{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:15:59Z","timestamp":1781554559537,"version":"3.54.5"},"reference-count":52,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science (JSPS)","doi-asserted-by":"publisher","award":["26861185"],"award-info":[{"award-number":["26861185"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK Royal Society","award":["IE140240"],"award-info":[{"award-number":["IE140240"]}]},{"DOI":"10.13039\/501100000620","name":"Gen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.joca.2016.05.019","type":"journal-article","created":{"date-parts":[[2016,6,5]],"date-time":"2016-06-05T15:34:52Z","timestamp":1465140892000},"page":"1786-1794","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Activation of a chondrocyte volume-sensitive Cl\u2212 conductance prior to macroscopic cartilage lesion formation in the rabbit knee anterior cruciate ligament transection osteoarthritis model"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4392-9795","authenticated-orcid":false,"given":"K.","family":"Kumagai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"Staunton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-0877","authenticated-orcid":false,"given":"T.","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Matsusue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-9972","authenticated-orcid":false,"given":"R.","family":"Barrett-Jolley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2016.05.019_bib1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1054\/mehy.2000.1180","article-title":"Role of chondrocyte death and hypocellularity in ageing human articular cartilage and the pathogenesis of osteoarthritis","volume":"58","author":"Mobasheri","year":"2002","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.joca.2016.05.019_bib2","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/art.1780341214","article-title":"Osteoarthritic changes in canine articular cartilage, subchondral bone, and synovium fifty-four months after transection of the anterior cruciate ligament","volume":"34","author":"Brandt","year":"1991","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2016.05.019_bib3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1063-4584(05)80318-8","article-title":"Characterization of a model of osteoarthritis in the rabbit knee","volume":"4","author":"Yoshioka","year":"1996","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2016.05.019_bib4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/ard.36.5.399","article-title":"Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. II. Swelling","volume":"36","author":"Maroudas","year":"1977","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.05.019_bib5","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S0006-3495(02)75434-9","article-title":"The effects of osmotic stress on the viscoelastic and physical properties of articular chondrocytes","volume":"82","author":"Guilak","year":"2002","journal-title":"Biophys J"},{"key":"10.1016\/j.joca.2016.05.019_bib6","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/jcp.1077","article-title":"Regulatory volume decrease (RVD) by isolated and in situ bovine articular chondrocytes","volume":"187","author":"Bush","year":"2001","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.joca.2016.05.019_bib7","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1113\/jphysiol.2013.258632","article-title":"CrossTalk proposal: cell volume changes are an essential step in the cell death machinery","volume":"591","author":"Lang","year":"2013","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.joca.2016.05.019_bib8","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1002\/jcp.22646","article-title":"The role of the membrane potential in chondrocyte volume regulation","volume":"226","author":"Lewis","year":"2011","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.joca.2016.05.019_bib9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1254\/jphs.08278FP","article-title":"Swelling-activated Cl- current in isolated rabbit articular chondrocytes: inhibition by arachidonic acid","volume":"109","author":"Isoya","year":"2009","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.joca.2016.05.019_bib10","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1113\/jphysiol.2009.174177","article-title":"Regulatory role of tyrosine phosphorylation in the swelling-activated chloride current in isolated rabbit articular chondrocytes","volume":"587","author":"Okumura","year":"2009","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.joca.2016.05.019_bib11","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1159\/000343316","article-title":"The role of swelling-activated chloride currents (I(CL,swell)) in the regulatory volume decrease response of freshly dissociated rat articular chondrocytes","volume":"30","author":"Ponce","year":"2012","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.joca.2016.05.019_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00232-005-0836-6","article-title":"Volume-sensitive chloride channels involved in apoptotic volume decrease and cell death","volume":"209","author":"Okada","year":"2006","journal-title":"J\u00a0Membr Biol"},{"key":"10.1016\/j.joca.2016.05.019_bib13","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/j.1476-5381.2011.01802.x","article-title":"17\u03b2-Estradiol inhibits the doxorubicin-induced apoptosis via block of volume-sensitive Cl\u2212 current in rabbit articular chondrocytes","volume":"166","author":"Kumagai","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.joca.2016.05.019_bib14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2106\/00004623-197153030-00009","article-title":"Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data","volume":"53","author":"Mankin","year":"1971","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.joca.2016.05.019_bib15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2016.05.019_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1113\/jphysiol.2003.058883","article-title":"A\u00a0voltage-dependent K+ current contributes to membrane potential of acutely isolated canine articular chondrocytes","volume":"557","author":"Wilson","year":"2004","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.joca.2016.05.019_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0165-0270(00)00271-5","article-title":"Measurement of voltage-gated potassium currents in identified spinally-projecting sympathetic neurones of the paraventricular nucleus","volume":"102","author":"Barrett-Jolley","year":"2000","journal-title":"J\u00a0Neurosci Methods"},{"key":"10.1016\/j.joca.2016.05.019_bib18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0968-0004(97)01085-2","article-title":"Caspases: killer proteases","volume":"22","author":"Nicholson","year":"1997","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.joca.2016.05.019_bib19","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jcb.10217","article-title":"Effects of cell swelling on intracellular calcium and membrane currents in bovine articular chondrocytes","volume":"86","author":"Yellowley","year":"2002","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.joca.2016.05.019_bib20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ceca.2005.06.028","article-title":"TRP channels: an overview","volume":"38","author":"Pedersen","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.joca.2016.05.019_bib21","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1124\/mol.107.043208","article-title":"Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel","volume":"73","author":"De La Fuente","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.joca.2016.05.019_bib22","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/sj.bjp.0704413","article-title":"DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration","volume":"134","author":"Decher","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.joca.2016.05.019_bib23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/iub.1266","article-title":"Functions of volume-sensitive and calcium-activated chloride channels","volume":"66","author":"Hoffmann","year":"2014","journal-title":"IUBMB Life"},{"key":"10.1016\/j.joca.2016.05.019_bib24","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1136\/ard.60.6.619","article-title":"Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage","volume":"60","author":"Garnero","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.05.019_bib25","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.berh.2011.11.013","article-title":"Biomechanical factors in osteoarthritis","volume":"25","author":"Guilak","year":"2011","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.joca.2016.05.019_bib26","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/jcp.21258","article-title":"Osteoarthritis","volume":"213","author":"Goldring","year":"2007","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.joca.2016.05.019_bib27","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1002\/1529-0131(200009)43:9<1916::AID-ANR2>3.0.CO;2-I","article-title":"The role of the chondrocyte in osteoarthritis","volume":"43","author":"Goldring","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2016.05.019_bib28","doi-asserted-by":"crossref","first-page":"459","DOI":"10.4161\/chan.26071","article-title":"Chondrocyte channel transcriptomics: do microarray data fit with expression and functional data?","volume":"7","author":"Lewis","year":"2013","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.joca.2016.05.019_bib29","doi-asserted-by":"crossref","first-page":"9487","DOI":"10.1073\/pnas.140216197","article-title":"Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis","volume":"97","author":"Maeno","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.joca.2016.05.019_bib30","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0006-2952(98)00225-1","article-title":"A\u00a0necessary role for cell shrinkage in apoptosis","volume":"56","author":"Bortner","year":"1998","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.joca.2016.05.019_bib31","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.281.5381.1312","article-title":"Caspases: enemies within","volume":"281","author":"Thornberry","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.joca.2016.05.019_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceca.2013.03.003","article-title":"Store-operated calcium entry and calcium influx via voltage-operated calcium channels regulate intracellular calcium oscillations in chondrogenic cells","volume":"54","author":"Fodor","year":"2013","journal-title":"Cell Calcium"},{"key":"10.1016\/j.joca.2016.05.019_bib33","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00424-014-1529-8","article-title":"Purinergic signalling is required for calcium oscillations in migratory chondrogenic progenitor cells","volume":"467","author":"Matta","year":"2015","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.joca.2016.05.019_bib34","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1159\/000335847","article-title":"Cell volume control in chondrocytes","volume":"28","author":"Lewis","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.joca.2016.05.019_bib35","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1111\/j.1476-5381.2012.02185.x","article-title":"Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes","volume":"168","author":"Lewis","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.joca.2016.05.019_bib36","doi-asserted-by":"crossref","first-page":"E5114","DOI":"10.1073\/pnas.1414298111","article-title":"Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage","volume":"111","author":"Lee","year":"2014","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.joca.2016.05.019_bib37","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/jcp.22075","article-title":"Characterization of a stretch-activated potassium channel in chondrocytes","volume":"223","author":"Mobasheri","year":"2010","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.joca.2016.05.019_bib38","doi-asserted-by":"crossref","first-page":"C786","DOI":"10.1152\/ajpcell.00469.2009","article-title":"Accelerated Ca2+ entry by membrane hyperpolarization due to Ca2+-activated K+ channel activation in response to histamine in chondrocytes","volume":"298","author":"Funabashi","year":"2010","journal-title":"Am J Physiol-Cell Physiol"},{"key":"10.1016\/j.joca.2016.05.019_bib39","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1002\/art.24799","article-title":"Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes","volume":"60","author":"Phan","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2016.05.019_bib40","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1073\/pnas.1319569111","article-title":"TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading","volume":"111","author":"O'Conor","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.joca.2016.05.019_bib41","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1002\/art.27624","article-title":"Chondroprotective role of the osmotically-sensitive ion channel TRPV4: age- and sex-dependent progression of osteoarthritis in Trpv4 deficient mice","volume":"10","author":"Clark","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2016.05.019_bib42","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00210-014-1078-x","article-title":"TRPV4 as a therapeutic target for joint diseases","volume":"388","author":"McNulty","year":"2015","journal-title":"Naunyn Schmiedeb Arch Pharmacol"},{"key":"10.1016\/j.joca.2016.05.019_bib43","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.tibs.2015.07.005","article-title":"TMEM16, LRRC8A, bestrophin: chloride channels controlled by Ca(2+) and cell volume","volume":"40","author":"Kunzelmann","year":"2015","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.joca.2016.05.019_bib44","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1113\/jphysiol.2004.075622","article-title":"Volume sensitivity of the bestrophin family of chloride channels","volume":"562","author":"Fischmeister","year":"2005","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.joca.2016.05.019_bib45","doi-asserted-by":"crossref","first-page":"19354","DOI":"10.1073\/pnas.1312014110","article-title":"Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels","volume":"110","author":"Terashima","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.joca.2016.05.019_bib46","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cell.2014.03.024","article-title":"SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel","volume":"157","author":"Qiu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.joca.2016.05.019_bib47","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1126\/science.1252826","article-title":"Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC","volume":"344","author":"Voss","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.joca.2016.05.019_bib48","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00424-016-1789-6","article-title":"Non-essential contribution of LRRC8A to volume regulation","volume":"468","author":"Sirianant","year":"2016","journal-title":"Pflugers Arch"},{"issue":"2","key":"10.1016\/j.joca.2016.05.019_bib49","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1080\/15476278.2016.1181238","article-title":"Membrane channel gene expression in human costal and articular chondrocytes","volume":"12","author":"Asmar","year":"2016","journal-title":"Organogenesis"},{"key":"10.1016\/j.joca.2016.05.019_bib50","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.joca.2012.05.006","article-title":"Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA","volume":"20","author":"Xu","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2016.05.019_bib51","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1002\/art.38713","article-title":"Characterization of the cartilage DNA methylome in knee and hip osteoarthritis","volume":"66","author":"Rushton","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2016.05.019_bib52","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1124\/mol.115.098160","article-title":"The ClC-7 chloride channel is downregulated by hypoosmotic stress in human chondrocytes","volume":"88","author":"Kurita","year":"2015","journal-title":"Mol Pharmacol"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458416301078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458416301078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:42:38Z","timestamp":1761018158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458416301078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1063458416301078"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2016.05.019","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of a chondrocyte volume-sensitive Cl\u2212 conductance prior to macroscopic cartilage lesion formation in the rabbit knee anterior cruciate ligament transection osteoarthritis model","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2016.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}