{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:55:50Z","timestamp":1792932950041,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.joca.2015.04.026","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T05:34:21Z","timestamp":1432877661000},"page":"1513-1522","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":129,"title":["Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9745-1208","authenticated-orcid":false,"given":"M.-C.","family":"Laiguillon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Courties","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Houard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Auclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sautet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Capeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"F\u00e8ve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8252-7815","authenticated-orcid":false,"given":"F.","family":"Berenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sellam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.joca.2015.04.026_bib1","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"9783","key":"10.1016\/j.joca.2015.04.026_bib2","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","article-title":"Osteoarthritis: an update with relevance for clinical practice","volume":"377","author":"Bijlsma","year":"2011","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.joca.2015.04.026_bib3","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1136\/ard.2010.146282","article-title":"Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis","volume":"70","author":"Yusuf","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"10.1016\/j.joca.2015.04.026_bib4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrrheum.2010.159","article-title":"The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis","volume":"6","author":"Sellam","year":"2010","journal-title":"Nat Rev Rheumatol"},{"issue":"10","key":"10.1016\/j.joca.2015.04.026_bib5","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/art.24739","article-title":"Knee osteoarthritis in obese women with cardiometabolic clustering","volume":"61","author":"Sowers","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.joca.2015.04.026_bib6","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.joca.2012.06.006","article-title":"Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study","volume":"20","author":"Yoshimura","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1016\/j.joca.2015.04.026_bib7","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/ard.2005.045724","article-title":"Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study","volume":"66","author":"Dahaghin","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"10.1016\/j.joca.2015.04.026_bib8","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jbspin.2013.09.007","article-title":"Is osteoarthritis a metabolic disease?","volume":"80","author":"Sellam","year":"2013","journal-title":"Joint Bone Spine"},{"issue":"2","key":"10.1016\/j.joca.2015.04.026_bib9","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2337\/dc12-0924","article-title":"Diabetes is an independent predictor for severe osteoarthritis: results from a longitudinal cohort study","volume":"36","author":"Schett","year":"2013","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.joca.2015.04.026_bib10","first-page":"1118","article-title":"Association between metabolic factors and knee osteoarthritis in women: the Chingford Study","volume":"22","author":"Hart","year":"1995","journal-title":"J\u00a0Rheumatol"},{"issue":"8","key":"10.1016\/j.joca.2015.04.026_bib11","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1136\/ard.2010.146399","article-title":"Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype","volume":"70","author":"Berenbaum","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"10.1016\/j.joca.2015.04.026_bib12","first-page":"1471","article-title":"Experimental diabetes modulates collagen remodelling of joints in rats","volume":"27","author":"Atayde","year":"2012","journal-title":"Histol Histopathol"},{"issue":"3","key":"10.1016\/j.joca.2015.04.026_bib13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/cbir.2001.0850","article-title":"Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9","volume":"26","author":"Mobasheri","year":"2002","journal-title":"Cell Biol Int"},{"issue":"4","key":"10.1016\/j.joca.2015.04.026_bib14","first-page":"1239","article-title":"Glucose transport and metabolism in chondrocytes: a key to understanding chondrogenesis, skeletal development and cartilage degradation in osteoarthritis","volume":"17","author":"Mobasheri","year":"2002","journal-title":"Histol Histopathol"},{"issue":"6865","key":"10.1016\/j.joca.2015.04.026_bib15","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.joca.2015.04.026_bib16","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1063-4584(03)00150-X","article-title":"The role of reactive oxygen species in homeostasis and degradation of cartilage","volume":"11","author":"Henrotin","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.joca.2015.04.026_bib17","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.freeradbiomed.2004.06.008","article-title":"Mitochondrial redox control of matrix metalloproteinases","volume":"37","author":"Nelson","year":"2004","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"10.1016\/j.joca.2015.04.026_bib18","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/jor.21091","article-title":"Rotenone prevents impact-induced chondrocyte death","volume":"28","author":"Goodwin","year":"2010","journal-title":"J\u00a0Orthop Res"},{"issue":"9","key":"10.1016\/j.joca.2015.04.026_bib19","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1002\/art.34508","article-title":"Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes","volume":"64","author":"Vaamonde-Garcia","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"18","key":"10.1016\/j.joca.2015.04.026_bib20","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1016\/j.yexcr.2013.08.026","article-title":"Production of reactive oxygen species by withaferin A causes loss of type collagen expression and COX-2 expression through the PI3K\/Akt, p38, and JNK pathways in rabbit articular chondrocytes","volume":"319","author":"Yu","year":"2013","journal-title":"Exp Cell Res"},{"issue":"1","key":"10.1016\/j.joca.2015.04.026_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/bbrc.1995.1003","article-title":"Nitric oxide activates metalloprotease enzymes in articular cartilage","volume":"206","author":"Murrell","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.joca.2015.04.026_bib22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1063-4584(96)80009-4","article-title":"The increased synthesis of inducible nitric oxide inhibits IL-1ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation","volume":"4","author":"Pelletier","year":"1996","journal-title":"Osteoarthritis Cartilage"},{"issue":"9","key":"10.1016\/j.joca.2015.04.026_bib23","first-page":"2002","article-title":"Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors","volume":"26","author":"Pelletier","year":"1999","journal-title":"J\u00a0Rheumatol"},{"issue":"3","key":"10.1016\/j.joca.2015.04.026_bib24","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/ar2713","article-title":"Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage","volume":"11","author":"Rosa","year":"2009","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"10.1016\/j.joca.2015.04.026_bib25","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.joca.2015.04.026_bib26","doi-asserted-by":"crossref","first-page":"R38","DOI":"10.1186\/ar4467","article-title":"Expression and function of visfatin (Nampt), an adipokine-enzyme involved in inflammatory pathways of osteoarthritis","volume":"16","author":"Laiguillon","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"10.1016\/j.joca.2015.04.026_bib27","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jbspin.2011.12.013","article-title":"Induction of the chemokine IL-8\/Kc by the articular cartilage: possible influence on osteoarthritis","volume":"79","author":"Chauffier","year":"2012","journal-title":"Joint Bone Spine"},{"issue":"8","key":"10.1016\/j.joca.2015.04.026_bib28","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nprot.2008.95","article-title":"Primary culture and phenotyping of murine chondrocytes","volume":"3","author":"Gosset","year":"2008","journal-title":"Nat Protoc"},{"issue":"3","key":"10.1016\/j.joca.2015.04.026_bib29","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.joca.2004.11.008","article-title":"Immature murine articular chondrocytes in primary culture: a new tool for investigating cartilage","volume":"13","author":"Salvat","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"10.1016\/j.joca.2015.04.026_bib30","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.4049\/jimmunol.167.12.7001","article-title":"Cytokine regulation of facilitated glucose transport in human articular chondrocytes","volume":"167","author":"Shikhman","year":"2001","journal-title":"J\u00a0Immunol"},{"issue":"5","key":"10.1016\/j.joca.2015.04.026_bib31","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s00424-003-1080-5","article-title":"Functional characterisation of glucose transport in bovine articular chondrocytes","volume":"446","author":"Windhaber","year":"2003","journal-title":"Pflugers Arch"},{"issue":"16","key":"10.1016\/j.joca.2015.04.026_bib32","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1056\/NEJM197304192881609","article-title":"The sorbitol pathway and the complications of diabetes","volume":"288","author":"Gabbay","year":"1973","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.joca.2015.04.026_bib33","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0022-3565(25)21830-4","article-title":"Effects of a new aldose reductase inhibitor on various tissues in\u00a0vitro","volume":"229","author":"Terashima","year":"1984","journal-title":"J\u00a0Pharmacol Exp Ther"},{"issue":"4","key":"10.1016\/j.joca.2015.04.026_bib34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.2040-1124.2010.00037.x","article-title":"Is there a place for inhibition of transforming growth factor-beta and the polyol pathway in therapy for diabetic retinopathy?","volume":"1","author":"Hotta","year":"2010","journal-title":"J\u00a0Diabetes Investig"},{"issue":"1","key":"10.1016\/j.joca.2015.04.026_bib35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.2040-1124.2010.00070.x","article-title":"Mechanism of diabetic neuropathy: where are we now and where to go?","volume":"2","author":"Yagihashi","year":"2011","journal-title":"J\u00a0Diabetes Investig"},{"issue":"3","key":"10.1016\/j.joca.2015.04.026_bib36","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/1056-8727(96)00113-4","article-title":"Clinical investigation of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy in Japan: multicenter study. Diabetic Neuropathy Study Group in Japan","volume":"10","author":"Hotta","year":"1996","journal-title":"J\u00a0Diabetes Complications"},{"issue":"5","key":"10.1016\/j.joca.2015.04.026_bib37","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jdiacomp.2009.07.005","article-title":"Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review","volume":"24","author":"Schemmel","year":"2010","journal-title":"J\u00a0Diabetes Complications"},{"issue":"12","key":"10.1016\/j.joca.2015.04.026_bib38","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1111\/j.1464-5491.2012.03684.x","volume":"29","author":"Hotta","year":"2012","journal-title":"Diabet Med"},{"issue":"3","key":"10.1016\/j.joca.2015.04.026_bib39","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrrheum.2010.213","article-title":"The role of mitochondria in osteoarthritis","volume":"7","author":"Blanco","year":"2011","journal-title":"Nat Rev Rheumatol"},{"issue":"5 Suppl","key":"10.1016\/j.joca.2015.04.026_bib40","article-title":"Lipid peroxidation: its mechanism, measurement, and significance","volume":"57","author":"Halliwell","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.joca.2015.04.026_bib41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0076-6879(94)33026-3","article-title":"Oxidative chemistry of peroxynitrite","volume":"233","author":"Beckman","year":"1994","journal-title":"Methods Enzymol"},{"issue":"1","key":"10.1016\/j.joca.2015.04.026_bib42","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol Rev"},{"issue":"Suppl 2","key":"10.1016\/j.joca.2015.04.026_bib43","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/ar2463","article-title":"Nitric oxide in inflammation and pain associated with osteoarthritis","volume":"10","author":"Abramson","year":"2008","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"10.1016\/j.joca.2015.04.026_bib44","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3109\/03008207.2012.754886","article-title":"Polyol pathway mediates enhanced degradation of extracellular matrix via p38 MAPK activation in intervertebral disc of diabetic rats","volume":"54","author":"Cheng","year":"2013","journal-title":"Connect Tissue Res"},{"issue":"2\u20134","key":"10.1016\/j.joca.2015.04.026_bib45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.vph.2012.05.003","article-title":"From excess adiposity to insulin resistance: the role of free fatty acids","volume":"57","author":"Capurso","year":"2012","journal-title":"Vascul Pharmacol"},{"issue":"7","key":"10.1016\/j.joca.2015.04.026_bib46","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/art.38399","article-title":"Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1","volume":"66","author":"Alvarez-Garcia","year":"2014","journal-title":"Arthritis Rheumatol"},{"issue":"6","key":"10.1016\/j.joca.2015.04.026_bib47","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/10611860108998778","article-title":"Insulin in tissue engineering of cartilage: a potential model system for growth factor application","volume":"9","author":"Kellner","year":"2001","journal-title":"J\u00a0Drug Target"},{"issue":"2","key":"10.1016\/j.joca.2015.04.026_bib48","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bone.2006.02.067","article-title":"Influence of 17beta-estradiol and insulin on type II collagen and protein synthesis of articular chondrocytes","volume":"39","author":"Claassen","year":"2006","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.joca.2015.04.026_bib49","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.proghi.2010.11.002","article-title":"Impact of sex hormones, insulin, growth factors and peptides on cartilage health and disease","volume":"45","author":"Claassen","year":"2011","journal-title":"Prog Histochem Cytochem"},{"issue":"6","key":"10.1016\/j.joca.2015.04.026_bib50","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.joca.2011.02.004","article-title":"Expression and function of the insulin receptor in normal and osteoarthritic human chondrocytes: modulation of anabolic gene expression, glucose transport and GLUT-1 content by insulin","volume":"19","author":"Rosa","year":"2011","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458415011474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458415011474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:38:45Z","timestamp":1761017925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458415011474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S1063458415011474"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2015.04.026","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2015.04.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}