{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:48:13Z","timestamp":1780480093224,"version":"3.54.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001279","name":"Orthopaedic Research and Education Foundation","doi-asserted-by":"publisher","award":["18-002"],"award-info":[{"award-number":["18-002"]}],"id":[{"id":"10.13039\/100001279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA091842"],"award-info":[{"award-number":["P30 CA091842"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000448"],"award-info":[{"award-number":["UL1 TR000448"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30-AR073752"],"award-info":[{"award-number":["P30-AR073752"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30-AR074992"],"award-info":[{"award-number":["P30-AR074992"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R00- AR064837"],"award-info":[{"award-number":["R00- AR064837"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P41 GM103422"],"award-info":[{"award-number":["P41 GM103422"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007930","name":"Institute of Clinical and Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG15768"],"award-info":[{"award-number":["AG15768"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG46927"],"award-info":[{"award-number":["AG46927"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.joca.2019.08.002","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T11:09:37Z","timestamp":1566040177000},"page":"1778-1789","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Proteomic analysis of synovial fluid identifies periostin as a biomarker for anterior cruciate ligament injury"],"prefix":"10.1016","volume":"27","author":[{"given":"R.H.","family":"Brophy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.R.","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Nunley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Guilak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4826-4331","authenticated-orcid":false,"given":"M.F.","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2019.08.002_bib1","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/art.24021","article-title":"Lifetime risk of symptomatic knee osteoarthritis","volume":"59","author":"Murphy","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.08.002_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1478-7954-4-11","article-title":"The burden of disease and injury in the United States 1996","volume":"4","author":"Michaud","year":"2006","journal-title":"Popul Health Metrics"},{"key":"10.1016\/j.joca.2019.08.002_bib3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.rdc.2014.07.012","article-title":"Identifying and treating preclinical and early osteoarthritis","volume":"40","author":"Felson","year":"2014","journal-title":"Rheum Dis Clin N Am"},{"key":"10.1016\/j.joca.2019.08.002_bib4","first-page":"285","article-title":"Pathogenetic mechanisms of posttraumatic osteoarthritis: opportunities for early intervention","volume":"4","author":"Kramer","year":"2011","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.joca.2019.08.002_bib5","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/jor.21359","article-title":"Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention","volume":"29","author":"Anderson","year":"2011","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.joca.2019.08.002_bib6","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.joca.2005.08.005","article-title":"Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament","volume":"14","author":"Nelson","year":"2006","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.08.002_bib7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1063-4584(05)80017-2","article-title":"Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age","volume":"3","author":"Roos","year":"1995","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.08.002_bib8","doi-asserted-by":"crossref","first-page":"e104681","DOI":"10.1371\/journal.pone.0104681","article-title":"Cruciate ligament reconstruction and risk of knee osteoarthritis: the association between cruciate ligament injury and post-traumatic osteoarthritis. a population based nationwide study in Sweden, 1987-2009","volume":"9","author":"Nordenvall","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2019.08.002_bib9","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1177\/0363546507307396","article-title":"The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis","volume":"35","author":"Lohmander","year":"2007","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.joca.2019.08.002_bib10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3892\/br.2014.404","article-title":"Posttraumatic knee osteoarthritis following anterior cruciate ligament injury: potential biochemical mediators of degenerative alteration and specific biochemical markers","volume":"3","author":"Li","year":"2015","journal-title":"Biomed Rep"},{"key":"10.1016\/j.joca.2019.08.002_bib11","doi-asserted-by":"crossref","first-page":"9387809","DOI":"10.1155\/2018\/9387809","article-title":"Select biomarkers on the day of anterior cruciate ligament reconstruction predict poor patient-reported outcomes at 2-year follow-up: a pilot study","volume":"2018","author":"Lattermann","year":"2018","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.joca.2019.08.002_bib12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.joca.2018.01.017","article-title":"Molecular influence of anterior cruciate ligament tear remnants on chondrocytes: a biologic connection between injury and osteoarthritis","volume":"26","author":"Chinzei","year":"2018","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.08.002_bib13","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1302\/0301-620X.89B8.19000","article-title":"Revision anterior cruciate ligament reconstruction: timing of surgery and the incidence of meniscal tears and degenerative change","volume":"89","author":"Ohly","year":"2007","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.joca.2019.08.002_bib14","doi-asserted-by":"crossref","DOI":"10.1177\/0363546517749834","article-title":"Synovial fluid profile at the time of anterior cruciate ligament reconstruction and its association with cartilage matrix composition 3 Years after surgery","author":"Amano","year":"2018","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.joca.2019.08.002_bib15","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1177\/0363546516643810","article-title":"Changes in transcriptome-wide gene expression of anterior cruciate ligament tears based on time from injury","volume":"44","author":"Brophy","year":"2016","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.joca.2019.08.002_bib16","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1359\/jbmr.1999.14.7.1239","article-title":"Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta","volume":"14","author":"Horiuchi","year":"1999","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.joca.2019.08.002_bib17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1196\/annals.1420.005","article-title":"Neonatal and adult cardiovascular pathophysiological remodeling and repair: developmental role of periostin","volume":"1123","author":"Norris","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.joca.2019.08.002_bib18","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/jcb.20115","article-title":"Expression and function of periostin-isoforms in bone","volume":"92","author":"Litvin","year":"2004","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.joca.2019.08.002_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00441-007-0439-x","article-title":"Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development","volume":"330","author":"Yoshiba","year":"2007","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.joca.2019.08.002_bib20","doi-asserted-by":"crossref","first-page":"14472","DOI":"10.1073\/pnas.0706793104","article-title":"Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue","volume":"104","author":"Roy","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2019.08.002_bib21","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jcb.21224","article-title":"Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues","volume":"101","author":"Norris","year":"2007","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.joca.2019.08.002_bib22","doi-asserted-by":"crossref","first-page":"e78347","DOI":"10.1371\/journal.pone.0078347","article-title":"Periostin deficiency increases bone damage and impairs injury response to fatigue loading in adult mice","volume":"8","author":"Bonnet","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2019.08.002_bib23","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1096\/fj.15-272427","article-title":"Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13","volume":"29","author":"Attur","year":"2015","journal-title":"FASEB J"},{"key":"10.1016\/j.joca.2019.08.002_bib24","doi-asserted-by":"crossref","first-page":"6096","DOI":"10.1021\/pr501024p","article-title":"Quantitative proteomic profiling of human articular cartilage degradation in osteoarthritis","volume":"13","author":"Lourido","year":"2014","journal-title":"J\u00a0Proteome Res"},{"key":"10.1016\/j.joca.2019.08.002_bib25","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jbspin.2015.01.023","article-title":"Association of plasma and synovial fluid periostin with radiographic knee osteoarthritis: cross-sectional study","volume":"82","author":"Honsawek","year":"2015","journal-title":"Jt Bone Spine"},{"key":"10.1016\/j.joca.2019.08.002_bib26","first-page":"69","article-title":"Influence of periostin on synoviocytes in knee osteoarthritis","volume":"31","author":"Tajika","year":"2017","journal-title":"In\u00a0Vivo"},{"key":"10.1016\/j.joca.2019.08.002_bib27","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/art.39677","article-title":"Acute molecular changes in synovial fluid following human knee injury: association with early clinical outcomes","volume":"68","author":"Watt","year":"2016","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.08.002_bib28","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/art.37823","article-title":"Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues","volume":"65","author":"Ritter","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.08.002_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12014-016-9113-1","article-title":"Synovial fluid proteome in rheumatoid arthritis","volume":"13","author":"Bhattacharjee","year":"2016","journal-title":"Clin Proteonomics"},{"key":"10.1016\/j.joca.2019.08.002_bib30","first-page":"1919845","article-title":"Ligament-derived stem cells: identification, characterisation, and therapeutic application","volume":"2017","author":"Lee","year":"2017","journal-title":"Stem Cell Int"},{"key":"10.1016\/j.joca.2019.08.002_bib31","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1089\/ten.tea.2010.0413","article-title":"Mesenchymal stem cell characteristics of human anterior cruciate ligament outgrowth cells","volume":"17","author":"Steinert","year":"2011","journal-title":"Tissue Eng A"},{"key":"10.1016\/j.joca.2019.08.002_bib32","doi-asserted-by":"crossref","first-page":"8386","DOI":"10.1096\/fj.201802281R","article-title":"Distinct expression pattern of periostin splice variants in chondrocytes and ligament progenitor cells","volume":"33","author":"Cai","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.joca.2019.08.002_bib33","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2106\/JBJS.K.00919","article-title":"Molecular analysis of age and sex-related gene expression in meniscal tears with and without a concomitant anterior cruciate ligament tear","volume":"94","author":"Brophy","year":"2012","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.joca.2019.08.002_bib34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12891-015-0682-3","article-title":"Expression and pathological effects of periostin in human osteoarthritis cartilage","volume":"16","author":"Chijimatsu","year":"2015","journal-title":"BMC Muscoskelet Disord"},{"key":"10.1016\/j.joca.2019.08.002_bib35","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.joca.2015.05.015","article-title":"Serum periostin is associated with prevalent knee osteoarthritis and disease incidence\/progression in women: the OFELY study","volume":"23","author":"Rousseau","year":"2015","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.08.002_bib36","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13569-018-0105-y","article-title":"Periostin expression in neoplastic and non-neoplastic diseases of bone and joint","volume":"8","author":"Brown","year":"2018","journal-title":"Clin Sarcoma Res"},{"key":"10.1016\/j.joca.2019.08.002_bib37","doi-asserted-by":"crossref","first-page":"R190","DOI":"10.1186\/ar4380","article-title":"Genome-wide expression profiles of subchondral bone in osteoarthritis","volume":"15","author":"Chou","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2019.08.002_bib38","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.joca.2012.11.016","article-title":"Direct assessment of articular cartilage and underlying subchondral bone reveals a progressive gene expression change in human osteoarthritic knees","volume":"21","author":"Chou","year":"2013","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.08.002_bib39","doi-asserted-by":"crossref","first-page":"e32356","DOI":"10.1371\/journal.pone.0032356","article-title":"Gene expression analyses of subchondral bone in early experimental osteoarthritis by microarray","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2019.08.002_bib40","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.joca.2017.12.004","article-title":"Transcriptome comparison of meniscus from patients with and without osteoarthritis","volume":"26","author":"Brophy","year":"2018","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.08.002_bib41","doi-asserted-by":"crossref","first-page":"e96526","DOI":"10.1371\/journal.pone.0096526","article-title":"Proteomic differences between male and female anterior cruciate ligament and patellar tendon","volume":"9","author":"Little","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2019.08.002_bib42","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/dbio.1998.8988","article-title":"Roles of transforming growth factor-alpha and epidermal growth factor in chick limb development","volume":"202","author":"Dealy","year":"1998","journal-title":"Dev Biol"},{"key":"10.1016\/j.joca.2019.08.002_bib43","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1083\/jcb.121.6.1433","article-title":"SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway","volume":"121","author":"Tremble","year":"1993","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.joca.2019.08.002_bib44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.joca.2007.06.013","article-title":"Gene expression profiling of normal and ruptured canine anterior cruciate ligaments","volume":"16","author":"Clements","year":"2008","journal-title":"Osteoarthr Cartil"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458419311720?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458419311720?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:56:06Z","timestamp":1778586966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458419311720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S1063458419311720"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2019.08.002","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic analysis of synovial fluid identifies periostin as a biomarker for anterior cruciate ligament injury","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2019.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}