{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:30:34Z","timestamp":1792611034364,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"vor","delay-in-days":379,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.joca.2015.05.035","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T19:18:56Z","timestamp":1445973536000},"page":"1906-1914","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":135,"title":["Interleukin-6 and tumor necrosis factor alpha in synovial fluid are associated with progression of radiographic knee osteoarthritis in subjects with previous meniscectomy"],"prefix":"10.1016","volume":"23","author":[{"given":"S.","family":"Larsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Englund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Struglics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.S.","family":"Lohmander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2015.05.035_bib1","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1177\/0363546507307396","article-title":"The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis","volume":"35","author":"Lohmander","year":"2007","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.joca.2015.05.035_bib2","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/1529-0131(199804)41:4<687::AID-ART16>3.0.CO;2-2","article-title":"Knee osteoarthritis after meniscectomy: prevalence of radiographic changes after twenty-one years, compared with matched controls","volume":"41","author":"Roos","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.05.035_bib3","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1002\/art.11088","article-title":"Impact of type of meniscal tear on radiographic and symptomatic knee osteoarthritis: a sixteen-year followup of meniscectomy with matched controls","volume":"48","author":"Englund","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.05.035_bib4","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0950-3579(96)80047-1","article-title":"Synovial fluid cell analysis","volume":"10","author":"Dougados","year":"1996","journal-title":"Baillieres Clin Rheumatol"},{"key":"10.1016\/j.joca.2015.05.035_bib5","doi-asserted-by":"crossref","first-page":"R262","DOI":"10.1186\/ar4107","article-title":"Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in\u00a0vitro regeneration model","volume":"14","author":"Tsuchida","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2015.05.035_bib6","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/art.24598","article-title":"Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the Chingford Study","volume":"60","author":"Livshits","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.05.035_bib7","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/art.1780360613","article-title":"Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis","volume":"36","author":"Venn","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.05.035_bib8","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1002\/art.20489","article-title":"Risk factors for symptomatic knee osteoarthritis fifteen to twenty-two years after meniscectomy","volume":"50","author":"Englund","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.05.035_bib9","doi-asserted-by":"crossref","first-page":"R230","DOI":"10.1186\/ar3217","article-title":"Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis","volume":"12","author":"Larsson","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2015.05.035_bib10","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.joca.2012.02.001","article-title":"The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study","volume":"20","author":"Larsson","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"Suppl A","key":"10.1016\/j.joca.2015.05.035_bib11","first-page":"3","article-title":"Atlas of individual radiographic features in osteoarthritis","volume":"3","author":"Altman","year":"1995","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.05.035_bib12","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1136\/ard.2005.035568","article-title":"Patellofemoral osteoarthritis coexistent with tibiofemoral osteoarthritis in a meniscectomy population","volume":"64","author":"Englund","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.05.035_bib13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2519\/jospt.1998.28.2.88","article-title":"Knee Injury and Osteoarthritis Outcome Score (KOOS)\u2013development of a self-administered outcome measure","volume":"28","author":"Roos","year":"1998","journal-title":"J\u00a0Orthop Sports Phys Ther"},{"key":"10.1016\/j.joca.2015.05.035_bib14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1600-0838.1998.tb00465.x","article-title":"Knee injury and Osteoarthritis Outcome Score (KOOS)\u2013validation of a Swedish version","volume":"8","author":"Roos","year":"1998","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.joca.2015.05.035_bib15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1477-7525-1-64","article-title":"The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis","volume":"1","author":"Roos","year":"2003","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/j.joca.2015.05.035_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/art.39146","article-title":"Changes in synovial fluid and serum cytokines and ARGS-aggrecan, and urine CTX-II and NTX-I over five years after anterior cruciate ligament rupture: an exploratory analysis in the KANON trial","author":"Struglics","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2015.05.035_bib17","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1002\/sim.1228","article-title":"Estimation of the area under the ROC curve","volume":"21","author":"Faraggi","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.joca.2015.05.035_bib18","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/ard.2007.074088","article-title":"Change in self-reported outcomes and objective physical function over 7 years in middle-aged subjects with or at high risk of knee osteoarthritis","volume":"67","author":"Roos","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.05.035_bib19","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.joca.2012.10.016","article-title":"Tenascin-C levels in synovial fluid are elevated after injury to the human and canine joint and correlate with markers of inflammation and matrix degradation","volume":"21","author":"Chockalingam","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.05.035_bib20","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nm.1987","article-title":"Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease","volume":"15","author":"Midwood","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.joca.2015.05.035_bib21","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/036354659702500605","article-title":"The natural history of the anterior cruciate ligament-deficient knee. Changes in synovial fluid cytokine and keratan sulfate concentrations","volume":"25","author":"Cameron","year":"1997","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.joca.2015.05.035_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0968-0160(02)00083-2","article-title":"Intraarticular inflammatory cytokines in acute anterior cruciate ligament injured knee","volume":"10","author":"Irie","year":"2003","journal-title":"Knee"},{"key":"10.1016\/j.joca.2015.05.035_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00264-005-0023-5","article-title":"Changes in biochemical parameters after anterior cruciate ligament injury","volume":"30","author":"Higuchi","year":"2006","journal-title":"Int Orthop"},{"key":"10.1016\/j.joca.2015.05.035_bib24","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.joca.2012.07.021","article-title":"Cartilage and bone markers and inflammatory cytokines are increased in synovial fluid in the acute phase of knee injury (hemarthrosis)\u2013a cross-sectional analysis","volume":"20","author":"Sw\u00e4rd","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.05.035_bib25","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.joca.2008.10.005","article-title":"Intra-articular injection of tumor necrosis factor-alpha in the rat: an acute and reversible in\u00a0vivo model of cartilage proteoglycan degradation","volume":"17","author":"Malfait","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.05.035_bib26","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.joca.2010.08.016","article-title":"Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults","volume":"18","author":"Stannus","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.05.035_bib27","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2474-12-144","article-title":"Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee","volume":"12","author":"Orita","year":"2011","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.joca.2015.05.035_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.joca.2012.09.015","article-title":"Assessing biomarkers in synovial fluid: consider the kinetics of clearance","volume":"21","author":"Simkin","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.05.035_bib29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2015.05.035_bib30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.joca.2011.12.009","article-title":"Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254)","volume":"20","author":"Kraus","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.05.035_bib31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.joca.2013.10.018","article-title":"Osteoarthritis\u2013a case for personalized health care?","volume":"22","author":"Karsdal","year":"2014","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458415011930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458415011930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:40:38Z","timestamp":1761018038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458415011930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S1063458415011930"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2015.05.035","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin-6 and tumor necrosis factor alpha in synovial fluid are associated with progression of radiographic knee osteoarthritis in subjects with previous meniscectomy","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2015.05.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}