{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:50:02Z","timestamp":1793307002550,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T00:00:00Z","timestamp":1596326400000},"content-version":"vor","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.joca.2019.04.009","type":"journal-article","created":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T01:35:05Z","timestamp":1555724105000},"page":"1118-1123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Inflammatory cytokines mediate the effects of diet and exercise on pain and function in knee osteoarthritis independent of BMI"],"prefix":"10.1016","volume":"27","author":[{"given":"J.","family":"Runhaar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.P.","family":"Beavers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.D.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.J.","family":"Nicklas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.F.","family":"Loeser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bierma-Zeinstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.P.","family":"Messier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.joca.2019.04.009_bib1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.semarthrit.2018.06.005","article-title":"Diet-induced weight loss alone or combined with exercise in overweight or obese people with knee osteoarthritis: a systematic review and meta-analysis","volume":"48","author":"Hall","year":"2019","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.04.009_bib2","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1002\/art.20256","article-title":"Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial","volume":"50","author":"Messier","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.04.009_bib3","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1001\/jama.2013.277669","article-title":"Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial","volume":"310","author":"Messier","year":"2013","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.joca.2019.04.009_bib4","first-page":"CD004376","article-title":"Exercise for osteoarthritis of the knee","volume":"1","author":"Fransen","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.joca.2019.04.009_bib5","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.joca.2014.12.027","article-title":"Identifying potential working mechanisms behind the positive effects of exercise therapy on pain and function in osteoarthritis; a systematic review","volume":"23","author":"Runhaar","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2019.04.009_bib6","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/BOR.0b013e32835a9414","article-title":"Osteoarthritis, inflammation and obesity","volume":"25","author":"Berenbaum","year":"2013","journal-title":"Curr Opin Rheumatol"},{"issue":"Suppl 3","key":"10.1016\/j.joca.2019.04.009_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/sms.12581","article-title":"Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases","volume":"25","author":"Pedersen","year":"2015","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.joca.2019.04.009_bib8","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1136\/annrheumdis-2013-204494","article-title":"Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis","volume":"74","author":"Jin","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2019.04.009_bib9","first-page":"2027","article-title":"Inflammatory markers and physical function among older adults with knee osteoarthritis","volume":"31","author":"Penninx","year":"2004","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2019.04.009_bib10","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1136\/bjsports-2016-096489","article-title":"Should exercise therapy for chronic musculoskeletal conditions focus on the anti-inflammatory effects of exercise?","volume":"51","author":"Runhaar","year":"2017","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.joca.2019.04.009_bib11","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.cca.2010.02.069","article-title":"Effect of exercise training on chronic inflammation","volume":"411","author":"Beavers","year":"2010","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.joca.2019.04.009_bib12","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/ajcn\/79.4.544","article-title":"Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial","volume":"79","author":"Nicklas","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.joca.2019.04.009_bib13","first-page":"95","article-title":"Mediation analysis with multiple mediators","volume":"2","author":"VanderWeele","year":"2014","journal-title":"Epidemiol Methods"},{"key":"10.1016\/j.joca.2019.04.009_bib14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1037\/a0031034","article-title":"Mediation analysis allowing for exposure-mediator interactions and causal interpretation: theoretical assumptions and implementation with SAS and SPSS macros","volume":"18","author":"Valeri","year":"2013","journal-title":"Psychol Methods"},{"key":"10.1016\/j.joca.2019.04.009_bib15","first-page":"1833","article-title":"Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy","year":"1988","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2019.04.009_bib16","first-page":"18","article-title":"Exercise and cytokines with particular focus on muscle-derived IL-6","volume":"7","author":"Pedersen","year":"2001","journal-title":"Exerc Immunol Rev"},{"key":"10.1016\/j.joca.2019.04.009_bib17","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/aje\/kwq332","article-title":"Odds ratios for mediation analysis for a dichotomous outcome","volume":"172","author":"Vanderweele","year":"2010","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.joca.2019.04.009_bib18","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1977"},{"key":"10.1016\/j.joca.2019.04.009_bib19","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.joca.2018.01.018","article-title":"Knee extensor strength gains mediate symptom improvement in knee osteoarthritis: secondary analysis of a randomised controlled trial","volume":"26","author":"Hall","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2019.04.009_bib20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s40520-014-0257-4","article-title":"Effects of 8-week combined training on body composition, isokinetic strength, and cardiovascular disease risk factors in older women","volume":"27","author":"Lee","year":"2015","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/j.joca.2019.04.009_bib21","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3109\/14397595.2015.1038425","article-title":"The effect of isokinetic and aerobic exercises on serum interleukin-6 and tumor necrosis factor alpha levels, pain, and functional activity in patients with knee osteoarthritis","volume":"25","author":"Samut","year":"2015","journal-title":"Mod Rheumatol"},{"issue":"1985","key":"10.1016\/j.joca.2019.04.009_bib22","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1152\/japplphysiol.00164.2004","article-title":"The anti-inflammatory effect of exercise","volume":"98","author":"Petersen","year":"2005","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.joca.2019.04.009_bib23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1469-7793.2001.0329c.xd","article-title":"Muscle-derived interleukin-6: possible biological effects","volume":"536","author":"Pedersen","year":"2001","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.joca.2019.04.009_bib24","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1096\/fj.01-0876rev","article-title":"Muscle-derived interleukin-6: mechanisms for activation and possible biological roles","volume":"16","author":"Febbraio","year":"2002","journal-title":"FASEB J"},{"key":"10.1016\/j.joca.2019.04.009_bib25","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1467-9280.2007.01882.x","article-title":"Required sample size to detect the mediated effect","volume":"18","author":"Fritz","year":"2007","journal-title":"Psychol Sci"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458419309410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458419309410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:50:22Z","timestamp":1761018622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458419309410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1063458419309410"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2019.04.009","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory cytokines mediate the effects of diet and exercise on pain and function in knee osteoarthritis independent of BMI","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2019.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}