{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:18:37Z","timestamp":1778840317875,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":439,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.joca.2016.10.013","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T15:31:54Z","timestamp":1477323114000},"page":"227-233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The interaction between weight and family history of total knee replacement with knee cartilage: a 10-year prospective study"],"prefix":"10.1016","volume":"25","author":[{"given":"F.","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Blizzard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cicuttini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Winzenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2016.10.013_bib1","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/art.1780300811","article-title":"The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study","volume":"30","author":"Felson","year":"1987","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2016.10.013_bib2","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.joca.2016.10.013_bib3","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/j.joca.2014.07.024","article-title":"Osteoarthritis year in review 2014: genetics and genomics","volume":"22","author":"Tsezou","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2016.10.013_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrrheum.2011.199","article-title":"Etiology of osteoarthritis: genetics and synovial joint development","volume":"8","author":"Sandell","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2016.10.013_bib5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/BOR.0b013e3283367a6e","article-title":"The genetic epidemiology of osteoarthritis","volume":"22","author":"Valdes","year":"2010","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.joca.2016.10.013_bib6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.joca.2015.01.004","article-title":"Familial effects on structural changes relevant to knee osteoarthritis: a prospective cohort study","volume":"23","author":"Pan","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2016.10.013_bib7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.joca.2014.11.019","article-title":"Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis","volume":"23","author":"Silverwood","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2016.10.013_bib8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.berh.2014.01.004","article-title":"The epidemiology of osteoarthritis","volume":"28","author":"Johnson","year":"2014","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.joca.2016.10.013_bib9","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1136\/annrheumdis-2013-203772","article-title":"The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a Mendelian randomisation study","volume":"73","author":"Panoutsopoulou","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.10.013_bib10","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1136\/ard.2004.021253","article-title":"Rate of cartilage loss at two years predicts subsequent total knee arthroplasty: a prospective study","volume":"63","author":"Cicuttini","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.10.013_bib11","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1136\/annrheumdis-2011-201164","article-title":"Quantitative MRI measures of cartilage predict knee replacement: a case-control study from the Osteoarthritis Initiative","volume":"72","author":"Eckstein","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.10.013_bib12","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1093\/rheumatology\/kei018","article-title":"The clinical correlates of articular cartilage defects in symptomatic knee osteoarthritis: a prospective study","volume":"44","author":"Wluka","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.joca.2016.10.013_bib13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/obr.12110","article-title":"Does obesity affect knee cartilage? A systematic review of magnetic resonance imaging data","volume":"15","author":"Mezhov","year":"2014","journal-title":"Obes Rev"},{"key":"10.1016\/j.joca.2016.10.013_bib14","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1136\/ard.2003.015875","article-title":"Genetic mechanisms of knee osteoarthritis: a population based case-control study","volume":"63","author":"Jones","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.10.013_bib15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1136\/ard.2004.023069","article-title":"Association between age and knee structural change: a cross sectional MRI based study","volume":"64","author":"Ding","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.10.013_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.joca.2003.08.010","article-title":"Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females","volume":"12","author":"Jones","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2016.10.013_bib17","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1002\/1529-0131(200011)43:11<2543::AID-ANR23>3.0.CO;2-K","article-title":"Sex and site differences in cartilage development: a possible explanation for variations in knee osteoarthritis in later life","volume":"43","author":"Jones","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2016.10.013_bib18","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1002\/art.22591","article-title":"Smoking interacts with family history with regard to change in knee cartilage volume and cartilage defect development","volume":"56","author":"Ding","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2016.10.013_bib19","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/art.20000","article-title":"Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changes","volume":"50","author":"Raynauld","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2016.10.013_bib20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S1063-4584(03)00029-3","article-title":"Reliability of a quantification imaging system using magnetic resonance images to measure cartilage thickness and volume in human normal and osteoarthritic knees","volume":"11","author":"Raynauld","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2016.10.013_bib21","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1136\/ard.2004.023796","article-title":"Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging","volume":"64","author":"Berthiaume","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.10.013_bib22","doi-asserted-by":"crossref","first-page":"R8","DOI":"10.1186\/ar1835","article-title":"Genetic mechanisms of knee osteoarthritis: a population-based longitudinal study","volume":"8","author":"Ding","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2016.10.013_bib23","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.joca.2004.11.007","article-title":"Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown","volume":"13","author":"Ding","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2016.10.013_bib24","series-title":"Multiple Regression: Testing and Interpreting Interactions","author":"Aiken","year":"1991"},{"key":"10.1016\/j.joca.2016.10.013_bib25","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/oby.2005.47","article-title":"Knee structural alteration and BMI: a cross-sectional study","volume":"13","author":"Ding","year":"2005","journal-title":"Obes Res"},{"key":"10.1016\/j.joca.2016.10.013_bib26","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s004290050149","article-title":"Quantitative relationships of normal cartilage volumes of the human knee joint\u2013assessment by magnetic resonance imaging","volume":"197","author":"Eckstein","year":"1998","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.joca.2016.10.013_bib27","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1186\/ar1962","article-title":"Knee cartilage loss in symptomatic knee osteoarthritis over 4.5 years","volume":"8","author":"Wluka","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2016.10.013_bib28","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1136\/ard.2006.064352","article-title":"Body composition and knee cartilage properties in healthy, community-based adults","volume":"66","author":"Wang","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.10.013_bib29","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1136\/ard.2004.029355","article-title":"Factors influencing longitudinal change in knee cartilage volume measured from magnetic resonance imaging in healthy men","volume":"64","author":"Hanna","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.10.013_bib30","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1136\/ard.2003.008433","article-title":"Tibial cartilage volume change in healthy postmenopausal women: a longitudinal study","volume":"63","author":"Wluka","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.10.013_bib31","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/art.10460","article-title":"The determinants of change in tibial cartilage volume in osteoarthritic knees","volume":"46","author":"Wluka","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2016.10.013_bib32","doi-asserted-by":"crossref","first-page":"R139","DOI":"10.1186\/ar3078","article-title":"Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women?","volume":"12","author":"Brennan","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2016.10.013_bib33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/acr.22715","article-title":"Body composition, hormonal and inflammatory factors are associated with tibial cartilage volume in young adults and contribute to the sex difference in cartilage volume","volume":"68","author":"Antony","year":"2015","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.joca.2016.10.013_bib34","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1136\/ard.2007.082651","article-title":"Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian older adult cohort (TASOAC) study","volume":"67","author":"Ding","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.10.013_bib35","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/ard.2010.144725","article-title":"Weight loss in obese people has structure-modifying effects on medial but not on lateral knee articular cartilage","volume":"71","author":"Anandacoomarasamy","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.10.013_bib36","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/annrheumdis-2013-204488","article-title":"Weight change and change in tibial cartilage volume and symptoms in obese adults","volume":"74","author":"Teichtahl","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.10.013_bib37","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.joca.2014.10.013","article-title":"Association of cartilage degeneration with four year weight gain\u20133T MRI data from the Osteoarthritis Initiative","volume":"23","author":"Bucknor","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2016.10.013_bib38","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nrrheum.2011.206","article-title":"OA in 2011: age-related OA\u2013a concept emerging from infancy?","volume":"8","author":"Aigner","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2016.10.013_bib39","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/rheumatology\/kep246","article-title":"Cartilage defects are associated with physical disability in obese adults","volume":"48","author":"Anandacoomarasamy","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.joca.2016.10.013_bib40","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00256-011-1259-3","article-title":"Obesity increases the prevalence and severity of focal knee abnormalities diagnosed using 3T MRI in middle-aged subjects\u2013data from the Osteoarthritis Initiative","volume":"41","author":"Laberge","year":"2012","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.joca.2016.10.013_bib41","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1186\/ar4214","article-title":"Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFbeta1) gene in knee and hip osteoarthritis","volume":"15","author":"Muthuri","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2016.10.013_bib42","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.joca.2007.10.012","article-title":"Risk factors in familial osteoarthritis: the GARP sibling study","volume":"16","author":"Riyazi","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2016.10.013_bib43","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1136\/annrheumdis-2012-202081","article-title":"Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data","volume":"72","author":"Elliott","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2016.10.013_bib44","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1136\/ard.2011.150052","article-title":"Risk factors for medial meniscal pathology on knee MRI in older US adults: a multicentre prospective cohort study","volume":"70","author":"Englund","year":"2011","journal-title":"Ann Rheum Dis"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345841630348X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345841630348X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:43:26Z","timestamp":1761018206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S106345841630348X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S106345841630348X"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2016.10.013","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The interaction between weight and family history of total knee replacement with knee cartilage: a 10-year prospective study","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2016.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}