{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:43:16Z","timestamp":1783399396535,"version":"3.54.6"},"reference-count":37,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T00:00:00Z","timestamp":1510790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Institute for Health Research (NIHR) Leeds Biomedical Research Centre"},{"name":"infirst Healthcare"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","oarsijournal.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.joca.2017.09.002","type":"journal-article","created":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T17:01:52Z","timestamp":1504976512000},"page":"1942-1951","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["A new lipid formulation of low dose ibuprofen shows non-inferiority to high dose standard ibuprofen: the FLARE study (flaring arthralgia relief evaluation in episodic flaring knee pain) \u2013 a randomised double-blind study"],"prefix":"10.1016","volume":"25","author":[{"given":"S.M.A.","family":"Bierma-Zeinstra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Brew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Stoner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kilbourn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.G.","family":"Conaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2017.09.002_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/rheumatology\/31.3.189","article-title":"Knee pain and disability in the community","volume":"31","author":"McAlindon","year":"1992","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.joca.2017.09.002_bib2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1136\/ard.55.12.931","article-title":"Screening for pain in knee osteoarthritis: Which question?","volume":"55","author":"O'Reilly","year":"1996","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 1","key":"10.1016\/j.joca.2017.09.002_bib3","doi-asserted-by":"crossref","first-page":"e000062","DOI":"10.1136\/rmdopen-2015-000062","article-title":"Early knee osteoarthritis","volume":"1","author":"Favero","year":"2015","journal-title":"RMD Open"},{"key":"10.1016\/j.joca.2017.09.002_bib4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.joca.2007.12.017","article-title":"Understanding the pain experience in hip and knee osteoarthritis \u2013 an OARSI\/OMERACT initiative","volume":"16","author":"Hawker","year":"2008","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"10.1016\/j.joca.2017.09.002_bib5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jbspin.2008.07.018","article-title":"Validation of the KOFUS (Knee Osteoarthritis Flare-Ups Score)","volume":"76","author":"Marty","year":"2009","journal-title":"Jt Bone Spine"},{"key":"10.1016\/j.joca.2017.09.002_bib6","unstructured":"Osteoarthritis: Care and Management Clinical Guideline [CG177] Published date: February 2014. Accessed 10-Feb-2017, at https:\/\/www.nice.org.uk\/guidance\/cg177."},{"issue":"10","key":"10.1016\/j.joca.2017.09.002_bib7","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.jclinepi.2004.02.012","article-title":"Statistical measures were proposed for identifying longitudinal patterns of change in quantitative health indicators","volume":"57","author":"Leffondr\u00e9","year":"2004","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.joca.2017.09.002_bib8","first-page":"729","article-title":"Differences in the osteoarthritic synovial fluid composition and rheology between patients with or without flare: a pilot study","volume":"30","author":"Conrozier","year":"2012","journal-title":"Clin Exp Rheumatol"},{"issue":"3","key":"10.1016\/j.joca.2017.09.002_bib9","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/art.30148","article-title":"Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging","volume":"63","author":"Zhang","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2017.09.002_bib10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.7326\/M14-1231","article-title":"Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis","volume":"162","author":"Bannuru","year":"2015","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.joca.2017.09.002_bib11","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.joca.2016.01.135","article-title":"Comparative pain reduction of oral non-steroidal anti-inflammatory drugs and opioids for knee osteoarthritis: systematic analytic review","volume":"24","author":"Smith","year":"2016","journal-title":"Osteoarthr Cartil"},{"issue":"8","key":"10.1016\/j.joca.2017.09.002_bib12","first-page":"404","article-title":"Pharmacological treatment of osteoarthritis of the hip and knee","volume":"52","author":"Kennedy","year":"2010","journal-title":"BCMJ"},{"key":"10.1016\/j.joca.2017.09.002_bib13","doi-asserted-by":"crossref","first-page":"h1225","DOI":"10.1136\/bmj.h1225","article-title":"Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials","volume":"350","author":"Machado","year":"2014","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.joca.2017.09.002_bib14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5001\/omj.2010.49","article-title":"An overview of clinical pharmacology of ibuprofen","volume":"25","author":"Bushra","year":"2010","journal-title":"Oman Med J"},{"key":"10.1016\/j.joca.2017.09.002_bib15","series-title":"Ibuprofen. A Critical Bibliographic Review","first-page":"1","article-title":"History and development of ibuprofen","author":"Rainsford","year":"1999"},{"key":"10.1016\/j.joca.2017.09.002_bib16","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1177\/009127009903900513","article-title":"The safety profile of non prescription ibuprofen in multiple-dose use: a meta-analysis","volume":"39","author":"Kellstein","year":"1999","journal-title":"J\u00a0Clin Pharmacol"},{"key":"10.1016\/j.joca.2017.09.002_bib17","first-page":"1061","article-title":"Adverse drug reactions and drug-drug interactions with over-the-counter NSAIDs","volume":"11","author":"Moore","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.joca.2017.09.002_bib18","series-title":"FDA Safety Announcement","year":"2015"},{"key":"10.1016\/j.joca.2017.09.002_bib19","series-title":"Recommendation of the Pharmacovigilance Risk Assessment Committee Pursuant to Article 31 of Directive 2001\/83\/EC Resulting from Pharmacovigilance Data, for Medicinal Products Containing Ibuprofen and Dexibuprofen (Systemic Formulations)","author":"Pharmacovigilance Risk Assessment Committee","year":"2015"},{"key":"10.1016\/j.joca.2017.09.002_bib20","series-title":"OARSI: Osteoarthritis \u2013 a Serious Disease","year":"2016"},{"key":"10.1016\/j.joca.2017.09.002_bib21","doi-asserted-by":"crossref","first-page":"j1909","DOI":"10.1136\/bmj.j1909","article-title":"Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data","volume":"357","author":"Bally","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.joca.2017.09.002_bib22","first-page":"1833","article-title":"Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy","year":"1988","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2017.09.002_bib23","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1093\/rheumatology\/kes043","article-title":"The use and reporting of WOMAC in the assessment of the benefit of physical therapies for the pain of osteoarthritis of the knee: findings from a systematic review of clinical trials","volume":"51","author":"Woolacott","year":"2012","journal-title":"Rheumatology"},{"key":"10.1016\/j.joca.2017.09.002_bib24","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.joca.2010.01.013","article-title":"OARSI recommendations for the management of hip and knee osteoarthritis Part III: changes in evidence following systematic cumulative update of research published through January 2009","volume":"18","author":"Zhang","year":"2010","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"10.1016\/j.joca.2017.09.002_bib25","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF01535722","article-title":"GSRS - a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease","volume":"33","author":"Svedlund","year":"1988","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.joca.2017.09.002_bib26","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.joca.2004.02.001","article-title":"OMERACT-OARSI initiative: osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited","volume":"12","author":"Pham","year":"2004","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"10.1016\/j.joca.2017.09.002_bib27","first-page":"131","article-title":"Minimal clinically important rehabilitation effects in patients with osteoarthritis of the lower extremities","volume":"29","author":"Angst","year":"2002","journal-title":"J\u00a0Rheumatol"},{"issue":"1","key":"10.1016\/j.joca.2017.09.002_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/ard.2004.025072","article-title":"Patient centred outcomes in osteoarthritis","volume":"64","author":"Bijlsma","year":"2005","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.joca.2017.09.002_bib29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/ard.2004.022905","article-title":"Evaluation of clinically relevant changes in patient reported outcomes in knee and hip osteoarthritis: the minimal clinically important improvement","volume":"64","author":"Tubach","year":"2005","journal-title":"Ann Rheum Dis"},{"issue":"7478","key":"10.1016\/j.joca.2017.09.002_bib30","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1136\/bmj.38273.626655.63","article-title":"Non-steroidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomised placebo controlled trials","volume":"329","author":"Bjordal","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.joca.2017.09.002_bib31","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2474-11-86","article-title":"Clinical predictors of elective total joint replacement in persons with end-stage knee osteoarthritis","volume":"11","author":"Zeni","year":"2010","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.joca.2017.09.002_bib32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2105\/AJPH.84.3.351","article-title":"The effects of specific medical conditions on the functional limitations of elders in the Framingham Study","volume":"84","author":"Guccione","year":"1994","journal-title":"Am J Public Health"},{"key":"10.1016\/j.joca.2017.09.002_bib33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/ard.60.2.91","article-title":"Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care","volume":"60","author":"Peat","year":"2001","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"10.1016\/j.joca.2017.09.002_bib34","first-page":"1373","article-title":"Comparison of the analgesic efficacy and safety of nonprescription doses of naproxen sodium and ibuprofen in the treatment of osteoarthritis of the knee","volume":"31","author":"Schiff","year":"2004","journal-title":"J\u00a0Rheumatol"},{"issue":"10033","key":"10.1016\/j.joca.2017.09.002_bib35","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0140-6736(16)30002-2","article-title":"Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis","volume":"387","author":"Da Costa","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.joca.2017.09.002_bib36","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1526-4637.2011.01060.x","article-title":"Predictors of response to cyclo-oxygenase-2 inhibitors in osteoarthritis: pooled results from two identical trials comparing Etoricoxib, Celecoxib, and placebo","volume":"12","author":"Bingham","year":"2011","journal-title":"Pain Med"},{"issue":"6","key":"10.1016\/j.joca.2017.09.002_bib37","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.addr.2007.09.007","article-title":"Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update","volume":"60","author":"Trevaskis","year":"2008","journal-title":"Adv Drug Deliv Rev"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458417311974?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458417311974?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T16:01:36Z","timestamp":1692979296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458417311974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S1063458417311974"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2017.09.002","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new lipid formulation of low dose ibuprofen shows non-inferiority to high dose standard ibuprofen: the FLARE study (flaring arthralgia relief evaluation in episodic flaring knee pain) \u2013 a randomised double-blind study","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2017.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}