{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:40:01Z","timestamp":1790019601780,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15gm0610007h0003"],"award-info":[{"award-number":["15gm0610007h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.joca.2017.10.011","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T15:48:54Z","timestamp":1508773734000},"page":"108-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor"],"prefix":"10.1016","volume":"26","author":[{"given":"H.","family":"Tanoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Morinaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Yoshizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yugami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Odagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sugizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kadomatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Terada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Yamagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mizuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Oike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2017.10.011_bib1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature01657","article-title":"Developmental regulation of the growth plate","volume":"423","author":"Kronenberg","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.joca.2017.10.011_bib2","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1101\/gad.934301","article-title":"Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival","volume":"15","author":"Schipani","year":"2001","journal-title":"Genes Dev"},{"key":"10.1016\/j.joca.2017.10.011_bib3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10237-006-0039-9","article-title":"A\u00a0theoretical analysis of water transport through chondrocytes","volume":"6","author":"Ateshian","year":"2007","journal-title":"Biomech Model Mechanobiol"},{"key":"10.1016\/j.joca.2017.10.011_bib4","first-page":"1067","article-title":"Genetic mouse models for the functional analysis of the perifibrillar components collagen IX, COMP and matrilin-3: implications for growth cartilage differentiation and endochondral ossification","volume":"24","author":"Zaucke","year":"2009","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.joca.2017.10.011_bib5","first-page":"119","article-title":"Integrins and cell signaling in chondrocytes","volume":"39","author":"Loeser","year":"2002","journal-title":"Biorheology"},{"key":"10.1016\/j.joca.2017.10.011_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/648459","article-title":"The ECM-cell interaction of cartilage extracellular matrix on chondrocytes","volume":"2014","author":"Gao","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.joca.2017.10.011_bib7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/bdrc.20126","article-title":"Regulation of cartilage formation and maturation by mitogen-activated protein kinase signaling","volume":"84","author":"Bobick","year":"2008","journal-title":"Birth Defects Res C Embryo Today"},{"key":"10.1016\/j.joca.2017.10.011_bib8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/jcb.22604","article-title":"Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes","volume":"110","author":"Beier","year":"2010","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.joca.2017.10.011_bib9","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/bonekey.2015.80","article-title":"Focus on the p38 MAPK signaling pathway in bone development and maintenance","volume":"4","author":"Thouverey","year":"2015","journal-title":"Bonekey Rep"},{"key":"10.1016\/j.joca.2017.10.011_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1042\/bj20030874","article-title":"p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation","volume":"378","author":"Stanton","year":"2004","journal-title":"Biochem J"},{"key":"10.1016\/j.joca.2017.10.011_bib11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tem.2014.03.012","article-title":"Diverse roles of ANGPTL2 in physiology and pathophysiology","volume":"25","author":"Kadomatsu","year":"2014","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.joca.2017.10.011_bib12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.cmet.2009.08.003","article-title":"Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance","volume":"10","author":"Tabata","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.joca.2017.10.011_bib13","doi-asserted-by":"crossref","first-page":"e85542","DOI":"10.1371\/journal.pone.0085542","article-title":"Angiopoietin-like protein 2 induced by mechanical stress accelerates degeneration and hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis","volume":"9","author":"Nakamura","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2017.10.011_bib14","doi-asserted-by":"crossref","first-page":"ra7","DOI":"10.1126\/scisignal.2004612","article-title":"The secreted protein ANGPTL2 promotes metastasis of osteosarcoma cells through integrin alpha5beta1, p38 MAPK, and matrix metalloproteinases","volume":"7","author":"Odagiri","year":"2014","journal-title":"Sci Signal"},{"key":"10.1016\/j.joca.2017.10.011_bib15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.kint.2015.12.021","article-title":"Angiopoietin-like protein 2 increases renal fibrosis by accelerating transforming growth factor-beta signaling in chronic kidney disease","volume":"89","author":"Morinaga","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.joca.2017.10.011_bib16","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1359\/jbmr.1997.12.8.1174","article-title":"Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in\u00a0vitro","volume":"12","author":"Shukunami","year":"1997","journal-title":"J\u00a0Bone Min Res"},{"key":"10.1016\/j.joca.2017.10.011_bib17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1083\/jcb.133.2.457","article-title":"Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in\u00a0vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)\/PTH-related peptide receptor","volume":"133","author":"Shukunami","year":"1996","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.joca.2017.10.011_bib18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.22203\/eCM.v012a08","article-title":"Ascorbate-enhanced chondrogenesis of ATDC5 cells","volume":"12","author":"Altaf","year":"2006","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.joca.2017.10.011_bib19","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/sj.gt.3301206","article-title":"Plat-E: an efficient and stable system for transient packaging of retroviruses","volume":"7","author":"Morita","year":"2000","journal-title":"Gene Ther"},{"key":"10.1016\/j.joca.2017.10.011_bib20","doi-asserted-by":"crossref","first-page":"8095","DOI":"10.1158\/0008-5472.CAN-06-3389","article-title":"Activation of insulin-like growth factor signaling induces apoptotic cell death under prolonged hypoxia by enhancing endoplasmic reticulum stress response","volume":"67","author":"Endo","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.joca.2017.10.011_bib21","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.2353\/ajpath.2008.071094","article-title":"Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen","volume":"172","author":"Posey","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.joca.2017.10.011_bib22","first-page":"2199","article-title":"Histomorphological and immunohistochemical evaluation of joint changes in a model of osteoarthritis induced by lateral meniscectomy in sheep","volume":"24","author":"Little","year":"1997","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2017.10.011_bib23","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1002\/jbmr.2275","volume":"29","author":"Tian","year":"2014","journal-title":"J\u00a0Bone Min Res"},{"key":"10.1016\/j.joca.2017.10.011_bib24","doi-asserted-by":"crossref","first-page":"L704","DOI":"10.1152\/ajplung.00005.2016","article-title":"Interstitial pneumonia induced by bleomycin treatment is exacerbated in Angptl2-deficient mice","volume":"311","author":"Motokawa","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.joca.2017.10.011_bib25","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1046\/j.0953-816x.2001.01498.x","article-title":"Phorbol esters promote postsynaptic accumulation of Vesl-1S\/Homer-1a protein","volume":"13","author":"Kato","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.joca.2017.10.011_bib26","doi-asserted-by":"crossref","first-page":"7502","DOI":"10.1158\/0008-5472.CAN-11-1758","article-title":"Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis","volume":"71","author":"Aoi","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.joca.2017.10.011_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0925-4773(97)00203-7","article-title":"Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair","volume":"71","author":"Vortkamp","year":"1998","journal-title":"Mech Dev"},{"key":"10.1016\/j.joca.2017.10.011_bib28","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/jor.20649","article-title":"Comparison of the healing of open tibial fractures covered with either muscle or fasciocutaneous tissue in a murine model","volume":"26","author":"Harry","year":"2008","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.joca.2017.10.011_bib29","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/jbmr.2166","article-title":"In\u00a0vivo analysis of Arg-Gly-Asp sequence\/integrin alpha5beta1-mediated signal involvement in embryonic enchondral ossification by exo utero development system","volume":"29","author":"Inoue","year":"2014","journal-title":"J\u00a0Bone Min Res"},{"key":"10.1016\/j.joca.2017.10.011_bib30","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1242\/dev.01345","article-title":"Coordination of chondrocyte differentiation and joint formation by alpha5beta1 integrin in the developing appendicular skeleton","volume":"131","author":"Garciadiego-Cazares","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.joca.2017.10.011_bib31","doi-asserted-by":"crossref","first-page":"e66206","DOI":"10.1371\/journal.pone.0066206","article-title":"Mice with a conditional deletion of the neurotrophin receptor TrkB are dwarfed, and are similar to mice with a MAPK14 deletion","volume":"8","author":"Hutchison","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2017.10.011_bib32","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.joca.2015.01.016","article-title":"CXC chemokine ligand 12a enhances chondrocyte proliferation and maturation during endochondral bone formation","volume":"23","author":"Kim","year":"2015","journal-title":"Osteoarthritis and Cartilage"},{"key":"10.1016\/j.joca.2017.10.011_bib33","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1096\/fj.08-115170","article-title":"Interaction of the coiled-coil domain with glycosaminoglycans protects angiopoietin-like 4 from proteolysis and regulates its antiangiogenic activity","volume":"23","author":"Chomel","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.joca.2017.10.011_bib34","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/00003086-199810001-00003","article-title":"The cell and molecular biology of fracture healing","author":"Einhorn","year":"1998","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.joca.2017.10.011_bib35","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fendo.2017.00080","article-title":"Multiple roles of angiopoietin-like 4 in osteolytic disease","volume":"8","author":"Knowles","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.joca.2017.10.011_bib36","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jor.20703","article-title":"Hypoxia upregulates the expression of angiopoietin-like-4 in human articular chondrocytes: role of angiopoietin-like-4 in the expression of matrix metalloproteinases and cartilage degradation","volume":"27","author":"Murata","year":"2009","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.joca.2017.10.011_bib37","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.1074\/jbc.M113.539825","article-title":"Involvement of angiopoietin-like 4 in matrix remodeling during chondrogenic differentiation of mesenchymal stem cells","volume":"289","author":"Mathieu","year":"2014","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.joca.2017.10.011_bib38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.metabol.2017.01.006","article-title":"Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation","volume":"69","author":"Takano","year":"2017","journal-title":"Metabolism"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458417312645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458417312645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:45:51Z","timestamp":1761018351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458417312645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S1063458417312645"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2017.10.011","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2017.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}