{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:03:45Z","timestamp":1789506225958,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K01AR061415"],"award-info":[{"award-number":["K01AR061415"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AR071734"],"award-info":[{"award-number":["R01AR071734"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-13-1-0465"],"award-info":[{"award-number":["W81XWH-13-1-0465"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["RB5-07230"],"award-info":[{"award-number":["RB5-07230"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["TRAN121"],"award-info":[{"award-number":["TRAN121"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.joca.2018.08.017","type":"journal-article","created":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T12:16:14Z","timestamp":1536408974000},"page":"158-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["CaMKII inhibition in human primary and pluripotent stem cell-derived chondrocytes modulates effects of TGF\u03b2 and BMP through SMAD signaling"],"prefix":"10.1016","volume":"27","author":[{"given":"B.","family":"Saitta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Elphingstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Limfat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Shkhyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Evseenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.joca.2018.08.017_bib1","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1073\/pnas.1419699112","article-title":"Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium\/calmodulin-dependent protein kinase 2","volume":"112","author":"Sugita","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.joca.2018.08.017_bib2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ydbio.2008.02.007","article-title":"Ca2+\/Calmodulin-dependent kinase II signaling causes skeletal overgrowth and premature chondrocyte maturation","volume":"317","author":"Taschner","year":"2008","journal-title":"Dev Biol"},{"issue":"2","key":"10.1016\/j.joca.2018.08.017_bib3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1242\/dev.052324","article-title":"Calcium\/calmodulin-dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes","volume":"138","author":"Li","year":"2011","journal-title":"Development"},{"issue":"3,4","key":"10.1016\/j.joca.2018.08.017_bib4","first-page":"223","article-title":"Calcium\/calmodulin-dependent protein kinase II in human articular chondrocytes","volume":"43","author":"Shimazaki","year":"2006","journal-title":"Biorheology"},{"issue":"3","key":"10.1016\/j.joca.2018.08.017_bib5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1083\/jcb.201011051","article-title":"WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways","volume":"193","author":"Nalesso","year":"2011","journal-title":"J\u00a0Cell Biol"},{"issue":"1","key":"10.1016\/j.joca.2018.08.017_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceca.2013.03.003","article-title":"Store-operated calcium entry and calcium influx via voltage-operated calcium channels regulate intracellular calcium oscillations in chondrogenic cells","volume":"54","author":"Fodor","year":"2013","journal-title":"Cell Calcium"},{"issue":"1","key":"10.1016\/j.joca.2018.08.017_bib7","doi-asserted-by":"crossref","first-page":"9421","DOI":"10.1038\/s41598-017-09892-w","article-title":"Enhancement of mesenchymal stem cell chondrogenesis with short-term low intensity pulsed electromagnetic fields","volume":"7","author":"Parate","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.joca.2018.08.017_bib8","doi-asserted-by":"crossref","first-page":"358","DOI":"10.22203\/eCM.v028a25","article-title":"The role of calcium signalling in the chondrogenic response of mesenchymal stem cells to hydrostatic pressure","volume":"28","author":"Steward","year":"2014","journal-title":"Eur Cell Mater"},{"issue":"32","key":"10.1016\/j.joca.2018.08.017_bib9","doi-asserted-by":"crossref","first-page":"28411","DOI":"10.1074\/jbc.M202807200","article-title":"STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration","volume":"277","author":"Li","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.joca.2018.08.017_bib10","article-title":"Correction: activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity","volume":"3","author":"Stratton","year":"2014","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.joca.2018.08.017_bib11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/cr.2008.327","article-title":"Phospho-control of TGF-beta superfamily signaling","volume":"19","author":"Wrighton","year":"2009","journal-title":"Cell Res"},{"issue":"21","key":"10.1016\/j.joca.2018.08.017_bib12","doi-asserted-by":"crossref","first-page":"8103","DOI":"10.1128\/.20.21.8103-8111.2000","article-title":"Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II","volume":"20","author":"Wicks","year":"2000","journal-title":"Mol Cell Biol"},{"issue":"12","key":"10.1016\/j.joca.2018.08.017_bib13","doi-asserted-by":"crossref","first-page":"8585","DOI":"10.1074\/jbc.M112.413997","article-title":"Dentin phosphophoryn activates Smad protein signaling through Ca2+-calmodulin-dependent protein kinase II in undifferentiated mesenchymal cells","volume":"288","author":"Eapen","year":"2013","journal-title":"J\u00a0Biol Chem"},{"issue":"6","key":"10.1016\/j.joca.2018.08.017_bib14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.stemcr.2013.10.012","article-title":"Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells","volume":"1","author":"Wu","year":"2013","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.joca.2018.08.017_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1472-6750-6-43","article-title":"The cumate gene-switch: a system for regulated expression in mammalian cells","volume":"6","author":"Mullick","year":"2006","journal-title":"BMC Biotechnol"},{"key":"10.1016\/j.joca.2018.08.017_bib16","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1136\/annrheumdis-2017-212037","article-title":"Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair","volume":"77","author":"Shkhyan","year":"2018","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.joca.2018.08.017_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/bdrc.21058","article-title":"TGFbeta signaling in cartilage development and maintenance","volume":"102","author":"Wang","year":"2014","journal-title":"Birth Defects Res C Embryo Today"},{"issue":"31","key":"10.1016\/j.joca.2018.08.017_bib18","doi-asserted-by":"crossref","first-page":"13742","DOI":"10.1073\/pnas.1002077107","article-title":"Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells","volume":"107","author":"Evseenko","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2018.08.017_bib19","article-title":"Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity","volume":"3","author":"Stratton","year":"2013","journal-title":"Elife"},{"issue":"13","key":"10.1016\/j.joca.2018.08.017_bib20","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1089\/scd.2014.0014","article-title":"Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFbeta1","volume":"23","author":"Saitta","year":"2014","journal-title":"Stem Cell Dev"},{"issue":"1","key":"10.1016\/j.joca.2018.08.017_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016421","article-title":"Interaction of TGFbeta and BMP signaling pathways during chondrogenesis","volume":"6","author":"Keller","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2018.08.017_bib22","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1016\/j.joca.2016.01.292","article-title":"Pharmacological blockade of CAMKII is detrimental for osteoarthritis progression","volume":"24","author":"Nalesso","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2018.08.017_bib23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.semcdb.2016.10.004","article-title":"Transcriptional control of chondrocyte specification and differentiation","volume":"62","author":"Liu","year":"2017","journal-title":"Semin Cell Dev Biol"},{"issue":"5","key":"10.1016\/j.joca.2018.08.017_bib24","doi-asserted-by":"crossref","first-page":"F456","DOI":"10.1152\/ajprenal.00631.2014","article-title":"Calmodulin and CaMKII modulate ENaC activity by regulating the association of MARCKS and the cytoskeleton with the apical membrane","volume":"309","author":"Alli","year":"2015","journal-title":"Am J Physiol Ren Physiol"},{"issue":"21","key":"10.1016\/j.joca.2018.08.017_bib25","doi-asserted-by":"crossref","first-page":"17871","DOI":"10.1074\/jbc.M008422200","article-title":"Flamin associates with Smads and regulates transforming growth factor-beta signaling","volume":"276","author":"Sasaki","year":"2001","journal-title":"J\u00a0Biol Chem"},{"issue":"3","key":"10.1016\/j.joca.2018.08.017_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005936","article-title":"TGFbeta and BMP dependent cell fate changes due to loss of filamin B produces disc degeneration and progressive vertebral fusions","volume":"12","author":"Zieba","year":"2016","journal-title":"PLoS Genet"},{"issue":"7","key":"10.1016\/j.joca.2018.08.017_bib27","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1172\/JCI27438","article-title":"CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy","volume":"116","author":"Backs","year":"2006","journal-title":"J\u00a0Clin Invest"},{"issue":"23","key":"10.1016\/j.joca.2018.08.017_bib28","doi-asserted-by":"crossref","first-page":"8704","DOI":"10.1128\/MCB.23.23.8704-8717.2003","article-title":"Smad-dependent recruitment of a histone deacetylase\/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2","volume":"23","author":"Kim","year":"2003","journal-title":"Mol Cell Biol"},{"issue":"14","key":"10.1016\/j.joca.2018.08.017_bib29","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1038\/sj.emboj.7600729","article-title":"Repression of Runx2 function by TGF-\u03b2 through recruitment of class II histone deacetylases by Smad3","volume":"24","author":"Kang","year":"2005","journal-title":"EMBO J"},{"issue":"4","key":"10.1016\/j.joca.2018.08.017_bib30","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2004.10.024","article-title":"Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis","volume":"119","author":"Vega","year":"2004","journal-title":"Cell"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458418314547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458418314547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:48:47Z","timestamp":1761018527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458418314547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S1063458418314547"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2018.08.017","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CaMKII inhibition in human primary and pluripotent stem cell-derived chondrocytes modulates effects of TGF\u03b2 and BMP through SMAD signaling","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2018.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}