{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:09:04Z","timestamp":1792462144957,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AR051568"],"award-info":[{"award-number":["R01-AR051568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P60-AR47785"],"award-info":[{"award-number":["P60-AR47785"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01-AG18947"],"award-info":[{"award-number":["U01-AG18947"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01-AG18832"],"award-info":[{"award-number":["U01-AG18832"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01-AG19069"],"award-info":[{"award-number":["U01-AG19069"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01-AG18820"],"award-info":[{"award-number":["U01-AG18820"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HD43500"],"award-info":[{"award-number":["R01-HD43500"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000770","name":"University of Manchester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000770","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015250","name":"NIHR Bristol Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.joca.2015.09.013","type":"journal-article","created":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T03:09:03Z","timestamp":1443755343000},"page":"458-464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":241,"title":["Synovitis and the risk of knee osteoarthritis: the MOST Study"],"prefix":"10.1016","volume":"24","author":[{"given":"D.T.","family":"Felson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Neogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Goggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Nevitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Roemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Torner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.E.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9374-8266","authenticated-orcid":false,"given":"A.","family":"Guermazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2015.09.013_bib1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/ard.60.2.91","article-title":"Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care","volume":"60","author":"Peat","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.09.013_bib2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.7326\/0003-4819-155-11-201112060-00004","article-title":"Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data","volume":"155","author":"Nguyen","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.joca.2015.09.013_bib3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/ard.2007.070565","article-title":"The association of bone attrition with knee pain and other MRI features of osteoarthritis","volume":"67","author":"Hernandez-Molina","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.09.013_bib4","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1001\/jama.286.2.188","article-title":"The role of knee alignment in disease progression and functional decline in knee osteoarthritis","volume":"286","author":"Sharma","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.joca.2015.09.013_bib5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.7326\/0003-4819-139-5_Part_1-200309020-00008","article-title":"Bone marrow edema and its relation to progression of knee osteoarthritis","volume":"139","author":"Felson","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.joca.2015.09.013_bib6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.joca.2005.01.005","article-title":"Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis \u2013 results of a 1 year longitudinal arthroscopic study in 422 patients","volume":"13","author":"Ayral","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.09.013_bib7","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1136\/ard.2011.150243","article-title":"Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study","volume":"70","author":"Roemer","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.09.013_bib8","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1136\/ard.2006.067470","article-title":"Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis","volume":"66","author":"Hill","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.09.013_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0730-725X(94)00119-N","article-title":"Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis","volume":"13","author":"Fernandez-Madrid","year":"1995","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.joca.2015.09.013_bib10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.semarthrit.2012.10.005","article-title":"The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI\u2013the MOST study","volume":"42","author":"Roemer","year":"2013","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.09.013_bib11","article-title":"Synovitis in knee osteoarthritis: a precursor of disease?","author":"Atukorala","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.09.013_bib12","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2014-eular.3882","article-title":"Association between MRI-detected knee joint regional effusion-synovitis and structural changes in older adults: a cohort study","author":"Wang","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.09.013_bib13","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1136\/ard.2010.129742","article-title":"Varus and valgus alignment and incident and progressive knee osteoarthritis","volume":"69","author":"Sharma","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.09.013_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00296-009-1236-5","article-title":"Reliability of lower limb alignment measures using an established landmark-based method with a customized computer software program","volume":"31","author":"Sled","year":"2011","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.joca.2015.09.013_bib15","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1002\/art.22557","article-title":"Longitudinal performance evaluation and validation of fixed-flexion radiography of the knee for detection of joint space loss","volume":"56","author":"Nevitt","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.09.013_bib16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.joca.2003.11.003","article-title":"Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis","volume":"12","author":"Peterfy","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.09.013_bib17","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1136\/ard.2011.155119","article-title":"Defining radiographic incidence and progression of knee osteoarthritis: suggested modifications of the Kellgren and Lawrence scale","volume":"70","author":"Felson","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.09.013_bib18","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.joca.2010.08.017","article-title":"Comparison of BLOKS and WORMS scoring systems part I. Cross sectional comparison of methods to assess cartilage morphology, meniscal damage and bone marrow lesions on knee MRI: data from the osteoarthritis initiative","volume":"18","author":"Lynch","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.09.013_bib19","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.joca.2010.06.016","article-title":"Comparison of BLOKS and WORMS scoring systems part II. Longitudinal assessment of knee MRIs for osteoarthritis and suggested approach based on their performance: data from the Osteoarthritis Initiative","volume":"18","author":"Felson","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2015.09.013_bib20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/annrheumdis-2011-201070","article-title":"The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study","volume":"72","author":"Sharma","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.09.013_bib21","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1002\/art.23078","article-title":"Histopathologic changes at \u201csynovio-entheseal complexes\u201d suggesting a novel mechanism for synovitis in osteoarthritis and spondylarthritis","volume":"56","author":"Benjamin","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.09.013_bib22","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1002\/art.21373","article-title":"Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity","volume":"52","author":"Loeuille","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2015.09.013_bib23","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1136\/ard.2009.121426","article-title":"Relation of synovitis to knee pain using contrast-enhanced MRIs","volume":"69","author":"Baker","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2015.09.013_bib24","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1002\/art.30471","article-title":"Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis","volume":"63","author":"Krasnokutsky","year":"2011","journal-title":"Arthritis Rheum"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458415013278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458415013278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:40:02Z","timestamp":1761018002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458415013278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S1063458415013278"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2015.09.013","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synovitis and the risk of knee osteoarthritis: the MOST Study","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2015.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}