{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:13:23Z","timestamp":1790205203404,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 136800"],"award-info":[{"award-number":["MOP 136800"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research Studentship","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alberta OA Team Studentship"},{"name":"NSERC CREATE Incentive Award"},{"name":"University of Calgary Faculty of Kinesiology"},{"name":"U.S. Department of Veterans Affairs Merit Reviews","award":["1I01BX002025-01"],"award-info":[{"award-number":["1I01BX002025-01"]}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK095761"],"award-info":[{"award-number":["DK095761"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.joca.2016.05.013","type":"journal-article","created":{"date-parts":[[2016,5,22]],"date-time":"2016-05-22T04:54:03Z","timestamp":1463892843000},"page":"1795-1806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Integrin \u03b11\u03b21 protects against signs of post-traumatic osteoarthritis in the female murine knee partially via regulation of epidermal growth factor receptor signalling"],"prefix":"10.1016","volume":"24","author":[{"given":"S.Y.","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.K.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.L.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2016.05.013_bib2","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/B978-0-323-06551-1.00173-1","article-title":"Pathogenesis and pathology of osteoarthritis","author":"Aigner","year":"2011","journal-title":"Rheumatology"},{"issue":"3","key":"10.1016\/j.joca.2016.05.013_bib3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1136\/ard.2003.008136","article-title":"High prevalence of osteoarthritis 14 years after an anterior cruciate ligament tear in male soccer players: a study of radiographic and patient relevant outcomes","volume":"63","author":"von Porat","year":"2004","journal-title":"Ann Rheum Dis"},{"issue":"50","key":"10.1016\/j.joca.2016.05.013_bib4","doi-asserted-by":"crossref","first-page":"46707","DOI":"10.1074\/jbc.M106176200","article-title":"Integrin \u03b21 signaling is necessary for transforming growth factor-\u03b2 activation of p38MAPK and epithelial plasticity","volume":"276","author":"Bhowmick","year":"2001","journal-title":"J\u00a0Biol Chem"},{"issue":"8","key":"10.1016\/j.joca.2016.05.013_bib5","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1172\/JCI71668","article-title":"Integrin-mediated type II TGF-\u03b2 receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling","volume":"124","author":"Chen","year":"2014","journal-title":"J\u00a0Clin Invest"},{"issue":"12","key":"10.1016\/j.joca.2016.05.013_bib6","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1128\/MCB.00892-09","article-title":"Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression","volume":"30","author":"Chen","year":"2010","journal-title":"Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.joca.2016.05.013_bib7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/ncb1209","article-title":"Negative regulation of EGFR signalling through integrin-[alpha]1[beta]1-mediated activation of protein tyrosine phosphatase TCPTP","volume":"7","author":"Mattila","year":"2005","journal-title":"Nat Cell Biol"},{"issue":"2","key":"10.1016\/j.joca.2016.05.013_bib8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/excr.1995.1084","article-title":"Expression of beta 1 integrins by cultured articular chondrocytes and in osteoarthritic cartilage","volume":"217","author":"Loeser","year":"1995","journal-title":"Exp Cell Res"},{"issue":"2","key":"10.1016\/j.joca.2016.05.013_bib9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/art.1780400211","article-title":"Growth factor regulation of chondrocyte integrins. Differential effects of insulin-like growth factor 1 and transforming growth factor beta on alpha 1 beta 1 integrin expression and chondrocyte adhesion to type VI collagen","volume":"40","author":"Loeser","year":"1997","journal-title":"Arthritis Rheum"},{"issue":"10","key":"10.1016\/j.joca.2016.05.013_bib10","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1002\/art.11246","article-title":"Accelerated, aging-dependent development of osteoarthritis in alpha1 integrin-deficient mice","volume":"48","author":"Zemmyo","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.joca.2016.05.013_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/35052073","article-title":"Untangling the ErbB signalling network","volume":"2","author":"Yarden","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"10.1016\/j.joca.2016.05.013_bib13","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/jcp.21635","article-title":"The epidermal growth factor receptor ligands at a glance","volume":"218","author":"Schneider","year":"2009","journal-title":"J\u00a0Cell Physiol"},{"issue":"11","key":"10.1016\/j.joca.2016.05.013_bib14","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1002\/art.22968","article-title":"Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis","volume":"56","author":"Appleton","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.joca.2016.05.013_bib15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/03009740510017715","article-title":"TGF-alpha and ErbB2 production in synovial joint tissue: increased expression in arthritic joints","volume":"34","author":"Hallbeck","year":"2005","journal-title":"Scand J Rheumatol"},{"issue":"3","key":"10.1016\/j.joca.2016.05.013_bib16","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-3083.1994.tb03465.x","article-title":"Sustained and distinctive patterns of gene activation in synovial fibroblasts and whole synovial tissue obtained from inflammatory synovitis","volume":"40","author":"Ritchlin","year":"1994","journal-title":"Scand J Immunol"},{"issue":"1","key":"10.1016\/j.joca.2016.05.013_bib17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/labinvest.2009.111","article-title":"Rho\/ROCK and MEK\/ERK activation by transforming growth factor-alpha induces articular cartilage degradation","volume":"90","author":"Appleton","year":"2010","journal-title":"Lab Invest"},{"issue":"33","key":"10.1016\/j.joca.2016.05.013_bib18","doi-asserted-by":"crossref","first-page":"11740","DOI":"10.1073\/pnas.0505171102","article-title":"Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease","volume":"102","author":"Zhang","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"10.1016\/j.joca.2016.05.013_bib19","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1073\/pnas.1400744111","article-title":"Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation","volume":"111","author":"Staal","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"10.1016\/j.joca.2016.05.013_bib20","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1002\/art.38758","article-title":"Disturbed cartilage and joint homeostasis resulting from a loss of mitogen-inducible gene 6 in a mouse model of joint dysfunction","volume":"66","author":"Pest","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2016.05.013_bib21","first-page":"2","article-title":"Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model","author":"Zhang","year":"2014","journal-title":"Bone Res"},{"issue":"6","key":"10.1016\/j.joca.2016.05.013_bib22","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.joca.2007.02.005","article-title":"TGF-\u03b2 and osteoarthritis","volume":"15","author":"Blaney Davidson","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.joca.2016.05.013_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1053\/joca.1999.0267","article-title":"Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-\u03b2 injections","volume":"8","author":"Van Beuningen","year":"2000","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.joca.2016.05.013_bib24","first-page":"279","article-title":"Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint","volume":"71","author":"van Beuningen","year":"1994","journal-title":"Lab Invest"},{"issue":"2","key":"10.1016\/j.joca.2016.05.013_bib25","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1053\/joca.2000.0368","article-title":"Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation","volume":"9","author":"Bakker","year":"2001","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.joca.2016.05.013_bib26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.clpt.2006.04.007","article-title":"Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure-safety relationship in patients with non\u2013small cell lung cancer*","volume":"80","author":"Lu","year":"2006","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.joca.2016.05.013_bib27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/dbio.1996.0116","article-title":"Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion","volume":"175","author":"Gardner","year":"1996","journal-title":"Dev Biol"},{"issue":"9","key":"10.1016\/j.joca.2016.05.013_bib28","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1016\/j.joca.2016.05.013_bib29","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.4049\/jimmunol.1102693","article-title":"Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis","volume":"188","author":"Swanson","year":"2012","journal-title":"J\u00a0Immunol"},{"issue":"21","key":"10.1016\/j.joca.2016.05.013_bib30","first-page":"4838","article-title":"Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase","volume":"57","author":"Moyer","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.joca.2016.05.013_bib31","unstructured":"Roche Inc. Tarceva. [Material Safety Data Sheet]. Retrieved from http:\/\/www.gene.com\/download\/pdf\/tarcevacombmsds.pdf on 2016 January 1."},{"key":"10.1016\/j.joca.2016.05.013_bib32","doi-asserted-by":"crossref","first-page":"e810","DOI":"10.1038\/cddis.2013.330","article-title":"The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells","volume":"4","author":"Chen","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.joca.2016.05.013_bib33","series-title":"Calibration of Micro-CT Data for Quantifying Bone Mineral and Biomaterial Density and Microarchitecture. Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials","first-page":"79","author":"Koller","year":"2007"},{"issue":"5","key":"10.1016\/j.joca.2016.05.013_bib34","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/archsurg.1935.01180110048003","article-title":"Fabella (sesamoid in the lateral head of the gastrocnemius)","volume":"30","author":"Sutro","year":"1935","journal-title":"Arch Surg"},{"issue":"1","key":"10.1016\/j.joca.2016.05.013_bib35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2818.1997.1340694.x","article-title":"A\u00a0new method for the model-independent assessment of thickness in three-dimensional images","volume":"185","author":"Hildebrand","year":"1997","journal-title":"J\u00a0Microsc"},{"issue":"10","key":"10.1016\/j.joca.2016.05.013_bib36","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1002\/art.27624","article-title":"Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age-and sex-dependent progression of osteoarthritis in Trpv4-deficient mice","volume":"62","author":"Clark","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"Suppl 3","key":"10.1016\/j.joca.2016.05.013_bib37","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative \u2013 recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthr Cartilage"},{"issue":"4","key":"10.1016\/j.joca.2016.05.013_bib38","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"},{"issue":"4","key":"10.1016\/j.joca.2016.05.013_bib39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.joca.2012.01.017","article-title":"What constitutes an \u201canimal model of osteoarthritis\u201d\u2013the need for consensus?","volume":"20","author":"Little","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.joca.2016.05.013_bib40","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.joca.2013.12.019","article-title":"Integrin \u03b11\u03b21 differentially regulates cytokine-mediated responses in chondrocytes","volume":"22","author":"Parekh","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"issue":"10","key":"10.1016\/j.joca.2016.05.013_bib41","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1002\/art.39255","article-title":"Reduction in disease progression by inhibition of transforming growth factor alpha-CCL2 signaling in experimental posttraumatic osteoarthritis","volume":"67","author":"Appleton","year":"2015","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"issue":"4","key":"10.1016\/j.joca.2016.05.013_bib42","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1074\/jbc.M205692200","article-title":"Proximal events in signaling by plasma membrane estrogen receptors","volume":"278","author":"Razandi","year":"2003","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"10.1016\/j.joca.2016.05.013_bib43","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0960-0760(01)00190-X","article-title":"Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer","volume":"80","author":"Filardo","year":"2002","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"issue":"2","key":"10.1016\/j.joca.2016.05.013_bib44","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3892\/ol_00000041","article-title":"Antitumor activity of erlotinib in combination with gemcitabine in in\u00a0vitro and in\u00a0vivo models of KRAS-mutated pancreatic cancers","volume":"1","author":"Furugaki","year":"2010","journal-title":"Oncol Lett"},{"issue":"6","key":"10.1016\/j.joca.2016.05.013_bib45","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S8756-3282(02)00723-8","article-title":"Gender differences in expression of androgen receptor in tibial growth plate and metaphyseal bone of the rat","volume":"30","author":"Van der Eerden","year":"2002","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.joca.2016.05.013_bib46","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.bbamcr.2012.12.022","article-title":"Sex-specific response of rat costochondral cartilage growth plate chondrocytes to 17\u03b2-estradiol involves differential regulation of plasma membrane associated estrogen receptors","volume":"1833","author":"Elbaradie","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"10.1016\/j.joca.2016.05.013_bib47","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1002\/jbmr.502","article-title":"The critical role of the epidermal growth factor receptor in endochondral ossification","volume":"26","author":"Zhang","year":"2011","journal-title":"J\u00a0Bone Miner Res"},{"issue":"11","key":"10.1016\/j.joca.2016.05.013_bib48","doi-asserted-by":"crossref","DOI":"10.1593\/neo.111016","article-title":"Disclosure of erlotinib as a multikinase inhibitor in pancreatic ductal adenocarcinoma","volume":"13","author":"Conradt","year":"2011","journal-title":"Neoplasia"},{"issue":"2","key":"10.1016\/j.joca.2016.05.013_bib49","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.joca.2010.11.006","article-title":"Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity","volume":"19","author":"Moodie","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.joca.2016.05.013_bib50","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.joca.2006.11.005","article-title":"Osteoarthritis severity is sex dependent in a surgical mouse model","volume":"15","author":"Ma","year":"2007","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458416300966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458416300966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:42:46Z","timestamp":1761018166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458416300966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1063458416300966"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2016.05.013","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrin \u03b11\u03b21 protects against signs of post-traumatic osteoarthritis in the female murine knee partially via regulation of epidermal growth factor receptor signalling","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2016.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}