{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T21:19:29Z","timestamp":1794345569184,"version":"4.9.0"},"reference-count":99,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000980","name":"Arthritis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000980","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["PR110507"],"award-info":[{"award-number":["PR110507"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["20581"],"award-info":[{"award-number":["20581"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["20413"],"award-info":[{"award-number":["20413"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["20258"],"award-info":[{"award-number":["20258"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["18768"],"award-info":[{"award-number":["18768"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/I014608\/1"],"award-info":[{"award-number":["BB\/I014608\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR048182"],"award-info":[{"award-number":["AR048182"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR050245"],"award-info":[{"award-number":["AR050245"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR057235"],"award-info":[{"award-number":["AR057235"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR062603"],"award-info":[{"award-number":["AR062603"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR063757"],"award-info":[{"award-number":["AR063757"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR064034"],"award-info":[{"award-number":["AR064034"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG015768"],"award-info":[{"award-number":["AG015768"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG046927"],"award-info":[{"award-number":["AG046927"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.joca.2015.05.009","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T06:18:19Z","timestamp":1432189099000},"page":"1627-1638","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":133,"title":["Non-invasive mouse models of post-traumatic osteoarthritis"],"prefix":"10.1016","volume":"23","author":[{"given":"B.A.","family":"Christiansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Guilak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.A.","family":"Lockwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.A.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Pitsillides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.J.","family":"Sandell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.H.","family":"van der Meulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"Haudenschild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2015.05.009_bib1","unstructured":"Arthritis Foundation, \u201cLearn About Osteoarthritis\u201d. Retrieved April 15, 2014, from Arthritis Foundation Web site: https:\/\/www.arthritis.org\/conditions-treatments\/disease-center\/osteoarthritis\/."},{"key":"10.1016\/j.joca.2015.05.009_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/oxfordjournals.epirev.a036019","article-title":"Epidemiology of hip and knee osteoarthritis","volume":"10","author":"Felson","year":"1988","journal-title":"Epidemiol Rev"},{"issue":"10","key":"10.1016\/j.joca.2015.05.009_bib3","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1177\/0363546507307396","article-title":"The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis","volume":"35","author":"Lohmander","year":"2007","journal-title":"Am J Sports Med"},{"issue":"7","key":"10.1016\/j.joca.2015.05.009_bib4","first-page":"1434","article-title":"Knee osteoarthritis after anterior cruciate ligament injury: a systematic review","volume":"37","author":"Oiestad","year":"2009","journal-title":"Am J Sports Med"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib5","doi-asserted-by":"crossref","first-page":"416","DOI":"10.5435\/00124635-200411000-00006","article-title":"Articular fractures","volume":"12","author":"Dirschl","year":"2004","journal-title":"J\u00a0Am Acad Orthop Surg"},{"issue":"7","key":"10.1016\/j.joca.2015.05.009_bib6","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.2106\/00004623-200207000-00026","article-title":"Articular fractures: does an anatomic reduction really change the result?","volume":"84-A","author":"Marsh","year":"2002","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"10","key":"10.1016\/j.joca.2015.05.009_bib7","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/01.bot.0000246468.80635.ef","article-title":"Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease","volume":"20","author":"Brown","year":"2006","journal-title":"J\u00a0Orthop Trauma"},{"issue":"8","key":"10.1016\/j.joca.2015.05.009_bib8","first-page":"1098","article-title":"Spontaneous osteoarthritis in rhesus macaques. I. Chemical and biochemical studies","volume":"16","author":"Chateauvert","year":"1989","journal-title":"J\u00a0Rheumatol"},{"issue":"1","key":"10.1016\/j.joca.2015.05.009_bib9","first-page":"73","article-title":"Spontaneous osteoarthritis in rhesus macaques. II. Characterization of disease and morphometric studies","volume":"17","author":"Chateauvert","year":"1990","journal-title":"J\u00a0Rheumatol"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib10","first-page":"627","article-title":"New histological observations in spontaneously developing osteoarthritis in the STR\/ORT mouse questioning its acceptability as a model of human osteoarthritis","volume":"74","author":"Das-Gupta","year":"1993","journal-title":"Int J Exp Pathol"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib11","first-page":"598","article-title":"Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: histologic, radiologic, and biochemical changes","volume":"47","author":"Jimenez","year":"1997","journal-title":"Lab Anim Sci"},{"key":"10.1016\/j.joca.2015.05.009_bib12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2174\/157339708785133523","article-title":"Animal models of osteoarthritis","volume":"4","author":"Little","year":"2008","journal-title":"Curr Rheumatol Rev"},{"issue":"3","key":"10.1016\/j.joca.2015.05.009_bib13","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/art.23288","article-title":"Absence of posttraumatic arthritis following intraarticular fracture in the MRL\/MpJ mouse","volume":"58","author":"Ward","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.joca.2015.05.009_bib14","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.joca.2008.03.014","article-title":"Evidence for articular cartilage regeneration in MRL\/MpJ mice","volume":"16","author":"Fitzgerald","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.joca.2015.05.009_bib15","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/ar4437","article-title":"Disrupting the Indian hedgehog signaling pathway in\u00a0vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl\/fl mice","volume":"16","author":"Zhou","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"10.1016\/j.joca.2015.05.009_bib16","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/art.37802","article-title":"Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury","volume":"65","author":"Roudier","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.joca.2015.05.009_bib17","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1093\/rheumatology\/kes178","article-title":"Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis","volume":"51","author":"Lodewyckx","year":"2012","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib18","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.joca.2012.01.022","article-title":"Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice","volume":"20","author":"Hashimoto","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.joca.2015.05.009_bib19","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.joca.2009.11.013","article-title":"ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization","volume":"18","author":"Malfait","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.joca.2015.05.009_bib20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1089\/ten.teb.2009.0452","article-title":"Animal models for cartilage regeneration and repair","volume":"16","author":"Chu","year":"2010","journal-title":"Tissue Eng Part B Rev"},{"issue":"4","key":"10.1016\/j.joca.2015.05.009_bib21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/ard.32.4.387","article-title":"Experimentally-induced osteoarthritis in the dog","volume":"32","author":"Pond","year":"1973","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.joca.2015.05.009_bib22","first-page":"436","article-title":"Anterior (cranial) cruciate ligament transection in the dog: a bona fide model of osteoarthritis, not merely of cartilage injury and repair","volume":"18","author":"Brandt","year":"1991","journal-title":"J\u00a0Rheumatol"},{"issue":"2","key":"10.1016\/j.joca.2015.05.009_bib23","first-page":"338","article-title":"Arthroscopic anterior cruciate ligament transection induces canine osteoarthritis","volume":"23","author":"Marshall","year":"1996","journal-title":"J\u00a0Rheumatol"},{"issue":"4","key":"10.1016\/j.joca.2015.05.009_bib24","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/jor.1100120404","article-title":"Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis","volume":"12","author":"Guilak","year":"1994","journal-title":"J\u00a0Orthop Res"},{"issue":"10","key":"10.1016\/j.joca.2015.05.009_bib25","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/art.1780251009","article-title":"Immobilization of the knee prevents osteoarthritis after anterior cruciate ligament transection","volume":"25","author":"Palmoski","year":"1982","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.joca.2015.05.009_bib26","first-page":"189","article-title":"Proteoglycan aggregation in injured articular cartilage. A comparison of healing lacerated cartilage with osteoarthritic cartilage","volume":"9","author":"Palmoski","year":"1982","journal-title":"J\u00a0Rheumatol"},{"issue":"4","key":"10.1016\/j.joca.2015.05.009_bib27","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/art.20124","article-title":"The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model","volume":"50","author":"Hayami","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.joca.2015.05.009_bib28","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.joca.2008.09.009","article-title":"Correlation between the MR T2 value at 4.7 T and relative water content in articular cartilage in experimental osteoarthritis induced by ACL transection","volume":"17","author":"Chou","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"issue":"Pt 1","key":"10.1016\/j.joca.2015.05.009_bib29","first-page":"103","article-title":"Effects of surgically induced instability on rat knee articular cartilage","volume":"134","author":"Williams","year":"1982","journal-title":"J\u00a0Anat"},{"issue":"12","key":"10.1016\/j.joca.2015.05.009_bib30","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.joca.2004.08.010","article-title":"Ex\u00a0vivo characterization of articular cartilage and bone lesions in a rabbit ACL transection model of osteoarthritis using MRI and micro-CT","volume":"12","author":"Batiste","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.joca.2015.05.009_bib31","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/art.20951","article-title":"Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis","volume":"52","author":"Tiraloche","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.joca.2015.05.009_bib32","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3109\/17453679308993633","article-title":"Proteoglycan fragments in rabbit joint fluid correlated to arthrosis stage","volume":"64","author":"Messner","year":"1993","journal-title":"Acta Orthop Scand"},{"issue":"3","key":"10.1016\/j.joca.2015.05.009_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.joca.2004.11.004","article-title":"Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis","volume":"13","author":"Boyd","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.joca.2015.05.009_bib34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1063-4584(05)80330-9","article-title":"Hindlimb loading, morphology and biochemistry of articular cartilage in the ACL-deficient cat knee","volume":"1","author":"Herzog","year":"1993","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.joca.2015.05.009_bib35","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/jor.20492","article-title":"Coefficients of friction, lubricin, and cartilage damage in the anterior cruciate ligament-deficient guinea pig knee","volume":"26","author":"Teeple","year":"2008","journal-title":"J\u00a0Orthop Res"},{"issue":"Suppl 2","key":"10.1016\/j.joca.2015.05.009_bib36","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1007\/BF01778296","article-title":"Induction of osteoarthritis in guinea pigs by transection of the anterior cruciate ligament: radiographic and histopathological changes","volume":"44","author":"Jimenez","year":"1995","journal-title":"Inflamm Res"},{"issue":"8","key":"10.1016\/j.joca.2015.05.009_bib37","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/jor.20370","article-title":"Periarticular ligament changes following ACL\/MCL transection in an ovine stifle joint model of osteoarthritis","volume":"25","author":"Funakoshi","year":"2007","journal-title":"J\u00a0Orthop Res"},{"issue":"9","key":"10.1016\/j.joca.2015.05.009_bib38","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1016\/j.joca.2015.05.009_bib39","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.joca.2005.03.004","article-title":"Osteoarthritis development in novel experimental mouse models induced by knee joint instability","volume":"13","author":"Kamekura","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"issue":"147","key":"10.1016\/j.joca.2015.05.009_bib40","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/00003086-198003000-00053","article-title":"Induction of osteoarthrosis in the rabbit knee joint","author":"Shapiro","year":"1980","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"10.1016\/j.joca.2015.05.009_bib41","first-page":"279","article-title":"Experimental osteoarthritis in guinea-pigs","volume":"71","author":"Meacock","year":"1990","journal-title":"J\u00a0Exp Pathol (Oxford)"},{"issue":"2","key":"10.1016\/j.joca.2015.05.009_bib42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1063-4584(05)80023-8","article-title":"Moderate exercise exacerbates the osteoarthritic lesions produced in cartilage by meniscectomy: a morphological study","volume":"1","author":"Armstrong","year":"1993","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib43","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S1063-4584(03)00050-5","article-title":"Quantitative assessment of articular cartilage and subchondral bone histology in the meniscectomized guinea pig model of osteoarthritis","volume":"11","author":"Pastoureau","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.joca.2015.05.009_bib44","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1080\/01926230590965364","article-title":"Anatomical localization of cartilage degradation markers in a surgically induced rat osteoarthritis model","volume":"33","author":"Wancket","year":"2005","journal-title":"Toxicol Pathol"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib45","first-page":"504","article-title":"Evaluation of the rat stifle joint after transection of the cranial cruciate ligament and partial medial meniscectomy","volume":"51","author":"Karahan","year":"2001","journal-title":"Comp Med"},{"issue":"9","key":"10.1016\/j.joca.2015.05.009_bib46","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1002\/art.27595","article-title":"In\u00a0vivo microfocal computed tomography and micro-magnetic resonance imaging evaluation of antiresorptive and antiinflammatory drugs as preventive treatments of osteoarthritis in the rat","volume":"62","author":"Jones","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib47","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.joca.2006.11.005","article-title":"Osteoarthritis severity is sex dependent in a surgical mouse model","volume":"15","author":"Ma","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib48","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nm.2153","article-title":"Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction","volume":"16","author":"Yang","year":"2010","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.joca.2015.05.009_bib49","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.joca.2010.11.006","article-title":"Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity","volume":"19","author":"Moodie","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.joca.2015.05.009_bib50","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/jor.21215","article-title":"Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models","volume":"29","author":"Li","year":"2011","journal-title":"J\u00a0Orthop Res"},{"issue":"1\u20133","key":"10.1016\/j.joca.2015.05.009_bib51","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF01972207","article-title":"Activity of anti-inflammatory drugs on an experimental model of osteoarthritis","volume":"6","author":"Marcelon","year":"1976","journal-title":"Agents Actions"},{"issue":"5","key":"10.1016\/j.joca.2015.05.009_bib52","first-page":"415","article-title":"The reaction of cartilage and osteophyte formation after the intraarticular injection of papain","volume":"56","author":"Inoue","year":"1982","journal-title":"Nihon Seikeigeka Gakkai Zasshi"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib53","first-page":"1001","article-title":"Development of osteoarthritic lesions in mice by \u201cmetabolic\u201d and \u201cmechanical\u201d alterations in the knee joints","volume":"135","author":"van der Kraan","year":"1989","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.joca.2015.05.009_bib54","first-page":"19","article-title":"Degenerative knee joint lesions in mice after a single intra-articular collagenase injection. A new model of osteoarthritis","volume":"71","author":"van der Kraan","year":"1990","journal-title":"J\u00a0Exp Pathol (Oxford)"},{"issue":"1\u20132","key":"10.1016\/j.joca.2015.05.009_bib55","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/BF01993285","article-title":"Rapid induction of early osteoarthritic-like lesions in the rabbit knee by continuous intra-articular infusion of mammalian collagenase or interleukin-1","volume":"34","author":"Borella","year":"1991","journal-title":"Agents Actions"},{"issue":"3","key":"10.1016\/j.joca.2015.05.009_bib56","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1063-4584(05)80088-3","article-title":"Induction of osteoarthritis by intra-articular injection of collagenase in mice. Strain and sex related differences","volume":"1","author":"van Osch","year":"1993","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"10.1016\/j.joca.2015.05.009_bib57","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1002\/art.11333","article-title":"Oncostatin M in combination with tumor necrosis factor alpha induces cartilage damage and matrix metalloproteinase expression in\u00a0vitro and in\u00a0vivo","volume":"48","author":"Hui","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.joca.2015.05.009_bib58","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.joca.2008.10.005","article-title":"Intra-articular injection of tumor necrosis factor-alpha in the rat: an acute and reversible in\u00a0vivo model of cartilage proteoglycan degradation","volume":"17","author":"Malfait","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.joca.2015.05.009_bib59","first-page":"279","article-title":"Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint","volume":"71","author":"van Beuningen","year":"1994","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.joca.2015.05.009_bib60","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1053\/joca.1999.0267","article-title":"Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections","volume":"8","author":"van Beuningen","year":"2000","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"10.1016\/j.joca.2015.05.009_bib61","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/art.1780340513","article-title":"In\u00a0vivo effects of interleukin-1 on articular cartilage. Prolongation of proteoglycan metabolic disturbances in old mice","volume":"34","author":"van Beuningen","year":"1991","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.joca.2015.05.009_bib62","first-page":"283","article-title":"Prolonged effect of iodoacetate on articular cartilage and its modification by an anti-rheumatic drug","volume":"74","author":"Dunham","year":"1993","journal-title":"Int J Exp Pathol"},{"issue":"2","key":"10.1016\/j.joca.2015.05.009_bib63","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/jor.1100120204","article-title":"Site-specific cartilage changes in murine degenerative knee joint disease induced by iodoacetate and collagenase","volume":"12","author":"van Osch","year":"1994","journal-title":"J\u00a0Orthop Res"},{"issue":"9","key":"10.1016\/j.joca.2015.05.009_bib64","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/art.1780400917","article-title":"Mono-iodoacetate-induced experimental osteoarthritis: a dose-response study of loss of mobility, morphology, and biochemistry","volume":"40","author":"Guingamp","year":"1997","journal-title":"Arthritis Rheum"},{"issue":"178","key":"10.1016\/j.joca.2015.05.009_bib65","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00003086-198309000-00037","article-title":"The effect of intra-articular colchicine on the knee joint of the rat","author":"Frankl","year":"1983","journal-title":"Clin Orthop Relat Res"},{"issue":"5","key":"10.1016\/j.joca.2015.05.009_bib66","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/jor.20331","article-title":"Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis","volume":"25","author":"Furman","year":"2007","journal-title":"J\u00a0Orthop Res"},{"issue":"7","key":"10.1016\/j.joca.2015.05.009_bib67","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.joca.2011.04.011","article-title":"Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee","volume":"19","author":"Lewis","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.joca.2015.05.009_bib68","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/art.37796","article-title":"Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL\/MpJ mice","volume":"65","author":"Lewis","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.1016\/j.joca.2015.05.009_bib69","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.joca.2008.04.013","article-title":"Novel synovial fluid recovery method allows for quantification of a marker of arthritis in mice","volume":"16","author":"Seifer","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"issue":"10","key":"10.1016\/j.joca.2015.05.009_bib70","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1002\/art.34533","article-title":"Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice","volume":"64","author":"Louer","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"8","key":"10.1016\/j.joca.2015.05.009_bib71","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3727\/096368912X653264","article-title":"Intra-articular delivery of purified mesenchymal stem cells from C57BL\/6 or MRL\/MpJ superhealer mice prevents posttraumatic arthritis","volume":"22","author":"Diekman","year":"2013","journal-title":"Cell Transplant"},{"key":"10.1016\/j.joca.2015.05.009_bib72","doi-asserted-by":"crossref","first-page":"124","DOI":"10.22203\/eCM.v029a10","article-title":"Sustained intra-articular delivery of IL-1Ra from a thermally-responsive elastin-like polypeptide as a therapy for post- traumatic arthritis","volume":"29","author":"Kimmerling","year":"2015","journal-title":"Eur Cell Mater"},{"issue":"3","key":"10.1016\/j.joca.2015.05.009_bib73","doi-asserted-by":"crossref","first-page":"R134","DOI":"10.1186\/ar4591","article-title":"Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis","volume":"16","author":"Furman","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib74","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.bone.2005.07.022","article-title":"Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element","volume":"37","author":"De Souza","year":"2005","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.joca.2015.05.009_bib75","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1002\/jbmr.96","article-title":"Aged mice have enhanced endocortical response and normal periosteal response compared to young-adult mice following 1 week of axial tibial compression","volume":"25","author":"Brodt","year":"2010","journal-title":"J\u00a0Bone Miner Res"},{"issue":"3","key":"10.1016\/j.joca.2015.05.009_bib76","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1152\/japplphysiol.00210.2010","article-title":"Cancellous bone adaptation to tibial compression is not sex dependent in growing mice","volume":"109","author":"Lynch","year":"2010","journal-title":"J\u00a0Appl Physiol"},{"issue":"8","key":"10.1016\/j.joca.2015.05.009_bib77","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1359\/jbmr.060504","article-title":"Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen","volume":"21","author":"Zaman","year":"2006","journal-title":"J\u00a0Bone Miner Res"},{"issue":"12","key":"10.1016\/j.joca.2015.05.009_bib78","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1359\/JBMR.050812","article-title":"Sympathetic nervous system does not mediate the load-induced cortical new bone formation","volume":"20","author":"De Souza","year":"2005","journal-title":"J\u00a0Bone Miner Res"},{"issue":"1","key":"10.1016\/j.joca.2015.05.009_bib79","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/art.27765","article-title":"Characterising a novel and adjustable non-invasive murine knee joint loading model","volume":"63","author":"Poulet","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.joca.2015.05.009_bib80","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.joca.2013.02.652","article-title":"Spontaneous osteoarthritis in Str\/ort mice is unlikely due to greater vulnerability to mechanical trauma","volume":"21","author":"Poulet","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib81","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.joca.2015.01.012","article-title":"Intermittent applied mechanical loading induces subchondral bone thickening that may be intensified locally by contiguous articular cartilage lesions","volume":"23","author":"Poulet","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib82","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/art.37906","article-title":"In\u00a0vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae","volume":"65","author":"Ko","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.joca.2015.05.009_bib83","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/art.38375","article-title":"Early response of mouse joint tissues to noninvasive knee injury suggests treatment targets","volume":"66","author":"Wu","year":"2014","journal-title":"Arthritis Rheumatol"},{"issue":"9\u201310","key":"10.1016\/j.joca.2015.05.009_bib84","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1089\/ten.tea.2012.0559","article-title":"Effects of serum and compressive loading on the cartilage matrix synthesis and spatiotemporal deposition around chondrocytes in 3D culture","volume":"19","author":"Wu","year":"2013","journal-title":"Tissue Eng Part A"},{"issue":"4","key":"10.1016\/j.joca.2015.05.009_bib85","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0945-053X(99)00029-3","article-title":"Cyclic compression of articular cartilage explants is associated with progressive consolidation and altered expression pattern of extracellular matrix proteins","volume":"18","author":"Wong","year":"1999","journal-title":"Matrix Biol"},{"issue":"4","key":"10.1016\/j.joca.2015.05.009_bib86","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/art.33444","article-title":"Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection","volume":"64","author":"Carames","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.joca.2015.05.009_bib87","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.joca.2012.04.014","article-title":"Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis","volume":"20","author":"Christiansen","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.joca.2015.05.009_bib88","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jss.2009.03.006","article-title":"Traumatic anterior cruciate ligament tear and its implications on meniscal degradation: a preliminary novel lapine osteoarthritis model","volume":"164","author":"Killian","year":"2010","journal-title":"J\u00a0Surg Res"},{"issue":"1","key":"10.1016\/j.joca.2015.05.009_bib89","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/jor.22480","article-title":"Comparison of loading rate-dependent injury modes in a murine model of post-traumatic osteoarthritis","volume":"32","author":"Lockwood","year":"2013","journal-title":"J\u00a0Orthop Res"},{"issue":"2","key":"10.1016\/j.joca.2015.05.009_bib90","first-page":"99","article-title":"The strength and failure characteristics of rat medial collateral ligaments","volume":"16","author":"Crowninshield","year":"1976","journal-title":"J\u00a0Trauma"},{"issue":"2","key":"10.1016\/j.joca.2015.05.009_bib91","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2106\/00004623-197456020-00002","article-title":"Biomechanics of anterior cruciate ligament failure: an analysis of strain-rate sensitivity and mechanisms of failure in primates","volume":"56","author":"Noyes","year":"1974","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"2","key":"10.1016\/j.joca.2015.05.009_bib92","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/jor.22509","article-title":"Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis","volume":"32","author":"Onur","year":"2014","journal-title":"J\u00a0Orthop Res"},{"issue":"5","key":"10.1016\/j.joca.2015.05.009_bib93","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/jor.1100130519","article-title":"Laxity characteristics of normal and pathological murine knee joints in\u00a0vitro","volume":"13","author":"van Osch","year":"1995","journal-title":"J\u00a0Orthop Res"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib94","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/art.1780330612","article-title":"The effect of marginal osteophytes on reduction of varus-valgus instability in osteoarthritic knees","volume":"33","author":"Pottenger","year":"1990","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.joca.2015.05.009_bib95","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1007\/s00167-013-2508-x","article-title":"Osteoarthritis of the patella, lateral femoral condyle and posterior medial femoral condyle correlate with range of motion","volume":"21","author":"Suzuki","year":"2013","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"10","key":"10.1016\/j.joca.2015.05.009_bib96","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.joca.2014.07.011","article-title":"In\u00a0vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis","volume":"22","author":"Satkunananthan","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.joca.2015.05.009_bib97","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00223-013-9744-4","article-title":"Adaptation of tibial structure and strength to axial compression depends on loading history in both C57BL\/6 and BALB\/c mice","volume":"93","author":"Holguin","year":"2013","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"10.1016\/j.joca.2015.05.009_bib98","doi-asserted-by":"crossref","DOI":"10.1115\/1.4028824","article-title":"Trabecular bone loss at a distant skeletal site following non-invasive knee injury in mice","volume":"137","author":"Christiansen","year":"2014","journal-title":"J\u00a0Biomech Eng"},{"issue":"6","key":"10.1016\/j.joca.2015.05.009_bib99","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/jor.21359","article-title":"Post-traumatic osteoarthritis: Improved understanding and opportunities for early intervention","volume":"29","author":"Anderson","year":"2011","journal-title":"J\u00a0Orthop Res"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458415011668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458415011668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:37:57Z","timestamp":1761017877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458415011668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":99,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1063458415011668"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2015.05.009","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-invasive mouse models of post-traumatic osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2015.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}