal tear as an osteoarthritis risk factor in a largely non-osteoarthritic cohort: a cross-sectional study","volume":"34","author":"Ding","year":"2007","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2015.01.004_bib17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1136\/ard.2004.023069","article-title":"Association between age and knee structural change: a cross sectional MRI based study","volume":"64","author":"Ding","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.01.004_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.joca.2003.08.010","article-title":"Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females","volume":"12","author":"Jones","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.01.004_bib19","doi-asserted-by":"crossref","first-page":"R8","DOI":"10.1186\/ar1835","article-title":"Genetic mechanisms of knee osteoarthritis: a population-based longitudinal study","volume":"8","author":"Ding","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2015.01.004_bib20","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1136\/ard.2004.023796","article-title":"Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging","volume":"64","author":"Berthiaume","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.01.004_bib21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2214\/ajr.180.1.1800093","article-title":"Meniscal tear configurations: categorization with MR imaging","volume":"180","author":"Jee","year":"2003","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.joca.2015.01.004_bib22","doi-asserted-by":"crossref","first-page":"R223","DOI":"10.1186\/ar3210","article-title":"Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults","volume":"12","author":"Dore","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2015.01.004_bib23","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.joca.2009.03.012","article-title":"MRI-detected subchondral bone marrow signal alterations of the knee joint: terminology, imaging appearance, relevance and radiological differential diagnosis","volume":"17","author":"Roemer","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.01.004_bib24","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1359\/jbmr.2000.15.2.369","article-title":"Assessment of significant change in BMD: a new approach","volume":"15","author":"Nguyen","year":"2000","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.joca.2015.01.004_bib25","doi-asserted-by":"crossref","first-page":"R149","DOI":"10.1186\/ar4611","article-title":"The clinical significance, natural history and predictors of bone marrow lesion change over eight years","volume":"16","author":"Foong","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2015.01.004_bib26","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/biomet\/75.4.800","article-title":"A\u00a0sharper Bonferroni procedure for multiple tests of significance","volume":"75","author":"Hochberg","year":"1988","journal-title":"Biometrika"},{"key":"10.1016\/j.joca.2015.01.004_bib27","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/art.22680","article-title":"Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: a prospective longitudinal cohort study","volume":"57","author":"Botha-Scheepers","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.01.004_bib28","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.joca.2006.09.004","article-title":"Genetic influence on the progression of radiographic knee osteoarthritis: a longitudinal twin study","volume":"15","author":"Zhai","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.01.004_bib29","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrrheum.2012.69","article-title":"Meniscus pathology, osteoarthritis and the treatment controversy","volume":"8","author":"Englund","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2015.01.004_bib30","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.joca.2010.10.029","article-title":"Systematic review of the concurrent and predictive validity of MRI biomarkers in OA","volume":"19","author":"Hunter","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.01.004_bib31","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1148\/radiol.12110986","article-title":"Factors associated with meniscal extrusion in knees with or at risk for osteoarthritis: the Multicenter Osteoarthritis study","volume":"264","author":"Crema","year":"2012","journal-title":"Radiology"},{"key":"10.1016\/j.joca.2015.01.004_bib32","first-page":"766","article-title":"Osteoarthritis: Where are we for pain and therapy in 2013?","volume":"42","author":"Jones","year":"2013","journal-title":"Aust Fam Physician"},{"key":"10.1016\/j.joca.2015.01.004_bib33","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1302\/0301-620X.89B7.18915","article-title":"Genetic influences in the aetiology of anteromedial osteoarthritis of the knee","volume":"89","author":"McDonnell","year":"2007","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.joca.2015.01.004_bib34","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1136\/ard.2003.014498","article-title":"Genetic risk of knee osteoarthritis: a sibling study","volume":"63","author":"Neame","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.01.004_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2474-11-19","article-title":"Analysis of meniscal degeneration and meniscal gene expression","volume":"11","author":"Sun","year":"2010","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.joca.2015.01.004_bib36","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1136\/ard.2011.150052","article-title":"Risk factors for medial meniscal pathology on knee MRI in older US adults: a multicentre prospective cohort study","volume":"70","author":"Englund","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.01.004_bib37","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.joca.2011.04.017","article-title":"Definition of osteoarthritis on MRI: results of a Delphi exercise","volume":"19","author":"Hunter","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.01.004_bib38","first-page":"181","article-title":"A\u00a0longitudinal study of the association between knee alignment and change in cartilage volume and chondral defects in a largely non-osteoarthritic population","volume":"34","author":"Zhai","year":"2007","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2015.01.004_bib39","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/art.24524","article-title":"Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand","volume":"60","author":"Evangelou","year":"2009","journal-title":"Arthritis Rheum"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458415000072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458415000072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:35:28Z","timestamp":1761017728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458415000072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1063458415000072"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2015.01.004","relation":{},"ISSN":["1063-4584"],"issn-type":[{"type":"print","value":"1063-4584"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Familial effects on structural changes relevant to knee osteoarthritis: a prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2015.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}