{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:36:43Z","timestamp":1792654603316,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.joca.2019.05.027","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T11:40:45Z","timestamp":1562326845000},"page":"1800-1810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Accelerated post traumatic osteoarthritis in a dual injury murine model"],"prefix":"10.1016","volume":"27","author":[{"given":"K.","family":"McCulloch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Huesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Dunning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.J.","family":"Litherland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Van \u2018T Hof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Lockhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.S.","family":"Goodyear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.joca.2019.05.027_bib1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1007\/s10067-006-0240-3","article-title":"The burden of musculoskeletal disease--a global perspective","volume":"25","author":"Brooks","year":"2006","journal-title":"Clin Rheumatol"},{"issue":"4","key":"10.1016\/j.joca.2019.05.027_bib2","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0749-8063(97)90124-9","article-title":"Cartilage injuries: a review of 31,516 knee arthroscopies","volume":"13","author":"Curl","year":"1997","journal-title":"Arthrosc J Arthrosc Relat Surg"},{"issue":"7","key":"10.1016\/j.joca.2019.05.027_bib3","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1053\/jars.2002.32839","article-title":"Articular cartilage defects in 1,000 knee arthroscopies","volume":"18","author":"Hjelle","year":"2002","journal-title":"Arthrosc J Arthrosc Relat Surg"},{"issue":"2","key":"10.1016\/j.joca.2019.05.027_bib4","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2016-000279","article-title":"Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation","volume":"2","author":"Punzi","year":"2016","journal-title":"RMD open"},{"issue":"10","key":"10.1016\/j.joca.2019.05.027_bib5","doi-asserted-by":"crossref","first-page":"578","DOI":"10.2519\/jospt.2003.33.10.578","article-title":"Sports, joint injury, and posttraumatic osteoarthritis","volume":"33","author":"Buckwalter","year":"2003","journal-title":"J\u00a0Orthop Sport Phys Ther"},{"issue":"10","key":"10.1016\/j.joca.2019.05.027_bib6","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.joca.2015.05.009","article-title":"Non-invasive mouse models of post-traumatic osteoarthritis","volume":"23","author":"Christiansen","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.joca.2019.05.027_bib7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jbiomech.2014.11.038","article-title":"Chronic changes in the articular cartilage and meniscus following traumatic impact to the lapine knee","volume":"48","author":"Fischenich","year":"2015","journal-title":"J\u00a0Biomech"},{"issue":"4","key":"10.1016\/j.joca.2019.05.027_bib8","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.joca.2016.10.010","article-title":"A\u00a0study of acute and chronic tissue changes in surgical and traumatically-induced experimental models of knee joint injury using magnetic resonance imaging and micro-computed tomography","volume":"25","author":"Fischenich","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"8","key":"10.1016\/j.joca.2019.05.027_bib9","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.joca.2014.05.023","article-title":"Bone-cartilage interface crosstalk in osteoarthritis: potential pathways and future therapeutic strategies","volume":"22","author":"Yuan","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2019.05.027_bib10","doi-asserted-by":"crossref","first-page":"16028","DOI":"10.1038\/boneres.2016.28","article-title":"Bone-cartilage crosstalk: a conversation for understanding osteoarthritis","volume":"4","author":"Findlay","year":"2016","journal-title":"Bone Res"},{"issue":"2","key":"10.1016\/j.joca.2019.05.027_bib11","first-page":"146","article-title":"The infrapatellar fat pad and the synovial membrane: an anatomo-functional unit","volume":"233","author":"Macchi","year":"2018","journal-title":"J\u00a0Anat"},{"issue":"1","key":"10.1016\/j.joca.2019.05.027_bib12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/BOR.0000000000000454","article-title":"Extracellular vesicles in cartilage homeostasis and osteoarthritis","volume":"30","author":"Miyaki","year":"2018","journal-title":"Curr Opin Rheumatol"},{"issue":"2","key":"10.1016\/j.joca.2019.05.027_bib13","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1208\/s12248-013-9454-x","article-title":"Animal models of osteoarthritis: challenges of model selection and analysis","volume":"15","author":"Teeple","year":"2013","journal-title":"AAPS J"},{"issue":"9","key":"10.1016\/j.joca.2019.05.027_bib14","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"10","key":"10.1016\/j.joca.2019.05.027_bib15","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.joca.2014.07.014","article-title":"Rapid, automated imaging of mouse articular cartilage by microCT for early detection of osteoarthritis and finite element modelling of joint mechanics","volume":"22","author":"Das Neves Borges","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"10.1016\/j.joca.2019.05.027_bib16","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1002\/art.38876","article-title":"Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms","volume":"66","author":"Jackson","year":"2014","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"issue":"5","key":"10.1016\/j.joca.2019.05.027_bib17","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/1529-0131(200105)44:5<1082::AID-ANR188>3.0.CO;2-X","article-title":"The splice variants VEGF121 and VEGF189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage","volume":"44","author":"Pufe","year":"2001","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.joca.2019.05.027_bib18","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1136\/annrheumdis-2015-208268","article-title":"Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology","volume":"75","author":"Huesa","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.joca.2019.05.027_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2174\/157339708785133523","article-title":"Animal models of osteoarthritis","volume":"4","author":"Little","year":"2008","journal-title":"Curr Rheumatol Rev"},{"issue":"6","key":"10.1016\/j.joca.2019.05.027_bib20","doi-asserted-by":"crossref","first-page":"064501","DOI":"10.1115\/1.4001111","article-title":"Development of a traumatic anterior cruciate ligament and meniscal rupture model with a pilot in\u00a0vivo study","volume":"132","author":"Isaac","year":"2010","journal-title":"J\u00a0Biomech Eng"},{"issue":"1","key":"10.1016\/j.joca.2019.05.027_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0749-8063(91)90077-B","article-title":"Occult osseous lesions documented by magnetic resonance imaging associated with anterior cruciate ligament ruptures","volume":"7","author":"Rosen","year":"1991","journal-title":"Arthroscopy"},{"issue":"8","key":"10.1016\/j.joca.2019.05.027_bib22","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1002\/art.11088","article-title":"Impact of type of meniscal tear on radiographic and symptomatic knee osteoarthritis: a sixteen-year followup of meniscectomy with matched controls","volume":"48","author":"Englund","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.joca.2019.05.027_bib23","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0736-0266(01)00135-8","article-title":"Chronic changes in rabbit retro-patellar cartilage and subchondral bone after blunt impact loading of the patellofemoral joint","volume":"20","author":"Ewers","year":"2002","journal-title":"J\u00a0Orthop Res"},{"issue":"3","key":"10.1016\/j.joca.2019.05.027_bib24","doi-asserted-by":"crossref","first-page":"R687","DOI":"10.1186\/ar1726","article-title":"The determinants of change in tibial plateau bone area in osteoarthritic knees: a cohort study","volume":"7","author":"Wang","year":"2005","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"10.1016\/j.joca.2019.05.027_bib25","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.joca.2006.05.010","article-title":"Factors affecting tibial plateau expansion in healthy women over 2.5 years: a longitudinal study","volume":"14","author":"Wang","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.joca.2019.05.027_bib26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF01409983","article-title":"The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee","volume":"16","author":"van Osch","year":"1996","journal-title":"Rheumatol Int"},{"issue":"6","key":"10.1016\/j.joca.2019.05.027_bib27","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/art.1780330612","article-title":"The effect of marginal osteophytes on reduction of varus-valgus instability in osteoarthritic knees","volume":"33","author":"Pottenger","year":"1990","journal-title":"Arthritis Rheum"},{"issue":"9","key":"10.1016\/j.joca.2019.05.027_bib28","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/art.1780330904","article-title":"The longitudinal course of hand osteoarthritis in a male population","volume":"33","author":"Kallman","year":"1990","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.joca.2019.05.027_bib29","doi-asserted-by":"crossref","first-page":"W164","DOI":"10.2214\/AJR.17.18664","article-title":"The clinical significance of osteophytes in compartments of the knee joint with normal articular cartilage","volume":"210","author":"Markhardt","year":"2018","journal-title":"Am J Roentgenol"},{"issue":"5","key":"10.1016\/j.joca.2019.05.027_bib30","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1136\/ard.2009.110114","article-title":"Subchondral bone attrition may be a reflection of compartment-specific mechanical load: the MOST Study","volume":"69","author":"Neogi","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 8","key":"10.1016\/j.joca.2019.05.027_bib31","doi-asserted-by":"crossref","first-page":"S847","DOI":"10.1007\/s00198-012-2162-z","article-title":"Subchondral bone and osteoarthritis: biological and cellular aspects","volume":"23","author":"Henrotin","year":"2012","journal-title":"Osteoporos Int : A J Establ Res Coop between Eur Found Osteoporos Natl Osteopor Found USA"},{"issue":"4","key":"10.1016\/j.joca.2019.05.027_bib32","doi-asserted-by":"crossref","first-page":"R152","DOI":"10.1186\/ar3103","article-title":"Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis","volume":"12","author":"Bellido","year":"2010","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"10.1016\/j.joca.2019.05.027_bib33","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/jor.20331","article-title":"Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis","volume":"25","author":"Furman","year":"2007","journal-title":"J\u00a0Orthop Res"},{"issue":"5","key":"10.1016\/j.joca.2019.05.027_bib34","doi-asserted-by":"crossref","first-page":"R139","DOI":"10.1186\/ar2029","article-title":"Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury","volume":"8","author":"Dell'Accio","year":"2006","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"10.1016\/j.joca.2019.05.027_bib35","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/art.23444","article-title":"Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis","volume":"58","author":"Dell'Accio","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"8","key":"10.1016\/j.joca.2019.05.027_bib36","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1002\/art.20369","article-title":"Induction of interleukin-1 in articular cartilage by explantation and cutting","volume":"50","author":"Gruber","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.1016\/j.joca.2019.05.027_bib37","doi-asserted-by":"crossref","first-page":"8259","DOI":"10.1073\/pnas.122033199","article-title":"Basic FGF mediates an immediate response of articular cartilage to mechanical injury","volume":"99","author":"Vincent","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10.1016\/j.joca.2019.05.027_bib38","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F","article-title":"Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets","volume":"44","author":"Pelletier","year":"2001","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.joca.2019.05.027_bib39","first-page":"204","article-title":"Inflammatory synovitis in degenerative joint disease","volume":"9","author":"Goldenberg","year":"1982","journal-title":"J\u00a0Rheumatol"},{"issue":"2","key":"10.1016\/j.joca.2019.05.027_bib40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/art.1780340205","article-title":"Synovial membrane histology and immunopathology in rheumatoid arthritis and osteoarthritis. In\u00a0vivo effects of antirheumatic drugs","volume":"34","author":"Haraoui","year":"1991","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.1016\/j.joca.2019.05.027_bib41","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/ard.52.12.870","article-title":"Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis","volume":"52","author":"Farahat","year":"1993","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.joca.2019.05.027_bib42","first-page":"365","article-title":"Synovial membrane inflammation and cytokine production in patients with early osteoarthritis","volume":"24","author":"Smith","year":"1997","journal-title":"J\u00a0Rheumatol"},{"issue":"10","key":"10.1016\/j.joca.2019.05.027_bib43","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1007\/s00296-011-2102-9","article-title":"Correlation of protease-activated receptor-2 expression and synovitis in rheumatoid and osteoarthritis","volume":"32","author":"Tindell","year":"2012","journal-title":"Rheumatol Int"},{"issue":"3","key":"10.1016\/j.joca.2019.05.027_bib44","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.joca.2008.07.016","article-title":"Evaluation of a Photographic Chondropathy Score (PCS) for pathological samples in a study of inflammation in tibiofemoral osteoarthritis","volume":"17","author":"Walsh","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.joca.2019.05.027_bib45","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/art.1780400419","article-title":"Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease","volume":"40","author":"Spector","year":"1997","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.joca.2019.05.027_bib46","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/ard.2004.029892","article-title":"Value of C reactive protein in the assessment of erosive osteoarthritis of the hand","volume":"64","author":"Punzi","year":"2005","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"10.1016\/j.joca.2019.05.027_bib47","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/art.24654","article-title":"Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis","volume":"60","author":"Chia","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.joca.2019.05.027_bib48","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pain.2006.12.022","article-title":"Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation","volume":"128","author":"Ivanavicius","year":"2007","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.joca.2019.05.027_bib49","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1136\/ard.57.7.395","article-title":"Correlation between radiographically diagnosed osteophytes and magnetic resonance detected cartilage defects in the patellofemoral joint","volume":"57","author":"Boegard","year":"1998","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.joca.2019.05.027_bib50","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.joca.2005.11.012","article-title":"High signal in knee osteophytes is not associated with knee pain","volume":"14","author":"Sengupta","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.joca.2019.05.027_bib51","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/art.39488","article-title":"Association of joint inflammation with pain sensitization in knee osteoarthritis: the multicenter osteoarthritis study","volume":"68","author":"Neogi","year":"2016","journal-title":"Arthritis Rheumatol"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458419311148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458419311148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:52:23Z","timestamp":1761018743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458419311148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S1063458419311148"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2019.05.027","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Accelerated post traumatic osteoarthritis in a dual injury murine model","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2019.05.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}