{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:20:42Z","timestamp":1792700442221,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.joca.2019.01.008","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T21:36:58Z","timestamp":1548970618000},"page":"823-832","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Changes in stiffness and biochemical composition of the pericellular matrix as a function of spatial chondrocyte organisation in osteoarthritic cartilage"],"prefix":"10.1016","volume":"27","author":[{"given":"M.","family":"Danalache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kleinert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.L.","family":"Erler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schwitalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Riester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Traub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.K.","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2019.01.008_bib1","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1096\/fasebj.3.9.2663581","article-title":"Structure and biology of cartilage and bone matrix noncollagenous macromolecules","volume":"3","author":"Heinegard","year":"1989","journal-title":"FASEB J"},{"key":"10.1016\/j.joca.2019.01.008_bib2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jsb.2008.01.010","article-title":"Distinct horizontal patterns in the spatial organization of superficial zone chondrocytes of human joints","volume":"162","author":"Rolauffs","year":"2008","journal-title":"J\u00a0Struct Biol"},{"key":"10.1016\/j.joca.2019.01.008_bib3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/ar.10063","article-title":"Horizontally oriented clusters of multiple chondrons in the superficial zone of ankle, but not knee articular cartilage","volume":"266","author":"Schumacher","year":"2002","journal-title":"Anat Rec"},{"key":"10.1016\/j.joca.2019.01.008_bib4","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/art.30217","article-title":"Onset of preclinical osteoarthritis: the angular spatial organization permits early diagnosis","volume":"63","author":"Rolauffs","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.01.008_bib5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1136\/annrheumdis-2013-204308","article-title":"The spatial organisation of joint surface chondrocytes: review of its potential roles in tissue functioning, disease and early, preclinical diagnosis of osteoarthritis","volume":"73","author":"Aicher","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2019.01.008_bib6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/art.27217","article-title":"Proliferative remodeling of the spatial organization of human superficial chondrocytes distant from focal early osteoarthritis","volume":"62","author":"Rolauffs","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.01.008_bib7","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.joca.2016.02.001","article-title":"Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in\u00a0vivo and in a novel in\u00a0vitro methodology","volume":"24","author":"Felka","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2019.01.008_bib8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1115\/1.1579047","article-title":"Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis","volume":"125","author":"Alexopoulos","year":"2003","journal-title":"J\u00a0Biomech Eng"},{"key":"10.1016\/j.joca.2019.01.008_bib9","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1002\/1529-0131(200108)44:8<1808::AID-ART318>3.0.CO;2-B","article-title":"Formation and phenotype of cell clusters in osteoarthritic meniscus","volume":"44","author":"Hellio Le Graverand","year":"2001","journal-title":"Arthritis Rheum"},{"issue":"Pt 4","key":"10.1016\/j.joca.2019.01.008_bib10","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1242\/jcs.103.4.1101","article-title":"Chondrons from articular cartilage. V. Immunohistochemical evaluation of type VI collagen organisation in isolated chondrons by light, confocal and electron microscopy","volume":"103","author":"Poole","year":"1992","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.joca.2019.01.008_bib11","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.joca.2006.02.017","article-title":"Zonal variations in the three-dimensional morphology of the chondron measured in situ using confocal microscopy","volume":"14","author":"Youn","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"issue":"Pt 1","key":"10.1016\/j.joca.2019.01.008_bib12","first-page":"1","article-title":"Articular cartilage chondrons: form, function and failure","volume":"191","author":"Poole","year":"1997","journal-title":"J\u00a0Anat"},{"key":"10.1016\/j.joca.2019.01.008_bib13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/bies.20748","article-title":"Perlecan, the \u201cjack of all trades\u201d proteoglycan of cartilaginous weight-bearing connective tissues","volume":"30","author":"Melrose","year":"2008","journal-title":"Bioessays"},{"key":"10.1016\/j.joca.2019.01.008_bib14","article-title":"The pericellular hyaluronan of articular chondrocytes","author":"Knudson","year":"2018","journal-title":"Matrix Biol"},{"key":"10.1016\/j.joca.2019.01.008_bib15","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1083\/jcb.93.3.921","article-title":"An immunoelectron microscope study of the organization of proteoglycan monomer, link protein, and collagen in the matrix of articular cartilage","volume":"93","author":"Poole","year":"1982","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.joca.2019.01.008_bib16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/excr.1996.0028","article-title":"Identification and immunolocalization of laminin in cartilage","volume":"222","author":"Durr","year":"1996","journal-title":"Exp Cell Res"},{"issue":"Pt 4","key":"10.1016\/j.joca.2019.01.008_bib17","first-page":"523","article-title":"Structural colocalisation of type VI collagen and fibronectin in agarose cultured chondrocytes and isolated chondrons extracted from adult canine tibial cartilage","volume":"190","author":"Chang","year":"1997","journal-title":"J\u00a0Anat"},{"key":"10.1016\/j.joca.2019.01.008_bib18","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1177\/39.9.1717545","article-title":"Chondrons from articular cartilage. (IV). Immunolocalization of proteoglycan epitopes in isolated canine tibial chondrons","volume":"39","author":"Poole","year":"1991","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1016\/j.joca.2019.01.008_bib19","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1177\/002215549904701212","article-title":"Development and aging of the articular cartilage of the rabbit knee joint: distribution of biglycan, decorin, and matrilin-1","volume":"47","author":"Kavanagh","year":"1999","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1016\/j.joca.2019.01.008_bib20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1063-4584(97)80014-3","article-title":"Immunolocalization of type IX collagen in normal and spontaneously osteoarthritic canine tibial cartilage and isolated chondrons","volume":"5","author":"Poole","year":"1997","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2019.01.008_bib21","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1196\/annals.1346.011","article-title":"The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage","volume":"1068","author":"Guilak","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.joca.2019.01.008_bib22","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1089\/ten.tea.2010.0601","article-title":"The protective role of the pericellular matrix in chondrocyte apoptosis","volume":"17","author":"Peters","year":"2011","journal-title":"Tissue Eng"},{"key":"10.1016\/j.joca.2019.01.008_bib23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0945-053X(02)00026-4","article-title":"Retention of the native chondrocyte pericellular matrix results in significantly improved matrix production","volume":"21","author":"Larson","year":"2002","journal-title":"Matrix Biol"},{"issue":"Pt 1","key":"10.1016\/j.joca.2019.01.008_bib24","first-page":"113","article-title":"Morphological and functional interrelationships of articular cartilage matrices","volume":"138","author":"Poole","year":"1984","journal-title":"J\u00a0Anat"},{"key":"10.1016\/j.joca.2019.01.008_bib25","doi-asserted-by":"crossref","first-page":"18947","DOI":"10.1074\/jbc.M100625200","article-title":"Biglycan and decorin bind close to the n-terminal region of the collagen VI triple helix","volume":"276","author":"Wiberg","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.joca.2019.01.008_bib26","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/jor.1100050406","article-title":"Chondrons in cartilage: ultrastructural analysis of the pericellular microenvironment in adult human articular cartilages","volume":"5","author":"Poole","year":"1987","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.joca.2019.01.008_bib27","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1016\/j.jbiomech.2007.01.009","article-title":"Zonal changes in the three-dimensional morphology of the chondron under compression: the relationship among cellular, pericellular, and extracellular deformation in articular cartilage","volume":"40","author":"Choi","year":"2007","journal-title":"J\u00a0Biomech"},{"key":"10.1016\/j.joca.2019.01.008_bib28","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1172\/JCI118357","article-title":"Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration","volume":"96","author":"Hollander","year":"1995","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.joca.2019.01.008_bib29","doi-asserted-by":"crossref","first-page":"D662","DOI":"10.2741\/Poole","article-title":"An introduction to the pathophysiology of osteoarthritis","volume":"4","author":"Poole","year":"1999","journal-title":"Front Biosci"},{"key":"10.1016\/j.joca.2019.01.008_bib30","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/jor.1100140502","article-title":"Contents and distributions of the proteoglycans decorin and biglycan in normal and osteoarthritic human articular cartilage","volume":"14","author":"Poole","year":"1996","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.joca.2019.01.008_bib31","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.joca.2004.07.004","article-title":"Perlecan in late stages of osteoarthritis of the human knee joint","volume":"12","author":"Tesche","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2019.01.008_bib32","first-page":"1669","article-title":"Expression of matrix metalloproteinases in normal and damaged articular cartilage from human knee and ankle joints","volume":"79","author":"Chubinskaya","year":"1999","journal-title":"Lab Invest"},{"key":"10.1016\/j.joca.2019.01.008_bib33","first-page":"99","article-title":"Role of metalloproteinases in human osteoarthritis","volume":"27","author":"Woessner","year":"1991","journal-title":"J\u00a0Rheumatol Suppl"},{"key":"10.1016\/j.joca.2019.01.008_bib34","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1172\/JCI117156","article-title":"Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay","volume":"93","author":"Hollander","year":"1994","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.joca.2019.01.008_bib35","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1172\/JCI117156","article-title":"Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay","volume":"93","author":"Hollander","year":"1994","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.joca.2019.01.008_bib36","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1053\/joca.2000.0390","article-title":"Type II collagen degradation in articular cartilage fibrillation after anterior cruciate ligament transection in rats","volume":"9","author":"Stoop","year":"2001","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2019.01.008_bib37","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/1529-0131(199806)41:6<986::AID-ART5>3.0.CO;2-N","article-title":"Severe disturbance of the distribution and expression of type VI collagen chains in osteoarthritic articular cartilage","volume":"41","author":"Hambach","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.01.008_bib38","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1126\/science.1411505","article-title":"From molecules to cells: imaging soft samples with the atomic force microscope","volume":"257","author":"Radmacher","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.joca.2019.01.008_bib39","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1136\/ard.50.11.787","article-title":"Immunolocalisation of type VI collagen in the intervertebral disc","volume":"50","author":"Roberts","year":"1991","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2019.01.008_bib40","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1369\/0022155411400869","article-title":"Chemical pretreatment of growth plate cartilage increases immunofluorescence sensitivity","volume":"59","author":"Ahrens","year":"2011","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1016\/j.joca.2019.01.008_bib41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jsb.2008.01.010","article-title":"Distinct horizontal patterns in the spatial organization of superficial zone chondrocytes of human joints","volume":"162","author":"Rolauffs","year":"2008","journal-title":"J\u00a0Struct Biol"},{"key":"10.1016\/j.joca.2019.01.008_bib42","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.joca.2013.08.026","article-title":"Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage. Osteoarthritis and cartilage\/OARS","volume":"21","author":"Wilusz","year":"2013","journal-title":"Osteoarthritis Res Soc"},{"key":"10.1016\/j.joca.2019.01.008_bib43","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/jor.1100090304","article-title":"Interspecies comparisons of in situ intrinsic mechanical properties of distal femoral cartilage","volume":"9","author":"Athanasiou","year":"1991","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.joca.2019.01.008_bib44","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/jor.1100150404","article-title":"Depth-dependent confined compression modulus of full-thickness bovine articular cartilage","volume":"15","author":"Schinagl","year":"1997","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.joca.2019.01.008_bib45","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jbiomech.2012.09.013","article-title":"Diurnal variations in articular cartilage thickness and strain in the human knee","volume":"46","author":"Coleman","year":"2013","journal-title":"J\u00a0Biomech"},{"key":"10.1016\/j.joca.2019.01.008_bib46","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1016\/j.bpj.2010.03.037","article-title":"Spatial mapping of the biomechanical properties of the pericellular matrix of articular cartilage measured in situ via atomic force microscopy","volume":"98","author":"Darling","year":"2010","journal-title":"Biophys J"},{"key":"10.1016\/j.joca.2019.01.008_bib47","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1098\/rsif.2012.0314","article-title":"Immunofluorescence-guided atomic force microscopy to measure the micromechanical properties of the pericellular matrix of porcine articular cartilage","volume":"9","author":"Wilusz","year":"2012","journal-title":"J\u00a0R Soc Interface"},{"key":"10.1016\/j.joca.2019.01.008_bib48","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jbiomech.2004.04.012","article-title":"Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage","volume":"38","author":"Alexopoulos","year":"2005","journal-title":"J\u00a0Biomech"},{"key":"10.1016\/j.joca.2019.01.008_bib49","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00776-003-0737-4","article-title":"Distribution of type VI collagen in chondrocyte microenvironment: study of chondrons isolated from human normal and degenerative articular cartilage and cultured chondrocytes","volume":"9","author":"Horikawa","year":"2004","journal-title":"J\u00a0Orthop Sci"},{"key":"10.1016\/j.joca.2019.01.008_bib50","doi-asserted-by":"crossref","first-page":"36905","DOI":"10.1074\/jbc.M608462200","article-title":"The structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages","volume":"281","author":"Melrose","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.joca.2019.01.008_bib51","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.119.4.945","article-title":"Endothelial cells interact with the core protein of basement membrane perlecan through beta 1 and beta 3 integrins: an adhesion modulated by glycosaminoglycan","volume":"119","year":"1992","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.joca.2019.01.008_bib52","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1432-1033.1997.t01-1-00039.x","article-title":"The C-terminal domain V of perlecan promotes pl integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans","volume":"250","author":"Brown","year":"1997","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.joca.2019.01.008_bib53","first-page":"511","article-title":"Perlecan: an important component of the cartilage pericellular matrix","volume":"2","author":"Gomes","year":"2002","journal-title":"J\u00a0Musculoskelet Neuronal Interact"},{"key":"10.1016\/j.joca.2019.01.008_bib54","doi-asserted-by":"crossref","first-page":"S400","DOI":"10.1016\/j.joca.2018.02.776","article-title":"Investigation of articular cartilage structural and biomechanical properties by atomic-force microscopy","volume":"26","author":"Prein","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2019.01.008_bib55","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jbiomech.2012.09.003","article-title":"Depth-Dependent anisotropy of the micromechanical properties of the extracellular and pericellular matrices of articular cartilage evaluated via atomic force microscopy","volume":"46","author":"McLeod","year":"2013","journal-title":"J\u00a0Biomech"},{"key":"10.1016\/j.joca.2019.01.008_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10237-010-0214-x","article-title":"Three-dimensional finite element modeling of pericellular matrix and cell mechanics in the nucleus pulposus of the intervertebral disk based on in situ morphology","volume":"10","author":"Cao","year":"2011","journal-title":"Biomechanics Model Mechanobiol"},{"key":"10.1016\/j.joca.2019.01.008_bib57","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/art.39034","article-title":"Type VI collagen regulates pericellular matrix properties, chondrocyte swelling, and mechanotransduction in mouse articular cartilage","volume":"67","author":"Zelenski","year":"2015","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.01.008_bib58","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.matbio.2018.05.008","article-title":"Osteoarthritis as a disease of the cartilage pericellular matrix","volume":"71\u201372","author":"Guilak","year":"2018","journal-title":"Matrix Biol"},{"key":"10.1016\/j.joca.2019.01.008_bib59","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0167-4838(90)90209-X","article-title":"Comparative analysis of collagens solubilized from human foetal, and normal and osteoarthritic adult articular cartilage, with emphasis on type VI collagen","volume":"1038","author":"Ronziere","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.joca.2019.01.008_bib60","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0006-291X(88)80040-8","article-title":"Experimental osteoarthritic articular cartilage is enriched in guanidine soluble type VI collagen","volume":"157","author":"McDevitt","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joca.2019.01.008_bib61","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ydbio.2016.08.029","article-title":"Knockdown of the pericellular matrix molecule perlecan lowers in situ cell and matrix stiffness in developing cartilage","volume":"418","author":"Xu","year":"2016","journal-title":"Dev Biol"},{"key":"10.1016\/j.joca.2019.01.008_bib62","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.matbio.2012.05.002","article-title":"A\u00a0biomechanical role for perlecan in the pericellular matrix of articular cartilage","volume":"31","author":"Wilusz","year":"2012","journal-title":"Matrix Biol"},{"key":"10.1016\/j.joca.2019.01.008_bib63","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/joca.2002.0512","article-title":"Ultrastructural localization of type VI collagen in normal adult and osteoarthritic human articular cartilage","volume":"10","author":"Soder","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2019.01.008_bib64","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1115\/1.2835074","article-title":"Analysis of indentation: implications for measuring mechanical properties with atomic force microscopy","volume":"121","author":"Costa","year":"1999","journal-title":"J\u00a0Biomech Eng"},{"key":"10.1016\/j.joca.2019.01.008_bib65","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1016\/S0006-3495(04)74375-1","article-title":"Dynamic elastic modulus of porcine articular cartilage determined at two different levels of tissue organization by indentation-type atomic force microscopy","volume":"86","author":"Stolz","year":"2004","journal-title":"Biophys J"},{"key":"10.1016\/j.joca.2019.01.008_bib66","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1243\/09544119JEIM516","article-title":"Mechanical properties of bovine articular cartilage under microscale indentation loading from atomic force microscopy","volume":"223","author":"Park","year":"2009","journal-title":"Proc Inst Mech Eng H"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458419300342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458419300342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:50:29Z","timestamp":1761018629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458419300342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S1063458419300342"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2019.01.008","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734998865.793558220","asserted-by":"object"}]},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in stiffness and biochemical composition of the pericellular matrix as a function of spatial chondrocyte organisation in osteoarthritic cartilage","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2019.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}